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MPAELLTAKGRQTRQAIEQAARKLFAERGFHGTTLADITSAAGKSPAVFYRYFADKEDLLAALAESFLHE VVTPSGLSVHLPDSPDDDAFFTAVVTGYWNMFKQNIGIMIAVAQLAATQQRFAAVQNEFRRFGIDLVAAS VRRAQEQGYGTELHPQHTAAAIALLFENFTTVFVGPSGLGIEISDEDAIATLSTIWKKTLYGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4026 | - | - | 100% (203) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4886 | - | 3e-27 | 36.71% (207) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1852 | - | 3e-12 | 33.06% (124) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0279c | - | 3e-20 | 31.63% (196) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4467 | - | 5e-97 | 86.00% (200) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0273c | - | 3e-20 | 31.63% (196) | transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01070 | - | 6e-09 | 25.00% (196) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4332 | - | 7e-22 | 31.79% (195) | transcriptional regulator TetR |
| M. marinum M | MMAR_1492 | - | 2e-93 | 82.76% (203) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_2071 | - | 1e-91 | 83.76% (197) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0641 | - | 4e-92 | 82.18% (202) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2448 | - | 4e-93 | 82.27% (203) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1893 | - | 8e-97 | 87.56% (201) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0279c|M.bovis_AF2122/97 -----------------MPDFPTQRGRRTQAAIDAAARTVVVRNGILATT
Rv0273c|M.tuberculosis_H37Rv -----------------MPDFPTQRGRRTQAAIDAAARTVVVRNGILATT
MAB_4332|M.abscessus_ATCC_1997 -----------------MVQ-PTVRGRQTQAAIDEAARTVIARKGILSTT
Mflv_4467|M.gilvum_PYR-GCK ------------MPPGS-SDALSAKGRQTRDALAQAARKLFAERGFHGTT
Mvan_1893|M.vanbaalenii_PYR-1 ------------MPPGP-AESLSAKGRQTRDAIEQAARKLFAERGFHGTT
MAV_4026|M.avium_104 ------------MP----AELLTAKGRQTRQAIEQAARKLFAERGFHGTT
TH_0641|M.thermoresistible__bu ------------MA----AETLSSKGRQTRLALEQAARKLFAERGFHGTT
MMAR_1492|M.marinum_M ------------MPARQESRELSSKGRQTRQAIEQAARKLFAERGFHGTT
MUL_2448|M.ulcerans_Agy99 ------------MPARQESRELSSKGRQTRQAIEQVARKLFAERGFHGTT
MSMEG_2071|M.smegmatis_MC2_155 ------------MA----SGELGSKGRQTRTAIELAARKLFAERGFHGTT
MLBr_01070|M.leprae_Br4923 MIVVGNFTQSNYVPASRGRRSSQLSGDDREQAILAVAERLLAERPLGDFS
* . *: .*. :.... : :
Mb0279c|M.bovis_AF2122/97 VADITAEAGRSAASFYNYYDSKEAMVRQWALRFRDDANQR--ALSVIRHG
Rv0273c|M.tuberculosis_H37Rv VADITAEAGRSAASFYNYYDSKEAMVRQWALRFRDDANQR--ALSVIRHG
MAB_4332|M.abscessus_ATCC_1997 VADIAAEAGRSTASFYNYYDSKEAMVAQWAMRFRTEAQER--VSAAIRHG
Mflv_4467|M.gilvum_PYR-GCK LSDITSAAGKSPAAFYRYFSDKEDLLAALAESFLHEVVAPSGLSVPLPES
Mvan_1893|M.vanbaalenii_PYR-1 LGDITSAAGKSPAVFYRYFADKEDLLAALAESFLHDVVAPSGLSVPLPES
MAV_4026|M.avium_104 LADITSAAGKSPAVFYRYFADKEDLLAALAESFLHEVVTPSGLSVHLPDS
TH_0641|M.thermoresistible__bu LADITSAAGKSPAVFYRYFVDKEDLLAALAESFLREVLAPGWLSVRLPDS
MMAR_1492|M.marinum_M LADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDVVTPSGVSLQLPDS
MUL_2448|M.ulcerans_Agy99 LADITSAAGKSSAVFYRYFTDKEDLLAALAQSFLHDVVTPSGVSLQLPDS
MSMEG_2071|M.smegmatis_MC2_155 LADITSAAGKSPAVFYRYFTDKEDLLAALAESFLHDVVEPSGLNLHLPDS
MLBr_01070|M.leprae_Br4923 VDELAKGAGISRPTFYFYFPSKNAVLLSLLDDLNMKSRSAVEALAEQLP-
: ::: ** * . ** *: .*: :: : .
Mb0279c|M.bovis_AF2122/97 LSDRERAYEAAAAHWYTYRNRLAEAISVSQLAMVSDDFAQYWSEICQIPI
Rv0273c|M.tuberculosis_H37Rv LSDRERAYEAAAAHWYTYRNRLAEAISVSQLAMVSDDFAQYWSEICQIPI
MAB_4332|M.abscessus_ATCC_1997 RSNKQRARDIATAHWLTWRHQLAEMISVSQLAMINTEFAEFWNQMCSEPI
Mflv_4467|M.gilvum_PYR-GCK PDDDAFFTAVVTGYWTMFKQNIGIMIAVAQLAATQPRFTLVQNEFRRFGM
Mvan_1893|M.vanbaalenii_PYR-1 PDDDAFFTMVVTGYWTMFKQNIGIMIAVAQLAATQSRFALVQNEFRRFGM
MAV_4026|M.avium_104 PDDDAFFTAVVTGYWNMFKQNIGIMIAVAQLAATQQRFAAVQNEFRRFGI
TH_0641|M.thermoresistible__bu PDDDEFFTTVVGGYWNMFKQNIGIMIAVDQLAATQQRFADVQNEFRRFGM
MMAR_1492|M.marinum_M PDDDTFFTAVVTGYWNIFKQNIGIMIAVDQLAATQQRFAAVQNQFRRFGM
MUL_2448|M.ulcerans_Agy99 PDDDTFFTAVVTGYWNIFKQNIGIMIAVDQLAATQQRFAAVQNQFRRFGM
MSMEG_2071|M.smegmatis_MC2_155 PDDAEFFTSVVTGYWNMFKQNIGIMIAVAQLAATQQRFAEVQNSFRRFGI
MLBr_01070|M.leprae_Br4923 ADPAAVWRSAITAFFEVCGTHRAVAVAGAAAKATSPEVRRLWSTVMQQWI
. ..: . . :: . . . . :
Mb0279c|M.bovis_AF2122/97 SFITETVKRAQAHGYCVGDDP-QLMAEAIVAMFNQFCYLQLSGKRSR---
Rv0273c|M.tuberculosis_H37Rv SFITETVKRAQAHGYCVGDDP-QLMAEAIVAMFNQFCYLQLSGKRSR---
MAB_4332|M.abscessus_ATCC_1997 DFLTTTIKRAQRDGYSPGNDP-HLMASAIVSMMNQFAYNQLSQGNS----
Mflv_4467|M.gilvum_PYR-GCK DIVAASVRRAQEQGYGTELNP-EHTAAAIALLFENFTTVFVGASG-----
Mvan_1893|M.vanbaalenii_PYR-1 DIVAASVRRAQEQGYGRELNA-EHTAAAIALLFENFTTVFVGASG-----
MAV_4026|M.avium_104 DLVAASVRRAQEQGYGTELHP-QHTAAAIALLFENFTTVFVGPSG-----
TH_0641|M.thermoresistible__bu DIVAASVRHAQQQGYGTDLDP-QHIAAAIALMFENFTAVFVGRGG-----
MMAR_1492|M.marinum_M DIIAASVRHAQDQGYGTELNP-DHTAVAIALLFENFTSVLVGTSGSSGPG
MUL_2448|M.ulcerans_Agy99 DIIAASVRHAQDQGYGTELNP-DHTAVAIALLFENFTSVLVGTSGSSGPG
MSMEG_2071|M.smegmatis_MC2_155 DIVVASVRRAQEQGHAVGLVP-EHIGAAIALLFENFTTVFVGSSG-----
MLBr_01070|M.leprae_Br4923 DYNTAAIQAERKCGVAPDTIPAEDLAVALQLMTERVMAATFSDEK-----
. . ::: : * . . . *: : :.. ..
Mb0279c|M.bovis_AF2122/97 --RGQPDDQACIQTLANIYYRAIYSKEDSSN
Rv0273c|M.tuberculosis_H37Rv --RGQPDDQACIQTLANIYYRAIYSKEDSSN
MAB_4332|M.abscessus_ATCC_1997 ---ATVDDDACIDTLAGICYRAIYSKEVC--
Mflv_4467|M.gilvum_PYR-GCK -LGVQMTDQDAIATLSRIWKKTLYGY-----
Mvan_1893|M.vanbaalenii_PYR-1 -LDVDIDDEAAIATLSRIWKKTLYGY-----
MAV_4026|M.avium_104 -LGIEISDEDAIATLSTIWKKTLYGV-----
TH_0641|M.thermoresistible__bu -PGLQISDADAVRTLATIWKKTLYGC-----
MMAR_1492|M.marinum_M GLGVTITDEDAITTLSRIWKKTLYGF-----
MUL_2448|M.ulcerans_Agy99 GLGVTITDEDAITTLSRIWKKTLYGF-----
MSMEG_2071|M.smegmatis_MC2_155 -LGVELDDREAITTLATIWKKTLYGF-----
MLBr_01070|M.leprae_Br4923 ---PLIPDKKVIDTLVHIWLASIYGS-----
* : ** * ::*.