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AERAGAQRRVALITGASRGLGFASAVRLYREGWGVVAAMRTPERGMPRLREATGASEDDDRLVGVQLDLM DAASIAAAAKSIDEAVGAPYAVVHNAGISAAGVVEETDIELWERMFTTHVMGPVALTKALLPSMRAAGQG RIVLVSSASGVRGQPATAPYSAAKGALERWGEAMAVEIAPFGLGVTILVTGTYDTDIITDAGTTDNRDLA GPYARIHQTMDSRGRFAMGMARPPERFTDGLVKALEDTAAFRRHGVGPDASMLLLSNRILPAAGMHHMSR VVLGIPRQGAMRDGAWPLTTAQRAMVAAAKVIPQPVMQRLVQWSTRRAAGSGGGTSEG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4152 | - | - | 100% (339) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_5243 | - | 5e-27 | 33.08% (260) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0295 | - | 2e-23 | 36.17% (188) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3083c | - | 5e-22 | 34.20% (193) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3057c | - | 5e-22 | 34.20% (193) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 2e-18 | 28.97% (290) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 4e-27 | 33.21% (268) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4002 | - | 2e-26 | 29.63% (297) | dehydrogenase/decarboxylase protein |
| M. avium 104 | MAV_1273 | - | 1e-143 | 76.31% (325) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_0524 | - | 1e-24 | 35.29% (221) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3605 | - | 1e-102 | 65.19% (293) | PUTATIVE NAD dependent epimerase/dehydratase family protein |
| M. ulcerans Agy99 | MUL_2794 | - | 2e-25 | 30.47% (279) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1012 | - | 2e-24 | 31.54% (260) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4152|M.gilvum_PYR-GCK ---MAERAGAQRRVALITGASRGLGFASAVRLYREGWGVVAAMRTPERGM
MAV_1273|M.avium_104 ---MAE-----PRSVVITGASRGLGFASALRMYREGWRVVAAMRTPDQGM
TH_3605|M.thermoresistible__bu ---VTDRQPAGPRSVVITGASRGLGLASATHLYRRGWRVVAAMRSVDAGM
MAB_1305|M.abscessus_ATCC_1997 --------MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSR---NPD
MMAR_4002|M.marinum_M -------MSCTRQHVVVTGASSGIGRSTALRLASAGWHVYAGVRRAADGE
MUL_2794|M.ulcerans_Agy99 -------MTSTPPVALITGVSSGIGAAIAVRLASAGFRVVGTSRAPQR--
Mvan_1012|M.vanbaalenii_PYR-1 -------MTT----VLITGCSSGYGLATAHRFLDEGWNVVATMRTPRQDV
Mb3083c|M.bovis_AF2122/97 MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRDGLA
Rv3057c|M.tuberculosis_H37Rv MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRDGLA
MSMEG_0524|M.smegmatis_MC2_155 -----------MTVWFITGASRGLGAQIARTALDHGADVAVGVRNPDLLP
MLBr_01094|M.leprae_Br4923 ------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLA
.:** . * * * * :
Mflv_4152|M.gilvum_PYR-GCK PRLR----EATGASEDDDRLVGVQLDLMDAASIAAAAKSIDEAVGAP--Y
MAV_1273|M.avium_104 PLLRRAIRDGTGQDPDDDRLIGVQLDLTDSASVAAAAKAIEEAVGAP--Y
TH_3605|M.thermoresistible__bu ARLA----ETTGAAADDPRLIPVALDLTDAASITAAAKEIEGSVGAP--Y
MAB_1305|M.abscessus_ATCC_1997 TITD---------RVPG--VQYLRLDQTDKASIAECV------AQAGEVD
MMAR_4002|M.marinum_M ALQA---------ASSGGQLSPLLMDVTVAEQIDAAVGIVCEHIGAAGLD
MUL_2794|M.ulcerans_Agy99 LAPIP-------------GVETLALDVTDDTAVRSVVSEVIDRTGHID--
Mvan_1012|M.vanbaalenii_PYR-1 LPPSD-------------RLRVIALDVTRPDSIAAAVAA----AGPID--
Mb3083c|M.bovis_AF2122/97 QTVCDAR------ALGAQVPEHRVLDVSDYQDVAAFAADIHARHPSMD--
Rv3057c|M.tuberculosis_H37Rv QTVCDAR------ALGAQVPEHRVLDVSDYQDVAAFAADIHARHPSMD--
MSMEG_0524|M.smegmatis_MC2_155 SDIAER-------------AFAVRLDVTHDADISAAVAAVVERFGRID--
MLBr_01094|M.leprae_Br4923 QTEGQLK-------AIGASARTDRLDVTEREAFLTYADVVHENFGKVN--
:* . .
Mflv_4152|M.gilvum_PYR-GCK AVVHNAGISAAGVVEETDIELWERMFTTHVMGPVALTKALLPSMRAAGQG
MAV_1273|M.avium_104 AIVHNAGISAAGMVEETDTALWQRMFATSVLGPVALTQALLPSMRAAGRG
TH_3605|M.thermoresistible__bu AVVHNAGISAAGMVEETPLSLWEQMFATTVFGPVALTRELLPGMRRAGRG
MAB_1305|M.abscessus_ATCC_1997 ILVNNAGESQIGALEDVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRG
MMAR_4002|M.marinum_M GLVDNAGIGVASPVEMVPLDALRQQLEVNVVGQIAVTQAFLPLLR-RAAG
MUL_2794|M.ulcerans_Agy99 VLVNNAGLGIAGAAEESSIDQARSLFDTNFFGLIRLTNEVLPHMRRRGSG
Mvan_1012|M.vanbaalenii_PYR-1 VLVNNAGIGAVGAFEATPMQTVRELFDTNTFGVMAMTQAVVPQMRARRSG
Mb3083c|M.bovis_AF2122/97 VVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRG
Rv3057c|M.tuberculosis_H37Rv VVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRG
MSMEG_0524|M.smegmatis_MC2_155 VLVNNAGRGLLGALEEVTDAEARSLFDLNVFGLINVTRAVLPHMRASGGG
MLBr_01094|M.leprae_Br4923 QIYNNAGIAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDG
: . ** . . : * : . .:* : *
Mflv_4152|M.gilvum_PYR-GCK R-IVLVSSASGVRGQPATAPYSAAKGALERWGEAMAVEIAPFG--LGVTI
MAV_1273|M.avium_104 R-IVLVSSAAGVRGQPGTAPYSAAKGALERWGESLAGEIAPFG--LGVTV
TH_3605|M.thermoresistible__bu R-IVLVSSQQGVWGMPSTAPYSAAKGALERWAEAMAGEVNPFG--IGVTV
MAB_1305|M.abscessus_ATCC_1997 A-VVMVGSMAGTLHVPFRSTYSSAKSALHTVADCLRYEVAPFG--ITVST
MMAR_4002|M.marinum_M R-IVVIASIGDRFTPPFGGPLAASKAAIATLADALRQEVAPWG--IKVVM
MUL_2794|M.ulcerans_Agy99 R-IINISSVLGFLPAPYAALYAASKHAVEGYTESLDHELREYG--VRALL
Mvan_1012|M.vanbaalenii_PYR-1 V-VVNVTSSVTLAAMPLAAAYTASKAAIEGFTGSLALELGFFG--VRAKL
Mb3083c|M.bovis_AF2122/97 GHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHG--IGVSV
Rv3057c|M.tuberculosis_H37Rv GHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHG--IGVSV
MSMEG_0524|M.smegmatis_MC2_155 K-LVHIGSRSGFEGEPGVGLYSASKFAVAGISEALSAELAPFG--IQSMV
MLBr_01094|M.leprae_Br4923 H-VINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTT
:: : * * . ::* .: : :: * :
Mflv_4152|M.gilvum_PYR-GCK LVTGTYDTDIITDAGTTD-------NRDLAGPYARIHQTMDSRGRFAMG-
MAV_1273|M.avium_104 LVAGTYDTEIITDAGTTD-------DRNFSGPYARLHTTMNTRGRLAVS-
TH_3605|M.thermoresistible__bu LVTGVYDTEIITDAGTTD-------CRDLQGVYARHHRTMDKRGRAAVAK
MAB_1305|M.abscessus_ATCC_1997 VEPGVIATGIETRRNR--------IVPDGS-PYRDAFRTVDAAMAAREE-
MMAR_4002|M.marinum_M IEPASINSGAADKLERDAKKAIDEFGADGARLYRDAYLGMVKAALSRER-
MUL_2794|M.ulcerans_Agy99 VEPSYTR-TDFESN---------MWEADTPQAAYADNRAAVRAVVANKIR
Mvan_1012|M.vanbaalenii_PYR-1 VEPGYGPGTQFASNGS-------HRMADLIPDEYQDFAAPIMESFG-SPA
Mb3083c|M.bovis_AF2122/97 VVPGAVKTPLVNTVEIAG---------------VDRDDPRVNRWVERFSG
Rv3057c|M.tuberculosis_H37Rv VVPGAVKTPLVNTVEIAG---------------VDRDDPRVNRWVERFSG
MSMEG_0524|M.smegmatis_MC2_155 VEPGVFRTDFLDGSSLSMP------ANRIDAYDGTPAHDTLDWVDDANHT
MLBr_01094|M.leprae_Br4923 VYPGGIKTAIARNATAAEG-----------------LDVSKIASRFDTWV
: ..
Mflv_4152|M.gilvum_PYR-GCK MARPPERFTDGLVKALEDTAAFRRHGVGPDASMLLLSNRILPAAGMHHMS
MAV_1273|M.avium_104 FARPPERFTDGLCKALDDRAPFRRRGVGPDASMLLAANRILPASGMHHLS
TH_3605|M.thermoresistible__bu AARPPEKFALALSKALDNPQPFVKRPAGPSARMLMIANRILPPATLHQMI
MAB_1305|M.abscessus_ATCC_1997 HGTATDELGRLVVDVALSPSPKPLYAKGSNAPIIMTAQRLLPARLFLKFL
MMAR_4002|M.marinum_M RGSPPTVVADLVLKVLTMARPHARNVVGKDARMLATVSRWLPTPALDALR
MUL_2794|M.ulcerans_Agy99 NAELPAVVADATYAAAIDKRIKLRYPAGRHARQLALLKRIAPAAVLDNGI
Mvan_1012|M.vanbaalenii_PYR-1 AVTTPDDVAEVVYLAATDASDRLRYAAGADAVALAQ--------------
Mb3083c|M.bovis_AF2122/97 HAVTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRV
Rv3057c|M.tuberculosis_H37Rv HAVTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRV
MSMEG_0524|M.smegmatis_MC2_155 QLGDPVKGAALIYEVANEDKLPRHLLLGRDAVERWRVKAAQMADDVTAWE
MLBr_01094|M.leprae_Br4923 AHTSPQHAARIILKAVRKKK--ARVLVGPDAKVANVVVRFSGGAGYQRLF
. . *
Mflv_4152|M.gilvum_PYR-GCK RVVLGIPRQGAMRDGAWPLTTAQRAMVAAAKVIPQPVMQRLVQWS---TR
MAV_1273|M.avium_104 RVVLGIPRQGSMRDGAWPLTHGQRAMVLVARVLPQPVLQRLAALAGRFSS
TH_3605|M.thermoresistible__bu RLSLGLPRFG-------RLTTREDTHA-----------------------
MAB_1305|M.abscessus_ATCC_1997 ARMHGLKVR-----------------------------------------
MMAR_4002|M.marinum_M RRVFGLPKPGSLAISRSA--------------------------------
MUL_2794|M.ulcerans_Agy99 RKQTGLNSPRPTPVLAER--------------------------------
Mvan_1012|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3083c|M.bovis_AF2122/97 NVFFTRALRPGP--------------------------------------
Rv3057c|M.tuberculosis_H37Rv NVFFTRALRPGP--------------------------------------
MSMEG_0524|M.smegmatis_MC2_155 MKSLATAHLA----------------------------------------
MLBr_01094|M.leprae_Br4923 AQVASRLILNQR--------------------------------------
Mflv_4152|M.gilvum_PYR-GCK RAAGSGGGTSEG
MAV_1273|M.avium_104 PKSAARQGDQEG
TH_3605|M.thermoresistible__bu ------------
MAB_1305|M.abscessus_ATCC_1997 ------------
MMAR_4002|M.marinum_M ------------
MUL_2794|M.ulcerans_Agy99 ------------
Mvan_1012|M.vanbaalenii_PYR-1 ------------
Mb3083c|M.bovis_AF2122/97 ------------
Rv3057c|M.tuberculosis_H37Rv ------------
MSMEG_0524|M.smegmatis_MC2_155 ------------
MLBr_01094|M.leprae_Br4923 ------------