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MARPRTFDEDEVIEAGRDLFWSQGYAATSIDDLSAATGLGRGSLYKAFGDKHSMFLRGLEQYCTEAIAGI RAELRDQDLSAYDRLVAHVRGRAADVVSDNDLRGCLLAKSAAELSSTDPEVARHVKRTLDAWLRELTATI SAAQADGDIPSSTEAKALAALILAVLRGMEALRKGGASAATVKATAEQLVAML
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0944 | - | - | 100% (193) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3237 | - | 8e-07 | 24.71% (170) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0963 | - | 7e-06 | 25.13% (199) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2184c | - | 9e-09 | 26.32% (152) | hypothetical protein Mb2184c |
| M. tuberculosis H37Rv | Rv3208 | - | 2e-06 | 24.46% (139) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 5e-06 | 23.48% (132) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1881c | - | 2e-09 | 27.33% (161) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0630 | - | 5e-48 | 47.15% (193) | transcriptional regulatory protein |
| M. avium 104 | MAV_1977 | - | 6e-07 | 24.39% (164) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5597 | - | 1e-20 | 32.81% (192) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3775 | - | 2e-09 | 24.87% (193) | PUTATIVE TetR-family protein transcriptional regulator |
| M. ulcerans Agy99 | MUL_4947 | - | 6e-07 | 38.46% (65) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5917 | - | 2e-88 | 82.90% (193) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0944|M.gilvum_PYR-GCK ------------------------MARP--------RTFDEDEVIEAGRD
Mvan_5917|M.vanbaalenii_PYR-1 ------------------------MARP--------RAFDEAAVVEASRD
MMAR_0630|M.marinum_M ------------------------MARP--------RAFDEAVVLSAARD
Rv3208|M.tuberculosis_H37Rv MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLLVVASD
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
MSMEG_5597|M.smegmatis_MC2_155 ------------------------MGRH--------REFDVDKALDAALC
TH_3775|M.thermoresistible__bu ------------------------MAETD----------DKNRVLATATT
MAB_1881c|M.abscessus_ATCC_199 --------MLSGMVGKSSPPSAAKLPATAHG------RRTRAAIIDAAAQ
MUL_4947|M.ulcerans_Agy99 ------------------------MSTS-----------GRDRLLSAALK
Mb2184c|M.bovis_AF2122/97 ------------------------MPSADVG------RQTRAQILRAAMD
MAV_1977|M.avium_104 -------------------MTRRRAGEPRKG------DLREAAILDAAEE
: ..
Mflv_0944|M.gilvum_PYR-GCK LFWSQGYAATSIDDLSAATGLG--RGSLYKAFGDKHSMFLRGLEQYCTEA
Mvan_5917|M.vanbaalenii_PYR-1 LFWDQGYAATSIDDLSAATGLG--RGSFYKAFGDKHSMFVRGLELYCTEA
MMAR_0630|M.marinum_M EFRSHGYAATSVDSLAAATGLN--RSSLYGSFGDKHRLFLRALDGYCEAT
Rv3208|M.tuberculosis_H37Rv VFVDRGYHAAGMDEIADRAGVS--KPVLYQHFSSKLELYLAVLHRHVENL
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVS--KPVLYQHFSSKLELYLAVLERHMNNL
MSMEG_5597|M.smegmatis_MC2_155 VFWRKGYEGASYSDLTQATGVE--RPALYSAFGNKEALFLRALDRYYERY
TH_3775|M.thermoresistible__bu LFNERGVQAVGMDAIRDAAGIS--LKRLYSCFRSKADLVAAVLEQRDADV
MAB_1881c|M.abscessus_ATCC_199 MMYQKGVAATSLDDILAASSTG--KSQLYHYFKDRSELVKAVVERQTELV
MUL_4947|M.ulcerans_Agy99 LFAVKGYAATSVADIQRCSGLAPGSGALYKHFGSKHELLEAAVEHRIDSI
Mb2184c|M.bovis_AF2122/97 IASVKGLSGLSIGELAGRLGMS--KSGLFRHFGAKEQLQLATVEAAVS-V
MAV_1977|M.avium_104 LLGAIGYDAMTIADIAARAGIT--RGALYFYFGSKQEVITALFARTVAVL
* . : . :: * : : .
Mflv_0944|M.gilvum_PYR-GCK IAGIRAELRDQDLSAYDRLVAHVRGRAADVVSDNDLRGCLLAKSAAELSS
Mvan_5917|M.vanbaalenii_PYR-1 VDGIRAELRNPDLSAYDRLVAHIRGAADSVASDTDRRGCLLAKSAAELSS
MMAR_0630|M.marinum_M LHDVREVLRERGVSARQRLINHVHAIVNGIVADTDRRGCMMSRSSAELAG
Rv3208|M.tuberculosis_H37Rv VSGVHQALS-TTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFEND----FV
MLBr_00815|M.leprae_Br4923 VSSVQQALR-TTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFEND----NI
MSMEG_5597|M.smegmatis_MC2_155 MDFIPVALEQPTSR--EVAEHLLRSAADLNTRYPDHTGCLGVQGCLVGTD
TH_3775|M.thermoresistible__bu RRAMTEYVQSRAADPRDRILAVFDFLAHWFAES-DFRGCMFINTIGELGG
MAB_1881c|M.abscessus_ATCC_199 LAAQPTLTQIDSMDG---VEQWAQAILANHDVPGGPFGCPLGSMAAELKN
MUL_4947|M.ulcerans_Agy99 VAAREQYDAGEPGGVEQAVRTAGHLIWTNLKQSEDLLKVMLREPGALGDL
Mb2184c|M.bovis_AF2122/97 FEAEVVAPAMAAPPGVDRVRALMHAWVGYLERDVFPGGCFFAAAAADVDS
MAV_1977|M.avium_104 HEKSRAATEDAASGAKAIDTAMRRTEDLWREHG------VVMRTAIDLAA
Mflv_0944|M.gilvum_PYR-GCK TDPEVARHVKRTLDAWLRELTATISAAQADGDIPSSTEA----KALAALI
Mvan_5917|M.vanbaalenii_PYR-1 TDPVVARHVKRTLDAWLRELTATISAAQADGDIPSETDA----KSMASLL
MMAR_0630|M.marinum_M ADPDVSGIVERSLEAWRRELADCIAEAQLEGAVAGDGSP----QALATVM
Rv3208|M.tuberculosis_H37Rv TEPEVAAQVRVATESCIDAVFALISADSGLDPHRARMIA----VGLVGMS
MLBr_00815|M.leprae_Br4923 TEPRVAAQVRVATESCIDAVFALISADSRLDPHRARMVA----VGLVGIS
MSMEG_5597|M.smegmatis_MC2_155 DSEPIRRALVDARASGEASLRARFEDAHATGDLPKSANP----AALAAFL
TH_3775|M.thermoresistible__bu TSTDVRRIARLHKTAVRDYLADLVAAAELPSELAEQLAI----LADGAIV
MAB_1881c|M.abscessus_ATCC_199 DP-AYQPALAAAFGQWQSLLADGLIRMQDRGHLDPHEDP----QRLAAAV
MUL_4947|M.ulcerans_Agy99 DEKTWQIITDNAYQRFADELAASNRSGRTRIPDPEAAAS----VAIASLS
Mb2184c|M.bovis_AF2122/97 QPGPVRDRIAATGRAGIAAITADVETAQRRGEIRADIEARQLAFELHAYA
MAV_1977|M.avium_104 TVPQLDALWKQTADIFVVAITAILEHMGVPAGKGPDKSA----AIAEALC
:
Mflv_0944|M.gilvum_PYR-GCK LAVLRGMEALRKGG--ASAATVKATAEQLVAML-----------------
Mvan_5917|M.vanbaalenii_PYR-1 LAVLRGMEALRKGG--ASAATIKSAAEQAIALLGVQPGTPPTPSMA----
MMAR_0630|M.marinum_M LSLMQGFEALGKGG--VGSAELRAAESAALALL-FGAGTDPKP-------
Rv3208|M.tuberculosis_H37Rv VDCARYWLDADKPI--SKSDAVEGTVQFAWGGLSHVPLTRS---------
MLBr_00815|M.leprae_Br4923 VDCARYWLDTNRPI--SKSDAVEGTVQFAWGGLSHVPLTRL---------
MSMEG_5597|M.smegmatis_MC2_155 MTVLHGMAVQAKAG--FSRETLDAIIDQALSSWPTPDRGSAGKATRKR--
TH_3775|M.thermoresistible__bu AATIWGDGTDAAAA--ARRAAATLISAS----------------------
MAB_1881c|M.abscessus_ATCC_199 LATLQGGMLMGRAT--MDITVLRDSLEMALDSIRRALRD-----------
MUL_4947|M.ulcerans_Agy99 YALTLQALTGRSPGNIDDSRYFEAWVNQTVSMLSQYTNPAPSRKPQADNK
Mb2184c|M.bovis_AF2122/97 MEANWALLLLDDDG---AGERARTAIDAALARVGTTQEGVES--------
MAV_1977|M.avium_104 WMIERNFYQASRVS----PARLTRARQTCTEIWLRVAS------------
Mflv_0944|M.gilvum_PYR-GCK ---
Mvan_5917|M.vanbaalenii_PYR-1 ---
MMAR_0630|M.marinum_M ---
Rv3208|M.tuberculosis_H37Rv ---
MLBr_00815|M.leprae_Br4923 ---
MSMEG_5597|M.smegmatis_MC2_155 ---
TH_3775|M.thermoresistible__bu ---
MAB_1881c|M.abscessus_ATCC_199 ---
MUL_4947|M.ulcerans_Agy99 FQE
Mb2184c|M.bovis_AF2122/97 ---
MAV_1977|M.avium_104 ---