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YLRYKNKYFFRGRLPATDGAGNNGGVAERWTRQRRVDHTRALLLDAAEEVVARQGFGAAALEVIADAAGY TRGAIYAHFGTKEELFLAVMERQLQRFLDGFTDIVESFRSLEEMDVDRLAGRWRELTIGNPDRAALGYEF TLFLVRNPEARVRVAEQRRRTADSLAEYISVHVEKIGGRLRIPAPTLARILIATYEGITLGGHIDGEDLA RPFLELVLADVQPAESPDSERWD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2461 | - | - | 100% (234) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2327 | - | 8e-68 | 62.94% (197) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2460 | - | 3e-50 | 48.99% (198) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 1e-12 | 26.70% (191) | TetR/ACRR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 8e-13 | 26.70% (191) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 7e-09 | 36.36% (88) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2913 | - | 1e-16 | 31.07% (177) | TetR family regulatory protein |
| M. marinum M | MMAR_4631 | - | 2e-14 | 28.29% (205) | transcriptional regulatory protein |
| M. avium 104 | MAV_1611 | - | 1e-13 | 29.71% (175) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6807 | - | 1e-48 | 48.96% (192) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0452 | - | 4e-10 | 35.87% (92) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY |
| M. ulcerans Agy99 | MUL_0245 | - | 4e-11 | 26.40% (178) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4193 | - | 4e-97 | 86.43% (199) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2461|M.gilvum_PYR-GCK MYLRYKNKYFFRGRLPATDGAGNNGGVAERWTRQRRVDHTRALLLDAAEE
Mvan_4193|M.vanbaalenii_PYR-1 --------------------------MAERWTRQRRVEHTRTLLLDAAEE
MSMEG_6807|M.smegmatis_MC2_155 --------------------------MVERWTRERRLEHTRSLLLDAAEN
Mb0310|M.bovis_AF2122/97 -------------------------MGVPAKKKQQQGERSRESILDATER
Rv0302|M.tuberculosis_H37Rv -------------------------MGVPAKKKQQQGERSRESILDATER
MMAR_4631|M.marinum_M --------------------MTPPANTATPARVTKRRAETRARLVDAAFR
MUL_0245|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
TH_0452|M.thermoresistible__bu MSEVADTTARQEITPTNGGTTSGAAAGANRRGNRLPRDERRNQLLIAASE
MAB_2913|M.abscessus_ATCC_1997 -------------MYPYRFTVITTGRLLMSTGSTRRREHTRARLMQAALD
MAV_1611|M.avium_104 --------------------MLLGMSPVKPLRSRPTRGEVRDRILDAAAK
Mflv_2461|M.gilvum_PYR-GCK VVARQGFGAAALEVIADAAGYTRGAIYAHFGTKEELFLAVMERQLQRFLD
Mvan_4193|M.vanbaalenii_PYR-1 VVARLGFGAAALEVIADAAGYTRGAIYSHFGTKEELFLAVMERQLQRFLD
MSMEG_6807|M.smegmatis_MC2_155 VFSEKGFTAATLDDIAFAAGYTKGAIYKHFATKEDLFLAVSDRYWRRYFD
Mb0310|M.bovis_AF2122/97 LMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA
Rv0302|M.tuberculosis_H37Rv LMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFA
MMAR_4631|M.marinum_M VFADKGFGHVRIEDVCAAAGYTRGAFYSQFDSLEELFFTLYDQRATLISE
MUL_0245|M.ulcerans_Agy99 MFADKGFGHVRIEDVCAAAGYTRGAFYSQFDSLEELFFTLYDQRATLISE
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
TH_0452|M.thermoresistible__bu VFVDRGYHAAGMDEIAERAGVSKPVLYQHFSSKLELYLAVLQRHVDNLVS
MAB_2913|M.abscessus_ATCC_1997 VFADRGFHGASIENICEKAGFTRGAFYSNFAGKDELFFTLFDASSEQLLT
MAV_1611|M.avium_104 VFAAEGFAGATIDAIGQAAGFTKGAVYSNFESKDELFLALLDREFELRGQ
:. *: . :. : .* : .* :* : :: :
Mflv_2461|M.gilvum_PYR-GCK GFTDIVESFRSLEEMDVDRLAGRWRELTIGN-PDRAALGYEFTLFLVRNP
Mvan_4193|M.vanbaalenii_PYR-1 GFTDIVESFQSLEELDVDKLAGRWRELTIGN-PDRAALGYEFTLFLVRNP
MSMEG_6807|M.smegmatis_MC2_155 NFAEVMASAASVGARELDEIAKRWRQLSVDRGAEQAALGLEFTLYLKRNP
Mb0310|M.bovis_AF2122/97 AIPTWDEAHGPVEQRSERQLT-ELVSLQSQH-PDFLRLFYLLSMERSQDP
Rv0302|M.tuberculosis_H37Rv AIPTWDEAHGPVEQRSERQLT-ELVSLQSQH-PDFLRLFYLLSMERSQDP
MMAR_4631|M.marinum_M QVGTAMASVDDPTDVP-GTVDRIASTLLLDR--DWLLIKTDFLMHAARHP
MUL_0245|M.ulcerans_Agy99 QVGTAMASVGDPTDVP-GTVDRIASTLLLDR--DWLLIKTDFLMHAARHP
MLBr_00815|M.leprae_Br4923 SVQQALRTTTNNRQRLHAAVQAFFDFIEHDG----QGYRLIFENDNITEP
TH_0452|M.thermoresistible__bu GVRQALRTTTDNRQRLRAAVQAFFDFIEHDG----QGYRLIFENDYVTEP
MAB_2913|M.abscessus_ATCC_1997 QLRAALDECRKSPDPLSTFIRTIDDKGPTQR--RWYLISMEFTLYAIREP
MAV_1611|M.avium_104 QIAIALDRSAGDTTAAAREVSRSVLDSVRDH-SDYYVLLVEYWLRAQRDP
. : .*
Mflv_2461|M.gilvum_PYR-GCK EARVRVAEQRRRTADSLAEYISVHVEKIG--GRLRIPAPTLARILIATYE
Mvan_4193|M.vanbaalenii_PYR-1 EARARVAAQRRQTADSLAGYITSHIEKIG--GRMRVPAATLARVLIATNE
MSMEG_6807|M.smegmatis_MC2_155 EARDRVAAKRSEVVAQLTAFIVASIEKLG--ATLLISPETFAHALVATSD
Mb0310|M.bovis_AF2122/97 VVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELTAFAVALSD
Rv0302|M.tuberculosis_H37Rv AVAAVVRRVRNTAIARFRDSITHLLPSDIPPGKADLVVAELTAFAVALSD
MMAR_4631|M.marinum_M DLAQRLAAHRAQLRAAVEDRLAGSDVELP---AAIGSVADAARAVVAAYD
MUL_0245|M.ulcerans_Agy99 DLAQRLAAHRAQLRAAVEDRLAGSDVELP---AAIGSVADAARAVVAAYD
MLBr_00815|M.leprae_Br4923 RVAAQVRVATESCIDAVFALISADSRLDP--HRARMVAVGLVGISVDCAR
TH_0452|M.thermoresistible__bu QVAAQVKVATEACTDAVFDLISQDSGLEA--HRARMIAVGLVAISVDCAR
MAB_2913|M.abscessus_ATCC_1997 SAAVVLAEHDARLRREAAGIINELMSIAHR--ELIIDTELIARLATALRE
MAV_1611|M.avium_104 QLRERLIERRRAAADQALHIVESTDTVPG-----DRRLTDIAQLVVTLNL
: : .
Mflv_2461|M.gilvum_PYR-GCK GITLGGHID-----GEDLARPFLELVLADVQPAESPDSERWD
Mvan_4193|M.vanbaalenii_PYR-1 GVTLGSHVD-----GEDLFRPFLEMVLGNVEPAG--------
MSMEG_6807|M.smegmatis_MC2_155 SVVLSSELD-----NVDLYRPMVEMYASMIKLPT--------
Mb0310|M.bovis_AF2122/97 GVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET-----
Rv0302|M.tuberculosis_H37Rv GVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET-----
MMAR_4631|M.marinum_M GVSIQLLLD----GDQDAARAWLSQLLGVVLIR---------
MUL_0245|M.ulcerans_Agy99 GVSIQLLLD----GDQDAARAWLSQLLGVVLIR---------
MLBr_00815|M.leprae_Br4923 -YWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL-------
TH_0452|M.thermoresistible__bu -YWLHADRPISKEDAVEGTVQFAWGGLSHVPLTRS-------
MAB_2913|M.abscessus_ATCC_1997 GVAAQFYVEPELAETRMLERLAFPAMLRAFSQPVGAD-----
MAV_1611|M.avium_104 GVAMEEVLRPG-TINPDLLAQLITALLESIPV----------
.