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TPQIKQSARELRRLQTRERILGAAIAEFQASGMAGADVGAIVSAAGVAHGTFFFHFPSKEHVLLELERRE EARMATEFVRYLRRSHDLTAALTKVVGLIAGLEQRLGPVLFRELLALHFSPTRPSDDDWSDHPVIVSLVR EIERARGDGEVHPEVDAFFSAAFFLLGVYGVLTTVTSSDTRDAMLANLITTARRGLESR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1774 | - | - | 100% (200) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4907 | - | 2e-56 | 56.02% (191) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1253 | - | 1e-54 | 57.30% (178) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3084c | - | 1e-05 | 31.82% (110) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3058c | - | 1e-05 | 31.82% (110) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00316 | - | 2e-05 | 39.68% (63) | putative TetR/AcrR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1379c | - | 3e-07 | 32.65% (98) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0249 | - | 2e-44 | 44.90% (196) | TetR family transcriptional regulator |
| M. avium 104 | MAV_2459 | - | 4e-59 | 58.64% (191) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6604 | - | 7e-58 | 56.84% (190) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1661 | - | 1e-61 | 60.00% (195) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_4864 | - | 9e-44 | 43.88% (196) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4973 | - | 2e-94 | 84.00% (200) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3084c|M.bovis_AF2122/97 -----MTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSVR
Rv3058c|M.tuberculosis_H37Rv -----MTSHAADEKQAAPPMRRRGDRHRQAILRAARELLEETPFAELSVR
Mflv_1774|M.gilvum_PYR-GCK --------MTPQIKQSARELRR--LQTRERILGAAIAEFQASGMAGADVG
Mvan_4973|M.vanbaalenii_PYR-1 -------MMAPQVRQTARELRR--LQTRERILGAAIAEFQASGMAGADIG
MAV_2459|M.avium_104 ----------MADRLSAREAKR--LQTRERLMGAAIAEFARAGMAEADVG
MSMEG_6604|M.smegmatis_MC2_155 --------MAGADGLTAREAKR--LQTRERLMGAAIAEFKRAGMADADVG
TH_1661|M.thermoresistible__bu --------MARAEKPSAREAKR--LQTRERLLGAAIAEFKRTGMAEADVR
MMAR_0249|M.marinum_M MGSTASTTAPHSPQQKVREAQR--LRTRARVFDAAVAEIGRRGLAGADVA
MUL_4864|M.ulcerans_Agy99 MGSTASTTAAHSPQQKVREAQR--LRTRARVFDAAVAEIGRRGLAGADVA
MLBr_00316|M.leprae_Br4923 -MSVPRSGLSVQMAQPARPLRADAARNRARILGVAYEAFATEGLS-VPID
MAB_1379c|M.abscessus_ATCC_199 ----------MPEQLSRFERRK--QETRREILGAALACFAERGYHATGIA
: . * :: .* : :
Mb3084c|M.bovis_AF2122/97 AISLRAGVARSGFYFYFDSKYSVLAQILAEATEELEEASQHFSARQP---
Rv3058c|M.tuberculosis_H37Rv AISLRAGVARSGFYFYFDSKYSVLAQILAEATEELEEASQHFSARQP---
Mflv_1774|M.gilvum_PYR-GCK AIVSAAGVAHGTFFFHFPSKEHVLLELERREEARMATEFVRYLRRS----
Mvan_4973|M.vanbaalenii_PYR-1 AIVSAAGVAHGTFFFHFPSKEHVLLELERREESRMATEFARYLDKK----
MAV_2459|M.avium_104 AIVAAAGVAHGTFFFHFPTKEHVLLELERREEERIAKQFAQFLKSE----
MSMEG_6604|M.smegmatis_MC2_155 TIVAAAGVAHGTFFFHFPTKEHVLLELEQREEERIAKQFAQFVKKP----
TH_1661|M.thermoresistible__bu AIVAAAGVAHGTFFFHFPTKEHVLLELERREEERIARQFSRFLETE----
MMAR_0249|M.marinum_M AIAAAAGVARGTFYFHFPTKEHVLVELERAEELAIVAKLRDPTADP----
MUL_4864|M.ulcerans_Agy99 AIAAAAGVARGTFYFHFPTKEHVLVELERAEELAIVAKLRDPTADS----
MLBr_00316|M.leprae_Br4923 EIARRAGVGAGTVYRHFPTKEALCAAVIGDRMPHLVDDGYVLLKSAGP--
MAB_1379c|M.abscessus_ATCC_199 DIVRRVGIAQGTFYLYFQSKREIVEQILDDLMERLSAALLDLPPSAPTSL
* .*:. . .: :* :* : : :
Mb3084c|M.bovis_AF2122/97 --GESPEQFVNRMIGSVAAVYANNDPVLRACNAARQSDMEI--RDILERQ
Rv3058c|M.tuberculosis_H37Rv --GESPEQFVNRMIGSVAAVYANNDPVLRACNAARQSDMEI--RDILERQ
Mflv_1774|M.gilvum_PYR-GCK ---HDLTAALTKVVGLIAGLEQRLGPVLFRELLALHFSPTR--PSDDDWS
Mvan_4973|M.vanbaalenii_PYR-1 ---HDLASALAKVVELISALERRFGPLLFKELLALHFSPTR--PSTDEWS
MAV_2459|M.avium_104 ---HDLASALNEAVRLVVGLERRLGDMLFNDFLALHFSQTR--PQTEDGR
MSMEG_6604|M.smegmatis_MC2_155 ---HDLEAALREIVRLVIGLERRLGDLLFKDFLALHFSQTR--PRVDEGM
TH_1661|M.thermoresistible__bu ---HDLVGTLKEAVRLVLDIEDRLGPVLFKDFLALHFSPTR--PPAEEGQ
MMAR_0249|M.marinum_M ---TDLVSVLSSLVHQVVAVERRLGPVVFRDMLGLHFAPTR--PVEDQLG
MUL_4864|M.ulcerans_Agy99 ---TDLVSVLSSLAHQVVAVERRLGPLVFRDMLGLHFAPTR--PVEDQLG
MLBr_00316|M.leprae_Br4923 --GEALFTYLRSLVLHWGATDRG-----LVDALAGAGGIDI--LGVAPDA
MAB_1379c|M.abscessus_ATCC_199 AEYRDQAEHISTSLTGVLSADPQAARFLLLQAAAVDDDMAERVLAFYDAA
: .
Mb3084c|M.bovis_AF2122/97 FQVLLRETIGVFEAEVKAGTAHPISEDLPTLVRTLAATTALMLTGDALLV
Rv3058c|M.tuberculosis_H37Rv FQVLLRETIGVFEAEVKAGTAHPISEDLPTLVRTLAATTALMLTGDALLV
Mflv_1774|M.gilvum_PYR-GCK DHPVIVSLVREIERARGDGEVHPEVDAFFSAAFFLLGVYGVLTT------
Mvan_4973|M.vanbaalenii_PYR-1 DHPVIVSLVGAIERARGDGEIHPEVDAFYSAAFFLLGIYGVLTT------
MAV_2459|M.avium_104 DHPLIVLVANEIEGAQQRGETDPHVNPMNSAVFFLLGLYALLIT------
MSMEG_6604|M.smegmatis_MC2_155 EHPVIARVTEEIEAARQRGDVAADVNPVNSAVFFLLGFYALLVT------
TH_1661|M.thermoresistible__bu DHPLIVSVAEEIERAQRAGEVDAEVNPWNSAVFFLLGLYALLTT------
MMAR_0249|M.marinum_M EHPLAEFVIETIARAQRANRVPPDADAGELGVIFLTGLFALLATG-----
MUL_4864|M.ulcerans_Agy99 EHPLAEFVIETIAQAQRADRVAPDADAGELGVIFLTGLFALLATG-----
MLBr_00316|M.leprae_Br4923 EDAFLTILSDLLYAAQYAGTARTDVG-VREVKSILVGCQAMEAYN-----
MAB_1379c|M.abscessus_ATCC_199 AAIQATYLQHGISAGYFRSDLDAGHAARAVNGMLLASAFYSLRDPS----
: . . * .
Mb3084c|M.bovis_AF2122/97 GPDSDAARRVRVLEQMWLNALWGGGKAP---
Rv3058c|M.tuberculosis_H37Rv GPDSDAARRVRVLEQMWLNALWGGGKAP---
Mflv_1774|M.gilvum_PYR-GCK --VTSSDTRDAMLANLITTARRGLESR----
Mvan_4973|M.vanbaalenii_PYR-1 --VARGDIRDAMLANLITTARRGLETR----
MAV_2459|M.avium_104 --TNHWPTGHALLEDYVARTLRSLKP-----
MSMEG_6604|M.smegmatis_MC2_155 --TNDWPTRDEVLDDYVRRTLRSMRP-----
TH_1661|M.thermoresistible__bu --THAWPNRAGMVDDFVANTLRSLRPRLTRR
MMAR_0249|M.marinum_M --ATTPDARTALLNRFVTTVVHGMEAR----
MUL_4864|M.ulcerans_Agy99 --ATTPDARTALLNGFVTTVVHGMEAR----
MLBr_00316|M.leprae_Br4923 ------SALAERVTDVVVDGLRAAR------
MAB_1379c|M.abscessus_ATCC_199 --PAAFEQLAHAVREILYYGLASDHHPQIAD
: .