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KLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQIRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRI LDAVDDAVDQARRIGTGAEGRLVVGCVGSATYSLLPRLVRELRAALPAVDLRVRGEMLAPEQLAALHAKD IDLALMRPPVDDPALTAVSLRRDRLLVALPAGHRCADRDEVSLADLRDEDFISHAGGGRSRMSALLAALC ADAGFSPRIRDEVDETSTLVTLVAGGLGVALVPEPTAALEIGGVTYRPLAAKAGATIELLAVYRSADASP LTAKVVDVLRATV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1346 | - | - | 100% (294) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1356 | - | 8e-53 | 41.72% (290) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3565 | - | 2e-28 | 34.23% (298) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 9e-15 | 29.27% (246) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 9e-15 | 29.27% (246) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 8e-21 | 29.55% (247) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4409 | - | 8e-28 | 34.17% (278) | hydrogen peroxide-inducible genes activator |
| M. marinum M | MMAR_2756 | oxyR | 3e-25 | 33.20% (250) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_1538 | - | 4e-28 | 32.40% (287) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_1895 | - | 1e-95 | 63.57% (291) | HTH-type transcriptional regulator AlsR |
| M. thermoresistible (build 8) | TH_3504 | - | 3e-21 | 31.46% (267) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 9e-26 | 33.60% (250) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 1e-52 | 41.72% (290) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1346|M.gilvum_PYR-GCK ---------------MKLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQ
MSMEG_1895|M.smegmatis_MC2_155 ---------------MELRHLRYFRAVGEELHFGRAAERLHMAQPPLSQQ
Mvan_1027|M.vanbaalenii_PYR-1 --------------MFSLARLSCFVAVAEELHFGRAAERLHMTQPPLSRQ
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
MAB_4409|M.abscessus_ATCC_1997 --------MSDRSYQPTVVGLRAFVAIARKRHFGSAAGELGVSQPSLSQA
Mb2303c|M.bovis_AF2122/97 --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
Rv2282c|M.tuberculosis_H37Rv --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
MAV_1538|M.avium_104 ---------------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRM
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
: * :: . . ** * : * .::
Mflv_1346|M.gilvum_PYR-GCK IRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRILDAVDDAVDQARRI
MSMEG_1895|M.smegmatis_MC2_155 IRQLERELGCTLLTRTTRSVELTPAGHTYLRRAVEILDAVDAANTEAQRI
Mvan_1027|M.vanbaalenii_PYR-1 VQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQLAEGAAQTVKRI
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
MAB_4409|M.abscessus_ATCC_1997 LSMLEEGLGVRLVERNTRKVLLTPEGDALLEKAISALNAVDEFTSAASGV
Mb2303c|M.bovis_AF2122/97 LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
Rv2282c|M.tuberculosis_H37Rv LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
MAV_1538|M.avium_104 LARLEQRLGVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :* :. * * * :. *
Mflv_1346|M.gilvum_PYR-GCK GTGAEGRLVVGCVGSATYSLLPRLVRELRAALP----AVDLRVRGEMLAP
MSMEG_1895|M.smegmatis_MC2_155 ASGIQGRIAIGCVGSATYSLLPQLVRALGESLP----GIEVTVRGEMLAP
Mvan_1027|M.vanbaalenii_PYR-1 PAGDLGTVVVGFTAASAHAVLPRLLERARERLP----DVKLDLR-EMVTA
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLP----TLTLRVV-EDQTE
MAB_4409|M.abscessus_ATCC_1997 RDPFAQTLRLGLIPTVAPYVLPMVLSGLSREFP----EMSLRVT-EDQTH
Mb2303c|M.bovis_AF2122/97 RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
Rv2282c|M.tuberculosis_H37Rv RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
MAV_1538|M.avium_104 ADPAVGEIRLAYLSSFGSTVVPRLIARFKESSP-----RVTFTLEEGAAE
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYP-----STSFTLRQLYPD
. : : .
Mflv_1346|M.gilvum_PYR-GCK EQLAALHAKDIDLALMRPPVDDPALTAVSLRRDRLLVALPAGHRCADRD-
MSMEG_1895|M.smegmatis_MC2_155 AQIEALLSGGIDLALLRPPVRQEAVLTHTVRRDGLVVALPADHALAIRD-
Mvan_1027|M.vanbaalenii_PYR-1 AQIEGLMTGELDLGMARPPLKRPGLVSRPLLHEQLLAALPEGHPLADMTR
MMAR_2756|M.marinum_M RLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLALPPGHPMADRH-
MUL_2998|M.ulcerans_Agy99 RLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLALPPGHPMADRH-
MLBr_02041|M.leprae_Br4923 HLLTALREGALDAAMIALPVETAGIAEIPIYDEDFVLALPPGHPLSGKR-
MAB_4409|M.abscessus_ATCC_1997 RLLRSLSDGTLDVAVMALPVQTQGMAEIPMYREDFVLALPSGHPLAGSK-
Mb2303c|M.bovis_AF2122/97 HAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVVVPPGHKWARRSR
Rv2282c|M.tuberculosis_H37Rv HAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVVVPPGHKWARRSR
MAV_1538|M.avium_104 SIADRVRSGGVDIGVVSPRPVERTLAWRSLFRQRLGVAVPDGHRFARGA-
TH_3504|M.thermoresistible__bu ALTDAVFDGTVQLGLRRGVVPTPELATAVIGYHRVRVAFVDSHPLAARE-
: : .. : : . . .. .* :
Mflv_1346|M.gilvum_PYR-GCK EVSLADLRDEDFISHAGGGRSRMSALLAALCAD---AGFSPRIR-DEVDE
MSMEG_1895|M.smegmatis_MC2_155 AVTVADLRDEDFVVHTGHGRSVMSNLVATVCAD---AGFLPRIR-QEVSE
Mvan_1027|M.vanbaalenii_PYR-1 ELTLIDLDGQDFVMYSPVQARYFNELLISTFTI---AGTTPRYV-QYVTQ
MMAR_2756|M.marinum_M GVPVAALSELPLLLLDEG--HCLRDQALDVCQN---AGVRAELADTRAAS
MUL_2998|M.ulcerans_Agy99 GVPVAALSELPLLLLDEG--HCLRDQALDVCQN---AGVRAEHADTRADS
MLBr_02041|M.leprae_Br4923 RVPTTALAQLPLLLLDEG--HCLRDQTLDICRK---SGVQAELANTRAAS
MAB_4409|M.abscessus_ATCC_1997 NVEPADLADMPLLLLDEG--HCLRDQALEVCQL---AGVRPDLGHTRAAS
Mb2303c|M.bovis_AF2122/97 VVSARELAQTPLVTREPN--SGIRDSLTAALRDTLGEDMQQAPPVLELSS
Rv2282c|M.tuberculosis_H37Rv VVSARELAQTPLVTREPN--SGIRDSLTAALRDTLGEDMQQAPPVLELSS
MAV_1538|M.avium_104 AVSMVDLADEPFVTMHPG--FGMRRLLDELCAA---AQFRPRVA-LQAPN
TH_3504|M.thermoresistible__bu SVDITELAREQVALWAPPGTSYYSDFLMGACRR---AGFEPDYVVSRVQG
: * .
Mflv_1346|M.gilvum_PYR-GCK TSTLVTLVAGGLGVALVPEPTAALEIGG-----VTYRPLAAKAGATIELL
MSMEG_1895|M.smegmatis_MC2_155 TSTLVTLVAAGLGVAIVPDPTTALDIAG-----VRYVPLRPTD-LGVDLV
Mvan_1027|M.vanbaalenii_PYR-1 VHTMLVLVRSGIGIALVPASAATLHPEG-----VVFRTIGAFRERPVELD
MMAR_2756|M.marinum_M LATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAPTPGRRIGLVYR
MUL_2998|M.ulcerans_Agy99 LATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIGLVYR
MLBr_02041|M.leprae_Br4923 LATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAFR
MAB_4409|M.abscessus_ATCC_1997 LATAVQCVEGGLGVTLIPGTAVTAETASGGLATATFAAPVPGRRIGLVYR
Mb2303c|M.bovis_AF2122/97 AAAVRAAVLAGAGPAAMSRLAIADDLAFG--RLLAVDIPALNLRRQLRAI
Rv2282c|M.tuberculosis_H37Rv AAAVRAAVLAGAGPAAMSRLAIADDLAFG--RLLAVDIPALNLRRQLRAI
MAV_1538|M.avium_104 LTTAASLVAAGLGISLVPIDGSSYPSGVS---VKPLADADAYRDVGMIWD
TH_3504|M.thermoresistible__bu AATVAAPLTTG-GIAFVTAAAGPTMNGR-------VQVVDLTPPLLVPVQ
: : * * : :. . :
Mflv_1346|M.gilvum_PYR-GCK AVYRSADASPLTAKVVDVLRATV-------------
MSMEG_1895|M.smegmatis_MC2_155 AAH--TGDSPLITNVLRVLRTLTEGPKSPTQAHPGT
Mvan_1027|M.vanbaalenii_PYR-1 AVWRGDSTNPALLRVLKDVLPQQEWTT---------
MMAR_2756|M.marinum_M ASSGRDEAYRQLAAIMGESISNEQQVRLVN------
MUL_2998|M.ulcerans_Agy99 ASSGRDEAYRQLAAIMGESISNEQQVRLVN------
MLBr_02041|M.leprae_Br4923 SASGRSASYRQIAKIIGELISTEHHVRLVA------
MAB_4409|M.abscessus_ATCC_1997 AISAREDAYRRLAELLTRLVSAVHPVTADAA-----
Mb2303c|M.bovis_AF2122/97 WVGGRTPPAGAIRDLLSHITSRST------------
Rv2282c|M.tuberculosis_H37Rv WVGGRTPPAGAIRDLLSHITSRST------------
MAV_1538|M.avium_104 SGRPLPRSARDFIAGAAAVGHGGW------------
TH_3504|M.thermoresistible__bu ALWQRHTLSAIRDRILEGLG----------------