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TLDGKVAFVAGASRGIGATVAAALARAGASVAVAARTEQEGRLPGTIGSVAQRITDEGGRALPVVCDVTR EESVEAAVAATVAEFGGIDILVANAGVLWLGPIESTPLKRWQLCLDVNTTGVFLVTKAVIPHVRARGGGS LIAVTTTGVTMTDHGANAYWVSKAAAERLYLGLAADLKPDNIAVNCLSPSRVVLTEGWQAGGAGMEIPPE MVEPPEAMGRATVMLAQQDASGVTGTIQRSEALAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2396 | - | - | 100% (246) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4691 | - | 2e-32 | 38.61% (202) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2386 | - | 1e-30 | 33.47% (239) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3251 | - | 2e-34 | 35.29% (238) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3224 | - | 2e-34 | 35.29% (238) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 6e-14 | 31.05% (190) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3946c | - | 4e-30 | 38.69% (199) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_1333 | - | 5e-34 | 36.44% (236) | iron-regulated short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_4172 | - | 4e-36 | 37.71% (236) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4872 | - | 1e-113 | 82.04% (245) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_0664 | - | 1e-31 | 36.40% (228) | POSSIBLE IRON-REGULATED SHORT-CHAIN DEHYDROGENASE/REDUCTASE |
| M. ulcerans Agy99 | MUL_2546 | - | 3e-34 | 36.44% (236) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4252 | - | 1e-123 | 90.98% (244) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mflv_2396|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4252|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4872|M.smegmatis_MC2_155 --------------------------------------------------
Mb3251|M.bovis_AF2122/97 --------------------------------------------------
Rv3224|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1333|M.marinum_M --------------------------------------------------
MUL_2546|M.ulcerans_Agy99 --------------------------------------------------
MAV_4172|M.avium_104 --------------------------------------------------
TH_0664|M.thermoresistible__bu --------------------------------------------------
MAB_3946c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mflv_2396|M.gilvum_PYR-GCK -----------------------MTLDGKVAFVAGASRGIGATVAAALAR
Mvan_4252|M.vanbaalenii_PYR-1 -----------------------MTLHGKVAFVAGASRGIGATVAAALAR
MSMEG_4872|M.smegmatis_MC2_155 -------------MRETPKPSTPGSLAGKVAFVAGASRGIGATIATALAA
Mb3251|M.bovis_AF2122/97 -----------------------MSLNGKTMFISGASRGIGLAIAKRAAR
Rv3224|M.tuberculosis_H37Rv -----------------------MSLNGKTMFISGASRGIGLAIAKRAAR
MMAR_1333|M.marinum_M -----------------------MSLNGKTMFISGASRGIGLAIAKRAAQ
MUL_2546|M.ulcerans_Agy99 -----------------------MSLNGKTMFISGASRGIGLAIAKRAAQ
MAV_4172|M.avium_104 -----------------------MSLNGKTMFISGASRGIGLAIAKRAAQ
TH_0664|M.thermoresistible__bu -----------------------MSLRGKTMFISGGSRGIGLAIAKRVAA
MAB_3946c|M.abscessus_ATCC_199 ----------------------MGSLAGKTIIMSGGSRGIGLAIALRAAR
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
:: .. ::*.. *** * *
Mflv_2396|M.gilvum_PYR-GCK AGASVAVAARTEQEG-RLPGTIGSVAQRITDEGGRALPVVCDVTREESVE
Mvan_4252|M.vanbaalenii_PYR-1 AGASVAVAARSEQEG-KLPGTIGSVAQGISAAGGRALPVACDVTSEESVN
MSMEG_4872|M.smegmatis_MC2_155 EGAAVAVAARSERPG-KLPGTIDSVASAITDAGGHALPVVCDVTDEQSVE
Mb3251|M.bovis_AF2122/97 DGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVA
Rv3224|M.tuberculosis_H37Rv DGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVA
MMAR_1333|M.marinum_M DGANIALIAKTAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVS
MUL_2546|M.ulcerans_Agy99 DGANIALIAKTAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPDSVS
MAV_4172|M.avium_104 DGANIALIAKTAEPHPKLPGTVYTAAKELEEAGGQALPIVGDVRDPESVE
TH_0664|M.thermoresistible__bu DGANVALVAKSAEPHPKLPGTIYTAAKEIEEAGGQALPIVGDIRDGDAVA
MAB_3946c|M.abscessus_ATCC_199 DGANVAIMAKTAEPHPKLPGTIYTAAEEIEAAGGHALPLLGDVRDDEVVA
MLBr_00862|M.leprae_Br4923 RGAEVVVSDID-------EAAAKNTAAQIVASGGVAYAYALDVSDAAAVE
** :.: .: ..* : ** * . *: *
Mflv_2396|M.gilvum_PYR-GCK AAVAATVAEFGGIDILVANAGVLWLGPIESTPLKRWQLCLDVNTTGVFLV
Mvan_4252|M.vanbaalenii_PYR-1 AAVAETVAEFGGIDILVANAGVLWLGPIETTPLKRWQLCLDVNTTGVFLV
MSMEG_4872|M.smegmatis_MC2_155 RAVAQTVSELGGIDILVANAGVLWLGPIENTPLKRWQLCLDVNLTGVFLV
Mb3251|M.bovis_AF2122/97 SAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
Rv3224|M.tuberculosis_H37Rv SAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
MMAR_1333|M.marinum_M AAVAKTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
MUL_2546|M.ulcerans_Agy99 AAVAKTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAV
MAV_4172|M.avium_104 AAVAKTVEQFGGIDICVNNASAINLGPITEVPMKRFDLMNGIQVRGTYAV
TH_0664|M.thermoresistible__bu AAVAKTVEQFGGIDICVNNASAINLGSIEEVPLKRFDLMNGIQVRGTYAV
MAB_3946c|M.abscessus_ATCC_199 SAVAQTVEKFGGIDIVVNNASALNLAPSESISMKAYDLMQDINARGSFSL
MLBr_00862|M.leprae_Br4923 AFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNC
. . : * ** * **. . . : :: :: *
Mflv_2396|M.gilvum_PYR-GCK TKAVIPHVRAR-GGGSLIAVTTTGVTMTDHGAN----AYWVSKAAAERLY
Mvan_4252|M.vanbaalenii_PYR-1 TKAVIPHVRAR-GGGSLIAVTTTGVNMTDHGAN----AYWVSKAAVERLY
MSMEG_4872|M.smegmatis_MC2_155 TKAVIPHVRAR-GGGSLIAITTTGVDMVEHGSN----AYWVSKAATERLY
Mb3251|M.bovis_AF2122/97 SQACIPHMKGR-ENPHILTLSPP-ILLEKKWLR--PTAYMMAKYGMTLCA
Rv3224|M.tuberculosis_H37Rv SQACIPHMKGR-ENPHILTLSPP-ILLEKKWLR--PTAYMMAKYGMTLCA
MMAR_1333|M.marinum_M SQACIPHLKGR-ENPHILTLSPP-VQLDKKWLK--PTAYMMAKFGMTLCA
MUL_2546|M.ulcerans_Agy99 SQACIPHLKGR-ENPHILTLSPP-VQLDKKWLK--PTAYMMAKFGMTLCA
MAV_4172|M.avium_104 SQACIPHLKGR-ENPHILTLSPP-VLLGKEWLK--PTAYMMAKFGMTLCA
TH_0664|M.thermoresistible__bu SQSCIPHMKGR-DNPHILTLSPP-IRLEPKWLR--PTPYMMAKYGMTLCA
MAB_3946c|M.abscessus_ATCC_199 STSAIGALKEA-DNPHILTLSPP-ITLEPKWFERTTTAYTISKFSMSLVA
MLBr_00862|M.leprae_Br4923 CRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLS----AYCTSKAATYMFS
: : . :: ::. . .* :* .
Mflv_2396|M.gilvum_PYR-GCK LGLAADLKPDNIAVNCLSPSRVVLTEGWQAGGAGMEIPPEMVEPPEAMGR
Mvan_4252|M.vanbaalenii_PYR-1 LGLAADLKPDNIAVNCLSPSRVVLTEGWQAGGAGMQIPPEMVEPPEAMAD
MSMEG_4872|M.smegmatis_MC2_155 TGLAADLRDDNIAVNCLSPSRVVLTEGWQAGGGGLKIPPEMIEPPEAMAR
Mb3251|M.bovis_AF2122/97 LGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKP-EVYAD
Rv3224|M.tuberculosis_H37Rv LGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKP-EVYAD
MMAR_1333|M.marinum_M LGIAEEMRDEGIASNTLWPRTLVATAAVQNLLGGDEAMGRARKP-DVYAD
MUL_2546|M.ulcerans_Agy99 LGIAEEMRDEGIASNTLWPRTLVATAAVQNLLGGEEAMGRARKP-DVYAD
MAV_4172|M.avium_104 LGIAEEMREAGIASNTLWPRTLVATAAVQNLLGGDEAMGRARKP-EVYSD
TH_0664|M.thermoresistible__bu LGIAEELRDAGIASNTLWPRTTVATAAVQNLLGGDEAMARSRKP-EVYAD
MAB_3946c|M.abscessus_ATCC_199 IGLAAELRQYGIASNALWPRTTIDTAAIRNILG-AELVARCRSA-QIMAD
MLBr_00862|M.leprae_Br4923 DCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLD
: :: .:. . : * . .
Mflv_2396|M.gilvum_PYR-GCK ATVMLAQQDASGVTGTIQRSEALAL-------------------------
Mvan_4252|M.vanbaalenii_PYR-1 AAVFLAGQDASGITGTIQRSEALTF-------------------------
MSMEG_4872|M.smegmatis_MC2_155 AAVLLAQQDGTGVTGTVQRSEALTL-------------------------
Mb3251|M.bovis_AF2122/97 AAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVE
Rv3224|M.tuberculosis_H37Rv AAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVE
MMAR_1333|M.marinum_M AAYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWVE
MUL_2546|M.ulcerans_Agy99 AAYVILNKNSREYTGNSALCEDVLLESGVSDLSIYNCVPGAKLGVDLWVE
MAV_4172|M.avium_104 AAYVILNKPAREFTGNMLLCEDVLVESGVTDLSVYNCVPGSQLGVDFWVD
TH_0664|M.thermoresistible__bu AAYVVLNKPSS-YTGNTLLCEDVLLESGVTDLSVYDCVPGSELGVDLWVD
MAB_3946c|M.abscessus_ATCC_199 AAYEILTKPSREVSGNCFIDDEVLREAGVTDFSQYRECAEEDLELDFWME
MLBr_00862|M.leprae_Br4923 MMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRS
: :..
Mflv_2396|M.gilvum_PYR-GCK ----------
Mvan_4252|M.vanbaalenii_PYR-1 ----------
MSMEG_4872|M.smegmatis_MC2_155 ----------
Mb3251|M.bovis_AF2122/97 DANPPGYLPA
Rv3224|M.tuberculosis_H37Rv DANPPGYLPA
MMAR_1333|M.marinum_M EVNPPGYTQP
MUL_2546|M.ulcerans_Agy99 EVNPPGYTQP
MAV_4172|M.avium_104 GVNPPGYTGP
TH_0664|M.thermoresistible__bu SPNPPGYTGP
MAB_3946c|M.abscessus_ATCC_199 RA--------
MLBr_00862|M.leprae_Br4923 TARIRVI---