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SPSRQPAMFRHMPDAKNPMAADRGQRRASFQRADSRETQRTLIQAAMALWRTKGYAATTVADICTAAGVS KALFYFYFPRKEDVLFEVGVLSTKAAHRRIHALLKKPYEIESVIAGALTAFEQSMARNPKDLVIETILEG YRHEHRLMAGGGHPDPDADMFTELFTRARDDGKLPASVDPVHLAYLAQTMVSEGSRHWAAGAFGDRSFAE VVTGDICTLVNGYRHTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2452 | - | - | 100% (228) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1253 | - | 3e-11 | 27.97% (143) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3637 | - | 3e-08 | 24.40% (168) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1561 | - | 1e-06 | 30.49% (82) | transcriptional regulator |
| M. tuberculosis H37Rv | Rv1534 | - | 1e-06 | 30.49% (82) | transcriptional regulator |
| M. leprae Br4923 | MLBr_01070 | - | 7e-06 | 31.13% (106) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4027 | - | 3e-07 | 29.30% (157) | TetR/AcrR family transcriptional regulator |
| M. marinum M | MMAR_1492 | - | 5e-08 | 50.00% (50) | transcriptional regulatory protein |
| M. avium 104 | MAV_4026 | - | 2e-08 | 46.55% (58) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4825 | - | 3e-74 | 67.98% (203) | transcriptional repressor, TetR family protein, putative |
| M. thermoresistible (build 8) | TH_0258 | - | 4e-80 | 69.46% (203) | transcriptional repressor, TetR family protein, putative |
| M. ulcerans Agy99 | MUL_2448 | - | 1e-07 | 48.00% (50) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4199 | - | 6e-99 | 85.64% (202) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2452|M.gilvum_PYR-GCK ------------MSPS---RQP----------------------------
Mvan_4199|M.vanbaalenii_PYR-1 MPHKPGREERRQLEPSGDERQQGEHQRGGPQHTHATHSAEDDLQVPIVRL
TH_0258|M.thermoresistible__bu --------------------------------------------------
MSMEG_4825|M.smegmatis_MC2_155 --------------------------------------------------
Mb1561|M.bovis_AF2122/97 --------------------------------------------------
Rv1534|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1492|M.marinum_M --------------------------------------------------
MUL_2448|M.ulcerans_Agy99 --------------------------------------------------
MAV_4026|M.avium_104 --------------------------------------------------
MLBr_01070|M.leprae_Br4923 --------------------------------------------------
MAB_4027|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2452|M.gilvum_PYR-GCK ---------AMFRHMPDAKNP-MAADRGQRRASFQRADSRETQRTLIQAA
Mvan_4199|M.vanbaalenii_PYR-1 RSTIGSHDFACYLHDVAATRPDTQPDHGQRRASFQRARSRETKRMLVQAA
TH_0258|M.thermoresistible__bu ---------------------VSRADGGQRRASYQRARSRETKRALVQAA
MSMEG_4825|M.smegmatis_MC2_155 ---------------MVASPRNTEADRGQRRATFQRANSHTTKQMLVHAA
Mb1561|M.bovis_AF2122/97 ----------------------MSRASARRRRAVSDEDKSQRRDEILAAA
Rv1534|M.tuberculosis_H37Rv ----------------------MSRASARRRRAVSDEDKSQRRDEILAAA
MMAR_1492|M.marinum_M -------------------------MPARQESRELSSKGRQTRQAIEQAA
MUL_2448|M.ulcerans_Agy99 -------------------------MPARQESRELSSKGRQTRQAIEQVA
MAV_4026|M.avium_104 -------------------------MPAEL----LTAKGRQTRQAIEQAA
MLBr_01070|M.leprae_Br4923 -------------MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVA
MAB_4027|M.abscessus_ATCC_1997 -------------------MASTSSGRRGPGRPPNPARARERQRALTEAA
. : .*
Mflv_2452|M.gilvum_PYR-GCK MALWRTKGYAATTVADICTAAGVSKALFYFYFPRKEDVLFEVGVLSTKAA
Mvan_4199|M.vanbaalenii_PYR-1 MALWRTKGYATTTVADICTAAGVSKALFYFYFPRKEDVLFEVGVLSTQSA
TH_0258|M.thermoresistible__bu MALWRTNGYANTTVADICRAAGVSRALFYFYFPAKEDILFEVGLLSTQAA
MSMEG_4825|M.smegmatis_MC2_155 MALWRTNGYANTTVAEICRGAGVSKALFYFYFPRKEDVLFEVGVMSTRSA
Mb1561|M.bovis_AF2122/97 KIVFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEAL
Rv1534|M.tuberculosis_H37Rv KIVFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEAL
MMAR_1492|M.marinum_M RKLFAERGFHGTTLADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDV
MUL_2448|M.ulcerans_Agy99 RKLFAERGFHGTTLADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDV
MAV_4026|M.avium_104 RKLFAERGFHGTTLADITSAAGKSPAVFYRYFADKEDLLAALAESFLHEV
MLBr_01070|M.leprae_Br4923 ERLLAERPLGDFSVDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKS
MAB_4027|M.abscessus_ATCC_1997 ALEFAEKGYHKASITDITQRAGVGRGTFYLYFDTKRDVLDAVIDSYFQRT
. :: :: ** . :* ** * :: :
Mflv_2452|M.gilvum_PYR-GCK HRRIHALLKKPYEIESV----IAGALTAFEQSMARNPKDLVIETILEGYR
Mvan_4199|M.vanbaalenii_PYR-1 HRTIHALLKKPYEIESV----VSAALTAFERSMARNPRELIIETILEGYR
TH_0258|M.thermoresistible__bu RRRIRSLLRGDYDVDSV----IAAALRSLERSMARNPRELIVQTILEGYR
MSMEG_4825|M.smegmatis_MC2_155 QRTIAKLLADDYDVMTV----VGAALTALERSMSSNPRELVIETILEGYR
Mb1561|M.bovis_AF2122/97 RAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYA
Rv1534|M.tuberculosis_H37Rv RAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYA
MMAR_1492|M.marinum_M VTPSGVSLQLPDSPDDD---TFFTAVVTGYWNIFKQNIG-IMIAVDQLAA
MUL_2448|M.ulcerans_Agy99 VTPSGVSLQLPDSPDDD---TFFTAVVTGYWNIFKQNIG-IMIAVDQLAA
MAV_4026|M.avium_104 VTPSGLSVHLPDSPDDD---AFFTAVVTGYWNMFKQNIG-IMIAVAQLAA
MLBr_01070|M.leprae_Br4923 RSAVEALAEQLPADPAA----VWRSAITAFFEVCGTHRA-VAVAGAAAKA
MAB_4027|M.abscessus_ATCC_1997 VAAVNDTSDLLGNASDF--ELHLRTVFTRLFDMLDNSPE-IMQVILREGL
: .. :
Mflv_2452|M.gilvum_PYR-GCK HEHRLMAGGGH-PDPDADMFTELFTRARDDGKLPASVDPVHLAYLAQTMV
Mvan_4199|M.vanbaalenii_PYR-1 HEHRIMADGSP-PDVDADMFTELFTRARSDGKLPGTVDTAHLAYLAQTMV
TH_0258|M.thermoresistible__bu HEHRILAGEED-PATGADMFGELFTRAQQDGKLAAGIDVDHLSRVAQMLV
MSMEG_4825|M.smegmatis_MC2_155 HEHRLLATGENRPDLDGGMFTTLFARAVADGKLPAGTDTDRLAHLAMMMV
Mb1561|M.bovis_AF2122/97 LGGRFEEHLGGIYERFIDDIEAVVVAAQRRG--EVVEAPSRMAAYTLAAL
Rv1534|M.tuberculosis_H37Rv LGGRFEEHLGGIYERFIDDIEAVVVAAQRRG--EVVEAPSRMAAYTLAAL
MMAR_1492|M.marinum_M TQQRFAAVQNQFRRFGMDIIAASVRHAQDQG--YGTELNPDHTAVAIALL
MUL_2448|M.ulcerans_Agy99 TQQRFAAVQNQFRRFGMDIIAASVRHAQDQG--YGTELNPDHTAVAIALL
MAV_4026|M.avium_104 TQQRFAAVQNEFRRFGIDLVAASVRRAQEQG--YGTELHPQHTAAAIALL
MLBr_01070|M.leprae_Br4923 TSPEVRRLWSTVMQQWIDYNTAAIQAERKCGVAPDTIPAEDLAVALQLMT
MAB_4027|M.abscessus_ATCC_1997 LDTAMTKRMFGILDLIEAINVTIIEQAVMDGAITAAVDIPFLAHAITGLS
. . * :
Mflv_2452|M.gilvum_PYR-GCK SEGSRHWAAGAFGDRSFAEVVTGDICTLVNGY---------RHTP----
Mvan_4199|M.vanbaalenii_PYR-1 SEGARHWAAGAFGSRSFAEVVTADICTLVNGYTARRPHVEFRDRP----
TH_0258|M.thermoresistible__bu SEGVRHWAAGGFGDRSFTEVVAGDIAALIDGYN-------LRLRR----
MSMEG_4825|M.smegmatis_MC2_155 SEGARHWAAGAFGARSFADVVASDIATLIAGSTG-------RRRP----
Mb1561|M.bovis_AF2122/97 VGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Rv1534|M.tuberculosis_H37Rv VGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
MMAR_1492|M.marinum_M FENFTSVLVGTSGSSGPGGLG---VTITDEDAITTLSRIWKKTLYGF--
MUL_2448|M.ulcerans_Agy99 FENFTSVLVGTSGSSGPGGLG---VTITDEDAITTLSRIWKKTLYGF--
MAV_4026|M.avium_104 FENFTTVFVG------PSGLG---IEISDEDAIATLSTIWKKTLYGV--
MLBr_01070|M.leprae_Br4923 ERVMAATFSDEKPLIPDKKVIDTLVHIWLASIYGS--------------
MAB_4027|M.abscessus_ATCC_1997 MAATLKAIRGELEGDAREAYIGSFIQLVRTATTGSTPVANS--------
. :