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MTADRPVAVVTGASRGAGAGIAHALGMHGCTVYVTGRTVDPDGPAAGTIGETADEVTAAGGQGIAVRVDH SDDQQVAAFFDQIAREHGRIDILVNNAAIIRDEMMGRTKFWEEPINVIDTLDVGVRSSYVATVYAAPLMV PNGRGLVVFTSSSGAVHYAFGPAYGVPKAATDKMAADMAYDFRDVGIAAVSIWMGSLLTDRVRGIIASNP EKFGRILDTAETPELTGHVIWALHQDPEVMALSGQTLIGAELAVKYGIRDEGDRQPPSYREMFDVHPPAQ CAHVMR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1260 | - | - | 100% (286) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2659 | - | 2e-74 | 53.02% (281) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2396 | - | 1e-17 | 32.82% (195) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 3e-16 | 28.68% (265) | short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv1941 | - | 3e-16 | 28.68% (265) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-10 | 31.40% (207) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4335 | - | 3e-15 | 28.76% (233) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_3513 | - | 9e-77 | 53.82% (275) | oxidoreductase |
| M. avium 104 | MAV_3035 | - | 2e-76 | 55.64% (266) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_2923 | - | 8e-78 | 55.76% (269) | dehydrogenase/reductase SDR family protein member 1 |
| M. thermoresistible (build 8) | TH_2904 | - | 1e-129 | 79.44% (287) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2755 | - | 4e-60 | 56.99% (193) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3919 | - | 1e-77 | 56.55% (267) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1260|M.gilvum_PYR-GCK --------------------------------------------------
TH_2904|M.thermoresistible__bu --------------------------------------------------
MMAR_3513|M.marinum_M --------------------------------------------------
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 --------------------------------------------------
MSMEG_2923|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mflv_1260|M.gilvum_PYR-GCK --------------------------------------------------
TH_2904|M.thermoresistible__bu --------------------------------------------------
MMAR_3513|M.marinum_M --------------------------------------------------
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 --------------------------------------------------
MSMEG_2923|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mflv_1260|M.gilvum_PYR-GCK --------------------------------------------------
TH_2904|M.thermoresistible__bu --------------------------------------------------
MMAR_3513|M.marinum_M --------------------------------------------------
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 --------------------------------------------------
MSMEG_2923|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mflv_1260|M.gilvum_PYR-GCK --------------------------------------------------
TH_2904|M.thermoresistible__bu --------------------------------------------------
MMAR_3513|M.marinum_M --------------------------------------------------
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 --------------------------------------------------
MSMEG_2923|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mflv_1260|M.gilvum_PYR-GCK --------------------------------------------------
TH_2904|M.thermoresistible__bu --------------------------------------------------
MMAR_3513|M.marinum_M --------------------------------------------------
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 --------------------------------------------------
MSMEG_2923|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mflv_1260|M.gilvum_PYR-GCK --------------------------------------------------
TH_2904|M.thermoresistible__bu --------------------------------------------------
MMAR_3513|M.marinum_M --------------------------------------------------
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 --------------------------------------------------
MSMEG_2923|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3919|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1976|M.bovis_AF2122/97 --------------------------------------------------
Rv1941|M.tuberculosis_H37Rv --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mflv_1260|M.gilvum_PYR-GCK -----------------------MTADRPVAVVTGASRGAGAGIAHALGM
TH_2904|M.thermoresistible__bu -----------------------MSENSPVVVVTGASRGAGAGIAHALGS
MMAR_3513|M.marinum_M -----------------------MSDEALVAVVTGASRGAGRGIAAALAA
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 -----------------------------MAVVTGASRGAGRGISAALAD
MSMEG_2923|M.smegmatis_MC2_155 -------------------------MDTPVAVVTGASRGAGRGIAAALLA
Mvan_3919|M.vanbaalenii_PYR-1 -----------------------MGDIAPVAVVTGASRGAGQGIATALAG
Mb1976|M.bovis_AF2122/97 --------------------MNHPDLAGKVAIVTGAGAGIGLAVARRLAD
Rv1941|M.tuberculosis_H37Rv --------------------MNHPDLAGKVAIVTGAGAGIGLAVARRLAD
MAB_4335|M.abscessus_ATCC_1997 -------------------MGTAVQLAGKVVAVTGGARGIGRAIATAFAA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
Mflv_1260|M.gilvum_PYR-GCK HGCTVYVTGRTVDP-DGPAAGTIGETADEVTAAGGQGIAVRVDHSDDQQV
TH_2904|M.thermoresistible__bu HGCTVYVTGRTQRSGAGGATGTIDDTADRVTAAGGTGIAVRVDHGDDDQV
MMAR_3513|M.marinum_M RGWRVYATSR------------------SVADAPPGGVAVRVDHRDDTAT
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 RGWRVYATSR------------------TIADTPSGVVPVRVDHRDDAAV
MSMEG_2923|M.smegmatis_MC2_155 AGWKVYVTGR------------------TVTDPGPGGVAVPVDHSDDVAV
Mvan_3919|M.vanbaalenii_PYR-1 RGWRVYGTGR------------------TVADAPAWGTGVRVDHRDDDAV
Mb1976|M.bovis_AF2122/97 EGCHVLCADIDG-----------DAADAAATKIGCGAAACRVDVSDEQQI
Rv1941|M.tuberculosis_H37Rv EGCHVLCADIDG-----------DAADAAATKIGCGAAACRVDVSDEQQI
MAB_4335|M.abscessus_ATCC_1997 EGAKVAIGDIDK-----------KLCENTAAEIGNSAIGLPLDVTDHGSF
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKN--------TAAQIVASGGVAYAYALDVSDAAAV
Mflv_1260|M.gilvum_PYR-GCK AAFFDQIAREHGRIDILVNNAAIIRDEMMGRTKFWEEPINVIDTLDVGVR
TH_2904|M.thermoresistible__bu RALFERIGREHGRIDILVNNAAIIRDEMMGRTKFWEEPINVIDTLHVGLR
MMAR_3513|M.marinum_M AALFERVQQESGRLDLLVNNAAAISDDLVDPKPFWEKPLALADVLDVGLR
MUL_2755|M.ulcerans_Agy99 ------MQQESGRLDLLVNNAAAISDDLVDPKPFWEKPLALADVLDVGLR
MAV_3035|M.avium_104 SDLFDRVRRESGRLDLLVNNAATISDNLVSSKPFWEKPLDLADVLDVGLR
MSMEG_2923|M.smegmatis_MC2_155 GALFRRVADESGRLDLLVNNAAAIHDALVDPKPFWEKPIELADVLDVGLR
Mvan_3919|M.vanbaalenii_PYR-1 GALFERVGAEAGRLDLLVNNAAVISDDLVSPKPFWEKPRALADVLDVGLR
Mb1976|M.bovis_AF2122/97 IAMVDACVAAFGGVDKLVANAGVVHLASLIDTTVED----FDRVIAINLR
Rv1941|M.tuberculosis_H37Rv IAMVDACVAAFGGVDKLVANAGVVHLASLIDTTVED----FDRVIAINLR
MAB_4335|M.abscessus_ATCC_1997 EAFFDTIAATVGPVDVIVNNAGIMPITPFDDESLES----IQRQLDINVR
MLBr_00862|M.leprae_Br4923 EAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEE----FDRVLAVNLG
* * :* **. . . . : :.:
Mflv_1260|M.gilvum_PYR-GCK SSYVATVYAAPLMVP--NGRGLVVFTSSSGAVHYAFGPAYGVPKAATDKM
TH_2904|M.thermoresistible__bu SSYVATVYAAPLMLP--QRRGLVVFTSSSGGVHYAFGPAYGVPKAGADKM
MMAR_3513|M.marinum_M SSYVASWYAAPLLVA--GGRGLIAFTSSPGSVCYMHGPAYGAQKAGIDKM
MUL_2755|M.ulcerans_Agy99 SSYVASWYAAPLLVA--GGRGLIAFTSSPGSVCYMHGPAYGAQKAGIDKM
MAV_3035|M.avium_104 SSYVASWYAAPLLVA--GGRGLIAFTSSPGSVCYMHGPAYGAQKAGVDKM
MSMEG_2923|M.smegmatis_MC2_155 SAYVASWHAAPLLLA--GDKGLIAFTSSPGSVCYMHGPAYGAQKAGVDKL
Mvan_3919|M.vanbaalenii_PYR-1 SAYIASWHAAPLLTA--QQRGLVVFTSSPGSVCYMHGPAYGAQKAGVDKM
Mb1976|M.bovis_AF2122/97 GAWLCTKHAAPRMIER-GGGAIVNLSSLAGQVAVGGTGAYGMSKAGIIQL
Rv1941|M.tuberculosis_H37Rv GAWLCTKHAAPRMIER-GGGAIVNLSSLAGQVAVGGTGAYGMSKAGIIQL
MAB_4335|M.abscessus_ATCC_1997 GVMWGSQLAIKRMKPR-GGGVIVNIASAAGKAGFPGLATYCATKHAVVGL
MLBr_00862|M.leprae_Br4923 GVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMF
. : :: .:* .. . :* * . :
Mflv_1260|M.gilvum_PYR-GCK AADMAYDFRDVGIAAVSIWMGSLLTDRVR-------GIIASNP---EKFG
TH_2904|M.thermoresistible__bu AADMAVDFREYGIAAVSIWMGSLLTERVR-------KIIASKP---EKFG
MMAR_3513|M.marinum_M AADMAVDFHDTGVATVSIWMGILLTEKLR-------GAFGQHPDGQLALA
MUL_2755|M.ulcerans_Agy99 AADMAVDFHDTGVATVSIWMGILLTEKLR-------GAFGQHPDGQRTLA
MAV_3035|M.avium_104 AADMAVDFRGTGVATVSIWMGILLTEKLR-------AAFGADP---AALA
MSMEG_2923|M.smegmatis_MC2_155 AADMAVDFRGTSVCTVSIWMGILLTEKLR-------AAFAGNP---EALA
Mvan_3919|M.vanbaalenii_PYR-1 AADMAVDFRGTGVSAVSIWMGILLTDKLR-------SAFDGSP---EALA
Mb1976|M.bovis_AF2122/97 SRITAAELRSSGIRSNTLLPAFVDTPMQQ-------TAMAMFD---GALG
Rv1941|M.tuberculosis_H37Rv SRITAAELRSSGIRSNTLLPAFVDTPMQQ-------TAMAMFD---GALG
MAB_4335|M.abscessus_ATCC_1997 SESLSLEYEPAGISVVCVMPGMVNTELISGLDTHWLLKTVEPEDIANAVV
MLBr_00862|M.leprae_Br4923 SDCLRAELDAVGVGLTTICPGVIDTNIIQ-------STRIDTPTAKQERV
: : .: : . : *
Mflv_1260|M.gilvum_PYR-GCK RILDTAETPELTGHVIWALHQDPEVMALSGQTLIGAELAVKYGIRDEGDR
TH_2904|M.thermoresistible__bu HILDTAETPELTGHVIWALYRDPGLMSVSGQTLIGAELAARYGIRDEDGR
MMAR_3513|M.marinum_M KTAEHAETPEFTGYLIDALYRDPALGELSGQTVIGAELAERYGITDEGGR
MUL_2755|M.ulcerans_Agy99 KTAEHAETPEFTGYLIGALYRDPALGELSGQTVIGAELAERYGITDEGGR
MAV_3035|M.avium_104 ATAEHAETPEFTGYVIDALFDDPGLAELSGQTLIGAELAQRYGITDEGGR
MSMEG_2923|M.smegmatis_MC2_155 ETAKHAETPEFTGRLIDALYRDPQLGELSGQTVIGAELATRYGITDEGGR
Mvan_3919|M.vanbaalenii_PYR-1 AFAEQAETPEFTGHVIDALFRDPELDDVSGHTLIAAELATRYGITDEGGR
Mb1976|M.bovis_AF2122/97 AGGARSMIARLQGRMAAPEEMAGIVVFLLSD---DASMITGTTQIADGGT
Rv1941|M.tuberculosis_H37Rv AGGARSMIARLQGRMAAPEEMAGIVVFLLSD---DASMITGTTQIADGGT
MAB_4335|M.abscessus_ATCC_1997 KAVRRGVFPVFVPKMFGGMYRTMSVLPRSTGKFLTRKLGIQDFMLNAHGS
MLBr_00862|M.leprae_Br4923 RDRRGQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISR
: : : .
Mflv_1260|M.gilvum_PYR-GCK QPPSYREMFDVHPPAQCAHVMR
TH_2904|M.thermoresistible__bu RPPSYRDLFGVHPRRQYGYMMR
MMAR_3513|M.marinum_M RPPSHRHMLGA-PRTPSTVVVR
MUL_2755|M.ulcerans_Agy99 RPPSHRHILGA-PRTPSTVVVR
MAV_3035|M.avium_104 RPPSHRDMLGS-PRTPSSVVVR
MSMEG_2923|M.smegmatis_MC2_155 IPPSHREMLGA-PRVAHPAVVR
Mvan_3919|M.vanbaalenii_PYR-1 TPPSHRQMLGA-PREPSPVIIR
Mb1976|M.bovis_AF2122/97 IAALW-----------------
Rv1941|M.tuberculosis_H37Rv IAALW-----------------
MAB_4335|M.abscessus_ATCC_1997 DARKAYEDRASHSGPSTE----
MLBr_00862|M.leprae_Br4923 VLPQVLRSTARIRVI-------