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VWAILWRVVKGLAGKGVLVTGAASGIGLATVRRLLEEGAAVVGMDVCTEAPADVPGDFTYHRGDVLDAAA VGRAVTAVVERTGRLDGVVHSAGVGGGGPIHLLPDDEWDRVVDVNLKGTFVVLRAALAQMTTQDRVTGER GSIVTLSSVEGLEGTAGGSAYNASKGGVVLLTKNAAIDYGPSGIRINAICPGFIETPLFDSVMGLPGMEG PRDGLRHEHKLRRFGRPEEVASVATFLVSAEASFVSGQAIAVDGGYTAGRDHHVTELLGLGEQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4508 | - | - | 100% (273) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4062 | - | 3e-37 | 38.17% (262) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 3e-36 | 38.43% (255) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 6e-36 | 37.89% (256) | 20-beta-hydroxysteroid dehydrogenase |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 6e-36 | 37.89% (256) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 6e-30 | 34.29% (245) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 8e-32 | 35.04% (254) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3470 | - | 1e-92 | 67.05% (258) | short chain membrane-associated dehydrogenase |
| M. avium 104 | MAV_3521 | - | 1e-90 | 65.87% (252) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_3009 | - | 2e-37 | 38.15% (249) | 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase |
| M. thermoresistible (build 8) | TH_4254 | - | 4e-38 | 39.45% (256) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_0336 | - | 3e-36 | 38.72% (266) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1861 | - | 1e-126 | 85.00% (260) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4508|M.gilvum_PYR-GCK -------MWAILWRVVKGLAGKGVLVTGAASGIGLATVRRLLEEGAAVVG
Mvan_1861|M.vanbaalenii_PYR-1 ------------MPMHNRLLGKGVLVTGAASGIGEATVRRLLDEGASVVG
MMAR_3470|M.marinum_M ------------ML--DHRASRTFVVTGASSGIGLATVGRLLEQGCAVVG
MAV_3521|M.avium_104 ---------MTGMVNPDRARSRTFVVTGAASGIGLATARRLLAEGGTVVG
MSMEG_3009|M.smegmatis_MC2_155 ---------------MNRLDGKVAIVTGTCRGIGHAIADALAREGAITVA
TH_4254|M.thermoresistible__bu -----------MTAGSTRLAGKVVLVTGAGGGLGTAIARRLADEGARLVL
Mb2025|M.bovis_AF2122/97 -----------MSGR---LIGKVALVSGGARGMGASHVRAMVAEGAKVVF
Rv2002|M.tuberculosis_H37Rv -----------MSGR---LIGKVALVSGGARGMGASHVRAMVAEGAKVVF
MAB_4680c|M.abscessus_ATCC_199 -----------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
MUL_0336|M.ulcerans_Agy99 --------------MVDELAGKIAIVTGGASGIGRATVARFIAEGARVVI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
.: :*:* *:* : : :* .
Mflv_4508|M.gilvum_PYR-GCK MDVCTE--------APADVPGDFTYHRGDVLDAAAVGRAVTAVVERTGRL
Mvan_1861|M.vanbaalenii_PYR-1 CDLAPG--------PPSDLPGDIGYLSGDVRDTATAERAVAAVIERTGRL
MMAR_3470|M.marinum_M ADVVT---------PPHDLGPRFTFVTADVTDEDAVAGVFDAVPD---RL
MAV_3521|M.avium_104 VDLAD---------PPGDLGPRFTFVPADVTDESAVAAVLAAVPG---RL
MSMEG_3009|M.smegmatis_MC2_155 TGRSKT------DEALGPRSAEVEYRQLDVASEEDWDSVVTETVERYGRI
TH_4254|M.thermoresistible__bu ADLQESQCAALADELPAPAGAHHPLG-FDVADETAWISAISTVSAQYGAL
Mb2025|M.bovis_AF2122/97 GDILDEE----GKAVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGL
Rv2002|M.tuberculosis_H37Rv GDILDEE----GKAVAAELADAARYVHLDVTQPAQWTAAVDTAVTAFGGL
MAB_4680c|M.abscessus_ATCC_199 ADVLDGD----GRQLAAELGDAARFTHLDVTDAEQWRELIDTTLAGFGTI
MUL_0336|M.ulcerans_Agy99 ADVEEER----GESLAAALGADAMFCRTDVSQPEQVAAVVAAAVDNFGGL
MLBr_01807|M.leprae_Br4923 T------------HRASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPV
** . . . :
Mflv_4508|M.gilvum_PYR-GCK DGVVHSAGVGGGGP--IHLLPDDEWDRVVDVNLKGTFVVLRAALAQMTTQ
Mvan_1861|M.vanbaalenii_PYR-1 DGVVHSAGVGGGGP--IHLLPDAEWDRVLDVNLKGTFVVLRAALAQMITQ
MMAR_3470|M.marinum_M DGVVHSAGVAGGGP--VHLLARAEWDRVIGVNLTGTFLVAKAALARMIEQ
MAV_3521|M.avium_104 DGVFHAAGVAGGGP--VHLLDRSEWDRVIGVNLTGTFLVAKAALARMIDQ
MSMEG_3009|M.smegmatis_MC2_155 DVLVNNAGIIAYQG--LHELTVPEWNRVVATNQTGTWLGMRAVIPHMVSQ
TH_4254|M.thermoresistible__bu HALVNNAAIGALGN--VAEERLERWDRILDVGATGVWLGMKHAVPLIRRS
Mb2025|M.bovis_AF2122/97 HVLVNNAGILNIGT--IEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEA
Rv2002|M.tuberculosis_H37Rv HVLVNNAGILNIGT--IEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEA
MAB_4680c|M.abscessus_ATCC_199 TGLVNNAGISSAAM--VADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAH
MUL_0336|M.ulcerans_Agy99 HVMVNNAGVSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAH
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDML--IMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQ
:. *.: . : ::: . *. : . :
Mflv_4508|M.gilvum_PYR-GCK DRVTGERGSIVTLSSVEGLEGTAG-GSAYNASKGGVVLLTKNAAIDYGPS
Mvan_1861|M.vanbaalenii_PYR-1 DRVDGERGAIVTLSSIEGLEGTAG-GSAYNASKGGVVLLTKNAAIDYGPS
MMAR_3470|M.marinum_M PRVDGERGSIVTLASIEGLEGTAG-GSSYNAAKGGVVLLTKNIALDYGPS
MAV_3521|M.avium_104 PRVDGERGSLVTVASVEGLEGTAG-GSSYNAAKGGVVLLTKNIALDYGPS
MSMEG_3009|M.smegmatis_MC2_155 -----HGGSIINISSIWGSAAVAG-AHAYHATKGAVRNMSKSAAISYAKD
TH_4254|M.thermoresistible__bu -----GGGSVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTKNAALHWAPD
Mb2025|M.bovis_AF2122/97 -----GRGSIINISSIEGLAGTVA-CHGYTATKFAVRGLTKSTALELGPS
Rv2002|M.tuberculosis_H37Rv -----GRGSIINISSIEGLAGTVA-CHGYTATKFAVRGLTKSTALELGPS
MAB_4680c|M.abscessus_ATCC_199 -----GCGSIVNISSAAGLVGLAL-TSGYGASKWGVRGLSKVAAIELGRE
MUL_0336|M.ulcerans_Agy99 -----GGGSIVNLTSIGGIQAGGG-VMTYRASKGAVIQFTKSAAIELAHY
MLBr_01807|M.leprae_Br4923 R-----FGRYIFMGSVVGLSGVPG-QANYAASKSGLIGMARSLARELGSR
* : : * * . * *:* .: ::: * .
Mflv_4508|M.gilvum_PYR-GCK GIRINAICPGFIETPLFDSVMGLPGMEGP-------RDGLRHEHKLRRFG
Mvan_1861|M.vanbaalenii_PYR-1 GIRVNAICPGFIETPLFESVIGIPGMEGP-------RDGLRHEHKLRRFG
MMAR_3470|M.marinum_M GIRANAICPGFIATPLAEGVFGMPGMEGP-------RASITNEHALQRLG
MAV_3521|M.avium_104 GIRANVICPGFIETPMAHNVFSIPGMEAP-------LASITREHALQRLG
MSMEG_3009|M.smegmatis_MC2_155 NVRVNSVHPGFIRTP-LTDAQETTIN-----------DYVVSQTPMGRAG
TH_4254|M.thermoresistible__bu GVRVNSLHPGFIETPQLRELYKGTERY----------ERMLAGTPLGRLG
Mb2025|M.bovis_AF2122/97 GIRVNSIHPGLVKTP--MTDWV---------------PEDIFQTALGRAA
Rv2002|M.tuberculosis_H37Rv GIRVNSIHPGLVKTP--MTDWV---------------PEDIFQTALGRAA
MAB_4680c|M.abscessus_ATCC_199 RIRVNSVHPGVIYTP--MTAKEGFREG----------EGNMPIAAMGRVG
MUL_0336|M.ulcerans_Agy99 EIRVNAIAPGNIPTPLLASSAAGLDQEQVERFTAQIRQTMREDRPLKREG
MLBr_01807|M.leprae_Br4923 SITANVVAPGFIDTEMTRAMDSKYQ------------EAALQAIPLGRIG
: * : ** : * : * .
Mflv_4508|M.gilvum_PYR-GCK RPEEVASVATFLVSAEASFVSGQAIAVDGGYTAGRDHHVTELLGLGEQ--
Mvan_1861|M.vanbaalenii_PYR-1 RPEEVAAVAAFLVSSDAAFVSGQAIAVDGGYTAGRDHHVTELMGLGGP--
MMAR_3470|M.marinum_M KPEEIAAMAAFLLSPDASFVTGQAIAVDGGYTAGRDHGVVRLFGLPQ---
MAV_3521|M.avium_104 RPEEIAAMAAFLLSTDASFVSGQAIAVDGGYTAGRDHGVVELFGFPS---
MSMEG_3009|M.smegmatis_MC2_155 TPDEIANGVVFLASDEASFVTGSELVIDGGYLAQ----------------
TH_4254|M.thermoresistible__bu RPDEIAAVVAFLVSDDASFITGSEVYADGGWTAR----------------
Mb2025|M.bovis_AF2122/97 EPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPE
Rv2002|M.tuberculosis_H37Rv EPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPE
MAB_4680c|M.abscessus_ATCC_199 NADEVAGAVAYLLSDAASYVTGAELAVDGGWTAGPT-----LTTITGQ--
MUL_0336|M.ulcerans_Agy99 TPEDIAEAALYFAGERSRYVTGTVLPVDGGTVAGKVIRRSR---------
MLBr_01807|M.leprae_Br4923 AVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH---------------
::: . :: . : : :* . ***
Mflv_4508|M.gilvum_PYR-GCK ---
Mvan_1861|M.vanbaalenii_PYR-1 ---
MMAR_3470|M.marinum_M ---
MAV_3521|M.avium_104 ---
MSMEG_3009|M.smegmatis_MC2_155 ---
TH_4254|M.thermoresistible__bu ---
Mb2025|M.bovis_AF2122/97 WVT
Rv2002|M.tuberculosis_H37Rv WVT
MAB_4680c|M.abscessus_ATCC_199 ---
MUL_0336|M.ulcerans_Agy99 ---
MLBr_01807|M.leprae_Br4923 ---