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VSTVRDNLVAAGVRLLEGGGVSALSARSVATEAGTSTMALYTHFGGMTGLLDAVAVDVFARFTEALTEVA PTDDPVADFLMMGLAYHRFALANPQRYQLIFGAAAPASISRFRADITETGSATNRAEWAASFGALHGAVH RMMAAGRIRRDDELAVAGRLWSINHGAVMLEMAGFFGHEGHGLVHILGPLIIDTLVGMGDDRDAATLSMQ TVVARLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2110 | - | - | 100% (218) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2132 | - | 5e-13 | 31.93% (166) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0941 | - | 1e-10 | 35.65% (115) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0672c | - | 1e-38 | 42.99% (214) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0653c | - | 1e-38 | 42.99% (214) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3875 | - | 6e-37 | 39.64% (222) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0992 | - | 2e-33 | 37.39% (230) | transcriptional regulatory protein |
| M. avium 104 | MAV_4506 | - | 1e-37 | 41.67% (216) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0042 | - | 6e-14 | 35.09% (171) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4347 | - | 2e-72 | 62.15% (214) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0743 | - | 4e-33 | 37.83% (230) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4572 | - | 1e-14 | 36.14% (166) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2110|M.gilvum_PYR-GCK ----------------MVST--------VRD---NLVAAGVRLLEGGGVS
TH_4347|M.thermoresistible__bu ---------------VTADD--------IRE---KLVDAGVRLLERDGVQ
Mb0672c|M.bovis_AF2122/97 --------------MTSQTG--------VRD---ELLHAGVRLLDDHGPD
Rv0653c|M.tuberculosis_H37Rv --------------MTSQTG--------VRD---ELLHAGVRLLDDHGPD
MMAR_0992|M.marinum_M -------MIGETTSPTQRSG--------VRD---EMLHAAVALLDAHGPD
MUL_0743|M.ulcerans_Agy99 -------MIGETTSPTQRSG--------VRD---EMLHAAVALLDAHGPD
MAV_4506|M.avium_104 ----------MTSQPAPQRN--------VRD---GMLAAAVALLHEHGAD
MAB_3875|M.abscessus_ATCC_1997 MNVLPLCEHGKTMSSSARRNSEGTDRAVVRNPRVDLVSAAVRLLNEQGPD
MSMEG_0042|M.smegmatis_MC2_155 ----------MAMEERRERE-----RAARRD---LIISTARRLAEAEGWQ
Mvan_4572|M.vanbaalenii_PYR-1 ----------MADVSAPRQRRHRAPRGAGEQLRAEILDAATDLLLETGDE
.: :: :. * * .
Mflv_2110|M.gilvum_PYR-GCK -ALSARSVATEAGTSTMALYTHFGGMTGLLDAVAVDVFARFTEALTEVA-
TH_4347|M.thermoresistible__bu -ALSARNLAAEAGTSTMAVYTRFGGMPGVLEAVAGEIFARFADALTQIP-
Mb0672c|M.bovis_AF2122/97 -ALQTRKVAAAAGTSTMAVYTHFGGMRGLIAAIAEEGLRQFDVALTVP--
Rv0653c|M.tuberculosis_H37Rv -ALQTRKVAAAAGTSTMAVYTHFGGMRGLIAAIAEEGLRQFDVALTVP--
MMAR_0992|M.marinum_M -ALQTRKVAGAAGTSTMAVYTHFGGMPELIAEVAEEGLRQFDTALAVP--
MUL_0743|M.ulcerans_Agy99 -ALQTRKVAGATGTSTMAVYTHFGGMPELIAEVADEGLRQFDTALAVP--
MAV_4506|M.avium_104 -ALQTRKVAGAAGTSTMAVYTHFGGMRGLIAEVAEEGLRQFDAALTVP--
MAB_3875|M.abscessus_ATCC_1997 -ALQTRKIAAAAGTSTMAVYTYFGGMRELIAEVAEAGLRQFAEAQAAVE-
MSMEG_0042|M.smegmatis_MC2_155 -AVTTRRLSAEIEYSQPVLYKHFAGMEELADAVALDGFGELAEAMRQARR
Mvan_4572|M.vanbaalenii_PYR-1 KAVSIRSVAQRVGVTPPSIYLHFVDKTALLDAVCGRYFEKLDEEMQEVAG
*: * :: : :* * . : :. : .:
Mflv_2110|M.gilvum_PYR-GCK PTDDPVADFLMMGLAYHRFALANPQRYQLIFGAAAPASISRFRADITETG
TH_4347|M.thermoresistible__bu QTGDPVADFLLMGAAYREYALTHPQRYLLMFGTATPASIAGSRADLTATG
Mb0672c|M.bovis_AF2122/97 QTADPVADLLAIGTAYRRYAIERPHMYRLMFGSTSAHGIN-VPARDVLTL
Rv0653c|M.tuberculosis_H37Rv QTADPVADLLAIGTAYRRYAIERPHMYRLMFGSTSAHGIN-VPARDVLTL
MMAR_0992|M.marinum_M PSDDPVADLVATGAAYRRYAIERPHMYRLMFGSTSAHGIN-APTQNVLTL
MUL_0743|M.ulcerans_Agy99 PSDDPVADLVATGAAYRRYAIERPHMYRLMFGSTSAHGIN-APAQNVLTL
MAV_4506|M.avium_104 PTDDPVADLFVIGAAYRRYAIKHRHMYRLMFGSTSAHGIN-APAHNVLTL
MAB_3875|M.abscessus_ATCC_1997 QSDDVIADFMLTGMAYRQFAIDYPHMYRLMFGVTSAHGVN-APRRNMFDT
MSMEG_0042|M.smegmatis_MC2_155 GDDHPDHAVTRIAQAYLDFARANPAVYDAMFARATNLRFAADDTP-----
Mvan_4572|M.vanbaalenii_PYR-1 AAATALDVLRAQGMAYVRFALKNPVLYRIAMMGPGSPGSD----------
. . ** :* * : .
Mflv_2110|M.gilvum_PYR-GCK SATNRAEWAASFGALHGAVHRMMAAGRIRRD-------------------
TH_4347|M.thermoresistible__bu EVSDRTEWAASFEALRTMVRRMIAAGRIRDD-------------------
Mb0672c|M.bovis_AF2122/97 KVAEIEHQHPSFAHVVRAVHRCLLAGRFATALGADD--------------
Rv0653c|M.tuberculosis_H37Rv KVAEIEHQHPSFAHVVRAVHRCLLAGRFATALGADD--------------
MMAR_0992|M.marinum_M TISQIEQRHPSFAHVVRGVRRSMLAGRITVNGGADRNRASAPDGLATDVP
MUL_0743|M.ulcerans_Agy99 TISQIEQRHPSFAHVVRGVRRSMLAGRITVNGGDDRNRAAAPDGLATDVL
MAV_4506|M.avium_104 TVAEIEQNYPSFAHVVRAVHRCMRAGRITAG-SADD--------------
MAB_3875|M.abscessus_ATCC_1997 --SHVTPEHPSAAYLFRCVQRAMAAGRIDGS--PED--------------
MSMEG_0042|M.smegmatis_MC2_155 -----SPLTEAFAQLRDAVGRNEDAD------------------------
Mvan_4572|M.vanbaalenii_PYR-1 --VDVALNSSAFGHLLMSVQALIAEGVYPQA-------------------
: : * .
Mflv_2110|M.gilvum_PYR-GCK --DELAVAGRLWSINHGAVMLEMAGF---FGHEGHGLVHILGPLIIDTLV
TH_4347|M.thermoresistible__bu --GEAAIAGRLWSLIHGEVMLELAGF---FGAEGHGLTKILTPMTVDMLV
Mb0672c|M.bovis_AF2122/97 DTAIVATAAQFWSQIHGFVMLELAGF---YGDRGAAVEPVLAAMTVNLLV
Rv0653c|M.tuberculosis_H37Rv DTAIVATAAQFWSQIHGFVMLELAGF---YGDRGAAVEPVLAAMTVNLLV
MMAR_0992|M.marinum_M DAEIVATAAQFWALIHGFVMLELAGF---FGDEGAAIEPVLASMTTNLLV
MUL_0743|M.ulcerans_Agy99 DAEIVATAAQFWALIHGFVMLELAGF---FGDEGAAIEPVLASMTTNLLV
MAV_4506|M.avium_104 DGAVVATAAQFWASIHGFVMLELAGY---CGDDGSAVLPVLGSMTSNLLV
MAB_3875|M.abscessus_ATCC_1997 AAKVAATAAKFWTVMHGFVMLELAGF---WGEDGAAVGPVLASMTTDLLV
MSMEG_0042|M.smegmatis_MC2_155 -----TLTEVLWAALHGLVMLGRTG----------RLRPDHETERLQLLV
Mvan_4572|M.vanbaalenii_PYR-1 --DPTMLALELWTAVHGIAAMLISRPYLPWGGAEEFADRLMRAVCCGQAL
: :*: ** . : : . :
Mflv_2110|M.gilvum_PYR-GCK GMGDDRD------AATLSMQTVVARLG-
TH_4347|M.thermoresistible__bu GLGDDRA------RVEASLTTAAEAHGR
Mb0672c|M.bovis_AF2122/97 ALGDSPERAQCSLRAEQTQKNTLGRAT-
Rv0653c|M.tuberculosis_H37Rv ALGDSPERAQCSLRAEQTQKNTLGRAT-
MMAR_0992|M.marinum_M ALGDSPE------LAKRSQRLATGAG--
MUL_0743|M.ulcerans_Agy99 ALGDSPE------LAKRSQRLTTGAG--
MAV_4506|M.avium_104 ALGDSPK------RVSQSMRSAMLGS--
MAB_3875|M.abscessus_ATCC_1997 ALGDTPERLN-SSAAAAAARLAPSA---
MSMEG_0042|M.smegmatis_MC2_155 DRMSR-----------------------
Mvan_4572|M.vanbaalenii_PYR-1 SVAIRPDESPREIMTWLKEVVDERQRG-