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IGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQALAALEAGLDLHLVERSTRRVFLTTEG RSLLPHAQAAVEAVEAFTTAAAGEADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLPTLTVRVIEDQTER LLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLALPPGHPMADRHGVPVAALSELPLLLLDEGHCLR DQALDVCQNAGVRAEHADTRADSLATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIGL VYRASSGRDEAYRQLAAIMGESISNEQQVRLVN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2998 | oxyR | - | 100% (314) | hydrogen peroxide-inducible genes activator, OxyR |
| M. ulcerans Agy99 | MUL_2698 | - | 2e-16 | 27.96% (304) | LysR family transcriptional regulator |
| M. ulcerans Agy99 | MUL_4020 | - | 4e-15 | 26.45% (242) | LuxR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2303c | - | 4e-15 | 28.44% (211) | LysR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1346 | - | 1e-25 | 33.60% (250) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv2282c | - | 4e-15 | 28.44% (211) | LysR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02041 | oxyR | 1e-127 | 71.29% (310) | putative LysR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4409 | - | 1e-101 | 61.26% (302) | hydrogen peroxide-inducible genes activator |
| M. marinum M | MMAR_2756 | oxyR | 1e-171 | 98.73% (314) | hydrogen peroxide-inducible genes activator, OxyR |
| M. avium 104 | MAV_2838 | - | 1e-129 | 75.65% (308) | hydrogen peroxide-inducible genes activator |
| M. smegmatis MC2 155 | MSMEG_5654 | - | 3e-28 | 31.00% (271) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-12 | 30.00% (250) | PUTATIVE putative transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 2e-23 | 31.40% (258) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2998|M.ulcerans_Agy99 -----MIGITDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MMAR_2756|M.marinum_M MLATILIGMTDKSYQPTLAGLRAFVAVAEKQHFGSAANALGVSQSTLSQA
MLBr_02041|M.leprae_Br4923 --------MSDKSYQPTIAGLRAFVAVVEKGHFSAAASFLGVRQSTLSQA
MAV_2838|M.avium_104 --------MPDKTYQPTIAGLRAFVAVAEKRQFSGAATALGVSQSTLSQA
MAB_4409|M.abscessus_ATCC_1997 --------MSDRSYQPTVVGLRAFVAIARKRHFGSAAGELGVSQPSLSQA
Mflv_1346|M.gilvum_PYR-GCK ---------------MKLRHLRYFRAVAEELHFGRAAQRLLIAQPPLSQQ
MSMEG_5654|M.smegmatis_MC2_155 -----------------MRHLRCFVVLAEELHFGRAAQRLHVAQPALSQL
Mvan_1027|M.vanbaalenii_PYR-1 --------------MFSLARLSCFVAVAEELHFGRAAERLHMTQPPLSRQ
Mb2303c|M.bovis_AF2122/97 --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
Rv2282c|M.tuberculosis_H37Rv --------MPLSSRMPGLTCFEIFLAIAEAGSLGGAARELGLTQQAVSRR
TH_3504|M.thermoresistible__bu ----------VPSPKIDLRRLAQFVAVAELGSFTRAAATLHLSQQALSSA
: : * .:.. : ** * : * .:*
MUL_2998|M.ulcerans_Agy99 LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MMAR_2756|M.marinum_M LAALEAGLDLHLVERSTRRVFLTTEGRSLLPHAQAAVEAVEAFTTAAAGE
MLBr_02041|M.leprae_Br4923 LAALESGLGVQLIERSTRRVFVTTQGRHLLPRAQAAIEAMDAFTAAAAGE
MAV_2838|M.avium_104 LAALEAGLGTQLVERSTRRVFLTPQGAELLPHAQAVVEAADAFTAAAAGS
MAB_4409|M.abscessus_ATCC_1997 LSMLEEGLGVRLVERNTRKVLLTPEGDALLEKAISALNAVDEFTSAASGV
Mflv_1346|M.gilvum_PYR-GCK IRQLEREVGADLLRRTTRSVELTEAGRAFLERTVRILDAVDDAVDQARRI
MSMEG_5654|M.smegmatis_MC2_155 IQRVERELGAQLFLRTRRTVSLTEAGQTLLPEARRILRDADRVTQAVRAV
Mvan_1027|M.vanbaalenii_PYR-1 VQQLENELGVQLIDRTTRNVTLTPAGAAFLPDARRILQLAEGAAQTVKRI
Mb2303c|M.bovis_AF2122/97 LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
Rv2282c|M.tuberculosis_H37Rv LASMEAQIGVRLAIRTTRGSQLTPAGIVVAEWAARLLEVADEIDAGLGSL
TH_3504|M.thermoresistible__bu VRALENDVGADLFTRDGRRISLTTAGRTLLAEGKPLLAAARTVAEHVRQT
: :* :. * * * :* * . :
MUL_2998|M.ulcerans_Agy99 ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
MMAR_2756|M.marinum_M ADPLNGSIRFGIIPTVAPYVLPTVLAGLTRRLP----TLTVRVI-EDQTE
MLBr_02041|M.leprae_Br4923 SDPLRGGMRLGLIPTVAPYVLPTMLTGLTHRLP----TLTLRVV-EDQTE
MAV_2838|M.avium_104 ADPLRAGMRLGLIPTVAPYVLPTVLAGIAERRP----GLTLRVT-EDQTE
MAB_4409|M.abscessus_ATCC_1997 RDPFAQTLRLGLIPTVAPYVLPMVLSGLSREFP----EMSLRVT-EDQTH
Mflv_1346|M.gilvum_PYR-GCK GTGAEGRLVVGCVGSATYSLLPRLVRELRAALP----AVDLRVRGEMLAP
MSMEG_5654|M.smegmatis_MC2_155 HRGETGSVTIGFVGSAADDVLPRLVAAHRRHHP----GVSIRLE-EGTTA
Mvan_1027|M.vanbaalenii_PYR-1 PAGDLGTVVVGFTAASAHAVLPRLLERARERLP----DVKLDLR-EMVTA
Mb2303c|M.bovis_AF2122/97 RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
Rv2282c|M.tuberculosis_H37Rv RTEGRQRIRVVASQTIAEQLMPHWMLSLRAADMRRGGTVPEVILTATNSE
TH_3504|M.thermoresistible__bu EAAAQAHYVIGHTPALSGAEAYALIEPAVTAYP----STSFTLR-QLYPD
. : : : : .
MUL_2998|M.ulcerans_Agy99 RLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLALPPGHPMADRH-
MMAR_2756|M.marinum_M RLLTALREGSLDTALIALPADYGGLTEIPIYEEDFVLALPPGHPMADRH-
MLBr_02041|M.leprae_Br4923 HLLTALREGALDAAMIALPVETAGIAEIPIYDEDFVLALPPGHPLSGKR-
MAV_2838|M.avium_104 RLLAVLREGALDAALIALPAETAGVTAIPIYDEDFVLALPPGHPLAGKR-
MAB_4409|M.abscessus_ATCC_1997 RLLRSLSDGTLDVAVMALPVQTQGMAEIPMYREDFVLALPSGHPLAGSK-
Mflv_1346|M.gilvum_PYR-GCK EQLAALHAKDIDLALMRPPVDDPALTAVSLRRDRLLVALPAGHRCADRD-
MSMEG_5654|M.smegmatis_MC2_155 QQLEWLRDQRITVGLGRTPIDDPAVSTVVLARESLVLAVPDSHALSGAE-
Mvan_1027|M.vanbaalenii_PYR-1 AQIEGLMTGELDLGMARPPLKRPGLVSRPLLHEQLLAALPEGHPLADMTR
Mb2303c|M.bovis_AF2122/97 HAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVVVPPGHKWARRSR
Rv2282c|M.tuberculosis_H37Rv HAIAAVRDGIADLGFIENPCPPTGLGSVVVARDELVVVVPPGHKWARRSR
TH_3504|M.thermoresistible__bu ALTDAVFDGTVQLGLRRGVVPTPELATAVIGYHRVRVAFVDSHPLAARE-
: .. : : . . .. .* :
MUL_2998|M.ulcerans_Agy99 GVPVAALSELPLLLLDEG--HCLRDQALDVCQN---AGVRAEHADTRADS
MMAR_2756|M.marinum_M GVPVAALSELPLLLLDEG--HCLRDQALDVCQN---AGVRAELADTRAAS
MLBr_02041|M.leprae_Br4923 RVPTTALAQLPLLLLDEG--HCLRDQTLDICRK---SGVQAELANTRAAS
MAV_2838|M.avium_104 RVPATALADLPLLLLDEG--HCLRDQALDVCHK---AGVRAELANTRAAS
MAB_4409|M.abscessus_ATCC_1997 NVEPADLADMPLLLLDEG--HCLRDQALEVCQL---AGVRPDLGHTRAAS
Mflv_1346|M.gilvum_PYR-GCK EVSLADLRDEDFISHAGGGRSRMSALLAALCAD---AGFSPRIRD-EVDE
MSMEG_5654|M.smegmatis_MC2_155 SAELAGLAEEPFIMFPRHLGPGLYDIIHSACAA---AGFTPSVVY-ETVR
Mvan_1027|M.vanbaalenii_PYR-1 ELTLIDLDGQDFVMYSPVQARYFNELLISTFTI---AGTTPRYVQ-YVTQ
Mb2303c|M.bovis_AF2122/97 VVSARELAQTPLVTREPN--SGIRDSLTAALRDTLGEDMQQAPPVLELSS
Rv2282c|M.tuberculosis_H37Rv VVSARELAQTPLVTREPN--SGIRDSLTAALRDTLGEDMQQAPPVLELSS
TH_3504|M.thermoresistible__bu SVDITELAREQVALWAPPGTSYYSDFLMGACRR---AGFEPDYVVSRVQG
* . .
MUL_2998|M.ulcerans_Agy99 LATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLTHFAAPTPGRRIGLVYR
MMAR_2756|M.marinum_M LATAVQCVNGGLGVTLIPQSAVSVEAARSRVGLAHFAAPTPGRRIGLVYR
MLBr_02041|M.leprae_Br4923 LATAVQCVTGGLGVTLLPQSAAPVESVRSKLGLAQFAAPCPGRRIGLAFR
MAV_2838|M.avium_104 LATAVQCVTGGLGVTLIPQSAVPVEASRSRLGLAQFAAPRPGRRIGLVFR
MAB_4409|M.abscessus_ATCC_1997 LATAVQCVEGGLGVTLIPGTAVTAETASGGLATATFAAPVPGRRIGLVYR
Mflv_1346|M.gilvum_PYR-GCK TSTLVTLVAGGLGVALVPEPTAALEI-GGVTYRPLAAKAGATIELLAVYR
MSMEG_5654|M.smegmatis_MC2_155 MQTIVGLVSGGLGVALVPESVRNLGR-KGVRYVHLADAP-PAIELSMMWR
Mvan_1027|M.vanbaalenii_PYR-1 VHTMLVLVRSGIGIALVPASAATLHP-EGVVFRTIGAFRERPVELDAVWR
Mb2303c|M.bovis_AF2122/97 AAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIWV
Rv2282c|M.tuberculosis_H37Rv AAAVRAAVLAGAGPAAMSRLAIADDLAFGRLLAVDIPALNLRRQLRAIWV
TH_3504|M.thermoresistible__bu AATVAAPLTTG-GIAFVTAAAGPTMN---GRVQVVDLTPPLLVPVQALWQ
: : * * : :. . : :
MUL_2998|M.ulcerans_Agy99 ASSGRDEAYRQLAAIMGESISNEQQVRLVN-
MMAR_2756|M.marinum_M ASSGRDEAYRQLAAIMGESISNEQQVRLVN-
MLBr_02041|M.leprae_Br4923 SASGRSASYRQIAKIIGELISTEHHVRLVA-
MAV_2838|M.avium_104 SSSGRDDSYRELAGLIGELISSQHQVRLVK-
MAB_4409|M.abscessus_ATCC_1997 AISAREDAYRRLAELLTRLVSAVHPVTADAA
Mflv_1346|M.gilvum_PYR-GCK SADASPLTAKVVDVLRATV------------
MSMEG_5654|M.smegmatis_MC2_155 NDCESPHLQPLRKTARHL-------------
Mvan_1027|M.vanbaalenii_PYR-1 GDSTNPALLRVLKDVLPQQEWTT--------
Mb2303c|M.bovis_AF2122/97 G--GRTPPAGAIRDLLSHITSRST-------
Rv2282c|M.tuberculosis_H37Rv G--GRTPPAGAIRDLLSHITSRST-------
TH_3504|M.thermoresistible__bu RHTLSAIRDRILEGLG---------------