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MDTHRLKYFLRIAEEGSITRAASLLGMAQPALSRQLQLLEEDLGVALFRRNRRGVELTDAGERLRSSTAA PLRQLELAVQYAAFPLARLKRAMLIGIPESAIDVLAAPLMTRLGSAFPDAQFAVTVGSTDHLVEAMLKGS VDIALINPVPDDRVFYREILTEEFVLVGGPDSPLEPEKPLQFADLVELPLVVPRSTTGLGQALYNAALRA KVTIDYRITTDSTRVMVCLIESGLAYGVLPLSACGREFAESRLRYSRICEPVLTQQLGVAATEQLDLPRE LVVKVGNALREEIAALIRSGSWRADLLSPEPWSPRRV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1833 | - | - | 100% (317) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3565 | - | 1e-17 | 29.39% (245) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1346 | - | 1e-15 | 29.96% (247) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 2e-11 | 30.84% (214) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 2e-11 | 30.84% (214) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 4e-21 | 27.72% (267) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4409 | - | 1e-19 | 27.41% (270) | hydrogen peroxide-inducible genes activator |
| M. marinum M | MMAR_2756 | oxyR | 5e-18 | 29.05% (296) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_3102 | - | 1e-110 | 63.38% (314) | LysR substrate binding domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0708 | - | 5e-34 | 30.36% (303) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 6e-15 | 27.39% (241) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 1e-18 | 27.65% (293) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 1e-15 | 29.15% (247) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1833|M.gilvum_PYR-GCK ---------------MDTHRLKYFLRIAEEGSITRAASLLGMAQPALSRQ
MAV_3102|M.avium_104 ---------------MDTHRLKYFLRIAEQGSITGAAASLGIAQPALSRQ
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
MAB_4409|M.abscessus_ATCC_1997 --------MSDRSYQPTVVGLRAFVAIARKRHFGSAAGELGVSQPSLSQA
Mb2303c|M.bovis_AF2122/97 --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
Rv2282c|M.tuberculosis_H37Rv --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
MSMEG_0708|M.smegmatis_MC2_155 ---------------MDLKGLNALLVVADAGSVTKAARILHVEQPAVSRQ
Mvan_3362|M.vanbaalenii_PYR-1 ---------------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVSAQ
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
: :: :. . ** : * ::*
Mflv_1833|M.gilvum_PYR-GCK LQLLEEDLGVALFRRNRRGVELTDAGERLRSSTAAPLRQLELAVQYAAFP
MAV_3102|M.avium_104 IRLLEEDLGVALFRRTRRGVQLTEEGERLRASTAAPLRQLELAMQYAGSP
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
MAB_4409|M.abscessus_ATCC_1997 LSMLEEGLGVRLVERNTRKVLLTPEGDALLEKAISALNAVDEFTSAASGV
Mb2303c|M.bovis_AF2122/97 LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
Rv2282c|M.tuberculosis_H37Rv LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
MSMEG_0708|M.smegmatis_MC2_155 IKLLETELGVALFERSRRGMVLTDAGRILVERARRVVDELEKAEAELRAE
Mvan_3362|M.vanbaalenii_PYR-1 IRRLERQVGQPLLTRSHRGVRVTPAGAALLPHARAALAAVRDAQAAVDDV
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :* :. * * * :* * : :
Mflv_1833|M.gilvum_PYR-GCK LARLKRAMLIGIPESAIDVLAAPLMTRLGSAFP-----DAQFAVTVGSTD
MAV_3102|M.avium_104 IARLARGVRLGILDTTVDVFAAHLLSSLAAAFP-----KVTFSVETGSTD
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP-----TLTVRVIEDQTE
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP-----TLTVRVIEDQTE
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLP-----TLTLRVVEDQTE
MAB_4409|M.abscessus_ATCC_1997 RDPFAQTLRLGLIPTVAPYVLPMVLSGLSREFP-----EMSLRVTEDQTH
Mb2303c|M.bovis_AF2122/97 RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
Rv2282c|M.tuberculosis_H37Rv RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
MSMEG_0708|M.smegmatis_MC2_155 VSGVRGIVSVGILDSVTDLVAEELVSDVRRRYP-----NVRLRVFTAFAG
Mvan_3362|M.vanbaalenii_PYR-1 ANLVRGAVAIGTVT-LHPVDVARLMADFHAEHP-----GVEITLGTDTSD
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYP-----STSFTLRQLYPD
. : . : .
Mflv_1833|M.gilvum_PYR-GCK HLVEAMLKGSVDIALIN-PVPDD--RVFYREILTEEFVLVGGPDSPLEPE
MAV_3102|M.avium_104 QLVEAMLKGAVDVAVIN-PVPDD--RIFYRDLLTEDLVVVGAATSGLDSG
MMAR_2756|M.marinum_M RLLTALREGSLDTALIALPADYG--GLTEIPIYEEDFVLALPPGHPMADR
MUL_2998|M.ulcerans_Agy99 RLLTALREGSLDTALIALPADYG--GLTEIPIYEEDFVLALPPGHPMADR
MLBr_02041|M.leprae_Br4923 HLLTALREGALDAAMIALPVETA--GIAEIPIYDEDFVLALPPGHPLSGK
MAB_4409|M.abscessus_ATCC_1997 RLLRSLSDGTLDVAVMALPVQTQ--GMAEIPMYREDFVLALPSGHPLAGS
Mb2303c|M.bovis_AF2122/97 HAIAAVRDGIADLGFIENPCPPT--GLGSVVVARDELVVVVPPGHKWARR
Rv2282c|M.tuberculosis_H37Rv HAIAAVRDGIADLGFIENPCPPT--GLGSVVVARDELVVVVPPGHKWARR
MSMEG_0708|M.smegmatis_MC2_155 QLRSWLYDGELDVALLFGVTDQT--ALKTLPVASEKLWAVAPKEAALQPD
Mvan_3362|M.vanbaalenii_PYR-1 VLLAKLEDGRLDAAIVSIGADEDPAGLEYEVITDEALEAAVTAQHRLARR
TH_3504|M.thermoresistible__bu ALTDAVFDGTVQLGLRRGVVPTP--ELATAVIGYHRVRVAFVDSHPLAAR
: .* : .. : : . . .
Mflv_1833|M.gilvum_PYR-GCK -KPLQFADLVELPLVVPRS-TTGLGQ---ALYNAALRAKVTIDYR-ITTD
MAV_3102|M.avium_104 -QMMPFTELVELPLVVPRS-HTGIGN---VIENAALRRKVKISWR-IATD
MMAR_2756|M.marinum_M -HGVPVAALSELPLLLLDE-GHCLRD---QALDVCQNAGVRAELADTRAA
MUL_2998|M.ulcerans_Agy99 -HGVPVAALSELPLLLLDE-GHCLRD---QALDVCQNAGVRAEHADTRAD
MLBr_02041|M.leprae_Br4923 -RRVPTTALAQLPLLLLDE-GHCLRD---QTLDICRKSGVQAELANTRAA
MAB_4409|M.abscessus_ATCC_1997 -KNVEPADLADMPLLLLDE-GHCLRD---QALEVCQLAGVRPDLGHTRAA
Mb2303c|M.bovis_AF2122/97 SRVVSARELAQTPLVTREP-NSGIRDSLTAALRDTLGEDMQQAPPVLELS
Rv2282c|M.tuberculosis_H37Rv SRVVSARELAQTPLVTREP-NSGIRDSLTAALRDTLGEDMQQAPPVLELS
MSMEG_0708|M.smegmatis_MC2_155 -IPVGFDEIARHPLIVPVR-GNALRS---LVDEAAARAGVDIDIS-VETN
Mvan_3362|M.vanbaalenii_PYR-1 -KSLSLKQLCEYPVISLPA-GTGLRS---RLDDACAAAGLRPRIA-FEAT
TH_3504|M.thermoresistible__bu -ESVDITELAREQVALWAPPGTSYYS--DFLMGACRRAGFEPDYVVSRVQ
: : : . .
Mflv_1833|M.gilvum_PYR-GCK STRVMVCLIESGLAYGVLPLSACGREFAESRLRYSRICEPVLTQQLGVAA
MAV_3102|M.avium_104 SLALTKRLVAAGLVYGVLPLSACLNEIDSNQLRYTPLTEPPLTHRVGVAA
MMAR_2756|M.marinum_M SLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAPTPGRRIGLVY
MUL_2998|M.ulcerans_Agy99 SLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIGLVY
MLBr_02041|M.leprae_Br4923 SLATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAF
MAB_4409|M.abscessus_ATCC_1997 SLATAVQCVEGGLGVTLIPGTAVTAETASGGLATATFAAPVPGRRIGLVY
Mb2303c|M.bovis_AF2122/97 SAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIW
Rv2282c|M.tuberculosis_H37Rv SAAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIW
MSMEG_0708|M.smegmatis_MC2_155 ASRVQKNLVAAGHGWAVLPAICLSDEMTSGKFSLAPLAEAMAMREL-VLA
Mvan_3362|M.vanbaalenii_PYR-1 SPLELADLARHGLGVAILPRSMARGSAGLHPLRLS----PELRGRLVWAW
TH_3504|M.thermoresistible__bu GAATVAAPLTTGG---IAFVTAAAGPTMNGRVQVVDLTPPLLVPVQALWQ
. * .
Mflv_1833|M.gilvum_PYR-GCK TEQLDLPRELVVKVGNALREEIAALIRSGSWRADLLSPEPWSPRRV
MAV_3102|M.avium_104 TSNLELPREVTAKVGNILREETAHLIKTGRWPARLLSPQPWDPAVT
MMAR_2756|M.marinum_M RASSGRD-EAYRQLAAIMGESISNEQ-----QVRLVN---------
MUL_2998|M.ulcerans_Agy99 RASSGRD-EAYRQLAAIMGESISNEQ-----QVRLVN---------
MLBr_02041|M.leprae_Br4923 RSASGRS-ASYRQIAKIIGELISTEH-----HVRLVA---------
MAB_4409|M.abscessus_ATCC_1997 RAISARE-DAYRRLAELLTRLVSAVH-----PVTADAA--------
Mb2303c|M.bovis_AF2122/97 VGGRTPPAGAIRDLLSHITSRST-----------------------
Rv2282c|M.tuberculosis_H37Rv VGGRTPPAGAIRDLLSHITSRST-----------------------
MSMEG_0708|M.smegmatis_MC2_155 TPRTNRSTGAVRAVAGALLRILHGAALEGRWPSVVWHLGEEPEARV
Mvan_3362|M.vanbaalenii_PYR-1 RTDISGP--AARLLNARARAMIAATG----TPAVIPGA--------
TH_3504|M.thermoresistible__bu RHT-------LSAIRDRILEGLG-----------------------
: