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MTSQPAPQRNVRDGMLAAAVALLHEHGADALQTRKVAGAAGTSTMAVYTHFGGMRGLIAEVAEEGLRQFD AALTVPPTDDPVADLFVIGAAYRRYAIKHRHMYRLMFGSTSAHGINAPAHNVLTLTVAEIEQNYPSFAHV VRAVHRCMRAGRITAGSADDDGAVVATAAQFWASIHGFVMLELAGYCGDDGSAVLPVLGSMTSNLLVALG DSPKRVSQSMRSAMLGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4506 | - | - | 100% (227) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4494 | - | 1e-07 | 26.84% (190) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_0728 | - | 1e-07 | 26.63% (169) | TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0672c | - | 2e-87 | 75.46% (216) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2110 | - | 1e-37 | 41.67% (216) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0653c | - | 2e-87 | 75.46% (216) | TetR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3875 | - | 6e-65 | 59.26% (216) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0992 | - | 3e-86 | 70.04% (237) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_5838 | - | 1e-08 | 28.40% (169) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4347 | - | 5e-38 | 43.98% (216) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0743 | - | 1e-86 | 69.36% (235) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5135 | - | 8e-11 | 28.72% (188) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2110|M.gilvum_PYR-GCK ----------------MVST--------VRD---NLVAAGVRLLEGGGVS
TH_4347|M.thermoresistible__bu ---------------VTADD--------IRE---KLVDAGVRLLERDGVQ
MMAR_0992|M.marinum_M -------MIGETTSPTQRSG--------VRD---EMLHAAVALLDAHGPD
MUL_0743|M.ulcerans_Agy99 -------MIGETTSPTQRSG--------VRD---EMLHAAVALLDAHGPD
Mb0672c|M.bovis_AF2122/97 --------------MTSQTG--------VRD---ELLHAGVRLLDDHGPD
Rv0653c|M.tuberculosis_H37Rv --------------MTSQTG--------VRD---ELLHAGVRLLDDHGPD
MAV_4506|M.avium_104 ----------MTSQPAPQRN--------VRD---GMLAAAVALLHEHGAD
MAB_3875|M.abscessus_ATCC_1997 MNVLPLCEHGKTMSSSARRNSEGTDRAVVRNPRVDLVSAAVRLLNEQGPD
MSMEG_5838|M.smegmatis_MC2_155 ----------MA----YHHGD-------LKA---VILQHAATLVAERGAD
Mvan_5135|M.vanbaalenii_PYR-1 ----------MSSRGTYHHGD-------LRA---TILARAADLVAERGAD
:: :: .. *: * .
Mflv_2110|M.gilvum_PYR-GCK ALSARSVATEAGTSTMALYTHFGGMTGLLDAVAVDVFARFTEALTEVAPT
TH_4347|M.thermoresistible__bu ALSARNLAAEAGTSTMAVYTRFGGMPGVLEAVAGEIFARFADALTQIPQT
MMAR_0992|M.marinum_M ALQTRKVAGAAGTSTMAVYTHFGGMPELIAEVAEEGLRQFDTALAVP-PS
MUL_0743|M.ulcerans_Agy99 ALQTRKVAGATGTSTMAVYTHFGGMPELIAEVADEGLRQFDTALAVP-PS
Mb0672c|M.bovis_AF2122/97 ALQTRKVAAAAGTSTMAVYTHFGGMRGLIAAIAEEGLRQFDVALTVP-QT
Rv0653c|M.tuberculosis_H37Rv ALQTRKVAAAAGTSTMAVYTHFGGMRGLIAAIAEEGLRQFDVALTVP-QT
MAV_4506|M.avium_104 ALQTRKVAGAAGTSTMAVYTHFGGMRGLIAEVAEEGLRQFDAALTVP-PT
MAB_3875|M.abscessus_ATCC_1997 ALQTRKIAAAAGTSTMAVYTYFGGMRELIAEVAEAGLRQFAEAQAAVEQS
MSMEG_5838|M.smegmatis_MC2_155 GISLRELARTAGVSHAAPAHHFTDRRGLFTALATEGYQLLADALKDV---
Mvan_5135|M.vanbaalenii_PYR-1 GVSLRELARAAGVSHAAPAHHFTDRRGLFTALATEGFRSLAEELSRA---
.:. *.:* :*.* * * . :: :* :
Mflv_2110|M.gilvum_PYR-GCK DDPVADFLMMGLAYHRFALANPQRYQLIFGAAAPASISRFRADITETGSA
TH_4347|M.thermoresistible__bu GDPVADFLLMGAAYREYALTHPQRYLLMFGTATPASIAGSRADLTATGEV
MMAR_0992|M.marinum_M DDPVADLVATGAAYRRYAIERPHMYRLMFGSTSAHGIN-APTQNVLTLTI
MUL_0743|M.ulcerans_Agy99 DDPVADLVATGAAYRRYAIERPHMYRLMFGSTSAHGIN-APAQNVLTLTI
Mb0672c|M.bovis_AF2122/97 ADPVADLLAIGTAYRRYAIERPHMYRLMFGSTSAHGIN-VPARDVLTLKV
Rv0653c|M.tuberculosis_H37Rv ADPVADLLAIGTAYRRYAIERPHMYRLMFGSTSAHGIN-VPARDVLTLKV
MAV_4506|M.avium_104 DDPVADLFVIGAAYRRYAIKHRHMYRLMFGSTSAHGIN-APAHNVLTLTV
MAB_3875|M.abscessus_ATCC_1997 DDVIADFMLTGMAYRQFAIDYPHMYRLMFGVTSAHGVN-APRRNMFDT--
MSMEG_5838|M.smegmatis_MC2_155 ---RGQFIDAAKAYVRFALDHPGHYAVMFDKSLYDDTD-----------P
Mvan_5135|M.vanbaalenii_PYR-1 ---RPEFLDAALAYVRFALANPGHYEVMFDKSLYHADD-----------P
::. . ** .:*: * ::*. :
Mflv_2110|M.gilvum_PYR-GCK TNRAEWAASFGALHGAVHRMMAAGRIRRD---------------------
TH_4347|M.thermoresistible__bu SDRTEWAASFEALRTMVRRMIAAGRIRDD---------------------
MMAR_0992|M.marinum_M SQIEQRHPSFAHVVRGVRRSMLAGRITVNGGADRNRASAPDGLATDVPDA
MUL_0743|M.ulcerans_Agy99 SQIEQRHPSFAHVVRGVRRSMLAGRITVNGGDDRNRAAAPDGLATDVLDA
Mb0672c|M.bovis_AF2122/97 AEIEHQHPSFAHVVRAVHRCLLAGRFATALGADD--------------DT
Rv0653c|M.tuberculosis_H37Rv AEIEHQHPSFAHVVRAVHRCLLAGRFATALGADD--------------DT
MAV_4506|M.avium_104 AEIEQNYPSFAHVVRAVHRCMRAGRITAG-SADD--------------DG
MAB_3875|M.abscessus_ATCC_1997 SHVTPEHPSAAYLFRCVQRAMAAGRIDGS--PED--------------AA
MSMEG_5838|M.smegmatis_MC2_155 GLVAAASAAGAELNRGVG-TLDDPKAKDD---------------------
Mvan_5135|M.vanbaalenii_PYR-1 ALVDAETAAGSELAAGVG-TLDDPRAKDD---------------------
.: : * : :
Mflv_2110|M.gilvum_PYR-GCK DELAVAGRLWSINHGAVMLEMAGFFGHEGHGLVHILGPLIIDTLVGMGDD
TH_4347|M.thermoresistible__bu GEAAIAGRLWSLIHGEVMLELAGFFGAEGHGLTKILTPMTVDMLVGLGDD
MMAR_0992|M.marinum_M EIVATAAQFWALIHGFVMLELAGFFGDEGAAIEPVLASMTTNLLVALGDS
MUL_0743|M.ulcerans_Agy99 EIVATAAQFWALIHGFVMLELAGFFGDEGAAIEPVLASMTTNLLVALGDS
Mb0672c|M.bovis_AF2122/97 AIVATAAQFWSQIHGFVMLELAGFYGDRGAAVEPVLAAMTVNLLVALGDS
Rv0653c|M.tuberculosis_H37Rv AIVATAAQFWSQIHGFVMLELAGFYGDRGAAVEPVLAAMTVNLLVALGDS
MAV_4506|M.avium_104 AVVATAAQFWASIHGFVMLELAGYCGDDGSAVLPVLGSMTSNLLVALGDS
MAB_3875|M.abscessus_ATCC_1997 KVAATAAKFWTVMHGFVMLELAGFWGEDGAAVGPVLASMTTDLLVALGDT
MSMEG_5838|M.smegmatis_MC2_155 -PAGAALAAWSMVHGFSLLWLNDAIDTDRDPIATVERLGAILFDG-----
Mvan_5135|M.vanbaalenii_PYR-1 -PQAAALAAWSLVHGFALLWLNGAVNTTGDPMATVRRVAGMLFGGEPVTC
. * *: ** :* : . . : :
Mflv_2110|M.gilvum_PYR-GCK RD------AATLSMQTVVARLG-
TH_4347|M.thermoresistible__bu RA------RVEASLTTAAEAHGR
MMAR_0992|M.marinum_M PE------LAKRSQRLATGAG--
MUL_0743|M.ulcerans_Agy99 PE------LAKRSQRLTTGAG--
Mb0672c|M.bovis_AF2122/97 PERAQCSLRAEQTQKNTLGRAT-
Rv0653c|M.tuberculosis_H37Rv PERAQCSLRAEQTQKNTLGRAT-
MAV_4506|M.avium_104 PK------RVSQSMRSAMLGS--
MAB_3875|M.abscessus_ATCC_1997 PERLN-SSAAAAAARLAPSA---
MSMEG_5838|M.smegmatis_MC2_155 -----------------------
Mvan_5135|M.vanbaalenii_PYR-1 PT---------------------