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NRLDGKVAIVTGTCRGIGHAIADALAREGAITVATGRSKTDEALGPRSAEVEYRQLDVASEEDWDSVVTE TVERYGRIDVLVNNAGIIAYQGLHELTVPEWNRVVATNQTGTWLGMRAVIPHMVSQHGGSIINISSIWGS AAVAGAHAYHATKGAVRNMSKSAAISYAKDNVRVNSVHPGFIRTPLTDAQETTINDYVVSQTPMGRAGTP DEIANGVVFLASDEASFVTGSELVIDGGYLAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3009 | - | - | 100% (243) | 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3515 | - | 3e-49 | 45.04% (242) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2477 | - | 9e-46 | 42.68% (246) | cyclopentanol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 3e-47 | 42.56% (242) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3281 | - | 2e-50 | 43.27% (245) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 3e-47 | 42.56% (242) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-26 | 30.17% (232) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4680c | - | 4e-40 | 38.17% (241) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0387 | fabG3 | 1e-51 | 44.40% (241) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. avium 104 | MAV_2509 | - | 6e-52 | 47.95% (244) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_4254 | - | 7e-49 | 44.40% (250) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 3e-51 | 43.98% (241) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_3000 | - | 3e-52 | 43.67% (245) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3009|M.smegmatis_MC2_155 ---------------MNRLDGKVAIVTGTCRGIGHAIADALAREGAITVA
TH_4254|M.thermoresistible__bu -----------MTAGSTRLAGKVVLVTGAGGGLGTAIARRLADEGARLVL
Mb2025|M.bovis_AF2122/97 --------------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVF
Rv2002|M.tuberculosis_H37Rv --------------MSGRLIGKVALVSGGARGMGASHVRAMVAEGAKVVF
MAV_2509|M.avium_104 --------------MAERLAGKVALVSGGARGMGASHVRSLVAEGAKVVF
Mflv_3281|M.gilvum_PYR-GCK ---------------MGRVDGKVALISGGAQGMGAEDARALIAEGAKVVI
Mvan_3000|M.vanbaalenii_PYR-1 ---------------MGRVDGKVALISGGAQGMGAADARALIAEGAKVVI
MMAR_0387|M.marinum_M ---------------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVI
MUL_1037|M.ulcerans_Agy99 ---------------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVI
MAB_4680c|M.abscessus_ATCC_199 -----------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
. .: :::* *:* : :* .
MSMEG_3009|M.smegmatis_MC2_155 TGRSKT------DEALGPRSAEVEYRQLDVASEEDWDSVVTETVERYGRI
TH_4254|M.thermoresistible__bu ADLQESQCAALADELPAPAGAHHPLG-FDVADETAWISAISTVSAQYGAL
Mb2025|M.bovis_AF2122/97 GDILDEEGKAVAAELA----DAARYVHLDVTQPAQWTAAVDTAVTAFGGL
Rv2002|M.tuberculosis_H37Rv GDILDEEGKAVAAELA----DAARYVHLDVTQPAQWTAAVDTAVTAFGGL
MAV_2509|M.avium_104 GDILDDEGKAVAAEVG----EATRYLHLDVTKPEDWDAAVATALAEFGRI
Mflv_3281|M.gilvum_PYR-GCK GDILDEKGQALADEINAQTPDSIRYVHLDVTQADQWEAAVATAVNDFGTL
Mvan_3000|M.vanbaalenii_PYR-1 GDILDDKGKALADEINAETPDSIRYVHLDVTQADQWEAAVATAVDAFGKL
MMAR_0387|M.marinum_M GDILDEEGKALAEEIG----DAARYVHLDVTQPDQWEAAVATAVDEFGKL
MUL_1037|M.ulcerans_Agy99 GDILDEEGKALAEEIG----DAARYVHLDVTQPDQWEAAVATAVDEFGKL
MAB_4680c|M.abscessus_ATCC_199 ADVLDGDGRQLAAELG----DAARFTHLDVTDAEQWRELIDTTLAGFGTI
MLBr_01807|M.leprae_Br4923 THRASVVP------------DWFFGVECDVTDNDAIGAAFKAVEEHQGPV
. **:. . . * :
MSMEG_3009|M.smegmatis_MC2_155 DVLVNNAGIIAYQGLHELTVPEWNRVVATNQTGTWLGMRAVIPHMVSQHG
TH_4254|M.thermoresistible__bu HALVNNAAIGALGNVAEERLERWDRILDVGATGVWLGMKHAVPLIRRSGG
Mb2025|M.bovis_AF2122/97 HVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGR
Rv2002|M.tuberculosis_H37Rv HVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVKPMKEAGR
MAV_2509|M.avium_104 DVLVNNAGIINIGTLEDYALSEWQRILDINLTGVFLGIRAVVKPMKKAGR
Mflv_3281|M.gilvum_PYR-GCK NVLVNNAGTVALGQIGQFDMAKWQKVIDVNLTGTFLGMQASVEAMKAAGG
Mvan_3000|M.vanbaalenii_PYR-1 NVLVNNAGTVALGQIGQFDMAKWQKVIDVNLTGTFLGMQASVEAMKTAGG
MMAR_0387|M.marinum_M DVLVNNAGIVALGQLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPMTAAGS
MUL_1037|M.ulcerans_Agy99 DVLVNNVGIVALGQLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPMTAAGS
MAB_4680c|M.abscessus_ATCC_199 TGLVNNAGISSAAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHGC
MLBr_01807|M.leprae_Br4923 EVLVANAGITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQRF
** *.. : .: ::: . .*.: : :
MSMEG_3009|M.smegmatis_MC2_155 GSIINISSIWGSAAVAG-AHAYHATKGAVRNMSKSAAISYAKDNVRVNSV
TH_4254|M.thermoresistible__bu GSVVNICSIFGTVGGFGDSAAYHAAKGAVRTLTKNAALHWAPDGVRVNSL
Mb2025|M.bovis_AF2122/97 GSIINISSIEGLAGTVA-CHGYTATKFAVRGLTKSTALELGPSGIRVNSI
Rv2002|M.tuberculosis_H37Rv GSIINISSIEGLAGTVA-CHGYTATKFAVRGLTKSTALELGPSGIRVNSI
MAV_2509|M.avium_104 GSIINISSIEGMAGTIA-CHGYTATKFAVRGLTKSAALELGPSGIRVNSI
Mflv_3281|M.gilvum_PYR-GCK GSIINISSIEGLRGAIM-VHPYVASKWAVRGLTKSAALELGQYNIRVNSV
Mvan_3000|M.vanbaalenii_PYR-1 GSIINISSIEGLRGAVM-VHPYVASKWAVRGLTKSAALELGSHNIRVNSV
MMAR_0387|M.marinum_M GSIINVSSIEGLRGAPA-VHPYVASKWAVRGLTKSAALELAPLNIRVNSI
MUL_1037|M.ulcerans_Agy99 GSIINVSSIEGLRGAPA-VHPYVASKWAVRGLTKSAALELAPLNIRVNSI
MAB_4680c|M.abscessus_ATCC_199 GSIVNISSAAGLVGLAL-TSGYGASKWGVRGLSKVAAIELGRERIRVNSV
MLBr_01807|M.leprae_Br4923 GRYIFMGSVVGLSGVPG-QANYAASKSGLIGMARSLARELGSRSITANVV
* : : * * . * *:* .: ::: * . : .* :
MSMEG_3009|M.smegmatis_MC2_155 HPGFIRTP-LTDAQETTIN-DYVVSQTPMGRAGTPDEIANGVVFLASDEA
TH_4254|M.thermoresistible__bu HPGFIETPQLRELYKGTERYERMLAGTPLGRLGRPDEIAAVVAFLVSDDA
Mb2025|M.bovis_AF2122/97 HPGLVKTP-------MTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDES
Rv2002|M.tuberculosis_H37Rv HPGLVKTP-------MTDWVPEDIFQTALGRAAEPVEVSNLVVYLASDES
MAV_2509|M.avium_104 HPGLIKTP-------MTEWVPEDIFQSALGRAAEPKEVSNLVVYLASDES
Mflv_3281|M.gilvum_PYR-GCK HPGFIRTP-------MTKHFPDNMLRIPLGRPGQPEEVATFVVFLASDES
Mvan_3000|M.vanbaalenii_PYR-1 HPGFIRTP-------MTKHFPDNMLRIPLGRPGQPEEVATFVVFLASDES
MMAR_0387|M.marinum_M HPGFIRTP-------MTANLPDDMVTIPLGRPAESREVSTFVVFLASDDA
MUL_1037|M.ulcerans_Agy99 HPGFIRTP-------MTANLPDDMVTIPLGRPAESREVSTFVVFLASDDA
MAB_4680c|M.abscessus_ATCC_199 HPGVIYTP--MTAKEGFREGEGNMPIAAMGRVGNADEVAGAVAYLLSDAA
MLBr_01807|M.leprae_Br4923 APGFIDTEMTR--AMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDA
**.: * : .:** . *:: * :* *: :
MSMEG_3009|M.smegmatis_MC2_155 SFVTGSELVIDGGYLAQ-------------------
TH_4254|M.thermoresistible__bu SFITGSEVYADGGWTAR-------------------
Mb2025|M.bovis_AF2122/97 SYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
Rv2002|M.tuberculosis_H37Rv SYSTGAEFVVDGGTVAGLAHNDFGAVEVSSQPEWVT
MAV_2509|M.avium_104 SYSTGSEFVVDGGTTAGLGHKDFSNVETDAQPDWVT
Mflv_3281|M.gilvum_PYR-GCK RYSTGAEFVMDGGLTNDVPHK---------------
Mvan_3000|M.vanbaalenii_PYR-1 RYATGAEFVMDGGLTNDVPHK---------------
MMAR_0387|M.marinum_M SYATGSEFVMDGGLVTDVPHKQF-------------
MUL_1037|M.ulcerans_Agy99 SYATGSEFVMDGGLVTDVPHKQF-------------
MAB_4680c|M.abscessus_ATCC_199 SYVTGAELAVDGGWTAGPTLTTITGQ----------
MLBr_01807|M.leprae_Br4923 GYISGAVIPVDGGLGMGH------------------
: :*: . ***