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MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLSTQYDSAATELTAVLTGSMPVWDGPTADRYVAA HMPYLAWLQLAGALSAEAAAQHQGVATAYTAALAAMPTLPELAANHATHAALVATNFFGVNTIPIAVNEA DYARMWTQAATTMTTYQATTEAVQMTSVAGSGTGGKAGSGSGSGTGAGTGTGTGTGTGTGTGTGTGTGAG SGTGGGTGAGGGGGTGSFQLPTPEEIWEMLFGPDGEQIPGQGQPNWSPSEYLQNLGNFFNGNAQAVAWLQ QNLSGLLNPSQFPALINYFIAWQTYRIINWTIRTLRFILQELPLLLQVGLSLSITSLGGLAGLAGLAGLA GLAAPASAPAPAAMPQPAGMGAQPPVVSAAPAMAPMAPTSPVAPATSAVSTPAPVASAIAPPATPPVPPA PVTGAEGFGYMVGSFGLGMDSKAQTRARSALAAGRPAASSAGAAAVEQEQGRTRRRPRSVIDPGYRYEFI EGDDEVVAVASAAQDRYRPSDSGGSIQGFAGTLPKSGVRASGLNTLAGNESGDGARIPMLPESWDGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0118 | - | - | 100% (557) | PPE family protein |
| M. avium 104 | MAV_4872 | - | 2e-94 | 42.02% (564) | PPE family protein |
| M. avium 104 | MAV_4349 | - | 3e-88 | 40.98% (571) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0288 | PPE3 | 3e-87 | 39.59% (581) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-75 | 37.13% (571) | PPE protein |
| M. tuberculosis H37Rv | Rv0280 | PPE3 | 2e-86 | 39.41% (581) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 7e-48 | 56.97% (165) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 2e-64 | 36.27% (568) | PPE family protein |
| M. marinum M | MMAR_0538 | - | 1e-78 | 37.39% (583) | PPE family protein, PPE3 |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-79 | 37.63% (566) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-71 | 38.65% (533) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 7e-78 | 37.00% (573) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-78 | 37.88% (565) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0288|M.bovis_AF2122/97 ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
Rv0280|M.tuberculosis_H37Rv ------------MTLWMASPPEVHSALLSSGPGPGSVLSAAGVWSSLSAE
MMAR_0538|M.marinum_M ----------MVAPVWFASPPEVHSALLSSGPGPASLLSGAAAWAGLSTE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
MAV_0118|M.avium_104 ----------MTAPVWMALPPEVHSTLLSSGPGPGPLLAAAATWTGLSTQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
:* ******::* ***...: .. * **
Mb0288|M.bovis_AF2122/97 YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
Rv0280|M.tuberculosis_H37Rv YAAVADELIGLLGAVQTGAWQGPSAAAYVAAHAPYLAWLMRASETSAEAA
MMAR_0538|M.marinum_M YASVADELMGVLAAVQGGAWEGLSAELYVAAHVPYLMWLMRASATSAQAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
MAV_0118|M.avium_104 YDSAATELTAVLTG-SMPVWDGPTADRYVAAHMPYLAWLQLAGALSAEAA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* * ** :: *:* . *. :: **: ** . .* .
Mb0288|M.bovis_AF2122/97 ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
Rv0280|M.tuberculosis_H37Rv ARHETVAAAYTTAVAAMPTLVELAANHTLHGVLVATNFFGINTIPIALNE
MMAR_0538|M.marinum_M AQHEAAAAAYTTALAAMPTMPELAANHVIHGVLMATNFFGINTIPIAANE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
MAV_0118|M.avium_104 AQHQGVATAYTAALAAMPTLPELAANHATHAALVATNFFGVNTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
. : *.*: ::* ***: ** *: * .*: ***:*:*:**** .*
Mb0288|M.bovis_AF2122/97 ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADD-----
Rv0280|M.tuberculosis_H37Rv ADYARMWTQAASTMATYQAVAEAAVASAPQTTPAPPILAAEAADD-----
MMAR_0538|M.marinum_M ADYVRMWIQAATTMSTYQAVSAAAVASTPPSTPAPRILAAPAAA------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEA-----
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEA-----
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEA-----
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEM-----
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQV-----
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEA-----
MAV_0118|M.avium_104 ADYARMWTQAATTMTTYQATTEAVQMTSVAGSGTGGKAGSGSGSGTGAGT
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTG-------
** *** :** :* *: .: .. : . .
Mb0288|M.bovis_AF2122/97 ----------------DHDHDHDHGGEPTPLDYLVAEILRIISGGRLIWD
Rv0280|M.tuberculosis_H37Rv ----------------DHDHDHDHGGEPTPLDYLVAEILRIISGGRLIWD
MMAR_0538|M.marinum_M -----------------HDHDHDHGGDPTPIDYFVAEVLRIISGGRIIWD
Mflv_0325|M.gilvum_PYR-GCK ----------------GRAAADMSAFAAQPMAAQAGAAFDVS---NIIAD
Mvan_0415|M.vanbaalenii_PYR-1 ----------------GRAAADVTAFAAQAQAAEAGSALDLS---NIIAD
MSMEG_0619|M.smegmatis_MC2_155 ----------------GSASASVQQMSAQATAAESGSSLDLS---SIISD
MAB_2230c|M.abscessus_ATCC_199 ----------------SRMSADMSGMAAQAQAAESGMALDDS---ESFFD
MUL_1208|M.ulcerans_Agy99 ----------------AHLAADAARAQSGAAAAGGSDPWQLLW--QLLQY
MLBr_01828|M.leprae_Br4923 ----------------SSDQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNT
MAV_0118|M.avium_104 GTGTGTGTGTGTGTGTGTGAGSGTGGGTGAGGGGGTGSFQLPTPEEIWEM
TH_3113|M.thermoresistible__bu ----------------ESATAAITGAHVTAELRAAESRTLLDEINELIDR
.
Mb0288|M.bovis_AF2122/97 PAEGTMNGIPFEDYTD--------------------AAQPIWWVVRAIEF
Rv0280|M.tuberculosis_H37Rv PAEGTMNGIPFEDYTD--------------------AAQPIWWVVRAIEF
MMAR_0538|M.marinum_M PAEGTVNGIPYDDYVN--------------------AAQPIWWLVRALEF
Mflv_0325|M.gilvum_PYR-GCK IIRLYGEVLRFLF-------------------------EPIFNFLRDPIG
Mvan_0415|M.vanbaalenii_PYR-1 LIRAYGELLRFLF-------------------------EPIFDFLRDPLG
MSMEG_0619|M.smegmatis_MC2_155 LLNQYLQGVPGG--------------------------QAILDFLKDPLG
MAB_2230c|M.abscessus_ATCC_199 KLMR-----------------------------------QIQEFFSDPLG
MUL_1208|M.ulcerans_Agy99 LWNAYTGFNTWMF-------------------------DLIWEFLQDPIG
MLBr_01828|M.leprae_Br4923 LVQPLITSLTNHPFFQGMFSGFDPWLPSLGNPLSFLSPFNIAFALGTPMD
MAV_0118|M.avium_104 LFGPDGEQIPGQGQPNWS------------------PSEYLQNLGNFFNG
TH_3113|M.thermoresistible__bu LFAPLFPPGFADALPDGL------------------LGTLLAPLLPGATG
:
Mb0288|M.bovis_AF2122/97 SKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIVQIVEALSQSPQLLAV
Rv0280|M.tuberculosis_H37Rv SKDFETFVQELFVNPVEAFQFYFELLLFDYPTHIVQIVEALSQSPQLLAV
MMAR_0538|M.marinum_M GQDFQTFIKELFTNPIGAIEFMVELVLFDWPTHIAQIIQALAQSPQLLAV
Mflv_0325|M.gilvum_PYR-GCK --NTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSL
Mvan_0415|M.vanbaalenii_PYR-1 --NTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSL
MSMEG_0619|M.smegmatis_MC2_155 --NLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASP
MAB_2230c|M.abscessus_ATCC_199 --TLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAP
MUL_1208|M.ulcerans_Agy99 --NTIKIIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSP
MLBr_01828|M.leprae_Br4923 IGSYVGYLSQTFAFIGADLAAAFASGNPVTIGFTLLFTTIEAIGTIITDT
MAV_0118|M.avium_104 NAQAVAWLQQNLSGLLNPSQFPALINYFIAWQTYRIINWTIRTLRFILQE
TH_3113|M.thermoresistible__bu DGPPMATIMSFLLMGLSN---PAYLFPVLVYLLFTGVVHTTVAVSGMLAQ
: :
Mb0288|M.bovis_AF2122/97 ALGSVISNLG--AVTGFAGLSGLAGMQPAAIPALAPVAAAPPTLPAVAMA
Rv0280|M.tuberculosis_H37Rv ALGSVISNLG--AVTGFAGLSGLAGMQPAAIPALAPVAAAPSTLPAVAMA
MMAR_0538|M.marinum_M ALGGVVANLG--AISGLAGLSGLAGLHSAALPA-AIAPIAPPMPPGVALA
Mflv_0325|M.gilvum_PYR-GCK FLLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQ
Mvan_0415|M.vanbaalenii_PYR-1 LLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQ
MSMEG_0619|M.smegmatis_MC2_155 FLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQ
MAB_2230c|M.abscessus_ATCC_199 LWLPLLLVG---------LAQLVNPVPV-EADAPADEPAPQQARVERSSP
MUL_1208|M.ulcerans_Agy99 FLLPAALGL-------ALSAIAFTPIQIAAEVPAAAAPLAAAAVTAKSVF
MLBr_01828|M.leprae_Br4923 IALVKTMIEQSFVLLPMILPLLTAPLAVATAGAAGSFAGLSELAGLVGVA
MAV_0118|M.avium_104 LPLLLQVGLSLSITSLGGLAG-LAGLAGLAGLAAPASAPAPAAMPQPAGM
TH_3113|M.thermoresistible__bu LVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPV
:
Mb0288|M.bovis_AF2122/97 PTMAAPGAAVASAAAPASAPAASTVASATPAPPPAPGAAG-FGYPYAIAP
Rv0280|M.tuberculosis_H37Rv PTMAAPGAAVASAAAPASAPAASTVASATPAPPPAPGAAG-FGYPYAIAP
MMAR_0538|M.marinum_M PTVATSVAAPTPPSAPPSA--TSTVANAAPPPPPAPAAAG-FGFPFVVGG
Mflv_0325|M.gilvum_PYR-GCK QSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAG
Mvan_0415|M.vanbaalenii_PYR-1 PSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAG
MSMEG_0619|M.smegmatis_MC2_155 P-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVAN
MAB_2230c|M.abscessus_ATCC_199 QQQPFAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQE
MUL_1208|M.ulcerans_Agy99 PAASLASPGTG-SAGAPASGAGAGAPGTAPPGPGAPAPAS---FLYAVGG
MLBr_01828|M.leprae_Br4923 PPGLPSAPPVAAVAPVVPPSMPTLASIPTPTPMPAPAASTAPVVTPPGPP
MAV_0118|M.avium_104 GAQPPVVSAAPAMAPMAPTSPVAPATSAVSTPAPVASAIAPPATPPVPPA
TH_3113|M.thermoresistible__bu PAGGPSLPSG-SSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPPAPHSA
. . . . . .
Mb0288|M.bovis_AF2122/97 ---PGIGFGSGMSAS--ASAQRKAPQPDSAAAAAAAAAVRDQARARRRRR
Rv0280|M.tuberculosis_H37Rv ---PGIGFGSGMSAS--ASAQRKAPQPDSAAAAAAAAAVRDQARARRRRR
MMAR_0538|M.marinum_M G--PGIGYGEGMSASAAASARRKAPEPD-SAALAAAAAAREEARRRRRKR
Mflv_0325|M.gilvum_PYR-GCK R-DPYEGFSPTVRDS----TGAKAPAGT-IPAAASGIAASAAERRKRRRR
Mvan_0415|M.vanbaalenii_PYR-1 R-DPGTGFSPTVRDS----TSAKAPASG-IPAAASGVAASAAERRKRRRR
MSMEG_0619|M.smegmatis_MC2_155 R-DPGEGFTPTLGNK----SQVAAPASG-VPAAASGVAASLASRRKRRRK
MAB_2230c|M.abscessus_ATCC_199 D-PPAARFGPTLNEG----SGAKAPAAG-ISAAAA-AAASARSRARRKRG
MUL_1208|M.ulcerans_Agy99 SGDWGPSLGPTVGGR----SGAKAPAVT-IPAAGAAAASRASARSRRRRR
MLBr_01828|M.leprae_Br4923 PVTAPPSVTGAGVESFGYLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDA
MAV_0118|M.avium_104 PVTGAEGFGYMVGSFGLGMDSKAQTRARSALAAGRPAASSAGAAAVEQEQ
TH_3113|M.thermoresistible__bu PPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAAARESA
. .
Mb0288|M.bovis_AF2122/97 VTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLG-FAGTA
Rv0280|M.tuberculosis_H37Rv VTRRGYGDEFMDMNIDVDPDWGPPPGEDPVTSTVASDRGAGHLG-FAGTA
MMAR_0538|M.marinum_M KTERGYGEEFMDV--EVDPDWGGPRDDEP----VASTQGAGRLG-FAGTV
Mflv_0325|M.gilvum_PYR-GCK QKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMG-FAGTV
Mvan_0415|M.vanbaalenii_PYR-1 QKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMG-FAGTV
MSMEG_0619|M.smegmatis_MC2_155 KGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMG-FTGTV
MAB_2230c|M.abscessus_ATCC_199 ARIKDPAPQFMDMNSPVDP-DFSEPATRHTAGVGASGRGAGQLG-FAGTL
MUL_1208|M.ulcerans_Agy99 ----TEMRDYGDEFLDMDANGVTGPAATDDA-ARASERGAGQFG-FAGTV
MLBr_01828|M.leprae_Br4923 AATPQEQARSRWRRRAKVTPFDSSGSPNPKAAPTASDQGAGTLG-LAGTA
MAV_0118|M.avium_104 GRTRRRPRSVIDPGYRYEFIEGDDEVVAVASAAQDRYRPSDSGGSIQGFA
TH_3113|M.thermoresistible__bu PIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAAG-IRVLGGAGRISRTR
: . * :
Mb0288|M.bovis_AF2122/97 RREA-VADAAGMTT-LAGDDFGDGPTTPMVPGSWDPDRDAP---------
Rv0280|M.tuberculosis_H37Rv RREA-VADAAGMTT-LAGDDFGDGPTTPMVPGSWDPDRDAP---------
MMAR_0538|M.marinum_M HSES-AATAAGLTT-LVADEFGGGPKMPMLPGTWDTDSDAP---------
Mflv_0325|M.gilvum_PYR-GCK SRGD--EQAGGLTT-LAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGH
Mvan_0415|M.vanbaalenii_PYR-1 SRDA--AQAGGLTT-LPGDPFGGGPKAPMLPGTWDPDTEPD------ERH
MSMEG_0619|M.smegmatis_MC2_155 TRHD--VTAAGLTT-LTGDTFDDRPVTPMLPGTWDGDENPAP------SP
MAB_2230c|M.abscessus_ATCC_199 PRTTSTTSAAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPA
MUL_1208|M.ulcerans_Agy99 STEA-VLQAAGLTE-LAVDEFGNGPRMPMVPGSWDSPQEGR---------
MLBr_01828|M.leprae_Br4923 RQAS-SGPATGLVT-LSNGTFSDSPRAPMLPRTWGADPTFCYN-------
MAV_0118|M.avium_104 GTLPKSGVRASGLNTLAGNESGDGARIPMLPESWDGP-------------
TH_3113|M.thermoresistible__bu GSVPHAEITPG--DPTEPSSPTDRAHRPAEPN------------------
. . . * *
Mb0288|M.bovis_AF2122/97 --GSAEPGDRG---
Rv0280|M.tuberculosis_H37Rv --GSAEPGDRG---
MMAR_0538|M.marinum_M --SD----------
Mflv_0325|M.gilvum_PYR-GCK DGHDGKEKP-----
Mvan_0415|M.vanbaalenii_PYR-1 NHHDGKDSQ-----
MSMEG_0619|M.smegmatis_MC2_155 DDPEGGPRR-----
MAB_2230c|M.abscessus_ATCC_199 PDEDWPPGERGAST
MUL_1208|M.ulcerans_Agy99 --EDGLQSE-----
MLBr_01828|M.leprae_Br4923 -AADIGPAGGWDDE
MAV_0118|M.avium_104 --------------
TH_3113|M.thermoresistible__bu --------------