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VSEHGVRRRRAPRGAGEHLRDEILDAATELLLESGDEKAVSVRSVAERVGVTPPSLYLHFADKNALLDAV CGRYFEKLDEQMQAVAAACPSTIEVLRAQGLAYVRFALQTPELYRIATMGHGNPGSGVDLTLNSAAFVHM RASVEALIAEGVYPPGDPTVFALELWTCAHGIAAQLISRPYLPWGDVEQFADRVLRAVCIGHMVSVAIGP DENAMDTVNWLKEVVDERRRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2132 | - | - | 100% (231) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2110 | - | 6e-13 | 31.93% (166) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0941 | - | 1e-07 | 32.99% (97) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0672c | - | 5e-11 | 27.01% (211) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0653c | - | 6e-11 | 27.01% (211) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 1e-08 | 34.95% (103) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1288 | - | 1e-60 | 53.27% (199) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4304 | - | 2e-76 | 63.35% (221) | TetR family transcriptional regulator |
| M. avium 104 | MAV_3917 | - | 2e-07 | 32.17% (115) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5177 | - | 2e-87 | 69.68% (221) | regulatory protein, TetR |
| M. thermoresistible (build 8) | TH_4347 | - | 5e-10 | 26.79% (168) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0990 | - | 2e-75 | 63.43% (216) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4572 | - | 2e-93 | 72.17% (230) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0672c|M.bovis_AF2122/97 --------------------------------------------------
Rv0653c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4347|M.thermoresistible__bu --------------------------------------------------
Mflv_2132|M.gilvum_PYR-GCK -----------------------------------MSEHGV------RRR
Mvan_4572|M.vanbaalenii_PYR-1 --------------------------------MADVSAPRQ------RRH
MSMEG_5177|M.smegmatis_MC2_155 -------------------------------MSTPNSHPGANSPCPIKRR
MMAR_4304|M.marinum_M -----------------------------------MSMGRL------RRA
MUL_0990|M.ulcerans_Agy99 ----------------------------------------M------RRA
MAB_1288|M.abscessus_ATCC_1997 -----------------------------------MT----------RRQ
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
MAV_3917|M.avium_104 MVR--------------------------MPRPARPHSATKPGAKVDARS
Mb0672c|M.bovis_AF2122/97 ---MTSQTGVRDELLHAGVRLLDDHG-PDALQTRKVAAAAGTSTMAVYTH
Rv0653c|M.tuberculosis_H37Rv ---MTSQTGVRDELLHAGVRLLDDHG-PDALQTRKVAAAAGTSTMAVYTH
TH_4347|M.thermoresistible__bu ----VTADDIREKLVDAGVRLLERDG-VQALSARNLAAEAGTSTMAVYTR
Mflv_2132|M.gilvum_PYR-GCK RAPRGAGEHLRDEILDAATELLLESGDEKAVSVRSVAERVGVTPPSLYLH
Mvan_4572|M.vanbaalenii_PYR-1 RAPRGAGEQLRAEILDAATDLLLETGDEKAVSIRSVAQRVGVTPPSIYLH
MSMEG_5177|M.smegmatis_MC2_155 RARRGSGELLREEILDATTDLLLETGHAKDVSIRAVAKRVGVTPPSIYLH
MMAR_4304|M.marinum_M RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTPPSIYLH
MUL_0990|M.ulcerans_Agy99 RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTSPSIYLH
MAB_1288|M.abscessus_ATCC_1997 RASRGSGDRLRDEIIDAAIALVLETKELRAPSIREVARKIGVTPPSIYLH
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLG--PEVSVREIAEEAGTAKPKIYRH
MAV_3917|M.avium_104 ERWREHRKKVRNEIVDAAFRAIDRLG--PELSVREIAEEAGTAKPKIYRH
:* :::.* : . * :* *.: :* :
Mb0672c|M.bovis_AF2122/97 FGGMRGLIAAIAEEGLRQFDVALT--VPQTADPVADLL-AIGTAYRRYAI
Rv0653c|M.tuberculosis_H37Rv FGGMRGLIAAIAEEGLRQFDVALT--VPQTADPVADLL-AIGTAYRRYAI
TH_4347|M.thermoresistible__bu FGGMPGVLEAVAGEIFARFADALTQ-IPQTGDPVADFL-LMGAAYREYAL
Mflv_2132|M.gilvum_PYR-GCK FADKNALLDAVCGRYFEKLDEQMQA-VAAACPSTIEVLRAQGLAYVRFAL
Mvan_4572|M.vanbaalenii_PYR-1 FVDKTALLDAVCGRYFEKLDEEMQE-VAGAAATALDVLRAQGMAYVRFAL
MSMEG_5177|M.smegmatis_MC2_155 FADKDALLDAVCARYFEKLDQQMQR-VAAGQPSTIDVLRAQGLAYVEFAT
MMAR_4304|M.marinum_M FQDKDALLDAVCARYLARLDEEMER-AAMGHTCVVEVLRAQGLAYVRFAL
MUL_0990|M.ulcerans_Agy99 FQDKDALLDAVCARYLARLDEEMER-AAMGHTCVVEVLRAQGLAYVRFAL
MAB_1288|M.abscessus_ATCC_1997 FADKDELMDAVCGQYFQRLNDKMVE-AARGDITALERLHAQGMAYVRFAI
MLBr_01733|M.leprae_Br4923 FTDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVD
MAV_3917|M.avium_104 FHDKSDLFQAIGERLRDMLWTAIFPSIDLKTDSAREVIRRSVEEYVTLVD
* . :: *: . : : . : : * .
Mb0672c|M.bovis_AF2122/97 ERPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHR
Rv0653c|M.tuberculosis_H37Rv ERPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHR
TH_4347|M.thermoresistible__bu THPQRYLLMFGTATPASIAGSRADLTATGEVSDRTEWAASFEALRTMVRR
Mflv_2132|M.gilvum_PYR-GCK QTPELYRIATMGHGNPGSG------------VDLTLNSAAFVHMRASVEA
Mvan_4572|M.vanbaalenii_PYR-1 KNPVLYRIAMMGPGSPGSD------------VDVALNSSAFGHLLMSVQA
MSMEG_5177|M.smegmatis_MC2_155 HTPELYRLATMAEGRPGSD------------VDITLNSSAFQHMRATIEK
MMAR_4304|M.marinum_M QTPELYRLATMGEWRSGSN------------VDSALDSSAFRHMCASVQA
MUL_0990|M.ulcerans_Agy99 QTPELYRLATMGEWRSGSN------------VDSALDSSAFRHMCASVQA
MAB_1288|M.abscessus_ATCC_1997 ATPLMYRLATVTQ--PEGE------------LDETMASAAFAHLHNGVKE
MLBr_01733|M.leprae_Br4923 KHPNVLRVFIQGRFSAQSEATVR------TLDEGREITLTMAEMFNNELR
MAV_3917|M.avium_104 KHPNVLRVFIQGRSTGTPQSTVT------ILNEGREITLAMADLFDNELR
* : : :: :
Mb0672c|M.bovis_AF2122/97 CLLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAG---FYGDRGA
Rv0653c|M.tuberculosis_H37Rv CLLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAG---FYGDRGA
TH_4347|M.thermoresistible__bu MIAAGRIR-------DDGEAAIAGRLWSLIHGEVMLELAG---FFGAEGH
Mflv_2132|M.gilvum_PYR-GCK LIAEGVYP-------PGDPTVFALELWTCAHGIAAQLISRPYLPWGDVEQ
Mvan_4572|M.vanbaalenii_PYR-1 LIAEGVYP-------QADPTMLALELWTAVHGIAAMLISRPYLPWGGAEE
MSMEG_5177|M.smegmatis_MC2_155 LMDEGIYP-------PGDATTWALELWTAAHGVAAMLIAKPYLPWGDTHE
MMAR_4304|M.marinum_M MMDEGIYR-------ADDPTTIALELWTAAHGVAALLIAKPHLPFGDVAA
MUL_0990|M.ulcerans_Agy99 MMDEGIYR-------ADDPTTIALELWTAAHGVAALLIAKPHLPFGDVAA
MAB_1288|M.abscessus_ATCC_1997 LVTEGLYP-------EGDTVAMALQLWVAAHGVASMLVTKPHLPWGDPEE
MLBr_01733|M.leprae_Br4923 EMELNRAASELAAFAAFGSVASATEWWLGPEPDSPRRMPR-----EQFVA
MAV_3917|M.avium_104 EMELDHAAVELAAHAAFGSAASATEWWLGPEPDSPRLMSR-----AQFVA
: . . * . * . :.
Mb0672c|M.bovis_AF2122/97 AVEPVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT-
Rv0653c|M.tuberculosis_H37Rv AVEPVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT-
TH_4347|M.thermoresistible__bu GLTKILTPMTVDMLVGLGDDRARVEASL---TTAAEAHGR---
Mflv_2132|M.gilvum_PYR-GCK FADRVLRAVCIGHMVSVAIGPDENAMDTVNWLKEVVDERRRR-
Mvan_4572|M.vanbaalenii_PYR-1 FADRLMRAVCCGQALSVAIRPDESPREIMTWLKEVVDERQRG-
MSMEG_5177|M.smegmatis_MC2_155 FADRVLRAVCSGHIVSGIIGNDVTPSEAVARLKGLADAPN---
MMAR_4304|M.marinum_M FADRVLGAVLCGHMVAGLVGPQATSRDLMDWVVQHRPSEESRV
MUL_0990|M.ulcerans_Agy99 FADRVLGAVLCGHMVAGLVGPQATSRDLMDWVVQHRPSEESRV
MAB_1288|M.abscessus_ATCC_1997 FASEVLRAACLGQAVS-----DIDLTEVLPRQK----------
MLBr_01733|M.leprae_Br4923 HLTIIMMAVIVGTAETLGISMNPDRPIHDAVPLDRSAS-----
MAV_3917|M.avium_104 HLSTIMMAVIIGTAETLGITMNPDQPIHDAVVRKPAVS-----
:: . .