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MSATPDPREVTRGLLTEPGDLRHGFLDVLGESTSSPVPTVAQRAMNSRFVATVYERLWRPAAFYLASGVT TRAEQHRAAAALHLSTAHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDISEPMLTRAVLDNSGPQTCYVR GDARMLPFDDETFDAVCCFGALYLMPEPFRIAREMVRVLGPGGRIAILTTYSGQRAPIRHALDAAAGAIG LTMFDQDSFVDLFSSAGLVDIDQQTQRGLQFVVAAKPK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4668 | - | - | 100% (248) | methyltransferase |
| M. ulcerans Agy99 | MUL_2377 | - | 3e-12 | 38.89% (108) | methyltransferase |
| M. ulcerans Agy99 | MUL_2765 | - | 3e-11 | 33.62% (116) | methyltransferase (methylase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2976 | - | 1e-11 | 37.96% (108) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_0738 | - | 8e-29 | 34.63% (231) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv2952 | - | 1e-11 | 37.96% (108) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_00130 | - | 5e-13 | 38.74% (111) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4018 | - | 6e-40 | 40.17% (234) | similarity with UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_4497 | - | 1e-139 | 99.19% (248) | methyltransferase |
| M. avium 104 | MAV_5229 | - | 2e-23 | 38.31% (154) | methyltransferase type 11 |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 6e-31 | 37.12% (229) | methyltransferase |
| M. thermoresistible (build 8) | TH_1636 | - | 2e-10 | 35.97% (139) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 7e-29 | 36.67% (240) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4668|M.ulcerans_Agy99 -----MSATPDPRE--VTRGLLTEPGDLRHGFLDVLG-----ESTSSPVP
MMAR_4497|M.marinum_M -----MSATPDPRE--VTRGLLTEPCDLRRGFLDVLG-----ESTSSPVP
MAB_4018|M.abscessus_ATCC_1997 -----MLHHPTLADSLIDPARIDHPPRRDHGYLDVLG-----PESDEPVS
MAV_5229|M.avium_104 MTDVHTSLPPALRRALDLLIDPPADPDVSKGYLDLLGGAADEDAGVPRNT
MSMEG_0098|M.smegmatis_MC2_155 -------MDTALRRAMDLLIDPPAEPDFSKGYLDLLG---RGDSTAPKNT
Mflv_0738|M.gilvum_PYR-GCK ------MTESALRMAERLLADPPEHPDVSKGYLDLLG------DRPAGDA
Mvan_0109|M.vanbaalenii_PYR-1 ------MTHTVLRMTERLLIDPPEHPDTSKGYLDLLG------DEPDSNR
Mb2976|M.bovis_AF2122/97 ------MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTR----GLGNDEIV
Rv2952|M.tuberculosis_H37Rv ------MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTR----GLGNDEIV
MLBr_00130|M.leprae_Br4923 ------MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTH----KLGTDEIM
TH_1636|M.thermoresistible__bu --------VRESRDQVFRKLNEKLTQHGQKFIYSYASR----RLDDDDVV
:
MUL_4668|M.ulcerans_Agy99 TVAQRAMNSRFVATVYERLWRPAAF--YLASGVTTRAEQHRAAAALHLST
MMAR_4497|M.marinum_M TVAQRAMNSRFVATVYERLWRPAAF--YLASGVTTRAEQHRAAAALHLST
MAB_4018|M.abscessus_ATCC_1997 -VANRFMQSPLLAAIYERAWRPMFTRGFSYGGKSTLKAHTALMDEIAGRG
MAV_5229|M.avium_104 GPIQAAWASPIGSLLYDNAQALSRR---------WISAWQLPLEWLQIPR
MSMEG_0098|M.smegmatis_MC2_155 GLIQKAWASPLGSKLYDRAQLLNRR---------LVASTRPPVEWLRIPP
Mflv_0738|M.gilvum_PYR-GCK GAIQALWASRLGSLFYDNAQTVMRR---------VLTAWHEPTEWLNLPV
Mvan_0109|M.vanbaalenii_PYR-1 GAIQALWASRLGSMFYDNAQTLARR---------LMTAWQQPTEWLNVPV
Mb2976|M.bovis_AF2122/97 FINWAYEEDPPMDLPLEASDEPNRA---------HINLYHRTATQVDLG-
Rv2952|M.tuberculosis_H37Rv FINWAYEEDPPMDLPLEASDEPNRA---------HINLYHRTATQVDLG-
MLBr_00130|M.leprae_Br4923 FINWAYEEDPPMALPLEASDEPNRA---------HINLYHRTATQVNLS-
TH_1636|M.thermoresistible__bu FLNYGYEEDPPMGLPLSETDEPNRY---------SIQLYHRTAGQADLT-
. .
MUL_4668|M.ulcerans_Agy99 AHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDISEPMLTRAVLDNSGPQT
MMAR_4497|M.marinum_M AHRLLDVACGPGNFTAPLVKQLPAGSLAVGLDISEPMLTRAVLDNSGPQT
MAB_4018|M.abscessus_ATCC_1997 DHKILDVACGPGLYTRELAAQLGTAGVCIGLDLSGPMLRRAVRDNSAERV
MAV_5229|M.avium_104 GGVALDVGSGPGNVTASLARAAGPDGLALGIDISEPMLARAVRNEAGPQV
MSMEG_0098|M.smegmatis_MC2_155 GGTVLDIGCGPGNITAQLARAAGLDGLALGVDISEPMLARAVAAEAGRQV
Mflv_0738|M.gilvum_PYR-GCK GGVALDVGSGPGNVTAALGRAVGPGGLALGVDVSEPMLARAVAAEAGPNV
Mvan_0109|M.vanbaalenii_PYR-1 GGTALDVGSGPGNVTGALGRAVGPGGLALGVDISEPMLARAVRAEAGPNV
Mb2976|M.bovis_AF2122/97 GKQVLEVSCGHGGGASYLTRTLHP-ASYTGLDLNQAGIKLCKKRHRLPGL
Rv2952|M.tuberculosis_H37Rv GKQVLEVSCGHGGGASYLTRTLHP-ASYTGLDLNQAGIKLCKKRHRLPGL
MLBr_00130|M.leprae_Br4923 GKRILEVSCGHGGGASYLTRALHP-ASYTGLDLNPAGIKLCQKRHQLPGL
TH_1636|M.thermoresistible__bu GKRVLEVGCGHGGGASYLMRTLGP-MSYVGLDLNPAGIEFCRKKHRLPGL
*::..* * : * *:*:. . : . .
MUL_4668|M.ulcerans_Agy99 CYVRGDARMLPFDDETFDAVCCFGALYLMPEPFRIAREMVRVLGPGGRIA
MMAR_4497|M.marinum_M CYVRGDARMLPFDDETFDAVCCFGALYLMPEPFRIAREMVRVLGPGGRIA
MAB_4018|M.abscessus_ATCC_1997 DYIRGSAHSLPFADATFDTVVCLAALYLIPDPEQAVRELCRVAGPDGQIV
MAV_5229|M.avium_104 GFIKADAQRLPLRDNTVDAAVSTAVLQLVPNPQAALVEIARVLRPGGRLA
MSMEG_0098|M.smegmatis_MC2_155 GFVRADAQQLPFRDEVFDAATSLAVFQLIPDPVAAVSEIVRVLKPGGRVA
Mflv_0738|M.gilvum_PYR-GCK GFLRADAQDLPLSDESVDGVVSIAMLQLIPEPARAVAEMVRVLRSGRRVA
Mvan_0109|M.vanbaalenii_PYR-1 GFIRADAQHLPFRDESFDAVVSIAMLQLIPDPAVALAEMVRVLRPGRRMA
Mb2976|M.bovis_AF2122/97 DFVRGDAENLPFDDESFDVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFP
Rv2952|M.tuberculosis_H37Rv DFVRGDAENLPFDDESFDVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFP
MLBr_00130|M.leprae_Br4923 EFVRGDAENLPFDNESFDVVINIEASHCYPHFPRFLAEVVRVLRPGGHLA
TH_1636|M.thermoresistible__bu EFVVGDAQDLPFGAESFDAVINIESSHLYPRFSRFLSEVARVLRPGGHFL
:: ..*. **: .* . * *: ** .. .
MUL_4668|M.ulcerans_Agy99 ILTTYSGQRAPIRHALDAAAGA--IGLTMFDQDSFVDLFSSAG-LVDIDQ
MMAR_4497|M.marinum_M ILTTYSGQRAPIRHALDAAAGA--IGLTMFDQDSFVDLFSSAG-LVDIDQ
MAB_4018|M.abscessus_ATCC_1997 VFTSLR-TRAASLPGVTTAMRI--GGFRAFGRDEVTGWLRAQG-WTDIDQ
MAV_5229|M.avium_104 VMVPTAGRLARYWRLLPNVG------AHAFDDDEIGDILEENG-FASVRV
MSMEG_0098|M.smegmatis_MC2_155 IMVPTAG-AVKPVTFLARGG------ARIFGDDELGDIFENVG-LVGVRV
Mflv_0738|M.gilvum_PYR-GCK VMVPTAGPAAAALRYLPHAG------AHSFGDDELADVFEGLG-LTSVRA
Mvan_0109|M.vanbaalenii_PYR-1 VMVPTAGPAAGLLRYLPNAG------AHAFGDDELGDTFESLG-LAGVRI
Mb2976|M.bovis_AF2122/97 YADLRPNNEIAAWEADLAATPLRQLSQRQINAEVLRGIGNNSQKSRDLVD
Rv2952|M.tuberculosis_H37Rv YADLRPNNEIAAWEADLAATPLRQLSQRQINAEVLRGIGNNSQKSRDLVD
MLBr_00130|M.leprae_Br4923 YADLRPSNKVGEWEVDFANSRLQQLSQREINAEVLRGIASNSQKSRDLVD
TH_1636|M.thermoresistible__bu YADARQPHEFAEWEAALAAAPLDMVSARVINAEVVRGMEQILPVWEDVIE
:. : . . .:
MUL_4668|M.ulcerans_Agy99 QTQRGLQFVVAAKPK---------------------------------
MMAR_4497|M.marinum_M QTQRGLQFVVAAKPK---------------------------------
MAB_4018|M.abscessus_ATCC_1997 TVTGQGQFIRARRAVALRVAT---------------------------
MAV_5229|M.avium_104 KNFGTFQWVR-AKLS---------------------------------
MSMEG_0098|M.smegmatis_MC2_155 KTHGFIQWVRGTKL----------------------------------
Mflv_0738|M.gilvum_PYR-GCK NTVGTIQWVRGKKP----------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 NTVGTIQWVRGRKS----------------------------------
Mb2976|M.bovis_AF2122/97 RHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD-------
Rv2952|M.tuberculosis_H37Rv RHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD-------
MLBr_00130|M.leprae_Br4923 RHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYSFAKD-------
TH_1636|M.thermoresistible__bu RVAPAFLRRRVREFAPARRAWEELRTEG-STEYRMYCFTKPPEHADIP
.