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MLDFAWLPPEINSTRIFSGAGSGPLFAAASAWEGLAQDLYASASSFDSVVSGLSSGSWSGPASVSMAAAA APYVGWLSAAAGQAESAANQARTAATAFEAALSATVHPAAVTANRMSLVSLVATNILGQNTPAIAANEFD YLEMWAQDVAAMVGYHGGASSVAAALVPFSLPPVDLAGLASQIGTQAFGMVTSASSALATPVQSVMAAVP TALTTLQSLPLQDASMLMYPFSMAMSPLMNLMSSSLRGSTAGVAGATAAGIPASAAKLVDAPVSGVKAMG GAGLGSSISAGLGKARMVGAVSVPPTWEGSMPTRMASSAMSGLGAAGVANEAEMAAAGRPAGMPMMPMPM GAGAGAGGGMPGGMLGRGGASPNPIQSRPSVVPRTGIG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4324 | - | - | 100% (389) | PPE family protein, PPE49 |
| M. marinum M | MMAR_3664 | - | e-139 | 66.33% (398) | PPE family protein |
| M. marinum M | MMAR_3661 | - | e-137 | 65.83% (398) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3148c | PPE49 | 1e-129 | 61.17% (394) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 7e-31 | 30.12% (415) | PPE protein |
| M. tuberculosis H37Rv | Rv2352c | PPE38 | 1e-136 | 63.82% (398) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 4e-47 | 33.92% (401) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 4e-29 | 29.67% (337) | PPE-family protein |
| M. avium 104 | MAV_2928 | - | 2e-65 | 40.94% (425) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-33 | 33.52% (355) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 8e-33 | 29.67% (418) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0947 | - | 1e-63 | 40.31% (392) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 1e-35 | 30.94% (417) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mb3148c|M.bovis_AF2122/97 -------MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAVDLWAS
Rv2352c|M.tuberculosis_H37Rv -------MILDFSWLPPEINSARIYAGAGSGPLFMAAAAWEGLAADLRAS
MMAR_4324|M.marinum_M -------MMLDFAWLPPEINSTRIFSGAGSGPLFAAASAWEGLAQDLYAS
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MUL_0947|M.ulcerans_Agy99 ---------MDFGSLPPEFNSGKMYAGAGSGSILVAAEAWDSVAVDLYSA
MAV_2928|M.avium_104 --------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAELGIA
MAB_0669|M.abscessus_ATCC_1997 ------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNNYANT
MSMEG_0619|M.smegmatis_MC2_155 ------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAA
TH_3113|M.thermoresistible__bu ------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAA
.** :: : *.*. .: ** * .. .
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQ-NWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQ-MWQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
Mb3148c|M.bovis_AF2122/97 ASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQAR
Rv2352c|M.tuberculosis_H37Rv ASSFDAVIAGLAAGPWSGPASVAMAGAAAPYVGWLSAAAGQAELSAGQAT
MMAR_4324|M.marinum_M ASSFDSVVSGLSSGSWSGPASVSMAAAAAPYVGWLSAAAGQAESAANQAR
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MUL_0947|M.ulcerans_Agy99 ASSCQSVIWGLAFGQWVGASASLMGAAAAPYVAWLGATATQAELAANQAR
MAV_2928|M.avium_104 ASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETASQGR
MAB_0669|M.abscessus_ATCC_1997 AVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIAAQHE
MSMEG_0619|M.smegmatis_MC2_155 AAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHE
TH_3113|M.thermoresistible__bu AVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLE
* : : * .: * ** : : . *
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADYI
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADYI
Mb3148c|M.bovis_AF2122/97 AAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDYL
Rv2352c|M.tuberculosis_H37Rv AAATAFEAALAATVHPAAVTANRVLLGALVATNILGQNTPAIAATEFDYV
MMAR_4324|M.marinum_M TAATAFEAALSATVHPAAVTANRMSLVSLVATNILGQNTPAIAANEFDYL
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT
MUL_0947|M.ulcerans_Agy99 GAAVAYESAFAATVPPALILENRLQLVTLIATNIFGQNTPAIATTEAEYG
MAV_2928|M.avium_104 AAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQYM
MAB_0669|M.abscessus_ATCC_1997 TTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNEADYV
MSMEG_0619|M.smegmatis_MC2_155 TAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYV
TH_3113|M.thermoresistible__bu AAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYA
* : * : : *: * :*.:* * .** .* :*
Mflv_0768|M.gilvum_PYR-GCK RMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPP--------------
Mvan_0077|M.vanbaalenii_PYR-1 RMWNQAAAVMTGYETETILNSTFEPVAPPKPITVFG--------------
Mb3148c|M.bovis_AF2122/97 EMWAQDVAAMVGYHAGAKSVAATLAPFSLPP-------------------
Rv2352c|M.tuberculosis_H37Rv EMWAQDVGAMVGYHAGAAAVAETLTPFSVPP-------------------
MMAR_4324|M.marinum_M EMWAQDVAAMVGYHGGASSVAAALVPFSLPP-------------------
MLBr_01182|M.leprae_Br4923 EMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVE-----
MUL_0947|M.ulcerans_Agy99 EMWAQDAAAMYGYAGSAAMLAETLTPFEEAPEVANAGG------------
MAV_2928|M.avium_104 EMWAQDAAAMYGYAA-ASQTASTLSPFAAPPNTTAPEG------------
MAB_0669|M.abscessus_ATCC_1997 RMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQSDVP-
MSMEG_0619|M.smegmatis_MC2_155 RMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASASVQQ
TH_3113|M.thermoresistible__bu RMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAITGAH
.** * . .* * *
Mflv_0768|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb3148c|M.bovis_AF2122/97 --------------------------------------------------
Rv2352c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4324|M.marinum_M --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MUL_0947|M.ulcerans_Agy99 --------------------------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
MAB_0669|M.abscessus_ATCC_1997 ----------GS--------PDQIMKMLQG----------FQQWFEKMG-
MSMEG_0619|M.smegmatis_MC2_155 MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQAILDFLKDPLGNLGR
TH_3113|M.thermoresistible__bu VTAELRAAESRTLLD---EINELIDRLFAPLFPPGFADALPDGLLGTLLA
Mflv_0768|M.gilvum_PYR-GCK ------GSEAAFAGAMSGAVPG----------------AGEAVMRNAIIS
Mvan_0077|M.vanbaalenii_PYR-1 ------STQAAMATAIGSAAPG----------------IASAAARNATFT
Mb3148c|M.bovis_AF2122/97 ------VSLAGLAAQVGTQVAG----------------MATTASAAVTPV
Rv2352c|M.tuberculosis_H37Rv ------LDLAGLASQAGAQLTG----------------MATSVSAALSPI
MMAR_4324|M.marinum_M ------VDLAGLASQIGTQAFG----------------MVTSASSALATP
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEAEQAISQAA--LDQAVNEGM--EATVVPQVDQQVNVDV
MUL_0947|M.ulcerans_Agy99 -----LVKQTAAVGQAIDSAA--AGQLMSN--------VPQALQQL-AAT
MAV_2928|M.avium_104 -----ESDQAAAVSQAMAQPAGSTAQTAANTS--SQLATPQALSAGTSQA
MAB_0669|M.abscessus_ATCC_1997 ----FNPATSAVLAVIMLFLYDLLWYPYY---------ASYLLPFLIPAL
MSMEG_0619|M.smegmatis_MC2_155 LLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPAL
TH_3113|M.thermoresistible__bu PLLPGATGDGPPMATIMSFLLMGLSNPAY--------LFPVLVYLLFTGV
Mflv_0768|M.gilvum_PYR-GCK KVSSTAKLDTANQIAGRAEGTLRGVVDRAGSHAEKSQGLEQAPQQGMQMG
Mvan_0077|M.vanbaalenii_PYR-1 KVSVVGKLDEVNQKAGHAEGLLQQAADSGRSQAEQGQLLQQAPQQGMQMG
Mb3148c|M.bovis_AF2122/97 VEGAMASVPTVMSGMQSLVSQLP----LQHASMLFLPVRILTSP---ITT
Rv2352c|M.tuberculosis_H37Rv AEGAVEGVPAVVAAAQSVAAGLPVDAALQVGQAAAYPASMLIGP---MMQ
MMAR_4324|M.marinum_M VQSVMAAVPTALTTLQSLP--------LQDASMLMYPFSMAMSP---LMN
MLBr_01182|M.leprae_Br4923 ATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMAN----AG
MUL_0947|M.ulcerans_Agy99 APQGASTATAPKSLLQSVTSSFSS--SNLSTIVGMENTHLSMAN----SG
MAV_2928|M.avium_104 ATQASSSSASQTGPFTWLTSALQN--LQQSGLPTPTNNYLGLSPTFYTVM
MAB_0669|M.abscessus_ATCC_1997 S--GLSGLAALMHLRPAAPGPVPAAALSPGDRPIRRPTQHVEPNLAALPL
MSMEG_0619|M.smegmatis_MC2_155 AALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQP------LAV
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
Mflv_0768|M.gilvum_PYR-GCK MQMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQQMSSLFGGM-------
Mvan_0077|M.vanbaalenii_PYR-1 MQMASQLGSTLGQLPQQMMQGVTQPFQQLTQPLQQMSSLFGQMG-----G
Mb3148c|M.bovis_AF2122/97 LASMARESATR--LGPPAGGLAAANTPNPSGAAIPA--------------
Rv2352c|M.tuberculosis_H37Rv LAQMGTTANTAGLAGAEAAGLAAADVPTFAGDIASG--------------
MMAR_4324|M.marinum_M LMSSSLRGSTAGVAGATAAGIPAS-AAKLVDAPVSG--------------
MLBr_01182|M.leprae_Br4923 LSLVNGMGSAMKSLAPTTTKAAESAFKAMG-SAVQS--------------
MUL_0947|M.ulcerans_Agy99 ASILKTMGDSVKGFIPSASKAAETAVEHAARNAVSM--------------
MAV_2928|M.avium_104 LKQTSGLGYFSNGITAFWSQLAQQLVSGPGGSTAGAGGAWYPT-------
MAB_0669|M.abscessus_ATCC_1997 PTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAA--ISYAIPG--LVPPG
MSMEG_0619|M.smegmatis_MC2_155 GISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVAN--RDP-G
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
Mflv_0768|M.gilvum_PYR-GCK MNGDKGAQIGMVGATPFSNHPAIGGTGPATGSGLVRAASLPGAGGSAPQT
Mvan_0077|M.vanbaalenii_PYR-1 LGGDRGAQIGMLGATPFSNHPAIGGSGAATGAGLVRAASLPGAGGTAART
Mb3148c|M.bovis_AF2122/97 --------FKPLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGS--IPISM
Rv2352c|M.tuberculosis_H37Rv --------TGLGGAGGLGAGMSAELGKARLVGAMSVPPTWEGS--VPARM
MMAR_4324|M.marinum_M --------VKAMGGAGLGSSISAGLGKARMVGAVSVPPTWEGS--MPTRM
MLBr_01182|M.leprae_Br4923 ------TGRGLLGSSSGG-HVTAQLGRAASIGSLRVPQTWTTA--SQPVT
MUL_0947|M.ulcerans_Agy99 ------VGGGGPAGIGGW-APQGGVGQALSVGGLKVPQAWAEA--NQAVV
MAV_2928|M.avium_104 -PQFASLGLGNLGSVGGASHVSAISAGAGRAGALSVPQQWATL--TSAVS
MAB_0669|M.abscessus_ATCC_1997 VSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRLRGKNK---AEAGG
MSMEG_0619|M.smegmatis_MC2_155 EGFTPTLGNKS-QVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
.
Mflv_0768|M.gilvum_PYR-GCK PLMSNLVGSGLQPT-SPVAVGAGAGPGAGVGLAPVGTGGGMGAGGPMGMF
Mvan_0077|M.vanbaalenii_PYR-1 PLMSNLVGSGLQPTVSAVAVGAGAGAGAGAGLAPVGAGSGMGGGGPMGML
Mb3148c|M.bovis_AF2122/97 ASSAMSGLGVPPNPVALTQAAGAAGGGMPMMLMPMSIS-GAGAGMPGGLM
Rv2352c|M.tuberculosis_H37Rv ASSAMAGLGAMPAEVP------AAGGPMGMMPMPMGMG-GAGAGMPAGMM
MMAR_4324|M.marinum_M ASSAMSGLGAAGVANEAEMAAAGRPAGMPMMPMPMGAGAGAGGGMPGGML
MLBr_01182|M.leprae_Br4923 AATR-----ALSPARVAVATE-SESAPLLGGGLPMAPMVPGGGSGTGGVN
MUL_0947|M.ulcerans_Agy99 PAAR-----ALPISPVTGAVEGAHGAPLPG--MPFGQLAGNGGNGVSGV-
MAV_2928|M.avium_104 PAVSEE--GSAVQAAAGGAPGGAANGLLRG--MPVGALG-RRGAAAGYVN
MAB_0669|M.abscessus_ATCC_1997 RRHEYLEETAGMGATATADVPAYAATGRGTGPLGFAGTAPAAASTHVAAT
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEEPDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLT
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAPSAAGIRV
Mflv_0768|M.gilvum_PYR-GCK GQRGKSGGNKPGLNAPAPLDHDLGEDEDEEW----------
Mvan_0077|M.vanbaalenii_PYR-1 GQRGKSGGNKPGLNAPAPLEHDLSEDDDDDW----------
Mb3148c|M.bovis_AF2122/97 DRDGAGWHVTQARLTVIPRTGVG------------------
Rv2352c|M.tuberculosis_H37Rv GRGGANPHVVQARPSVVPRVGIG------------------
MMAR_4324|M.marinum_M GRGGASPNPIQSRPSVVPRTGIG------------------
MLBr_01182|M.leprae_Br4923 TA-----LRLQPRAFVMPRNPAAG-----------------
MUL_0947|M.ulcerans_Agy99 -------LRVTPKAYVMPRPPAAG-----------------
MAV_2928|M.avium_104 --------KYGFRYSVLTRPPSAG-----------------
MAB_0669|M.abscessus_ATCC_1997 VRLSSD--EARQVIPMLPSTWDAD-----------GGDQN-
MSMEG_0619|M.smegmatis_MC2_155 T-LTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR-
TH_3113|M.thermoresistible__bu LGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN