For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TGMVNPDRARSRTFVVTGAASGIGLATARRLLAEGGTVVGVDLADPPGDLGPRFTFVPADVTDESAVAAV LAAVPGRLDGVFHAAGVAGGGPVHLLDRSEWDRVIGVNLTGTFLVAKAALARMIDQPRVDGERGSLVTVA SVEGLEGTAGGSSYNAAKGGVVLLTKNIALDYGPSGIRANVICPGFIETPMAHNVFSIPGMEAPLASITR EHALQRLGRPEEIAAMAAFLLSTDASFVSGQAIAVDGGYTAGRDHGVVELFGFPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3521 | - | - | 100% (266) | NAD dependent epimerase/dehydratase family protein |
| M. avium 104 | MAV_3714 | - | 1e-36 | 38.34% (253) | short chain dehydrogenase |
| M. avium 104 | MAV_0942 | - | 3e-36 | 40.00% (240) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2882c | - | 3e-34 | 37.01% (254) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4508 | - | 1e-90 | 65.87% (252) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2857c | - | 3e-34 | 37.01% (254) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 4e-34 | 38.78% (245) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0368 | - | 7e-31 | 38.25% (251) | Short-chain dehydrogenase/reductas |
| M. marinum M | MMAR_3470 | - | 1e-119 | 82.95% (258) | short chain membrane-associated dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2598 | - | 7e-36 | 37.15% (253) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4254 | - | 7e-34 | 38.37% (258) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 5e-39 | 42.23% (251) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_1861 | - | 1e-92 | 66.28% (261) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3521|M.avium_104 ---------MTGMVNPDRARSRTFVVTGAASGIGLATARRLLAEGGTVVG
MMAR_3470|M.marinum_M ------------ML--DHRASRTFVVTGASSGIGLATVGRLLEQGCAVVG
Mflv_4508|M.gilvum_PYR-GCK -------MWAILWRVVKGLAGKGVLVTGAASGIGLATVRRLLEEGAAVVG
Mvan_1861|M.vanbaalenii_PYR-1 ------------MPMHNRLLGKGVLVTGAASGIGEATVRRLLDEGASVVG
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MUL_0315|M.ulcerans_Agy99 ---------MRPD-SSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
Mb2882c|M.bovis_AF2122/97 -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
Rv2857c|M.tuberculosis_H37Rv -----------MMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVV
MSMEG_2598|M.smegmatis_MC2_155 ------------MDLTQRLAGKVAVITGGASGIGLATGRRLRAEGATVVV
TH_4254|M.thermoresistible__bu -----------MTAGSTRLAGKVVLVTGAGGGLGTAIARRLADEGARLVL
MAB_0368|M.abscessus_ATCC_1997 ----------------MDINGVSAIVTGGASGLGAATARLLAAQGAKVVI
::**. *:* * : :* :.
MAV_3521|M.avium_104 VDLAD-PPGDLGPRF-------TFVPADVTDESAVAAVLAAVPG---RLD
MMAR_3470|M.marinum_M ADVVT-PPHDLGPRF-------TFVTADVTDEDAVAGVFDAVPD---RLD
Mflv_4508|M.gilvum_PYR-GCK MDVCTEAPADVPGDF-------TYHRGDVLDAAAVGRAVTAVVERTGRLD
Mvan_1861|M.vanbaalenii_PYR-1 CDLAPGPPSDLPGDI-------GYLSGDVRDTATAERAVAAVIERTGRLD
MLBr_01807|M.leprae_Br4923 THRASVVPDWFFG-----------VECDVTDNDAIGAAFKAVEEHQGPVE
MUL_0315|M.ulcerans_Agy99 LDLK--TPDGGLA-----------FSADVTNRSQVDAALAAIRQRLGPVT
Mb2882c|M.bovis_AF2122/97 GDVDVEAGGAAADEL---SGLFVPT--DVCDEDAVNGLFDGAAETYGRID
Rv2857c|M.tuberculosis_H37Rv GDVDVEAGGAAADEL---SGLFVPT--DVCDEDAVNGLFDGAAETYGRID
MSMEG_2598|M.smegmatis_MC2_155 GDIDPTTGKAAADEL---EGLFVPV--DVSEQEAVDNLFDTAASTFGRVD
TH_4254|M.thermoresistible__bu ADLQESQCAALADELPAPAGAHHPLGFDVADETAWISAISTVSAQYGALH
MAB_0368|M.abscessus_ATCC_1997 ADVQDEKGEALAKELG-----GAFVHTDVTSEADGIAAVDAAKELG-PVR
. ** . . :
MAV_3521|M.avium_104 GVFHAAGVA--------GGGPVHLLDRSEWDRVIGVNLTGTFLVAKAALA
MMAR_3470|M.marinum_M GVVHSAGVA--------GGGPVHLLARAEWDRVIGVNLTGTFLVAKAALA
Mflv_4508|M.gilvum_PYR-GCK GVVHSAGVG--------GGGPIHLLPDDEWDRVVDVNLKGTFVVLRAALA
Mvan_1861|M.vanbaalenii_PYR-1 GVVHSAGVG--------GGGPIHLLPDAEWDRVLDVNLKGTFVVLRAALA
MLBr_01807|M.leprae_Br4923 VLVANAGIT--------SDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASR
MUL_0315|M.ulcerans_Agy99 ILVNAAGLD--------GFKRFSNITFEDWQRVIDVNLNGVFHTIQAVLP
Mb2882c|M.bovis_AF2122/97 IAFNNAGISPP------EDNLIENTELAAWQRVQDVNLKSVYLCCRAALR
Rv2857c|M.tuberculosis_H37Rv IAFNNAGISPP------EDNLIENTELAAWQRVQDVNLKSVYLCCRAALR
MSMEG_2598|M.smegmatis_MC2_155 IAFNNAGISPP------EDDLIENTDLPAWQRVQDINLKSVYLSCRAALR
TH_4254|M.thermoresistible__bu ALVNNAAIGAL------GN--VAEERLERWDRILDVGATGVWLGMKHAVP
MAB_0368|M.abscessus_ATCC_1997 VLINCAGVGWPGRTIGKDGQYASAHSLDIFSKVIGINLIGSFNLIRLAAT
. *.: :.:: .:. . : : .
MAV_3521|M.avium_104 RMIDQPRVDGE--RGSLVTVASVEGLEG-TAGGSSYNAAKGGVVLLTKNI
MMAR_3470|M.marinum_M RMIEQPRVDGE--RGSIVTLASIEGLEG-TAGGSSYNAAKGGVVLLTKNI
Mflv_4508|M.gilvum_PYR-GCK QMTTQDRVTGE--RGSIVTLSSVEGLEG-TAGGSAYNASKGGVVLLTKNA
Mvan_1861|M.vanbaalenii_PYR-1 QMITQDRVDGE--RGAIVTLSSIEGLEG-TAGGSAYNASKGGVVLLTKNA
MLBr_01807|M.leprae_Br4923 NMIKQR-------FGRYIFMGSVVGLSG-VPGQANYAASKSGLIGMARSL
MUL_0315|M.ulcerans_Agy99 DMVAAG-------WGRIVNISSSSTHSG-TPYMTHYVAAKSAVNGLTKAL
Mb2882c|M.bovis_AF2122/97 HMVLAG-------KGSIVNTASFVAVMGSATSQISYTASKGGVLAMSREL
Rv2857c|M.tuberculosis_H37Rv HMVLAG-------KGSIVNTASFVAVMGSATSQISYTASKGGVLAMSREL
MSMEG_2598|M.smegmatis_MC2_155 HMVPAG-------KGSIINTASFVAVMGSATSQISYTASKGGVLAMSREL
TH_4254|M.thermoresistible__bu LIRRSG-------GGSVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTKNA
MAB_0368|M.abscessus_ATCC_1997 AISQEEPVDEFGERGAIVNTASVAAFDG-QIGQAAYSASKGGIVGMTLPI
: * : * * * *:*..: ::
MAV_3521|M.avium_104 ALDYGPSGIRANVICPGFIETPMAHNVFSIPGMEAPLASITREHALQRLG
MMAR_3470|M.marinum_M ALDYGPSGIRANAICPGFIATPLAEGVFGMPGMEGPRASITNEHALQRLG
Mflv_4508|M.gilvum_PYR-GCK AIDYGPSGIRINAICPGFIETPLFDSVMGLPGMEGPRDGLRHEHKLRRFG
Mvan_1861|M.vanbaalenii_PYR-1 AIDYGPSGIRVNAICPGFIETPLFESVIGIPGMEGPRDGLRHEHKLRRFG
MLBr_01807|M.leprae_Br4923 ARELGSRSITANVVAPGFIDTEMTR-AMDSK----YQEAALQAIPLGRIG
MUL_0315|M.ulcerans_Agy99 ALEYGPSGITVNAVPPGFIDTPMLR-NAAAQGHLGDIEQNIARTPVRRIG
Mb2882c|M.bovis_AF2122/97 GVQFARQGIRVNALCPGPVNTPLLQELFAKNPER--AARRMVHVPLGRFA
Rv2857c|M.tuberculosis_H37Rv GVQFARQGIRVNALCPGPVNTPLLQELFAKNPER--AARRMVHVPLGRFA
MSMEG_2598|M.smegmatis_MC2_155 GVQYARQGIRVNALCPGPVNTPLLQELFAKDPER--AARRLVHIPLGRFA
TH_4254|M.thermoresistible__bu ALHWAPDGVRVNSLHPGFIETPQLRELY-KGTER--YERMLAGTPLGRLG
MAB_0368|M.abscessus_ATCC_1997 ARDLSVVGIRVNTIAPGLIDTPIYGEGESAQQFKDRLAPNVLYP--QRLG
. . . .: * : ** : * *:.
MAV_3521|M.avium_104 RPEEIAAMAAFLLSTDASFVSGQAIAVDGGYTAGRDHGVVELFGFPS-
MMAR_3470|M.marinum_M KPEEIAAMAAFLLSPDASFVTGQAIAVDGGYTAGRDHGVVRLFGLPQ-
Mflv_4508|M.gilvum_PYR-GCK RPEEVASVATFLVSAEASFVSGQAIAVDGGYTAGRDHHVTELLGLGEQ
Mvan_1861|M.vanbaalenii_PYR-1 RPEEVAAVAAFLVSSDAAFVSGQAIAVDGGYTAGRDHHVTELMGLGGP
MLBr_01807|M.leprae_Br4923 AVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-------------
MUL_0315|M.ulcerans_Agy99 KPEDIAAACAFLVSEEAGYITGQILGVNGGRNT---------------
Mb2882c|M.bovis_AF2122/97 EPDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------
Rv2857c|M.tuberculosis_H37Rv EPDEIAAAVAFLASDDASFITASTFLVDGGISSAYVTPL---------
MSMEG_2598|M.smegmatis_MC2_155 EPEELAAAVAFLASDDASFITGSTFLVDGGISSAYVTPL---------
TH_4254|M.thermoresistible__bu RPDEIAAVVAFLVSDDASFITGSEVYADGGWTAR--------------
MAB_0368|M.abscessus_ATCC_1997 NPEEFASLALELVTN--SYMNAETIRIDGGARLQPK------------
::.*. * : .::.. . :**