For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VPHKPGREERRQLEPSGDERQQGEHQRGGPQHTHATHSAEDDLQVPIVRLRSTIGSHDFACYLHDVAATR PDTQPDHGQRRASFQRARSRETKRMLVQAAMALWRTKGYATTTVADICTAAGVSKALFYFYFPRKEDVLF EVGVLSTQSAHRTIHALLKKPYEIESVVSAALTAFERSMARNPRELIIETILEGYRHEHRIMADGSPPDV DADMFTELFTRARSDGKLPGTVDTAHLAYLAQTMVSEGARHWAAGAFGSRSFAEVVTADICTLVNGYTAR RPHVEFRDRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4199 | - | - | 100% (290) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0989 | - | 2e-08 | 27.27% (209) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0384 | - | 9e-08 | 40.00% (85) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2534 | - | 9e-07 | 37.18% (78) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2452 | - | 7e-99 | 85.64% (202) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2506 | - | 9e-07 | 37.18% (78) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4946 | - | 3e-07 | 40.51% (79) | putative transcriptional regulator, TetR |
| M. marinum M | MMAR_0249 | - | 2e-08 | 25.23% (218) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4026 | - | 1e-08 | 46.55% (58) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4825 | - | 2e-81 | 69.59% (217) | transcriptional repressor, TetR family protein, putative |
| M. thermoresistible (build 8) | TH_0258 | - | 2e-80 | 68.75% (208) | transcriptional repressor, TetR family protein, putative |
| M. ulcerans Agy99 | MUL_2448 | - | 8e-08 | 45.28% (53) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4199|M.vanbaalenii_PYR-1 MPHKPGREERRQLEPSGDERQQGEHQRGGPQHTHATHSAEDDLQVPIVRL
Mflv_2452|M.gilvum_PYR-GCK ------------MSPS---RQP----------------------------
MSMEG_4825|M.smegmatis_MC2_155 --------------------------------------------------
TH_0258|M.thermoresistible__bu --------------------------------------------------
MAV_4026|M.avium_104 --------------------------------------------------
MUL_2448|M.ulcerans_Agy99 --------------------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0249|M.marinum_M --------------------------------------------------
MAB_4946|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4199|M.vanbaalenii_PYR-1 RSTIGSHDFACYLHDVAATRPDTQPDHGQRRASFQRARSR-ETKRMLVQA
Mflv_2452|M.gilvum_PYR-GCK ---------AMFRHMPDAKNP-MAADRGQRRASFQRADSR-ETQRTLIQA
MSMEG_4825|M.smegmatis_MC2_155 --------------MVASPRN-TEADRGQRRATFQRANSH-TTKQMLVHA
TH_0258|M.thermoresistible__bu ---------------------VSRADGGQRRASYQRARSR-ETKRALVQA
MAV_4026|M.avium_104 ---------------------MPAEL----LTAKGR-----QTRQAIEQA
MUL_2448|M.ulcerans_Agy99 ---------------------MPARQESRELSSKGR-----QTRQAIEQV
Mb2534|M.bovis_AF2122/97 -----------------MTASAPDGRPGQPEATNRRSQLKSDRRFQLLAA
Rv2506|M.tuberculosis_H37Rv -----------------MTASAPDGRPGQPEATNRRSQLKSDRRFQLLAA
MMAR_0249|M.marinum_M ------------------MGSTASTTAPHSPQQKVREAQRLRTRARVFDA
MAB_4946|M.abscessus_ATCC_1997 --------------------MEDPAEPPIRMADRQRARRSELVKEEVVEA
* : : .
Mvan_4199|M.vanbaalenii_PYR-1 AMALWRTKGYATTTVADICTAAGVSKALFYFYFPRKEDVLFEVGVLSTQS
Mflv_2452|M.gilvum_PYR-GCK AMALWRTKGYAATTVADICTAAGVSKALFYFYFPRKEDVLFEVGVLSTKA
MSMEG_4825|M.smegmatis_MC2_155 AMALWRTNGYANTTVAEICRGAGVSKALFYFYFPRKEDVLFEVGVMSTRS
TH_0258|M.thermoresistible__bu AMALWRTNGYANTTVADICRAAGVSRALFYFYFPAKEDILFEVGLLSTQA
MAV_4026|M.avium_104 ARKLFAERGFHGTTLADITSAAGKSPAVFYRYFADKEDLLAALAESFLHE
MUL_2448|M.ulcerans_Agy99 ARKLFAERGFHGTTLADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHD
Mb2534|M.bovis_AF2122/97 AERLFAERGFLAVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVGVSAR
Rv2506|M.tuberculosis_H37Rv AERLFAERGFLAVRLEDIGAAAGVSGPAIYRHFPNKESLLVELLVGVSAR
MMAR_0249|M.marinum_M AVAEIGRRGLAGADVAAIAAAAGVARGTFYFHFPTKEHVLVELERAEELA
MAB_4946|M.abscessus_ATCC_1997 ALAEFSERGYHQTSIAHIAERLGTGHSMFYRYFTNKRDILEHVVQHATQR
* .* . : * * . :* :*. *. :* :
Mvan_4199|M.vanbaalenii_PYR-1 AHR----TIHALLKKPYEIESVVSAALTAFERSMARNPRELIIETILEGY
Mflv_2452|M.gilvum_PYR-GCK AHR----RIHALLKKPYEIESVIAGALTAFEQSMARNPKDLVIETILEGY
MSMEG_4825|M.smegmatis_MC2_155 AQR----TIAKLLADDYDVMTVVGAALTALERSMSSNPRELVIETILEGY
TH_0258|M.thermoresistible__bu ARR----RIRSLLRGDYDVDSVIAAALRSLERSMARNPRELIVQTILEGY
MAV_4026|M.avium_104 VVTPS--GLSVHLPDSPDDDAFFTAVVTGYWNMFKQNIG--IMIAVAQLA
MUL_2448|M.ulcerans_Agy99 VVTPS--GVSLQLPDSPDDDTFFTAVVTGYWNIFKQNIG--IMIAVDQLA
Mb2534|M.bovis_AF2122/97 LLA----GARDVTTRSANLAAALDGLIEFHLDFALGEAD--LIRIQDRDL
Rv2506|M.tuberculosis_H37Rv LLA----GARDVTTRSANLAAALDGLIEFHLDFALGEAD--LIRIQDRDL
MMAR_0249|M.marinum_M IVA----KLRDPTADPTDLVSVLSSLVHQVVAVERRLGP--VVFRDMLGL
MAB_4946|M.abscessus_ATCC_1997 TIETLSHTLPGRITSLNEFHDFSVNLGLAYIDLVVADPR-LSRLLLQQGA
:
Mvan_4199|M.vanbaalenii_PYR-1 RHEHRIMADG-SPPDVDADMFTELFTRARSDGKLPGTVDTAHLAYLAQTM
Mflv_2452|M.gilvum_PYR-GCK RHEHRLMAGG-GHPDPDADMFTELFTRARDDGKLPASVDPVHLAYLAQTM
MSMEG_4825|M.smegmatis_MC2_155 RHEHRLLATGENRPDLDGGMFTTLFARAVADGKLPAGTDTDRLAHLAMMM
TH_0258|M.thermoresistible__bu RHEHRILAGE-EDPATGADMFGELFTRAQQDGKLAAGIDVDHLSRVAQML
MAV_4026|M.avium_104 ATQQRFAAVQNEFRRFGIDLVAASVRRAQEQG-YGTELHPQHTAAAIALL
MUL_2448|M.ulcerans_Agy99 ATQQRFAAVQNQFRRFGMDIIAASVRHAQDQG-YGTELNPDHTAVAIALL
Mb2534|M.bovis_AF2122/97 AHLPAVAERQVRKAQRQYVEVWVGVLRELNPG-LAEADARLMAHAVFGLL
Rv2506|M.tuberculosis_H37Rv AHLPAVAERQVRKAQRQYVEVWVGVLRELNPG-LAEADARLMAHAVFGLL
MMAR_0249|M.marinum_M HFAPTRPVEDQLGEHPLAEFVIETIARAQRANRVPPDADAGELG---VIF
MAB_4946|M.abscessus_ATCC_1997 AVDAEMTAQFCGVFDAGAAVLGGLLRDGIESGYVREDIDVEAVADSVVGI
. . . :
Mvan_4199|M.vanbaalenii_PYR-1 VSEGARHWAAG-------AFGSRSFAEVVTADICTLVNGYTARRPHVEFR
Mflv_2452|M.gilvum_PYR-GCK VSEGSRHWAAG-------AFGDRSFAEVVTGDICTLVNGY---------R
MSMEG_4825|M.smegmatis_MC2_155 VSEGARHWAAG-------AFGARSFADVVASDIATLIAGSTG-------R
TH_0258|M.thermoresistible__bu VSEGVRHWAAG-------GFGDRSFTEVVAGDIAALIDGYN-------LR
MAV_4026|M.avium_104 FENFTTVFVG------PSGLGIEISDEDAIATLSTIWKKTLYGV------
MUL_2448|M.ulcerans_Agy99 FENFTSVLVGTSGSSGPGGLGVTITDEDAITTLSRIWKKTLYGF------
Mb2534|M.bovis_AF2122/97 NSTPHSMKAAD------SKPARTVRARAVLRAMTVAALSAADRCL-----
Rv2506|M.tuberculosis_H37Rv NSTPHSMKAAD------SKPARTVRARAVLRAMTVAALSAADRCL-----
MMAR_0249|M.marinum_M LTGLFALLATG-------ATTPDARTALLNRFVTTVVHGMEAR-------
MAB_4946|M.abscessus_ATCC_1997 PLGILARYGHE--------PNQDILAARVRATADLVCRGIAP--------
Mvan_4199|M.vanbaalenii_PYR-1 DRP
Mflv_2452|M.gilvum_PYR-GCK HTP
MSMEG_4825|M.smegmatis_MC2_155 RRP
TH_0258|M.thermoresistible__bu LRR
MAV_4026|M.avium_104 ---
MUL_2448|M.ulcerans_Agy99 ---
Mb2534|M.bovis_AF2122/97 ---
Rv2506|M.tuberculosis_H37Rv ---
MMAR_0249|M.marinum_M ---
MAB_4946|M.abscessus_ATCC_1997 ---