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ELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQIRRLERSVGQPLLTRTSREVRLTRAGEALLPHARAA LAAVRDGRAAVDDVAGLLRGSVAIGTVTLHPMNVAHLIAEFHADHPDVEITLGTATSDVLIAELGDGRLD LAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHRRSLSLEQLSRHPLISLPAGTGLRTRLDTACAA AGLRPRIAFEATSPAELAELARHGLGVAILPQSMARGGSGLHALRLAPELRGRLVWAWRADGANPAARVL GERARAMAVSPGSGAPAVVPGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3565 | - | - | 100% (303) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1346 | - | 2e-28 | 34.23% (298) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1356 | - | 4e-20 | 32.52% (286) | LysR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 5e-18 | 28.86% (298) | oxidative stress response regulatory protein OXYS |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 5e-18 | 28.86% (298) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02041 | oxyR | 2e-25 | 31.38% (290) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2238 | - | 4e-72 | 49.48% (289) | LysR family transcriptional regulator |
| M. marinum M | MMAR_4157 | - | 6e-31 | 32.38% (281) | LuxR family transcriptional regulator |
| M. avium 104 | MAV_1538 | - | 3e-26 | 29.73% (259) | transcriptional regulator, LysR family protein |
| M. smegmatis MC2 155 | MSMEG_3840 | - | 6e-87 | 58.55% (304) | LysR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3504 | - | 7e-23 | 30.97% (268) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4020 | - | 2e-30 | 32.38% (281) | LuxR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_3362 | - | 1e-124 | 76.24% (303) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3565|M.gilvum_PYR-GCK -------MELRQLEYFVAIVEEGGFTRAASRERVAQPAVSAQIRRLERSV
Mvan_3362|M.vanbaalenii_PYR-1 -------MELRQLEYLVAVVEERSFTKAAQRERVAQPAVSAQIRRLERQV
MSMEG_3840|M.smegmatis_MC2_155 -------MELRQLEYFVAVAEEANFTRAAQRIHVAQPAVSASIRQLEREL
MAB_2238|M.abscessus_ATCC_1997 -------MEIHQLRYLLAVADTSSFTKAAAALHVAQPGVSAQIRLLEREL
MMAR_4157|M.marinum_M -------MELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLEAEI
MUL_4020|M.ulcerans_Agy99 -------MELYQLRYFQAVAECGTLRGASEQLLVSQSAVSRAITLLEAEI
Mb0121|M.bovis_AF2122/97 -------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLEREL
Rv0117|M.tuberculosis_H37Rv -------MLFRQLEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLEREL
MAV_1538|M.avium_104 -------MAVGDYEWFITLAELQHVTAAAEQLHVAQPTLTRMLARLEQRL
MLBr_02041|M.leprae_Br4923 MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQALAALESGL
TH_3504|M.thermoresistible__bu --VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDV
. : ::.: . *: : * :: : ** :
Mflv_3565|M.gilvum_PYR-GCK GQPLLTRTSREVRLTRAGEALLPHARAALAAVRDGRAAVDDVAGLLRGSV
Mvan_3362|M.vanbaalenii_PYR-1 GQPLLTRSHRGVRVTPAGAALLPHARAALAAVRDAQAAVDDVANLVRGAV
MSMEG_3840|M.smegmatis_MC2_155 GQPLFDRSRREVRLTAAGEAVLPHAHAALRSVAAARTAVAEVSGLVRGSV
MAB_2238|M.abscessus_ATCC_1997 GQDLFDRSGRQVRLTDAGKAVIPYARAALAAVDGVREAADEIGGLIRGHI
MMAR_4157|M.marinum_M GVQLFTRRGRTNELNRYGQALLVGSRLAQRSVSSAIDNVRELAGVSGGTV
MUL_4020|M.ulcerans_Agy99 GVQLFTRRGRTNELNRYGQALLVGSRLAQRSVSSAIDNVRELAGVSGGTV
Mb0121|M.bovis_AF2122/97 NVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTL
Rv0117|M.tuberculosis_H37Rv NVTLINRGHSFEGLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTL
MAV_1538|M.avium_104 GVALFDRHGRRLSLNTYGRIFYEHARRAQLELDSARRAIADLADPAVGEI
MLBr_02041|M.leprae_Br4923 GVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGESDPLRGGM
TH_3504|M.thermoresistible__bu GADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHY
. *: * :. * . .: .
Mflv_3565|M.gilvum_PYR-GCK AIGTVTLHPMN-VAHLIAEFHADHPDVEITLGT-ATSDVLIAELGDGRLD
Mvan_3362|M.vanbaalenii_PYR-1 AIGTVTLHPVD-VARLMADFHAEHPGVEITLGT-DTSDVLLAKLEDGRLD
MSMEG_3840|M.smegmatis_MC2_155 VVGTVTAHDFD-MAGLLAEFHGAHQLVDITLGT-DESDALIDGLLAGRLD
MAB_2238|M.abscessus_ATCC_1997 AFGTVTSHGAD-LSSLLSAFHRDHPAISITLTE-AGCEELVAGLREGRLD
MMAR_4157|M.marinum_M ALGFLHSLGMQTVPHLIRLHHSRFPQARFELHQ-RSGQGVLSDLVSGVTD
MUL_4020|M.ulcerans_Agy99 ALGFLHSLGMQTVPHLIRLHHSRFPQARFELHQ-RSGQGVLSDLVSGVTD
Mb0121|M.bovis_AF2122/97 RLGTVPTASTT-ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELD
Rv0117|M.tuberculosis_H37Rv RLGTVPTASTT-ASLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELD
MAV_1538|M.avium_104 RLAYLSSFGSTVVPRLIARFKESSPRVTFTLEE-GAAESIADRVRSGGVD
MLBr_02041|M.leprae_Br4923 RLGLIPTVAPYVLPTMLTGLTHRLPTLTLRVVE-DQTEHLLTALREGALD
TH_3504|M.thermoresistible__bu VIGHTPALSGAEAYALIEPAVTAYPSTSFTLRQ-LYPDALTDAVFDGTVQ
.. :: . : : : :
Mflv_3565|M.gilvum_PYR-GCK LAIVSIAVDEDLPGLEVAVITDEAVEAAVADGHPLAHRRSLSLEQLSRHP
Mvan_3362|M.vanbaalenii_PYR-1 AAIVSIGADEDPAGLEYEVITDEALEAAVTAQHRLARRKSLSLKQLCEYP
MSMEG_3840|M.smegmatis_MC2_155 AAIISVGSG-LPEGLAAEVVTDQRIVAAVGDGHPWRRRRRIALTDLAGVP
MAB_2238|M.abscessus_ATCC_1997 GAIVALGAQ-RLAGLGLQVIDDQPLVAAVAADDLLATRRTITLQRLCEHT
MMAR_4157|M.marinum_M VSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGRRLIRFPELAAYP
MUL_4020|M.ulcerans_Agy99 VSLSFPAAFEGYGEIAWQTLFTQQLYAVVSTDHPLAGRRLIRFPELAAYP
Mb0121|M.bovis_AF2122/97 AVIVHPETQ-DSDDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLP
Rv0117|M.tuberculosis_H37Rv AVIVHPETQ-DSDDVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLP
MAV_1538|M.avium_104 IGVVSPRPV--ERTLAWRSLFRQRLGVAVPDGHRFARGAAVSMVDLADEP
MLBr_02041|M.leprae_Br4923 AAMIALPVE--TAGIAEIPIYDEDFVLALPPGHPLSGKRRVPTTALAQLP
TH_3504|M.thermoresistible__bu LGLRRGVVP--TPELATAVIGYHRVRVAFVDSHPLAARESVDITELAREQ
: : : . : .
Mflv_3565|M.gilvum_PYR-GCK LISLPAG--TGLRTRLDTACAAAGLRPRIA-FEATSPAELAELARHGLGV
Mvan_3362|M.vanbaalenii_PYR-1 VISLPAG--TGLRSRLDDACAAAGLRPRIA-FEATSPLELADLARHGLGV
MSMEG_3840|M.smegmatis_MC2_155 LITLPRG--TGIRRQLDRACRAAGVDVRVA-FEATTPGALADLAERGLGA
MAB_2238|M.abscessus_ATCC_1997 LICLPTG--SGVRSILESECRSLGLSPNVA-FEASSPRALVSLVEQGLGI
MMAR_4157|M.marinum_M FVVLDRD--HTLRRIVDAACARHGIDPTLA-FEGTDVGTLRGLIGANLGV
MUL_4020|M.ulcerans_Agy99 FVVLDRD--HTLRRIVDAACARHGIDPTPA-FEGTDVGTLRGLIGANLGV
Mb0121|M.bovis_AF2122/97 LALLTAD--MRDRQVIDAAFADHAVSAIPQ-VETDSVASLFAQVATGNWA
Rv0117|M.tuberculosis_H37Rv LALLTAD--MRDRQVIDAAFADHAVSAIPQ-VETDSVASLFAQVATGNWA
MAV_1538|M.avium_104 FVTMHPG--FGMRRLLDELCAAAQFRPRVA-LQAPNLTTAASLVAAGLGI
MLBr_02041|M.leprae_Br4923 LLLLDEG--HCLRDQTLDICRKSGVQAELANTRAASLATAVQCVTGGLGV
TH_3504|M.thermoresistible__bu VALWAPPGTSYYSDFLMGACRRAGFEPDYVVSRVQGAATVAAPLTTG-GI
. . . .
Mflv_3565|M.gilvum_PYR-GCK AILPQSMARGG--------SGLHALRLAPELRGRLVWAWRADGAN-PAAR
Mvan_3362|M.vanbaalenii_PYR-1 AILPRSMARGS--------AGLHPLRLSPELRGRLVWAWRTDISG-PAAR
MSMEG_3840|M.smegmatis_MC2_155 AVLPESVARAR--------AALHPLPITPELRGRLVFAWRATGPMSPAAR
MAB_2238|M.abscessus_ATCC_1997 AVVPAPYVRNR--------AGVLALDIRPALRGRLALAWRLDGPVGPAAR
MMAR_4157|M.marinum_M GVLPQATARPA--------DIIEIAIDDAQLVRPIAIGWIADRCLPSSAV
MUL_4020|M.ulcerans_Agy99 GVLPQATARPA--------DIIEIAIDDAQLVRPIAIGWIADRCLPSSAV
Mb0121|M.bovis_AF2122/97 SIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVAR
Rv0117|M.tuberculosis_H37Rv SIVPHTWLWAMPMSGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVAR
MAV_1538|M.avium_104 SLVPIDGSSYP-------SGVSVKPLADADAYRDVGMIWDSGRPLPRSAR
MLBr_02041|M.leprae_Br4923 TLLPQSAAPVESVR----SKLGLAQFAAPCPGRRIGLAFRSASGRSASYR
TH_3504|M.thermoresistible__bu AFVTAAAGPTMN-------GRVQVVDLTPPLLVPVQALWQRHTLSAIRDR
.:. . :
Mflv_3565|M.gilvum_PYR-GCK VLGERARAMAVSPGSGAPAVVPGA--
Mvan_3362|M.vanbaalenii_PYR-1 LLNARARAMIAATG--TPAVIPGA--
MSMEG_3840|M.smegmatis_MC2_155 ALVTMARRRLGLGD---PDRVGGHE-
MAB_2238|M.abscessus_ATCC_1997 AFLERARAVL----------------
MMAR_4157|M.marinum_M AFRETALGCYGHRVSAAGV-------
MUL_4020|M.ulcerans_Agy99 AFRETAFGCYGHRDSAAGV-------
Mb0121|M.bovis_AF2122/97 ALITCAQALALNEFFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv ALITCAQALALNEFFDTQLRGITRRR
MAV_1538|M.avium_104 DFIAGAAAVGHGGW------------
MLBr_02041|M.leprae_Br4923 QIAKIIGELISTEHHVRLVA------
TH_3504|M.thermoresistible__bu ILEGLG--------------------
: