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SAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQYTTAATELTQLLAATGSGSWQGPSAAQYVAS HAPYLAWLTQQSAMSATNAVLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNEA DYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPGGEMSRMSADMSGMAAQAQAAESGMALDDSE SFFDKLMRQIQEFFSDPLGTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSAPLWL PLLLVGLAQLVNPVPVEADAPADEPAPQQARVERSSPQQQPFAMGGMPGGGGAPATPANAPATPANAPAS PAAAAATPAYMVYAVQEDPPAARFGPTLNEGSGAKAPAAGISAAAAAAASARSRARRKRGARIKDPAPQF MDMNSPVDPDFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTSAAGLIEREAASEMDGTRTVPMLPT SWGTDPEPDPDRAPSVPAPDEDWPPGERGAST*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2230c | - | - | 100% (523) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 0.0 | 73.62% (527) | PPE family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | e-168 | 61.93% (507) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0294 | PPE4 | 1e-109 | 47.45% (510) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-116 | 46.42% (530) | PPE protein |
| M. tuberculosis H37Rv | Rv0286 | PPE4 | 1e-108 | 47.45% (510) | PPE family protein |
| M. leprae Br4923 | MLBr_01991 | PPE | 3e-73 | 38.72% (514) | PPE-family protein |
| M. marinum M | MMAR_0545 | - | 1e-112 | 46.58% (526) | PPE family protein, PPE4 |
| M. avium 104 | MAV_4867 | - | 1e-118 | 51.49% (505) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-126 | 49.81% (530) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-92 | 53.15% (333) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_1208 | - | 1e-110 | 46.01% (526) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-118 | 46.42% (517) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0294|M.bovis_AF2122/97 ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
Rv0286|M.tuberculosis_H37Rv ----------MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAE
MMAR_0545|M.marinum_M -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MUL_1208|M.ulcerans_Agy99 -------MAVAAGPIWIASPPEVHSAMLSSGPGPASLLAAAGVWSALSAE
MAV_4867|M.avium_104 -------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSLSAQ
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAB_2230c|M.abscessus_ATCC_199 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSVQ
MLBr_01991|M.leprae_Br4923 ----------------MAIPPEVHSVLLSAGQGAESLLVAATQWQELSKQ
:* ****** :** * *. .::.*. * ** :
Mb0294|M.bovis_AF2122/97 YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
Rv0286|M.tuberculosis_H37Rv YASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAA
MMAR_0545|M.marinum_M YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MUL_1208|M.ulcerans_Agy99 YALTAAELSEVLAAVQAGAWQGPSGFQYVAAHLPYVAWLLQASADGAGKA
MAV_4867|M.avium_104 YATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSAGAA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAB_2230c|M.abscessus_ATCC_199 YTTAATELTQLLAATGSGSWQGPSAAQYVASHAPYLAWLTQQSAMSATNA
MLBr_01991|M.leprae_Br4923 YTYAAAELTRLLTHVQATSWRGTSATRFVAAHGAYLVWLEQTSINNAITA
*: :*:**: :* . . :*.* *. :.*:* .*: ** * * * *
Mb0294|M.bovis_AF2122/97 AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
Rv0286|M.tuberculosis_H37Rv AQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNE
MMAR_0545|M.marinum_M AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MUL_1208|M.ulcerans_Agy99 AEHEAAAVAYSGALAAMPTLTELGANHALHGVLVATNFFGLNAIPIALNE
MAV_4867|M.avium_104 AQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIAVNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAB_2230c|M.abscessus_ATCC_199 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MLBr_01991|M.leprae_Br4923 KQHEIAAIAYSSALAAMPTLAELTANRATRGFLIATNFFGINTIPIALNE
:: :* **: ***:***:.** *: : .*:.***:*:*:***::.*
Mb0294|M.bovis_AF2122/97 ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
Rv0286|M.tuberculosis_H37Rv ADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGG-------
MMAR_0545|M.marinum_M ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MUL_1208|M.ulcerans_Agy99 ADYVRMWVQAATTMGLYQATAGAALASAPRTGPPPKVVNPGGGQVAHLAA
MAV_4867|M.avium_104 ADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPGGE-------
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVG-EAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVG-EAGRAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVG-EAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVS-EAADAM
MAB_2230c|M.abscessus_ATCC_199 ADYIRMWIQAATTMGVYQGVSTAAVTSVAPTPPAPTIMAPGGE--MSRMS
MLBr_01991|M.leprae_Br4923 ADYVRMWVQAADTMATYQAISEAVTATILPTQVAPPILAPGSA-------
*** ***:*** *. **. : :. : : .* :: **
Mb0294|M.bovis_AF2122/97 -------AASTVGAVNPWQ-WLLALLQQLWNAYTGFYGWMLQLIWQFLQD
Rv0286|M.tuberculosis_H37Rv -------AASTVGAVNPWQ-WLLALLQQLWNAYTGFYGWMLQLIWQFLQD
MMAR_0545|M.marinum_M DAAQAQSGAAAAGGSDPWQ-LLWQLLQYLWNAYTGFNTWMFDLIWEFLQD
MUL_1208|M.ulcerans_Agy99 DAARAQSGAAAAGGSDPWQ-LLWQLLQYLWNAYTGFNTWMFDLIWEFLQD
MAV_4867|M.avium_104 ----ANNLAANAAQNSSGD-WWQNFIQQLS---------------QFFQN
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAF-DVSNIIADIIRLYGEVLRFLFEPIFNFLRD
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSAL-DLSNIIADLIRAYGELLRFLFEPIFDFLRD
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSL-DLSSIISDLLNQYLQGVPGGQ-AILDFLKD
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTAL-NLSDLIANLLQYYQDYLDQLFGPIVDFLRD
MAB_2230c|M.abscessus_ATCC_199 ADMSGMAAQAQAAESGMALDDSESFFDKLMR-----------QIQEFFSD
MLBr_01991|M.leprae_Br4923 --------TQNVLQS------VPDWIVQLLT-----------DILDFIAD
. : : :*: :
Mb0294|M.bovis_AF2122/97 PIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSS
Rv0286|M.tuberculosis_H37Rv PIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSS
MMAR_0545|M.marinum_M PIGNTIKIIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSS
MUL_1208|M.ulcerans_Agy99 PIGNTIKIIIAFLTNPLQAIITYGPLLFALSYQIFFNLVGWPTWALILSS
MAV_4867|M.avium_104 ----IQKMLQDFWANLPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTA
Mflv_0325|M.gilvum_PYR-GCK PIGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLL
Mvan_0415|M.vanbaalenii_PYR-1 PLGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLL
MSMEG_0619|M.smegmatis_MC2_155 PLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFAS
TH_3569|M.thermoresistible__bu PIGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILAS
MAB_2230c|M.abscessus_ATCC_199 PLGTLQKILQDFMRNPLEALVAWGPLLFFIAYEAFFIPFGFTFWGVMLSA
MLBr_01991|M.leprae_Br4923 PYKYFLRFFQRLGFRPAIAVVLA---IIALQLYDFLWYPYYASYG-MLLL
:: : . : : : . : ::
Mb0294|M.bovis_AF2122/97 PFLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAV
Rv0286|M.tuberculosis_H37Rv PFLLPAGLGLGLAAIAFLPIVLAP--AVIPPASTPLAAAAVAAGSVWPAV
MMAR_0545|M.marinum_M PFLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKSVFPAA
MUL_1208|M.ulcerans_Agy99 PFLLPAALGLALSAIAFTPIQIA---AEVPAAAAPLAAAAVTAKSVFPAA
MAV_4867|M.avium_104 PFLLPLLLGIGLSSLLAAPAEIAP--VAAPAAITPVLASNKPP-TLPAAV
Mflv_0325|M.gilvum_PYR-GCK PLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFP
Mvan_0415|M.vanbaalenii_PYR-1 PLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPA
MSMEG_0619|M.smegmatis_MC2_155 PFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLA
TH_3569|M.thermoresistible__bu PVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP-------
MAB_2230c|M.abscessus_ATCC_199 PLWLPLLL-VGLAQLVNPVPVEAD----APADEPAPQQARVERSSPQQQP
MLBr_01991|M.leprae_Br4923 PFFAPALSVLGTLSVLWNGQLSAG-----LPPNPAGSHPDNNAGPRIHVG
*. . : . .
Mb0294|M.bovis_AF2122/97 SMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATAS--FAYAVGGSGDWG
Rv0286|M.tuberculosis_H37Rv SMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATAS--FAYAVGGSGDWG
MMAR_0545|M.marinum_M SLASPGTGSAGAPASGAGAGAPGSAPPGPAAPAPAS--FLYAVGGSGDWG
MUL_1208|M.ulcerans_Agy99 SLASPGTGSAGAPASGAGAGAPGTAPPGPGAPAPAS--FLYAVGGSGDWG
MAV_4867|M.avium_104 ALAPSVATPAGAPASTVAAGSGAAAAPGP-AAAAGN--FAYLVAFGGDPD
Mflv_0325|M.gilvum_PYR-GCK ATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT--FVPYVVAGRDPY
Mvan_0415|M.vanbaalenii_PYR-1 IAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS--FVPYAVAGRDPG
MSMEG_0619|M.smegmatis_MC2_155 VGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT--FVPYAVANRDPG
TH_3569|M.thermoresistible__bu ------------VRAEPQNPLPLTXXX-----------------------
MAB_2230c|M.abscessus_ATCC_199 FAMGGMPGGGGAPATPANAPATPANAPASPAAAAATPAYMVYAVQEDPPA
MLBr_01991|M.leprae_Br4923 VAPPASATSSGNSYTSNSAPSTSASATTDNPLSSPS--IRYAIPGLSPPE
.
Mb0294|M.bovis_AF2122/97 PSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----ELRDY
Rv0286|M.tuberculosis_H37Rv PSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRS----ELRDY
MMAR_0545|M.marinum_M PSLGPTVGGRSGAKAPAATIPAAGAAAASRASARSRRRRRT----EMRDY
MUL_1208|M.ulcerans_Agy99 PSLGPTVGGRSGAKAPAVTIPAAGAAAASRASARSRRRRRT----EMRDY
MAV_4867|M.avium_104 TGVGPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRA----ALHDY
Mflv_0325|M.gilvum_PYR-GCK EGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGY
Mvan_0415|M.vanbaalenii_PYR-1 TGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAY
MSMEG_0619|M.smegmatis_MC2_155 EGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 ARFGPTLNEGSGAKAPAAGISAAAAAAAS-ARSRARRKRGAR----IKDP
MLBr_01991|M.leprae_Br4923 VSSGPKAGTKS-PDTATNTIGITAAARTNSPSARAHRKRGNKTRGGARGY
Mb0294|M.bovis_AF2122/97 GDEFLDMDS----DSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRA
Rv0286|M.tuberculosis_H37Rv GDEFLDMDS----DSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRA
MMAR_0545|M.marinum_M GDEFLDMDA----NGVTGPAATDDAARASERGAGQFGFAGTVSTEAVLQA
MUL_1208|M.ulcerans_Agy99 GDEFLDMDA----NGVTGPAATDDAARASERGAGQFGFAGTVSTEAVLQA
MAV_4867|M.avium_104 SDEFLDMDSGFGVPPDYGAEEELAAAVASGQGAGTLGFAGTQQRRKAFQA
Mflv_0325|M.gilvum_PYR-GCK ADAYADYEEL---PDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD-EQA
Mvan_0415|M.vanbaalenii_PYR-1 ADAYADYEPE---PDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA-AQA
MSMEG_0619|M.smegmatis_MC2_155 ADAYMDYEE----PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD-VTA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 APQFMDMNSPVDPDFSEPATRHTAGVGASGRGAGQLGFAGTLPRTTSTTS
MLBr_01991|M.leprae_Br4923 RYEFVEGTATMADTVDAPDHSEPTSHTISNHSAGPIGFAGTVPTTA----
Mb0294|M.bovis_AF2122/97 VG--LTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHD
Rv0286|M.tuberculosis_H37Rv VG--LTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHD
MMAR_0545|M.marinum_M AG--LTELAVDEFGNGPRMPMVPGSWDS----PQE------GREDGLQSE
MUL_1208|M.ulcerans_Agy99 AG--LTELAVDEFGNGPRMPMVPGSWDS----PQE------GREDGLQSE
MAV_4867|M.avium_104 AG--LTKLADDDFGGSPRMPMVPGTWEQD---TQN------GAHPTEPGK
Mflv_0325|M.gilvum_PYR-GCK GG--LTTLAGDSFGGGPREPMLPGTWDPD--ATDDRHTDGRDGHDGHDGK
Mvan_0415|M.vanbaalenii_PYR-1 GG--LTTLPGDPFGGGPKAPMLPGTWDPD--TEPD------ERHNHHDGK
MSMEG_0619|M.smegmatis_MC2_155 AG--LTTLTGDTFDDRPVTPMLPGTWDGD--ENPA------PSPDDPEGG
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_2230c|M.abscessus_ATCC_199 AAGLIEREAASEMDGTRTVPMLPTSWGTDPEPDPDRAPSVPAPDEDWPPG
MLBr_01991|M.leprae_Br4923 -----STPTGMAASTSSSVPLLPTTWITG-------------TSETAVHE
Mb0294|M.bovis_AF2122/97 SK----
Rv0286|M.tuberculosis_H37Rv SK----
MMAR_0545|M.marinum_M ------
MUL_1208|M.ulcerans_Agy99 ------
MAV_4867|M.avium_104 GG----
Mflv_0325|M.gilvum_PYR-GCK EKP---
Mvan_0415|M.vanbaalenii_PYR-1 DSQ---
MSMEG_0619|M.smegmatis_MC2_155 PRR---
TH_3569|M.thermoresistible__bu ------
MAB_2230c|M.abscessus_ATCC_199 ERGAST
MLBr_01991|M.leprae_Br4923 ------