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SKVLLISGASRGLGRAITESALAAGHLVVAGVRATSSLSDLATREPDRLAVVELDVTDDRHARAAVATAV ERFGRLDVLVNNAGYANMSAIEDVDVDDFRAQIETNFFGVVNLTRAALPAMRRQRDGHIVQISSVGGRLV RPGLAAYQSAKWAVTGFSGVLAVEVAPLGIKVTVLEPGGMRTDWAGSSMRIAPVREEYAATVGAAASLSD PNVLGASDPAKVAGLLLDVIGMPDPPRRLLVGPDAYRYATAAGRDLLAVDERWRTLSMSTAADDVSPEQL DPLGSASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0295 | - | - | 100% (289) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0930 | - | 6e-35 | 36.76% (253) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4505 | - | 4e-26 | 38.17% (186) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1079 | - | 4e-26 | 37.63% (186) | oxidoreductase |
| M. tuberculosis H37Rv | Rv1050 | - | 4e-26 | 37.63% (186) | oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 7e-24 | 35.83% (254) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1305 | - | 2e-29 | 35.06% (251) | short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1614 | - | 8e-52 | 44.28% (271) | short chain dehydrogenase |
| M. avium 104 | MAV_4982 | - | 2e-74 | 54.78% (272) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_3302 | - | 6e-63 | 43.82% (283) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3670 | - | 8e-55 | 43.28% (268) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3423 | - | 4e-52 | 44.28% (271) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0982 | - | 3e-54 | 43.07% (267) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4982|M.avium_104 ------------MPKTWFITGSSRGLGRALTTAVLDHGDHVVATARRPAQ
MSMEG_3302|M.smegmatis_MC2_155 ---------MAHETRTWFITGSSRGFGRALVKAALDAGDNVAATARKPGQ
Mflv_0295|M.gilvum_PYR-GCK ------------MSKVLLISGASRGLGRAITESALAAGHLVVAGVRATSS
MMAR_1614|M.marinum_M -------------MSTWLITGCSTGLGRALAEAVIDAGHHTVATARSVGG
MUL_3423|M.ulcerans_Agy99 -------------MSTWLITGCSTGLGRALAEAVIDAGHHTVATARSVGG
TH_3670|M.thermoresistible__bu MGSNVWG------SKVWFITGASRGFGREWAIAALDRGDRVAATARDVST
Mvan_0982|M.vanbaalenii_PYR-1 MPGHPTGIDPGMTEKVWFITGASRGFGREWAIAALDRGDKVAATARDLST
Mb1079|M.bovis_AF2122/97 ------MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGA
Rv1050|M.tuberculosis_H37Rv ------MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGA
MAB_1305|M.abscessus_ATCC_1997 ----------MSEHWTVLVTGASSGIGASAARIFAERGHRVFGTSRNPDT
MLBr_01094|M.leprae_Br4923 --------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEG
. .::*.. *:* . *
MAV_4982|M.avium_104 LDELV---DRYGPRIRACELDVTDRAAARRAIAAAVTAFGRIDVVVNNAG
MSMEG_3302|M.smegmatis_MC2_155 LADFA---ETYGDRVLALPLDVTDPSAARTAVATAREAFGRIDIVVNNAG
Mflv_0295|M.gilvum_PYR-GCK LSDLA---TREPDRLAVVELDVTDDRHARAAVATAVERFGRLDVLVNNAG
MMAR_1614|M.marinum_M VADLV---QRSPERVLPLALDITEPDQITAAVQAAQQRFGGIDVLVNNAG
MUL_3423|M.ulcerans_Agy99 VADLA---QRSPERVLPLALDITEPDQITAAMQAAQQRFGGIDVLVNNAG
TH_3670|M.thermoresistible__bu LDDLR---DRFGDAVLAMTLDVTDRAADFAAVQRAHDHFGRLDIVVNNAG
Mvan_0982|M.vanbaalenii_PYR-1 LDDLT---AKYGDALLPLTLDVTDRDADFAAVTQAHDHFGRLDIVVNNAG
Mb1079|M.bovis_AF2122/97 LRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAG
Rv1050|M.tuberculosis_H37Rv LRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAG
MAB_1305|M.abscessus_ATCC_1997 ITDRVP-------GVQYLRLDQTD----KASIAECVAQAGEVDILVNNAG
MLBr_01094|M.leprae_Br4923 LAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAG
: ** :. * :: : ****
MAV_4982|M.avium_104 YANSAPVE-EVSDDDFRAQVETNFFGVVNVTKAALPVLHRQRAGHIVQIS
MSMEG_3302|M.smegmatis_MC2_155 YANVAPIE-TGDDEDFRTQFETNFWGVYNVSKAALPVLREQRGGLIIQFS
Mflv_0295|M.gilvum_PYR-GCK YANMSAIE-DVDVDDFRAQIETNFFGVVNLTRAALPAMRRQRDGHIVQIS
MMAR_1614|M.marinum_M YGYRAAVE-EGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNIS
MUL_3423|M.ulcerans_Agy99 YGYRAAVE-EGDDAEVRDLFETHFFGTVALIKAVLPDMRARRSGAIVNIS
TH_3670|M.thermoresistible__bu YGHFGFVE-ELTETEVRDQMETNFFGALWVTQAALPYLRRQRSGHIIQVS
Mvan_0982|M.vanbaalenii_PYR-1 YGQFGFVE-ELSEQEARAQIDTNVFGALWITQAALPYLRAQRSGHLIQVS
Mb1079|M.bovis_AF2122/97 VSLVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMS
Rv1050|M.tuberculosis_H37Rv VSLVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMS
MAB_1305|M.abscessus_ATCC_1997 ESQIGALE-DVSMDDFEKLYMTNVFGPVALTKAVLPGMRERRRGAVVMVG
MLBr_01094|M.leprae_Br4923 IAFTGDVE-VSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINIS
. . :: : . . * : ** : * :: ..
MAV_4982|M.avium_104 SVGGRVGGSPGIAAYQASKFAVAGFSEALAAEVAPLG--IKVTIAEPGAL
MSMEG_3302|M.smegmatis_MC2_155 SMGGRVGGSPGIGSYQAAKFAIDGFSRVLLAETAPFG--VKVLVVEPSGF
Mflv_0295|M.gilvum_PYR-GCK SVGGRLVR-PGLAAYQSAKWAVTGFSGVLAVEVAPLG--IKVTVLEPGGM
MMAR_1614|M.marinum_M SIAVALTP-VGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAF
MUL_3423|M.ulcerans_Agy99 SIAVALTP-VGSGYYAAAKAAMEGMSGALHGELAPLG--ISVTVVEPGAF
TH_3670|M.thermoresistible__bu SIGG-VSAFADLGAYHASKWALEGLSQSLSLEVAPFG--IHVTLIEPGGY
Mvan_0982|M.vanbaalenii_PYR-1 SIGG-IVAFPNLGIYHASKWALEGFSQALAQEVAEFG--IHVTLIEPGGY
Mb1079|M.bovis_AF2122/97 SVVG-RKAFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALT
Rv1050|M.tuberculosis_H37Rv SVVG-RKAFARFAGYSSAMHAIAGFSDALRQELRGSG--IAVSVIHPALT
MAB_1305|M.abscessus_ATCC_1997 SMAG-TLHVPFRSTYSSAKSALHTVADCLRYEVAPFG--ITVSTVEPGVI
MLBr_01094|M.leprae_Br4923 SVFG-LFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGI
*: . * :: *: .: * * * : * *.
MAV_4982|M.avium_104 RTEWAGSSMAVAT-VSPDYESTVGAMNRRRAGFNRNAPGDPARAAHAIIE
MSMEG_3302|M.smegmatis_MC2_155 ATDWAGASMEVHD-IPADYADTVGGMSAIRQ-SDSVTAGDPVRAAEILVQ
Mflv_0295|M.gilvum_PYR-GCK RTDWAGSSMRIAP-VREEYAATVGAAASLSD-PNVLGASDPAKVAGLLLD
MMAR_1614|M.marinum_M RTDFAGRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIIT
MUL_3423|M.ulcerans_Agy99 RTDFAGRSLVQSTRMINDYAATAGQRRKENDTMHGNQPGDPAKAAAAIIT
TH_3670|M.thermoresistible__bu ATDWGGSSARRSA-TMPEYAESRAEADRVRS-QRVARPGDPKASAAALLK
Mvan_0982|M.vanbaalenii_PYR-1 STDWAGASAKRAT-ALPAYAEAHAATERTRQ-ARTARPGDPQASARALLT
Mb1079|M.bovis_AF2122/97 QTPLLAN-VDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQP
Rv1050|M.tuberculosis_H37Rv QTPLLAN-VDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQP
MAB_1305|M.abscessus_ATCC_1997 ATGIETRRNRIVPDGSPYRDAFRTVDAAMAAREEHGTATD--ELGRLVVD
MLBr_01094|M.leprae_Br4923 KTAIARNATAAEG---------LDVSKIASRFDTWVAHTSPQHAARIILK
* .
MAV_4982|M.avium_104 VVIADDPPLRLLLGSDALSAALAKSHQQIAEANRWAELSKSIDYP---PV
MSMEG_3302|M.smegmatis_MC2_155 MSRRDDIPYHLPIGVHSVEGCLQQDEFLLGEDRKWAAVGRSADFSEAYPV
Mflv_0295|M.gilvum_PYR-GCK VIGMPDPPRRLLVGPDAYRYATAAGRDLLAVDERWRTLSMSTAADDVSPE
MMAR_1614|M.marinum_M AVESPAPPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----
MUL_3423|M.ulcerans_Agy99 AVESPAPPAFLLLGPDALMAYRHIAQRRDVEITDWEQLTAGTNLTP----
TH_3670|M.thermoresistible__bu VVDAEKPPLRVFFGELPLQIVNADYQSRLQTWEEWQPIAVLAQG------
Mvan_0982|M.vanbaalenii_PYR-1 VVDAPEPPLRVFFGELPLELARADYESRLANWEKWQPVAIEAQG------
Mb1079|M.bovis_AF2122/97 RLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQA
Rv1050|M.tuberculosis_H37Rv RLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQA
MAB_1305|M.abscessus_ATCC_1997 VALSPSPKPLYAKGSNAPIIMTAQRLLPARLFLKFLARMHGLKVR-----
MLBr_01094|M.leprae_Br4923 AVRKKK--ARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR--
*
MAV_4982|M.avium_104 ATPHRAARSR-
MSMEG_3302|M.smegmatis_MC2_155 AFPPDTVSSSA
Mflv_0295|M.gilvum_PYR-GCK QLDPLGSASR-
MMAR_1614|M.marinum_M -----------
MUL_3423|M.ulcerans_Agy99 -----------
TH_3670|M.thermoresistible__bu -----------
Mvan_0982|M.vanbaalenii_PYR-1 -----------
Mb1079|M.bovis_AF2122/97 AQPERGYSSAR
Rv1050|M.tuberculosis_H37Rv AQPERGYSSAR
MAB_1305|M.abscessus_ATCC_1997 -----------
MLBr_01094|M.leprae_Br4923 -----------