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VLKSRTPERGRKGEQTRERLLGAAIAEFKRDGMAAADIGAIVSAAGVAHGTFFFHFPTKEHVLVELENRE QERMAAELTRFYRRPHDVRATLTKAVTVLEALERRLGSRLFKDFLALHFSTRRPPSEEWSAHPVIVAVVE DLERARDRGEIPADVDVMLRGVSFLVGLYALLITMPESREIRAPVIDEYVTTYMDALHAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1253 | - | - | 100% (200) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1774 | - | 1e-54 | 57.30% (178) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4907 | - | 2e-54 | 57.67% (189) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 8e-08 | 29.03% (155) | TetR/ACRR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 2e-07 | 28.39% (155) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1379c | - | 3e-08 | 36.76% (68) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0249 | - | 6e-39 | 43.78% (185) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2459 | - | 5e-52 | 60.00% (170) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6527 | - | 4e-77 | 70.05% (197) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1791 | - | 8e-85 | 76.65% (197) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4864 | - | 4e-36 | 41.62% (185) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4973 | - | 6e-54 | 57.87% (178) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1253|M.gilvum_PYR-GCK --------MLKS-RTPERGRKGEQTRERLLGAAIAEFKRDGMAAADIGAI
TH_1791|M.thermoresistible__bu --------VLNE-RTSDRGSKGRQTRERLLGAAIAEFKRGGMAAADVASI
MSMEG_6527|M.smegmatis_MC2_155 --------MLRQ-ERTGRWRKGMQTRERLLGAALAEFKRNGIAAADTAAI
MAV_2459|M.avium_104 --------MAD--RLSAREAKRLQTRERLMGAAIAEFARAGMAEADVGAI
Mvan_4973|M.vanbaalenii_PYR-1 -------MMAPQVRQTARELRRLQTRERILGAAIAEFQASGMAGADIGAI
MMAR_0249|M.marinum_M MGSTASTTAPHSPQQKVREAQRLRTRARVFDAAVAEIGRRGLAGADVAAI
MUL_4864|M.ulcerans_Agy99 MGSTASTTAAHSPQQKVREAQRLRTRARVFDAAVAEIGRRGLAGADVAAI
Mb0310|M.bovis_AF2122/97 ----------MGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDI
Rv0302|M.tuberculosis_H37Rv ----------MGVPAKKKQQQGERSRESILDATERLMATKGYAATSISDI
MAB_1379c|M.abscessus_ATCC_199 ----------MPEQLSRFERRKQETRREILGAALACFAERGYHATGIADI
: .:* ::.*: : * :. . *
Mflv_1253|M.gilvum_PYR-GCK VSAAGVAHGTFFFHFPTKEHVLVELENREQERMAAELTRFY-RRPHDVRA
TH_1791|M.thermoresistible__bu VAAAGVAHGTFFFHFPTKEHVLVELERREEERMAAELNRYF-RTPHTVRQ
MSMEG_6527|M.smegmatis_MC2_155 VAAAGVAHGTFFFHFPTKEHVLIELEAREQERMVTELTRLY-TRPHSVRD
MAV_2459|M.avium_104 VAAAGVAHGTFFFHFPTKEHVLLELERREEERIAKQFAQFL-KSEHDLAS
Mvan_4973|M.vanbaalenii_PYR-1 VSAAGVAHGTFFFHFPSKEHVLLELERREESRMATEFARYL-DKKHDLAS
MMAR_0249|M.marinum_M AAAAGVARGTFYFHFPTKEHVLVELERAEELAIVAKLRDPT-ADPTDLVS
MUL_4864|M.ulcerans_Agy99 AAAAGVARGTFYFHFPTKEHVLVELERAEELAIVAKLRDPT-ADSTDLVS
Mb0310|M.bovis_AF2122/97 RDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWD-EAHGPVEQ
Rv0302|M.tuberculosis_H37Rv RDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWD-EAHGPVEQ
MAB_1379c|M.abscessus_ATCC_199 VRRVGIAQGTFYLYFQSKREIVEQILDDLMERLSAALLDLPPSAPTSLAE
*:* .::: :* :*. :: : : : :
Mflv_1253|M.gilvum_PYR-GCK TLTKAVTVLEALERRLG-SRLFKDFLALHFSTRRPPSEEWSA---HPVIV
TH_1791|M.thermoresistible__bu TLAEIVRLLEDLERRLG-TRLFKDFLALHFSTTRPPSEEWSR---HPVIA
MSMEG_6527|M.smegmatis_MC2_155 TLAETVRLLEKLERRLG-RRLFKDFLALHFSTTRPPSQEWTR---YPALT
MAV_2459|M.avium_104 ALNEAVRLVVGLERRLG-DMLFNDFLALHFSQTRPQTEDGRD---HPLIV
Mvan_4973|M.vanbaalenii_PYR-1 ALAKVVELISALERRFG-PLLFKELLALHFSPTRPSTDEWSD---HPVIV
MMAR_0249|M.marinum_M VLSSLVHQVVAVERRLG-PVVFRDMLGLHFAPTRPVEDQLGE---HPLAE
MUL_4864|M.ulcerans_Agy99 VLSSLAHQVVAVERRLG-PLVFRDMLGLHFAPTRPVEDQLGE---HPLAE
Mb0310|M.bovis_AF2122/97 RSERQLTELVSLQSQHP-DFLRLFYLLSMERSQDPVVAAVVRRVRNTAIA
Rv0302|M.tuberculosis_H37Rv RSERQLTELVSLQSQHP-DFLRLFYLLSMERSQDPAVAAVVRRVRNTAIA
MAB_1379c|M.abscessus_ATCC_199 YRDQAEHISTSLTGVLSADPQAARFLLLQAAAVDDDMAERVLAFYDAAAA
: * .
Mflv_1253|M.gilvum_PYR-GCK AVVEDLERARDRGEIPADVDVMLRG-----VSFLVGLYALLITMPESREI
TH_1791|M.thermoresistible__bu AVVEELQRARDRGEIPEDVDVMHNG-----VSFLTGLYALLITMPESHDL
MSMEG_6527|M.smegmatis_MC2_155 VIISELQRAQQRGEIPADVDVMHVG-----VSFVVGLYALLITIPEARDA
MAV_2459|M.avium_104 LVANEIEGAQQRGETDPHVNPMNSA-----VFFLLGLYALLITTNH-WPT
Mvan_4973|M.vanbaalenii_PYR-1 SLVGAIERARGDGEIHPEVDAFYSA-----AFFLLGIYGVLTTVAR-GDI
MMAR_0249|M.marinum_M FVIETIARAQRANRVPPDADAGELG-----VIFLTGLFALLATGATTPDA
MUL_4864|M.ulcerans_Agy99 FVIETIAQAQRADRVAPDADAGELG-----VIFLTGLFALLATGATTPDA
Mb0310|M.bovis_AF2122/97 RFRDSITHLLPSDIPPGKADLVVAE-----LTAFAVALSDGVYFAGHLEP
Rv0302|M.tuberculosis_H37Rv RFRDSITHLLPSDIPPGKADLVVAE-----LTAFAVALSDGVYFAGHLEP
MAB_1379c|M.abscessus_ATCC_199 IQATYLQHGISAGYFRSDLDAGHAARAVNGMLLASAFYSLRDPSPAAFEQ
: . . : .
Mflv_1253|M.gilvum_PYR-GCK RAPVIDEYVTTYMDALHAA--------
TH_1791|M.thermoresistible__bu RAPALSEYLTTYVHGMRVRSDPPAIAR
MSMEG_6527|M.smegmatis_MC2_155 RAPVLEVYLTTYLYGLRVLP-------
MAV_2459|M.avium_104 GHALLEDYVARTLRSLKP---------
Mvan_4973|M.vanbaalenii_PYR-1 RDAMLANLITTARRGLETR--------
MMAR_0249|M.marinum_M RTALLNRFVTTVVHGMEAR--------
MUL_4864|M.ulcerans_Agy99 RTALLNGFVTTVVHGMEAR--------
Mb0310|M.bovis_AF2122/97 DTTDVERMYRRLRQALEALIPVLLEET
Rv0302|M.tuberculosis_H37Rv DTTDVERMYRRLRQALEALIPVLLEET
MAB_1379c|M.abscessus_ATCC_199 LAHAVREILYYGLASDHHPQIAD----
: . .