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VTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSAVVAAVGAGVWQGPSAELFVA AYVPYVAWLVQASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPFGELAKFLEMAA QAFTEVGELIMKSAEAWAVGFVELITGLVNFEPWLVLTGMIDMFFATVGFALGVFVLVPLLEFAVVLELA ILSIGWIISNIFGAIPVLAGPLLGALAAAVVPGVAGVTGLAGLAAVPAVGAAAGAPAALVGSVAPVSGGV VSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWG PDLVGVAGDGGLVSV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | - | 100% (435) | PPE family protein |
| M. bovis AF2122 / 97 | Mb3043c | PPE46 | 0.0 | 80.79% (432) | PPE family protein |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 4e-88 | 40.97% (515) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 5e-71 | 43.88% (376) | PPE protein |
| M. tuberculosis H37Rv | Rv3021c | PPE47 | 0.0 | 98.59% (354) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 2e-59 | 35.98% (453) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2230c | - | 1e-70 | 38.24% (510) | PPE family protein |
| M. marinum M | MMAR_0545 | - | 2e-88 | 42.57% (498) | PPE family protein, PPE4 |
| M. avium 104 | MAV_4867 | - | 2e-81 | 40.29% (489) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 8e-78 | 38.31% (509) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 1e-75 | 49.70% (334) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 2e-88 | 42.77% (498) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 4e-83 | 39.57% (513) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3047c|M.bovis_AF2122/97 ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
Rv3021c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0545|M.marinum_M -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
Mb3047c|M.bovis_AF2122/97 YAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
Rv3021c|M.tuberculosis_H37Rv -------------MVGA------------------------ASADSAAAA
MMAR_0545|M.marinum_M YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
. *. .* *
Mb3047c|M.bovis_AF2122/97 GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
Rv3021c|M.tuberculosis_H37Rv GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
MMAR_0545|M.marinum_M AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
:. *..* :** ***:.** *: * **: ***:*:*:**** .*
Mb3047c|M.bovis_AF2122/97 ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
Rv3021c|M.tuberculosis_H37Rv ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
MMAR_0545|M.marinum_M ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGG-EANNLAA
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPG-GEMSRMSA
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
** ***::** *. *: . .: :.. : ..* :: .. : .
Mb3047c|M.bovis_AF2122/97 AAT-----------------------------------------------
Rv3021c|M.tuberculosis_H37Rv AAT-----------------------------------------------
MMAR_0545|M.marinum_M DAAQAQSGAAAAGGSDPWQLL-----------------------------
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDPWQLL-----------------------------
MAV_4867|M.avium_104 NAAQNSSG-------DWWQNF-----------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQ-AGAAFDV-----------------------------
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAE-AGSALDL-----------------------------
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAE-SGSSLDL-----------------------------
TH_3569|M.thermoresistible__bu TTQQIGSQATAAD-SGTALNL-----------------------------
MAB_2230c|M.abscessus_ATCC_199 DMSGMAAQAQAAE-SGMALDD-----------------------------
MLBr_01828|M.leprae_Br4923 SPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSG
Mb3047c|M.bovis_AF2122/97 --------------------------------ITPFPFGELAKFLEMAAQ
Rv3021c|M.tuberculosis_H37Rv --------------------------------ITPFPFGELAKFLEMAAQ
MMAR_0545|M.marinum_M -----------WQLLQYLWNAYTGFNTWMFDLIWEFLQDPIGNTIKIIIA
MUL_1208|M.ulcerans_Agy99 -----------WQLLQYLWNAYTGFNTWMFDLIWEFLQDPIGNTIKIIIA
MAV_4867|M.avium_104 -----------IQQLS------------------QFFQN----IQKMLQD
Mflv_0325|M.gilvum_PYR-GCK -----------SNIIADIIRLYGEVLRFLFEPIFNFLRDPIGNTFALITD
Mvan_0415|M.vanbaalenii_PYR-1 -----------SNIIADLIRAYGELLRFLFEPIFDFLRDPLGNTIKLITD
MSMEG_0619|M.smegmatis_MC2_155 -----------SSIISDLLNQYLQGVPGGQ-AILDFLKDPLGNLGRLLTD
TH_3569|M.thermoresistible__bu -----------SDLIANLLQYYQDYLDQLFGPIVDFLRDPIGNLFQLIDD
MAB_2230c|M.abscessus_ATCC_199 -----------S----------ESFFDKLMRQIQEFFSDPLGTLQKILQD
MLBr_01828|M.leprae_Br4923 FDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAA
:
Mb3047c|M.bovis_AF2122/97 AFTEVGELIMKSAEAWAVGFVELITGLVNFEPWLVLTGMIDMFF-----A
Rv3021c|M.tuberculosis_H37Rv AFTEVGELIMKSAEAWAVGFVELITGLVNFEPWLVLTGMIDMFF-----A
MMAR_0545|M.marinum_M FLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSPFLLP---AAL
MUL_1208|M.ulcerans_Agy99 FLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSSPFLLP---AAL
MAV_4867|M.avium_104 FWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAPFLLP---LLL
Mflv_0325|M.gilvum_PYR-GCK FLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVA
Mvan_0415|M.vanbaalenii_PYR-1 FLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVL
MSMEG_0619|M.smegmatis_MC2_155 FMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALG
TH_3569|M.thermoresistible__bu FLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLG
MAB_2230c|M.abscessus_ATCC_199 FMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPLWLP----LL
MLBr_01828|M.leprae_Br4923 AFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPL
. :
Mb3047c|M.bovis_AF2122/97 TVGFALGVFVLVPLLEFAVVLELAILSIGWIISNIFGAIPVLAGPLLGAL
Rv3021c|M.tuberculosis_H37Rv TVGFALGVFVLVPLLEFAVVLELAILSIGWIISNIFGAIPVLGGPLLGAL
MMAR_0545|M.marinum_M GLALSAIAFTPIQIAAEVPAAAAPLAAAAVTAKSVFPAASLASPGTGSAG
MUL_1208|M.ulcerans_Agy99 GLALSAIAFTPIQIAAEVPAAAAPLAAAAVTAKSVFPAASLASPGTGSAG
MAV_4867|M.avium_104 GIGLSSLLAAPAEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAG
Mflv_0325|M.gilvum_PYR-GCK GVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSG
Mvan_0415|M.vanbaalenii_PYR-1 GVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSS
MSMEG_0619|M.smegmatis_MC2_155 ITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGS
TH_3569|M.thermoresistible__bu VAGLVMIADQAQP-----PAEEAAPEEDVAAP------------------
MAB_2230c|M.abscessus_ATCC_199 LVGLAQLVN-PVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPGGGG
MLBr_01828|M.leprae_Br4923 LTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSM
.
Mb3047c|M.bovis_AF2122/97 AAAVVPGVAGVTGLAGLAAVPAVGA--------AAGAPAALVGSVAPVSG
Rv3021c|M.tuberculosis_H37Rv AAAVVPGVAGLAGVAGLAALPAVGA--------AAGAPAALVGSVAPVSG
MMAR_0545|M.marinum_M APASGAGAGAPGSAPPGPAAPAPAS--FLYAVGGSGDWGPSLGPTVGGRS
MUL_1208|M.ulcerans_Agy99 APASGAGAGAPGTAPPGPGAPAPAS--FLYAVGGSGDWGPSLGPTVGGRS
MAV_4867|M.avium_104 APASTVAAGSGAAAAPGP-AAAAGN--FAYLVAFGGDPDTGVGPTLSGRG
Mflv_0325|M.gilvum_PYR-GCK APIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGRDPYEGFSPTVRDST
Mvan_0415|M.vanbaalenii_PYR-1 AAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGRDPGTGFSPTVRDST
MSMEG_0619|M.smegmatis_MC2_155 AATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANRDPGEGFTPTLGNKS
TH_3569|M.thermoresistible__bu -VRAEPQNPLPLTXXX----------------------------------
MAB_2230c|M.abscessus_ATCC_199 APATPANAPATPANAPASPAAAAATPAYMVYAVQEDPPAARFGPTLNEGS
MLBr_01828|M.leprae_Br4923 PTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGYLVG
Mb3047c|M.bovis_AF2122/97 GVVSPQARLVSAVEPAPASTS-----------------------------
Rv3021c|M.tuberculosis_H37Rv GVVSPQARLVSAVEPAPASTS-----------------------------
MMAR_0545|M.marinum_M GAKAPAATIPAAGAAAASRASARSRRRRRTEMRDYGDEFLDMDAN-GVT-
MUL_1208|M.ulcerans_Agy99 GAKAPAVTIPAAGAAAASRASARSRRRRRTEMRDYGDEFLDMDAN-GVT-
MAV_4867|M.avium_104 GAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFGVPP
Mflv_0325|M.gilvum_PYR-GCK GAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELP
Mvan_0415|M.vanbaalenii_PYR-1 SAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEP
MSMEG_0619|M.smegmatis_MC2_155 QVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-P
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 GAKAPAAGISAAAA-AAASARSRARRKRGARIKDPAPQFMDMNSPVDP-D
MLBr_01828|M.leprae_Br4923 RLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKVTPF
Mb3047c|M.bovis_AF2122/97 ---------VSVLASDRGAGALGFVGTAGKESVGQ--PAGLTVLA-DEFG
Rv3021c|M.tuberculosis_H37Rv ---------VSVLASDRGAGALGFVGTAGKESVGQ--PAGLTVLA-DEFG
MMAR_0545|M.marinum_M --GPAATDDAAR-ASERGAGQFGFAGTVSTEAVLQ--AAGLTELAVDEFG
MUL_1208|M.ulcerans_Agy99 --GPAATDDAAR-ASERGAGQFGFAGTVSTEAVLQ--AAGLTELAVDEFG
MAV_4867|M.avium_104 DYGAEEELAAAV-ASGQGAGTLGFAGTQQRRKAFQ--AAGLTKLADDDFG
Mflv_0325|M.gilvum_PYR-GCK DDGPPEQPAPRVTASTRGAGPMGFAGTVSRGDEQ---AGGLTTLAGDSFG
Mvan_0415|M.vanbaalenii_PYR-1 DDEPPVRQEPRIAATERGAGPMGFAGTVSRDAAQ---AGGLTTLPGDPFG
MSMEG_0619|M.smegmatis_MC2_155 DEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVT---AAGLTTLTGDTFD
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 FSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAASEMD
MLBr_01828|M.leprae_Br4923 DSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGP--ATGLVTLSNGTFS
Mb3047c|M.bovis_AF2122/97 DGAPVPMLPGSWGPDLVGV---------AGDGGLVSV-----
Rv3021c|M.tuberculosis_H37Rv DGAPVPMLPGSWGPDLVGV---------AGDGGLVSV-----
MMAR_0545|M.marinum_M NGPRMPMVPGSWDSPQEGR--------EDGLQSE--------
MUL_1208|M.ulcerans_Agy99 NGPRMPMVPGSWDSPQEGR--------EDGLQSE--------
MAV_4867|M.avium_104 GSPRMPMVPGTWEQDTQNG--------AHPTEPGKGG-----
Mflv_0325|M.gilvum_PYR-GCK GGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP-----
Mvan_0415|M.vanbaalenii_PYR-1 GGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ-----
MSMEG_0619|M.smegmatis_MC2_155 DRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR-----
TH_3569|M.thermoresistible__bu ------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 GTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPGERGAST
MLBr_01828|M.leprae_Br4923 DSPRAPMLPRTWGADPTFCYNAADIGPAGGWDDE--------