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GDIAPVAVVTGASRGAGQGIATALAGRGWRVYGTGRTVADAPAWGTGVRVDHRDDDAVGALFERVGAEAG RLDLLVNNAAVISDDLVSPKPFWEKPRALADVLDVGLRSAYIASWHAAPLLTAQQRGLVVFTSSPGSVCY MHGPAYGAQKAGVDKMAADMAVDFRGTGVSAVSIWMGILLTDKLRSAFDGSPEALAAFAEQAETPEFTGH VIDALFRDPELDDVSGHTLIAAELATRYGITDEGGRTPPSHRQMLGAPREPSPVIIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3919 | - | - | 100% (268) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4967 | - | 3e-15 | 32.64% (193) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_5265 | - | 1e-14 | 29.43% (265) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3579c | - | 9e-14 | 30.24% (205) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2659 | - | 1e-126 | 80.88% (272) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3549c | - | 9e-14 | 30.24% (205) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 6e-15 | 30.56% (180) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_2723c | - | 9e-12 | 28.49% (179) | 3-oxoacyl- |
| M. marinum M | MMAR_3513 | - | 1e-116 | 76.38% (271) | oxidoreductase |
| M. avium 104 | MAV_3035 | - | 1e-114 | 77.48% (262) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_2923 | - | 1e-113 | 75.67% (263) | dehydrogenase/reductase SDR family protein member 1 |
| M. thermoresistible (build 8) | TH_1294 | - | 1e-110 | 72.35% (264) | dehydrogenase/reductase SDR family protein member 1 |
| M. ulcerans Agy99 | MUL_2755 | - | 1e-86 | 75.24% (206) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3919|M.vanbaalenii_PYR-1 MGDIA----------------PVAVVTGASRGAGQGIATALAGRGWRVYG
Mflv_2659|M.gilvum_PYR-GCK MSDIAP------------VTGPVAVVTGAGRGAGLGIATALAAHGWRVYG
MSMEG_2923|M.smegmatis_MC2_155 --MDT----------------PVAVVTGASRGAGRGIAAALLAAGWKVYV
TH_1294|M.thermoresistible__bu VTSEA----------------PVAVVTGASRGAGRGIARALLSRGWRVYG
MMAR_3513|M.marinum_M MSDEA----------------LVAVVTGASRGAGRGIAAALAARGWRVYA
MUL_2755|M.ulcerans_Agy99 --------------------------------------------------
MAV_3035|M.avium_104 ----------------------MAVVTGASRGAGRGISAALADRGWRVYA
Mb3579c|M.bovis_AF2122/97 MTLAEAADAINFG-----LAGRVVLVTGGVRGVGAGISSVFAEQGATVIT
Rv3549c|M.tuberculosis_H37Rv MTLAEAADAINFG-----LAGRVVLVTGGVRGVGAGISSVFAEQGATVIT
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_2723c|M.abscessus_ATCC_199 MTNA-------------EFVPRSVLVTGGNRGIGLAVAQRLAADGHKVAV
Mvan_3919|M.vanbaalenii_PYR-1 TGRTVADAPAWGTGVRVDHRDDDAVGALFERVGAEAGRLDLLVNNAAVIS
Mflv_2659|M.gilvum_PYR-GCK TGRGIAEDPAWGTGIRVDHRDDDAVGRVFDRVGAEAGRLDLLVNNAAAIS
MSMEG_2923|M.smegmatis_MC2_155 TGRTVTDPGPGGVAVPVDHSDDVAVGALFRRVADESGRLDLLVNNAAAIH
TH_1294|M.thermoresistible__bu TGRTVTDAD-GVIPAPLDHADDSAVAALFDRVAAECGRLDLLVNNAAAVH
MMAR_3513|M.marinum_M TSRSVADAPPGGVAVRVDHRDDTATAALFERVQQESGRLDLLVNNAAAIS
MUL_2755|M.ulcerans_Agy99 -------------------------------MQQESGRLDLLVNNAAAIS
MAV_3035|M.avium_104 TSRTIADTPSGVVPVRVDHRDDAAVSDLFDRVRRESGRLDLLVNNAATIS
Mb3579c|M.bovis_AF2122/97 CAR-RAVDGQPYEFHRCDIRDEDSVKRLVGEIGERHGRLDMLVNNAGGSP
Rv3549c|M.tuberculosis_H37Rv CAR-RAVDGQPYEFHRCDIRDEDSVKRLVGEIGERHGRLDMLVNNAGGSP
MLBr_01807|M.leprae_Br4923 THR-ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPVEVLVANAGITS
MAB_2723c|M.abscessus_ATCC_199 THR-GSGAPEGLLGVQCDITDNDQIDAAFKEVEEKQGPVEVLVANAGITA
: . * :::** **.
Mvan_3919|M.vanbaalenii_PYR-1 DDLVSPKPFWEKPRALADVLDVGLRSAYIASWHAAPLLTAQQRG--LVVF
Mflv_2659|M.gilvum_PYR-GCK DNLVSAAPFWEKPRDLADVLTVGLRSSYIASWYAAPLLAAQDRA--LIAF
MSMEG_2923|M.smegmatis_MC2_155 DALVDPKPFWEKPIELADVLDVGLRSAYVASWHAAPLLLAGDKG--LIAF
TH_1294|M.thermoresistible__bu PALTDPRPFWQKSVELADILDIGLRSAYVAAYHAAPLLLAADRA--LIAF
MMAR_3513|M.marinum_M DDLVDPKPFWEKPLALADVLDVGLRSSYVASWYAAPLLVAGGRG--LIAF
MUL_2755|M.ulcerans_Agy99 DDLVDPKPFWEKPLALADVLDVGLRSSYVASWYAAPLLVAGGRG--LIAF
MAV_3035|M.avium_104 DNLVSSKPFWEKPLDLADVLDVGLRSSYVASWYAAPLLVAGGRG--LIAF
Mb3579c|M.bovis_AF2122/97 YALAAEATHNF----HRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNI
Rv3549c|M.tuberculosis_H37Rv YALAAEATHNF----HRKIVELNVLAPLLVSQHANVLMQAQPNGGSIVNI
MLBr_01807|M.leprae_Br4923 DMLIMRMSEEQ----FQKVIDVNLTGVFRVAKLASRNMIKQRFG-RYIFM
MAB_2723c|M.abscessus_ATCC_199 DMLIMRMSEEQ----FLKVIDANLIGTFRLAKRASRNMIKKRFG-RLIFM
* . .:: .: . : * : . : :
Mvan_3919|M.vanbaalenii_PYR-1 TSSPGSVCYMHGPAYGAQKAGVDKMAADMAVDFRGTGVSAVSIWMGILLT
Mflv_2659|M.gilvum_PYR-GCK TSSPGSVCYMHGPAYGAQKAGVDKMAADMAVDFRGTGVATVSVWMGILLT
MSMEG_2923|M.smegmatis_MC2_155 TSSPGSVCYMHGPAYGAQKAGVDKLAADMAVDFRGTSVCTVSIWMGILLT
TH_1294|M.thermoresistible__bu TSSPGSVCYMHGPAYGAQKAGIDKMAADMAVDFRGTPVCTVSIWMGILLT
MMAR_3513|M.marinum_M TSSPGSVCYMHGPAYGAQKAGIDKMAADMAVDFHDTGVATVSIWMGILLT
MUL_2755|M.ulcerans_Agy99 TSSPGSVCYMHGPAYGAQKAGIDKMAADMAVDFHDTGVATVSIWMGILLT
MAV_3035|M.avium_104 TSSPGSVCYMHGPAYGAQKAGVDKMAADMAVDFRGTGVATVSIWMGILLT
Mb3579c|M.bovis_AF2122/97 CSVSGRRPTPGTAAYGAAKAGLENLTTTLAVEWAPK-VRVNAVVVGMVET
Rv3549c|M.tuberculosis_H37Rv CSVSGRRPTPGTAAYGAAKAGLENLTTTLAVEWAPK-VRVNAVVVGMVET
MLBr_01807|M.leprae_Br4923 GSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANVVAPGFIDT
MAB_2723c|M.abscessus_ATCC_199 GSVAGQIGLPGQANYSASKAGLVGMARALTRELGSRSITANVVAPGFIDT
* * . *.* *:*: :: :: : : . : *:: *
Mvan_3919|M.vanbaalenii_PYR-1 DKLRSAFDGSP---EALAAFAEQAETPEFTGHVIDALFRDPELDDVSGHT
Mflv_2659|M.gilvum_PYR-GCK AKLRGAFDSDP---DALAAFAAHAETPEFTGHVIDALFRDPGLADLSGHT
MSMEG_2923|M.smegmatis_MC2_155 EKLRAAFAGNP---EALAETAKHAETPEFTGRLIDALYRDPQLGELSGQT
TH_1294|M.thermoresistible__bu EQMRRAFTGRP---DALAAMAEHAETPEFTGHILDALYRDPQLEQLSGHT
MMAR_3513|M.marinum_M EKLRGAFGQHPDGQLALAKTAEHAETPEFTGYLIDALYRDPALGELSGQT
MUL_2755|M.ulcerans_Agy99 EKLRGAFGQHPDGQRTLAKTAEHAETPEFTGYLIGALYRDPALGELSGQT
MAV_3035|M.avium_104 EKLRAAFGADP---AALAATAEHAETPEFTGYVIDALFDDPGLAELSGQT
Mb3579c|M.bovis_AF2122/97 ERSELFYGDAESIARVAATVPLGRLARPADIGWAAAFLASDAASYISGAT
Rv3549c|M.tuberculosis_H37Rv ERSELFYGDAESIARVAATVPLGRLARPADIGWAAAFLASDAASYISGAT
MLBr_01807|M.leprae_Br4923 EMTRAMD--SKYQEAALQAIPLGRIGAVEEIAGAVSFLASEDAGYISGAV
MAB_2723c|M.abscessus_ATCC_199 DMTRELG--EKHVETALTAIPMGRIGEPSEVAGVVSWLASPDAAYVSGAV
. . . : . :** .
Mvan_3919|M.vanbaalenii_PYR-1 LIAAELATRYGITDEGGRTPPSHRQMLGAPREPSPVIIR
Mflv_2659|M.gilvum_PYR-GCK VIGAELAARYGITDEGGRTPPSHRGMLGEPRTPSAVVVR
MSMEG_2923|M.smegmatis_MC2_155 VIGAELATRYGITDEGGRIPPSHREMLGAPRVAHPAVVR
TH_1294|M.thermoresistible__bu LIGAELAERYNITDEGGRRPPSHRAMLGDPRPPSDVVVR
MMAR_3513|M.marinum_M VIGAELAERYGITDEGGRRPPSHRHMLGAPRTPSTVVVR
MUL_2755|M.ulcerans_Agy99 VIGAELAERYGITDEGGRRPPSHRHILGAPRTPSTVVVR
MAV_3035|M.avium_104 LIGAELAQRYGITDEGGRRPPSHRDMLGSPRTPSSVVVR
Mb3579c|M.bovis_AF2122/97 LE-----------VHGGGEPPPY---LGASSANK-----
Rv3549c|M.tuberculosis_H37Rv LE-----------VHGGGEPPPY---LGASSANK-----
MLBr_01807|M.leprae_Br4923 IP-----------VDGG---------LGMGH--------
MAB_2723c|M.abscessus_ATCC_199 IP-----------VDGG---------LGMGH--------
: .** **