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ADVSAPRQRRHRAPRGAGEQLRAEILDAATDLLLETGDEKAVSIRSVAQRVGVTPPSIYLHFVDKTALLD AVCGRYFEKLDEEMQEVAGAAATALDVLRAQGMAYVRFALKNPVLYRIAMMGPGSPGSDVDVALNSSAFG HLLMSVQALIAEGVYPQADPTMLALELWTAVHGIAAMLISRPYLPWGGAEEFADRLMRAVCCGQALSVAI RPDESPREIMTWLKEVVDERQRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4572 | - | - | 100% (234) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5135 | - | 5e-11 | 32.72% (162) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0895 | - | 2e-08 | 26.12% (245) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3076c | - | 2e-09 | 27.71% (231) | AsnC family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2132 | - | 2e-93 | 72.17% (230) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3050c | - | 2e-09 | 27.71% (231) | AsnC family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 6e-10 | 31.82% (132) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1288 | - | 1e-60 | 51.90% (210) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4304 | - | 9e-72 | 59.73% (221) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0728 | - | 7e-11 | 31.25% (160) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5177 | - | 7e-77 | 63.18% (220) | regulatory protein, TetR |
| M. thermoresistible (build 8) | TH_4347 | - | 8e-10 | 26.19% (168) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0990 | - | 4e-70 | 59.53% (215) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4572|M.vanbaalenii_PYR-1 -------------------------------MADVSAPRQ-------RRH
Mflv_2132|M.gilvum_PYR-GCK ----------------------------------MSEHGV-------RRR
MSMEG_5177|M.smegmatis_MC2_155 ------------------------------MSTPNSHPGANS-PCPIKRR
MMAR_4304|M.marinum_M ----------------------------------MSMGRL-------RRA
MUL_0990|M.ulcerans_Agy99 ---------------------------------------M-------RRA
MAB_1288|M.abscessus_ATCC_1997 ----------------------------------MT-----------RRQ
Mb3076c|M.bovis_AF2122/97 -----------------------------MVRIPRPHPSAKPGVKVDARS
Rv3050c|M.tuberculosis_H37Rv -----------------------------MVRIPRPHPSAKPGVKVDARS
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
MAV_0728|M.avium_104 ------------------------------------------------MT
TH_4347|M.thermoresistible__bu --------------------------------------------------
Mvan_4572|M.vanbaalenii_PYR-1 RAPRGAGEQLRAEILDAATDLLLETGDEKAVSIRSVAQRVGVTPPSIYLH
Mflv_2132|M.gilvum_PYR-GCK RAPRGAGEHLRDEILDAATELLLESGDEKAVSVRSVAERVGVTPPSLYLH
MSMEG_5177|M.smegmatis_MC2_155 RARRGSGELLREEILDATTDLLLETGHAKDVSIRAVAKRVGVTPPSIYLH
MMAR_4304|M.marinum_M RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTPPSIYLH
MUL_0990|M.ulcerans_Agy99 RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTSPSIYLH
MAB_1288|M.abscessus_ATCC_1997 RASRGSGDRLRDEIIDAAIALVLETKELRAPSIREVARKIGVTPPSIYLH
Mb3076c|M.bovis_AF2122/97 ERWREHRKKVRNEIVDAAFRAIDRLG--PELSVRQIAEEAGTAKPKIYRH
Rv3050c|M.tuberculosis_H37Rv ERWREHRKKVRNEIVDAAFRAIDRLG--PELSVRQIAEEAGTAKPKIYRH
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLG--PEVSVREIAEEAGTAKPKIYRH
MAV_0728|M.avium_104 RHSYHHGD-LPAVILAEAARLVAERG-AERVSLRELARCAGVSHAAPAHH
TH_4347|M.thermoresistible__bu ----VTADDIREKLVDAGVRLLERDG-VQALSARNLAAEAGTSTMAVYTR
. : :: : . * * :* *.: :
Mvan_4572|M.vanbaalenii_PYR-1 FVDKTALLDAVCGRYFEKLDEEMQE-VAGAAATALDVLRAQGMAYVRFAL
Mflv_2132|M.gilvum_PYR-GCK FADKNALLDAVCGRYFEKLDEQMQA-VAAACPSTIEVLRAQGLAYVRFAL
MSMEG_5177|M.smegmatis_MC2_155 FADKDALLDAVCARYFEKLDQQMQR-VAAGQPSTIDVLRAQGLAYVEFAT
MMAR_4304|M.marinum_M FQDKDALLDAVCARYLARLDEEMER-AAMGHTCVVEVLRAQGLAYVRFAL
MUL_0990|M.ulcerans_Agy99 FQDKDALLDAVCARYLARLDEEMER-AAMGHTCVVEVLRAQGLAYVRFAL
MAB_1288|M.abscessus_ATCC_1997 FADKDELMDAVCGQYFQRLNDKMVE-AARGDITALERLHAQGMAYVRFAI
Mb3076c|M.bovis_AF2122/97 FTDKSDLLEAIGMRLRDMLWAAIFPSLDLATDSAREVIRRSVEEYVNLVD
Rv3050c|M.tuberculosis_H37Rv FTDKSDLLEAIGMRLRDMLWAAIFPSLDLATDSAREVIRRSVEEYVNLVD
MLBr_01733|M.leprae_Br4923 FTDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVD
MAV_0728|M.avium_104 FTDRRGLFTALATQGFELLTRALAD--------ARGDFADAALAYVQFAL
TH_4347|M.thermoresistible__bu FGGMPGVLEAVAGEIFARFADALTQ--IPQTGDPVADFLLMGAAYREYAL
* . :: *: . : : : * .
Mvan_4572|M.vanbaalenii_PYR-1 KNPVLYRIAM---MGPGSPGSDVDVALN---------SSAFGHLLMSVQA
Mflv_2132|M.gilvum_PYR-GCK QTPELYRIAT---MGHGNPGSGVDLTLN---------SAAFVHMRASVEA
MSMEG_5177|M.smegmatis_MC2_155 HTPELYRLAT---MAEGRPGSDVDITLN---------SSAFQHMRATIEK
MMAR_4304|M.marinum_M QTPELYRLAT---MGEWRSGSNVDSALD---------SSAFRHMCASVQA
MUL_0990|M.ulcerans_Agy99 QTPELYRLAT---MGEWRSGSNVDSALD---------SSAFRHMCASVQA
MAB_1288|M.abscessus_ATCC_1997 ATPLMYRLAT---VTQ--PEGELDETMA---------SAAFAHLHNGVKE
Mb3076c|M.bovis_AF2122/97 QHPNVLRVFI---QGRSAKQSEATVRTL---------NEGREITLAMAEM
Rv3050c|M.tuberculosis_H37Rv QHPNVLRVFI---QGRSAKQSEATVRTL---------NEGREITLAMAEM
MLBr_01733|M.leprae_Br4923 KHPNVLRVFI---QGRFSAQSEATVRTL---------DEGREITLTMAEM
MAV_0728|M.avium_104 DHPGHYQVMF---NRSLLDASDGGLAAA---------EGAAGAELSRGVA
TH_4347|M.thermoresistible__bu THPQRYLLMFGTATPASIAGSRADLTATGEVSDRTEWAASFEALRTMVRR
* : . .
Mvan_4572|M.vanbaalenii_PYR-1 LIAEGVYPQADPTMLALELWTAVHGIAAM----LISRPYLPWGGAEEFAD
Mflv_2132|M.gilvum_PYR-GCK LIAEGVYPPGDPTVFALELWTCAHGIAAQ----LISRPYLPWGDVEQFAD
MSMEG_5177|M.smegmatis_MC2_155 LMDEGIYPPGDATTWALELWTAAHGVAAM----LIAKPYLPWGDTHEFAD
MMAR_4304|M.marinum_M MMDEGIYRADDPTTIALELWTAAHGVAAL----LIAKPHLPFGDVAAFAD
MUL_0990|M.ulcerans_Agy99 MMDEGIYRADDPTTIALELWTAAHGVAAL----LIAKPHLPFGDVAAFAD
MAB_1288|M.abscessus_ATCC_1997 LVTEGLYPEGDTVAMALQLWVAAHGVASM----LVTKPHLPWGDPEEFAS
Mb3076c|M.bovis_AF2122/97 FNNELREMELNRAALELAAFAAFGSAASATEWWLGPEPDSPRRMPREQFV
Rv3050c|M.tuberculosis_H37Rv FNNELREMELNRAALELAAFAAFGSAASATEWWLGPEPDSPRRMPREQFV
MLBr_01733|M.leprae_Br4923 FNNELREMELNRAASELAAFAAFGSVASATEWWLGPEPDSPRRMPREQFV
MAV_0728|M.avium_104 TLRD-PHARADPGGAELAAWSLVHGFATLWLN-DAVDAAVRAADPMDTVR
TH_4347|M.thermoresistible__bu MIAAGRIRDDGEAAIAGRLWSLIHGEVML-------ELAGFFGAEGHGLT
. : . .
Mvan_4572|M.vanbaalenii_PYR-1 RLMRAVCCGQALSVAIRPDESPREIMTWLKEVVDERQRG-
Mflv_2132|M.gilvum_PYR-GCK RVLRAVCIGHMVSVAIGPDENAMDTVNWLKEVVDERRRR-
MSMEG_5177|M.smegmatis_MC2_155 RVLRAVCSGHIVSGIIGNDVTPSEAVARLKGLADAPN---
MMAR_4304|M.marinum_M RVLGAVLCGHMVAGLVGPQATSRDLMDWVVQHRPSEESRV
MUL_0990|M.ulcerans_Agy99 RVLGAVLCGHMVAGLVGPQATSRDLMDWVVQHRPSEESRV
MAB_1288|M.abscessus_ATCC_1997 EVLRAACLGQAVS-----DIDLTEVLPRQK----------
Mb3076c|M.bovis_AF2122/97 AHLTTIMMGVIVGTAEALGIAVDPDQPIHDAVPNNPAVR-
Rv3050c|M.tuberculosis_H37Rv AHLTTIMMGVIVGTAEALGIAVDPDQPIHDAVPNNPAVR-
MLBr_01733|M.leprae_Br4923 AHLTIIMMAVIVGTAETLGISMNPDRPIHDAVPLDRSAS-
MAV_0728|M.avium_104 RIATMLFAG-------------------------------
TH_4347|M.thermoresistible__bu KILTPMTVDMLVGLGDDRARVEASLTTAAEAHGR------