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ENETLSVSAGRKRGRPVAADSEQTRRTVLAAARDIIAERGYQATTFQQIAQRAGVSRPTLHYYFATREDL YDALLADVCERLGRCAAAAAGQDSLRGQLAAFMAEMNRLAVAEPAMMKLVVTARIDHHGARIGTGEGRGA ATDIVSTVHDFYDAVVLAAAARGELPAGHDPHAVADMLAAVFWGLGFHARMLTADIGVDGVPEVARQLLS VLDSGLLDGALRAPADA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3637 | - | - | 100% (228) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0744 | - | 5e-20 | 33.33% (195) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4624 | - | 9e-09 | 29.63% (162) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0149 | - | 3e-20 | 30.29% (208) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0144 | - | 3e-20 | 30.29% (208) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 4e-07 | 38.89% (54) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1379c | - | 2e-12 | 30.68% (176) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0355 | - | 2e-23 | 33.33% (186) | TetR family transcriptional regulator |
| M. avium 104 | MAV_5151 | - | 6e-20 | 30.41% (217) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_3177 | - | 6e-30 | 37.38% (214) | transcriptional regulatory protein, putative |
| M. thermoresistible (build 8) | TH_3831 | - | 1e-27 | 37.93% (174) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_4765 | - | 2e-23 | 33.33% (186) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2776 | - | 6e-65 | 60.18% (221) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3637|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2776|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3177|M.smegmatis_MC2_155 --------------------------------------------------
Mb0149|M.bovis_AF2122/97 MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAKLTSSV
Rv0144|M.tuberculosis_H37Rv MPHSWTPTSVMTPPLVVAAFRPVGHYRLATDRAGGPCSPPATGAKLTSSV
MMAR_0355|M.marinum_M --------------------------------------------------
MUL_4765|M.ulcerans_Agy99 --------------------------------------------------
MAV_5151|M.avium_104 --------------------------------------------------
TH_3831|M.thermoresistible__bu --------------------------------------------------
MAB_1379c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00815|M.leprae_Br4923 -------------------------------------------------M
Mflv_3637|M.gilvum_PYR-GCK --------------MENETLSVSAGRKRGRPVAADSEQTRRTVLAAARDI
Mvan_2776|M.vanbaalenii_PYR-1 ---------------------MPAVRRPGRPVGANSDQTRRTILCAARDV
MSMEG_3177|M.smegmatis_MC2_155 --------------MTEAGQPRPLRRAPGRPVGADSAQTRMHILRVGCEL
Mb0149|M.bovis_AF2122/97 ASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQV
Rv0144|M.tuberculosis_H37Rv ASRPTVGTKPQWWHTLVMSMSLTAGRGPGRPPAAKADETRKRILHAARQV
MMAR_0355|M.marinum_M -------------------MQLTASRGPGRPPAAKADDTRRRIVGAAREV
MUL_4765|M.ulcerans_Agy99 ------------------MMQLTASRGPGRPPAAKADDTRRRIVGAAREV
MAV_5151|M.avium_104 -------------------MLPRGNRRPGRPPAAKADETRQRIIQAARLV
TH_3831|M.thermoresistible__bu ----------------------------MRPARTASSDTRARILEAARRI
MAB_1379c|M.abscessus_ATCC_199 ------------------------MPEQLSRFERRKQETRREILGAALAC
MLBr_00815|M.leprae_Br4923 NNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASDV
. * :: ..
Mflv_3637|M.gilvum_PYR-GCK IAERGYQATTFQQIAQRAGVSRPTLHYYFATR----EDLYDALLADVCER
Mvan_2776|M.vanbaalenii_PYR-1 IAEHGYRAATFQQIALRAGVSRPTLHYYFATR----EQLYEVLLADVRAE
MSMEG_3177|M.smegmatis_MC2_155 INERGFAALTFQGVAKRSGLSRPTLNYYFATR----DELFHALVHEGNAI
Mb0149|M.bovis_AF2122/97 FSERGYDGATFQEIAVRADLTRPAINHYFANK----RVLYQEVVEQTHEL
Rv0144|M.tuberculosis_H37Rv FSERGYDGATFQEIAVRADLTRPAINHYFANK----RVLYQEVVEQTHEL
MMAR_0355|M.marinum_M FSERGYDGATFQAIAVSADLTRPAINHYFASK----QALYREVVVQTNEL
MUL_4765|M.ulcerans_Agy99 FSERGYDGATFQAIAVSADLTRPAINHYFASK----QALYREVVVQTNEL
MAV_5151|M.avium_104 FSERGYDGATFQAIAARADLTRPAINHYFSSK----RALYQEVMDETNEF
TH_3831|M.thermoresistible__bu IVERGYPAATCQGIARAAGVSRPTLHYYFASR----EEIYDCLVEQSRNL
MAB_1379c|M.abscessus_ATCC_199 FAERGYHATGIADIVRRVGIAQGTFYLYFQSKREIVEQILDDLMERLSAA
MLBr_00815|M.leprae_Br4923 FVDHGYHAAGMDEIADRAGVSKPVLYQHFSSK----LELYLAVLERHMNN
: ::*: . :. .::: .: :* .: : ::
Mflv_3637|M.gilvum_PYR-GCK LGRCAAAAAGQ-DSLRGQLAAFMAEMNRLAVAEPAMMKLVVTARIDHHGA
Mvan_2776|M.vanbaalenii_PYR-1 VARCAAEATLA-GSLLRQLEVFIAEMHRLGGAEPALMGLVVTARVDHRGV
MSMEG_3177|M.smegmatis_MC2_155 VQECIAAAKQQ-EDPLERVCALLDAMADAWSADPCLCQFLVNARLEAGRN
Mb0149|M.bovis_AF2122/97 VIVAGIERARREPTLMGRLAVVVDFAMEADAQYPASTAFLATTVLESQRH
Rv0144|M.tuberculosis_H37Rv VIVAGIERARREPTLMGRLAVVVDFAMEADAQYPASTAFLATTVLESQRH
MMAR_0355|M.marinum_M VVAAGVERARSVQTLLGQLCTFVMVAKEADASHPATTAFLATAVLESQRH
MUL_4765|M.ulcerans_Agy99 VVAAGVERARSVQTLLGQLCTFVMVAKEADASHPATTAFLATAVLESQRH
MAV_5151|M.avium_104 VIGVGIKEADRETTLVGRLTAFISAAVKANAENPAGSAFIIGGVLESQRH
TH_3831|M.thermoresistible__bu LAEC-AERAMRYDTLVERLTEFGLRLREVDSRDRSTIAFLISARLEGMRN
MAB_1379c|M.abscessus_ATCC_199 LLDLPPSAPTSLAEYRDQAEHISTSLTGVLSADPQAARFLLLQAAAVDDD
MLBr_00815|M.leprae_Br4923 LVSSVQQALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPR
: : ::
Mflv_3637|M.gilvum_PYR-GCK RIGTGEGRGAATDIVSTVHDFYDAVVLAAAARGELPAGHDPHAVADMLAA
Mvan_2776|M.vanbaalenii_PYR-1 LR-----HEAATAVVATVHAFFDAVVVDAVRRGELAFDTDAHAVADLLGA
MSMEG_3177|M.smegmatis_MC2_155 -------PALPNGIATAIRDFLDDVVGDAIAGGALSAHTDPAPVAQLLHA
Mb0149|M.bovis_AF2122/97 P----ELSRTENDAVRATREFLVWAVNDAIERGELAADVDVSSLAETLLV
Rv0144|M.tuberculosis_H37Rv P----ELSRTENDAVRATREFLVWAVNDAIERGELAADVDVSSLAETLLV
MMAR_0355|M.marinum_M P----ELRRSDHDAVAATREFLDTAVRDAIQRGELEAGVDASQLAEALLL
MUL_4765|M.ulcerans_Agy99 P----ELRRSDHDAVAATREFLDTAVRDAIQRGELEAGVDASQLAEALLL
MAV_5151|M.avium_104 P----EWNTAENDSVRIAREFLIRVVNDAIEHGEVAADIDASALVETLLV
TH_3831|M.thermoresistible__bu R----ELG---EDPAMALREFFTELLADAVAAGELPSDIDIESAVEVMYT
MAB_1379c|M.abscessus_ATCC_199 M------AERVLAFYDAAAAIQATYLQHGISAGYFRSDLDAGHAARAVNG
MLBr_00815|M.leprae_Br4923 V----------AAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVG
: . . :
Mflv_3637|M.gilvum_PYR-GCK VFWGLGFHARMLTADIGVDGVPEVARQLLSVLDSGLLDGALRAPADA
Mvan_2776|M.vanbaalenii_PYR-1 LFWGLVFHAGFIS---GADGAPEIARQLLRMVGFGLLDTPEPASVDA
MSMEG_3177|M.smegmatis_MC2_155 MVWGVGLCLGYGG----TSDPKLITKQLESAIAGGLLTESRQAS---
Mb0149|M.bovis_AF2122/97 VLCGVGFYIGFVG---SYQRMATITDSFQQLLAGTLWRPPT------
Rv0144|M.tuberculosis_H37Rv VLCGVGFYIGFVG---SYQRMATITDSFQQLLAGTLWRPPT------
MMAR_0355|M.marinum_M LLCGVGFYAGFVG---SYRDMENILDTLCKMMAGTLWKPRS------
MUL_4765|M.ulcerans_Agy99 LLCGVGFYAGFVG---SYRDMENILDTLCKMMAGTLWKPRS------
MAV_5151|M.avium_104 VMCGVGLYAGYVE---TYQEMLAVTGMLRQLLEGALWRPGS------
TH_3831|M.thermoresistible__bu VLWGLGFYTGFVE---RSTDMLVLAEQLENLFASA------------
MAB_1379c|M.abscessus_ATCC_199 MLLASAFYSLRDP---SPAAFEQLAHAVREILYYGLASDHHPQIAD-
MLBr_00815|M.leprae_Br4923 ISVDCARYWLDTN---RPISKSDAVEGTVQFAWGGLSHVPLTRL---
: