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MDLKGLNALLVVADAGSVTKAARILHVEQPAVSRQIKLLETELGVALFERSRRGMVLTDAGRILVERARR VVDELEKAEAELRAEVSGVRGIVSVGILDSVTDLVAEELVSDVRRRYPNVRLRVFTAFAGQLRSWLYDGE LDVALLFGVTDQTALKTLPVASEKLWAVAPKEAALQPDIPVGFDEIARHPLIVPVRGNALRSLVDEAAAR AGVDIDISVETNASRVQKNLVAAGHGWAVLPAICLSDEMTSGKFSLAPLAEAMAMRELVLATPRTNRSTG AVRAVAGALLRILHGAALEGRWPSVVWHLGEEPEARV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0708 | - | - | 100% (317) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_5654 | - | 4e-27 | 32.78% (241) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_6677 | - | 2e-25 | 29.97% (287) | transcriptional regulator, LysR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 1e-13 | 26.35% (277) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1833 | - | 4e-34 | 30.36% (303) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 1e-13 | 26.35% (277) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 4e-23 | 26.33% (300) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2238 | - | 3e-25 | 33.06% (245) | LysR family transcriptional regulator |
| M. marinum M | MMAR_4157 | - | 5e-20 | 31.71% (246) | LuxR family transcriptional regulator |
| M. avium 104 | MAV_3102 | - | 8e-34 | 32.13% (305) | LysR substrate binding domain-containing protein |
| M. thermoresistible (build 8) | TH_3504 | - | 4e-14 | 25.76% (229) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_2998 | oxyR | 1e-19 | 26.55% (290) | hydrogen peroxide-inducible genes activator, OxyR |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 5e-25 | 30.53% (285) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1833|M.gilvum_PYR-GCK ----------MDTHRLKYFLRIAEEGSITRAASLLGMAQPALSRQLQLLE
MAV_3102|M.avium_104 ----------MDTHRLKYFLRIAEQGSITGAAASLGIAQPALSRQIRLLE
MAB_2238|M.abscessus_ATCC_1997 ----------MEIHQLRYLLAVADTSSFTKAAAALHVAQPGVSAQIRLLE
Mvan_3362|M.vanbaalenii_PYR-1 ----------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVSAQIRRLE
MLBr_02041|M.leprae_Br4923 ---MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALE
MUL_2998|M.ulcerans_Agy99 MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQALAALE
Mb2303c|M.bovis_AF2122/97 ---MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRRLASME
Rv2282c|M.tuberculosis_H37Rv ---MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRRLASME
MSMEG_0708|M.smegmatis_MC2_155 ----------MDLKGLNALLVVADAGSVTKAARILHVEQPAVSRQIKLLE
MMAR_4157|M.marinum_M ----------MELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLE
TH_3504|M.thermoresistible__bu -----VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSAVRALE
: : :.: . *: : * :* : :*
Mflv_1833|M.gilvum_PYR-GCK EDLGVALFRRNRRGVELTDAGERLRSSTAAPLRQLELAVQYAAFPLARLK
MAV_3102|M.avium_104 EDLGVALFRRTRRGVQLTEEGERLRASTAAPLRQLELAMQYAGSPIARLA
MAB_2238|M.abscessus_ATCC_1997 RELGQDLFDRSGRQVRLTDAGKAVIPYARAALAAVD-GVREAADEIGGLI
Mvan_3362|M.vanbaalenii_PYR-1 RQVGQPLLTRSHRGVRVTPAGAALLPHARAALAAVR-DAQAAVDDVANLV
MLBr_02041|M.leprae_Br4923 SGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLR
MUL_2998|M.ulcerans_Agy99 AGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGEADPLN
Mb2303c|M.bovis_AF2122/97 AQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSLRTEGR
Rv2282c|M.tuberculosis_H37Rv AQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSLRTEGR
MSMEG_0708|M.smegmatis_MC2_155 TELGVALFERSRRGMVLTDAGRILVERARRVVDELEKAEAELRAEVSGVR
MMAR_4157|M.marinum_M AEIGVQLFTRRGRTNELNRYGQALLVGSRLAQRSVSSAIDNVRELAGVSG
TH_3504|M.thermoresistible__bu NDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQ
:. * * * :. * :
Mflv_1833|M.gilvum_PYR-GCK RAMLIGIPESAIDVLAAPLMTRLGSAFP-----DAQFAVTVGSTDHLVEA
MAV_3102|M.avium_104 RGVRLGILDTTVDVFAAHLLSSLAAAFP-----KVTFSVETGSTDQLVEA
MAB_2238|M.abscessus_ATCC_1997 RGHIAFGTVTSHGADLSSLLSAFHRDHP-----AISITLTEAGCEELVAG
Mvan_3362|M.vanbaalenii_PYR-1 RGAVAIGTVTLHPVDVARLMADFHAEHP-----GVEITLGTDTSDVLLAK
MLBr_02041|M.leprae_Br4923 GGMRLGLIPTVAPYVLPTMLTGLTHRLP-----TLTLRVVEDQTEHLLTA
MUL_2998|M.ulcerans_Agy99 GSIRFGIIPTVAPYVLPTVLAGLTRRLP-----TLTVRVIEDQTERLLTA
Mb2303c|M.bovis_AF2122/97 QRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSEHAIAA
Rv2282c|M.tuberculosis_H37Rv QRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSEHAIAA
MSMEG_0708|M.smegmatis_MC2_155 GIVSVGILDSVTDLVAEELVSDVRRRYP-----NVRLRVFTAFAGQLRSW
MMAR_4157|M.marinum_M GTVALGFLHSLGMQTVPHLIRLHHSRFP-----QARFELHQRSGQGVLSD
TH_3504|M.thermoresistible__bu AHYVIGHTPALSGAEAYALIEPAVTAYP-----STSFTLRQLYPDALTDA
: : . :
Mflv_1833|M.gilvum_PYR-GCK MLKGSVDIALINPVPDD---RVFYREILTEEFVLVGGPDSPLEPE-KPLQ
MAV_3102|M.avium_104 MLKGAVDVAVINPVPDD---RIFYRDLLTEDLVVVGAATSGLDSG-QMMP
MAB_2238|M.abscessus_ATCC_1997 LREGRLDGAIVALGAQR-LAGLGLQVIDDQPLVAAVAADDLLATR-RTIT
Mvan_3362|M.vanbaalenii_PYR-1 LEDGRLDAAIVSIGADEDPAGLEYEVITDEALEAAVTAQHRLARR-KSLS
MLBr_02041|M.leprae_Br4923 LREGALDAAMIALPVET--AGIAEIPIYDEDFVLALPPGHPLSGK-RRVP
MUL_2998|M.ulcerans_Agy99 LREGSLDTALIALPADY--GGLTEIPIYEEDFVLALPPGHPMADR-HGVP
Mb2303c|M.bovis_AF2122/97 VRDGIADLGFIENPCPP--TGLGSVVVARDELVVVVPPGHKWARRSRVVS
Rv2282c|M.tuberculosis_H37Rv VRDGIADLGFIENPCPP--TGLGSVVVARDELVVVVPPGHKWARRSRVVS
MSMEG_0708|M.smegmatis_MC2_155 LYDGELDVALLFGVTDQ--TALKTLPVASEKLWAVAPKEAALQPD-IPVG
MMAR_4157|M.marinum_M LVSGVTDVSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGR-RLIR
TH_3504|M.thermoresistible__bu VFDGTVQLGLRRGVVPT--PELATAVIGYHRVRVAFVDSHPLAAR-ESVD
: .* : .. : : . . . :
Mflv_1833|M.gilvum_PYR-GCK FADLV--ELPLVVPRSTTGLGQALYNAALRAK---VTIDYR-ITTDSTRV
MAV_3102|M.avium_104 FTELV--ELPLVVPRSHTGIGNVIENAALRRK---VKISWR-IATDSLAL
MAB_2238|M.abscessus_ATCC_1997 LQRLC--EHTLICLPTGSGVRSILESECRSLG---LSPNVA-FEASSPRA
Mvan_3362|M.vanbaalenii_PYR-1 LKQLC--EYPVISLPAGTGLRSRLDDACAAAG---LRPRIA-FEATSPLE
MLBr_02041|M.leprae_Br4923 TTALA--QLPLLLLDEGHCLRDQTLDICRKSG---VQAELANTRAASLAT
MUL_2998|M.ulcerans_Agy99 VAALS--ELPLLLLDEGHCLRDQALDVCQNAG---VRAEHADTRADSLAT
Mb2303c|M.bovis_AF2122/97 ARELA--QTPLVTREPNSGIRDSLTAALRDTLGEDMQQAPPVLELSSAAA
Rv2282c|M.tuberculosis_H37Rv ARELA--QTPLVTREPNSGIRDSLTAALRDTLGEDMQQAPPVLELSSAAA
MSMEG_0708|M.smegmatis_MC2_155 FDEIA--RHPLIVPVRGNALRSLVDEAAARAG---VDIDIS-VETNASRV
MMAR_4157|M.marinum_M FPELA--AYPFVVLDRDHTLRRIVDAACARHG---IDPTLA-FEGTDVGT
TH_3504|M.thermoresistible__bu ITELAREQVALWAPPGTSYYSDFLMGACRRAG---FEPDYVVSRVQGAAT
: .. .
Mflv_1833|M.gilvum_PYR-GCK MVCLIESGLAYGVLPLSACGREFAESRLRYSRICEPVLTQQLGVAATEQL
MAV_3102|M.avium_104 TKRLVAAGLVYGVLPLSACLNEIDSNQLRYTPLTEPPLTHRVGVAATSNL
MAB_2238|M.abscessus_ATCC_1997 LVSLVEQGLGIAVVPAPYVRNRAGVLALDIR----PALRGRLALAWRLDG
Mvan_3362|M.vanbaalenii_PYR-1 LADLARHGLGVAILPRSMARGSAGLHPLRLS----PELRGRLVWAWRTD-
MLBr_02041|M.leprae_Br4923 AVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAFRSAS
MUL_2998|M.ulcerans_Agy99 AVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIGLVYRASS
Mb2303c|M.bovis_AF2122/97 VRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIWVGGR
Rv2282c|M.tuberculosis_H37Rv VRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIWVGGR
MSMEG_0708|M.smegmatis_MC2_155 QKNLVAAGHGWAVLPAICLSDEMTSGKFSLAPLAEAMAMRELVLATPRTN
MMAR_4157|M.marinum_M LRGLIGANLGVGVLPQATAR----PADIIEIAIDDAQLVRPIAIGWIADR
TH_3504|M.thermoresistible__bu VAAPLTTG---GIAFVTAAAGPTMNGRVQVVDLTPPLLVP-VQALWQRHT
. . :
Mflv_1833|M.gilvum_PYR-GCK DLPRELVVKVGNALREEIAALIRSGSWRADLLSPEPWSPRRV
MAV_3102|M.avium_104 ELPREVTAKVGNILREETAHLIKTGRWPARLLSPQPWDPAVT
MAB_2238|M.abscessus_ATCC_1997 -----PVGPAARAFLERARAVL--------------------
Mvan_3362|M.vanbaalenii_PYR-1 -----ISGPAARLLNARARAMIAATGTPAVIPGA--------
MLBr_02041|M.leprae_Br4923 -----GRSASYRQIAKIIGELISTEHHVRLVA----------
MUL_2998|M.ulcerans_Agy99 -----GRDEAYRQLAAIMGESISNEQQVRLVN----------
Mb2303c|M.bovis_AF2122/97 -------TPPAGAIRDLLSHITSRST----------------
Rv2282c|M.tuberculosis_H37Rv -------TPPAGAIRDLLSHITSRST----------------
MSMEG_0708|M.smegmatis_MC2_155 RSTG-AVRAVAGALLRILHGAALEGRWPSVVWHLGEEPEARV
MMAR_4157|M.marinum_M -----CLPSSAVAFRETALGCYGHRVSAAGV-----------
TH_3504|M.thermoresistible__bu ----------LSAIRDRILEGLG-------------------
: