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VGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAMMERGA QRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLLSMERSQDPAVAAVVRRVRNTAIARF RDSITHLLPSDIPPGKADLVVAELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0302 | - | - | 100% (210) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY) |
| M. tuberculosis H37Rv | Rv3050c | - | 8e-09 | 27.42% (186) | AsnC family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 3e-07 | 22.58% (155) | transcriptional repressor (probably TETR-family) MCE3R |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 1e-116 | 99.52% (210) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2461 | - | 9e-13 | 26.70% (191) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 2e-07 | 24.74% (190) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2541c | - | 2e-08 | 24.10% (166) | transcriptional regulatory protein TetR |
| M. marinum M | MMAR_1504 | - | 6e-20 | 29.21% (202) | transcriptional regulatory protein |
| M. avium 104 | MAV_1852 | - | 6e-10 | 36.36% (77) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4022 | - | 7e-11 | 44.83% (58) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_2719 | - | 1e-10 | 25.91% (193) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_4947 | - | 4e-10 | 45.45% (77) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0594 | - | 3e-21 | 32.20% (205) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0302|M.tuberculosis_H37Rv -----------------------------------------MGVPAK---
Mb0310|M.bovis_AF2122/97 -----------------------------------------MGVPAK---
MMAR_1504|M.marinum_M ------------------------------------MAKETESRPRKRAP
Mvan_0594|M.vanbaalenii_PYR-1 ----------------------------------------MTDQPKR---
TH_2719|M.thermoresistible__bu -------------------------------------------MASR---
Mflv_2461|M.gilvum_PYR-GCK -----------------MYLRYKNKYFFRGRLPATDGAGNNGGVAER---
MSMEG_4022|M.smegmatis_MC2_155 -------------------------------------------MTRRR--
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
MAB_2541c|M.abscessus_ATCC_199 -------------------------------------------MMVG---
MAV_1852|M.avium_104 -------------------------------MTVTYSRSMTPSSSTAAAP
MUL_4947|M.ulcerans_Agy99 --------------------------------------------------
Rv0302|M.tuberculosis_H37Rv -KKQQQGERSRESILDATERLMATKGYAATSISDIRDACGLAPSS--IYW
Mb0310|M.bovis_AF2122/97 -KKQQQGERSRESILDATERLMATKGYAATSISDIRDACGLAPSS--IYW
MMAR_1504|M.marinum_M RRGRADGELSRARILDAATEIAAERGYEGTSIALVSAKCGLPASS--IYW
Mvan_0594|M.vanbaalenii_PYR-1 RRRRADGELSRRRILDAATEIAAERGYEGTSIGAVSAKCGLPASS--IYW
TH_2719|M.thermoresistible__bu --RAQISEESRRLLIAAATELFAEQGFRRTTFADIAERSGISRGS--IPW
Mflv_2461|M.gilvum_PYR-GCK WTRQRRVDHTRALLLDAAEEVVARQGFGAAALEVIADAAGYTRGA--IYA
MSMEG_4022|M.smegmatis_MC2_155 STAPSKGDRRREAVLDAAEALLSTTGYHAMTIADIADGAGITRGA--LYF
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLG-PEVSVREIAEEAGTAKPK--IYR
MAB_2541c|M.abscessus_ATCC_199 ---NRRGVASRAALLEAGRTAFSAQRYDEVSIVDVARSLGVAAGS--ISY
MAV_1852|M.avium_104 QLDTSRGERTRSAILDASRRLFLERGYAGTPINAITEACGISRAG--FYT
MUL_4947|M.ulcerans_Agy99 -----MSTSGRDRLLSAALKLFAVKGYAATSVADIQRCSGLAPGSGALYK
* :: * .. : * . :
Rv0302|M.tuberculosis_H37Rv HFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGP----VEQRSERQLTELV
Mb0310|M.bovis_AF2122/97 HFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGP----VEQRSERQLTELV
MMAR_1504|M.marinum_M HFKDKDDLIAAVIERSFGGWLTAWQIPEGQSGD----ETIQGAEQFVGLA
Mvan_0594|M.vanbaalenii_PYR-1 HFKDKDDLIAAVIERSFANWLTVWQLP----------DDVMARDRLMEVA
TH_2719|M.thermoresistible__bu HFGNKDGLLRAVIED-----FIAGVIELDASEQ----TLSEGLDRIRDYV
Mflv_2461|M.gilvum_PYR-GCK HFGTKEELFLAVMERQLQRFLDGFTDIVESFRS----LEEMDVDRLAGRW
MSMEG_4022|M.smegmatis_MC2_155 YFGSKQEVITALFARCVEVLHEKSRAAAADAASGA-AAIDMAMERTEALW
MLBr_01733|M.leprae_Br4923 HFTDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLV
MAB_2541c|M.abscessus_ATCC_199 HFGGKRGFYLAVVEQAAEEFWSDLIQMRGPALERLADGIGKFLDRAQQEP
MAV_1852|M.avium_104 YFKDKREIFNVLGKTAYHDALAVIAEWAEAPEPLGPADIRVWVGHYFDYM
MUL_4947|M.ulcerans_Agy99 HFGSKHELLEAAVEHRIDSIVAAREQYDAGEPGGVEQAVRTAGHLIWTNL
:* * . .
Rv0302|M.tuberculosis_H37Rv SLQS---------QHPDFLRLFYLLSMER-SQDPAVAAVVR-RVRNTAIA
Mb0310|M.bovis_AF2122/97 SLQS---------QHPDFLRLFYLLSMER-SQDPVVAAVVR-RVRNTAIA
MMAR_1504|M.marinum_M TQTAKAL-----LDSPDFIRLGLMLALERRPAEPRARTMFL-EVRAQAFG
Mvan_0594|M.vanbaalenii_PYR-1 MGTAKAV-----LDSPDFLRLGLMLALERRPVEPKARAMFI-QVREQAFA
TH_2719|M.thermoresistible__bu RRPT--------------TRLLITLVAEAVEPDSPVHAFYA-QLHDTLRK
Mflv_2461|M.gilvum_PYR-GCK RELTIGN-----PDRAALGYEFTLFLVRNPEARVRVAEQRR-RTADSLAE
MSMEG_4022|M.smegmatis_MC2_155 REHG----------------VVMRTAIDLASTVEELDRLWA-DTADLFID
MLBr_01733|M.leprae_Br4923 DKHPNVLRVFIQGRFSAQSEATVRTLDEGREITLTMAEMFNNELREMELN
MAB_2541c|M.abscessus_ATCC_199 RAFEALL-----ADVADAEVRRIREQHRQRLAHALAVEITGTESTPILRA
MAV_1852|M.avium_104 DQHG----------------AFVLASAHSAPDDDEFRNSRN-RMVTRASW
MUL_4947|M.ulcerans_Agy99 KQSE------------DLLKVMLREPGALGDLDEKTWQIITDNAYQRFAD
Rv0302|M.tuberculosis_H37Rv RFRDSITHLLPS-------DIPPGKADLVVAELTAF--------AVALSD
Mb0310|M.bovis_AF2122/97 RFRDSITHLLPS-------DIPPGKADLVVAELTAF--------AVALSD
MMAR_1504|M.marinum_M QLIGNFGRFM------------PGLTEAQIYQLATY--------AMAGAD
Mvan_0594|M.vanbaalenii_PYR-1 ALATSIRDLG------------LDLSEEQVRHLSTY--------AIAGAD
TH_2719|M.thermoresistible__bu WLSDWIDDKD----------IPPGVSRE---NFVTV--------LIGAVI
Mflv_2461|M.gilvum_PYR-GCK YISVHVEKIG-------------GRLRIPAPTLARI--------LIATYE
MSMEG_4022|M.smegmatis_MC2_155 AIRAILENMG----------VPAGSGVDESSSLAKT--------LCWMIE
MLBr_01733|M.leprae_Br4923 RAASELAAFAAFGSVASATEWWLGPEPDSPRRMPRE--------QFVAHL
MAB_2541c|M.abscessus_ATCC_199 AISGSLSFMEG---IVLHWMHTDGVSRDAIRDLITANFIGTILSAVRSDP
MAV_1852|M.avium_104 KLGQAIAGGG-------------GVHSPDVVGVAVMG----------LLD
MUL_4947|M.ulcerans_Agy99 ELAASNRSGRTR---------IPDPEAAASVAIASLSYALTLQALTGRSP
. .
Rv0302|M.tuberculosis_H37Rv GVYFAGHLEPDTTDVER-MYRRLRQALEALIPVLLEET---
Mb0310|M.bovis_AF2122/97 GVYFAGHLEPDTTDVER-MYRRLRQALEALIPVLLEET---
MMAR_1504|M.marinum_M GLFIAKEIDGDAVNLIE-MFELHGRALYDAARRFIEDGATR
Mvan_0594|M.vanbaalenii_PYR-1 GLFIAKEIGGDTVDLMA-LFALHGQALYDTALRMIEENNR-
TH_2719|M.thermoresistible__bu GVHQQWRVAPHHVDLDA-CFAALKQLASGD-----------
Mflv_2461|M.gilvum_PYR-GCK GITLGGHIDGEDLARPF-LELVLADVQPAESPDSERWD---
MSMEG_4022|M.smegmatis_MC2_155 RNFYQASRISN-AELAK-ASRTCAEIWRRAARSA-------
MLBr_01733|M.leprae_Br4923 TIIMMAVIVGTAETLGI-SMNPDRPIHDAVPLDRSAS----
MAB_2541c|M.abscessus_ATCC_199 DIELSQRVVEAVLPDAR-LLSVFADPASLIPVTNNTQ----
MAV_1852|M.avium_104 RAWHTVHRQTVAVDRSE-MIAVVAEMIVAMTRR--------
MUL_4947|M.ulcerans_Agy99 GNIDDSRYFEAWVNQTVSMLSQYTNPAPSRKPQADNKFQE-