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FDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAELGIAASGYHSVIAELTSGPWVGPASLSMVSAIT PYVGWLSAVAAQAEETASQGRAAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQY MEMWAQDAAAMYGYAAASQTASTLSPFAAPPNTTAPEGESDQAAAVSQAMAQPAGSTAQTAANTSSQLAT PQALSAGTSQAATQASSSSASQTGPFTWLTSALQNLQQSGLPTPTNNYLGLSPTFYTVMLKQTSGLGYFS NGITAFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASLGLGNLGSVGGASHVSAISAGAGRAGALSVPQQ WATLTSAVSPAVSEEGSAVQAAAGGAPGGAANGLLRGMPVGALGRRGAAAGYVNKYGFRYSVLTRPPSAG *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2928 | - | - | 100% (421) | PPE family protein |
| M. avium 104 | MAV_2925 | - | 0.0 | 93.10% (406) | PPE family protein |
| M. avium 104 | MAV_2924 | - | 3e-87 | 46.34% (423) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1815 | PPE25 | 1e-105 | 52.38% (420) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0768 | - | 1e-35 | 30.07% (429) | PPE protein |
| M. tuberculosis H37Rv | Rv1787 | PPE25 | 1e-105 | 52.62% (420) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 7e-48 | 33.48% (442) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_2254c | - | 1e-32 | 35.71% (210) | PPE family protein |
| M. marinum M | MMAR_2669 | - | 1e-122 | 57.61% (427) | PPE family protein, PPE25 |
| M. smegmatis MC2 155 | MSMEG_0064 | - | 2e-34 | 32.04% (412) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 5e-34 | 40.20% (204) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3089 | - | 1e-122 | 57.38% (427) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0077 | - | 7e-42 | 32.63% (426) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
Mvan_0077|M.vanbaalenii_PYR-1 MATIGIPIPPIWGAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
MSMEG_0064|M.smegmatis_MC2_155 ----------MWIALPPEINTARLMVGAGPAPMLQAAAGWEGLAVLLETQ
Mb1815|M.bovis_AF2122/97 ---------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLA
Rv1787|M.tuberculosis_H37Rv ---------MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLA
MAV_2928|M.avium_104 --------MFDFGALPPEINSGRMYAGPGSGPLMAAAAAWDEVAAELGIA
MMAR_2669|M.marinum_M --------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAELSSA
MUL_3089|M.ulcerans_Agy99 --------MFDFGALPPEINSGRMYTGPGSGPMMAAASAWDALAAELSSA
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MAB_2254c|M.abscessus_ATCC_199 ------MSAPIWMAFPPEVHSALLGAGPGPGPLLAAAAQWHALSYEYSMA
TH_3569|M.thermoresistible__bu -----MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAEYASA
: *:.** :: : *.*. .:: **: * .:
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLSQN-WQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
Mvan_0077|M.vanbaalenii_PYR-1 ADELAASLATLSQM-WQGTASERAVMATMPMVMWLRMLSLQAQKRAAQAS
MSMEG_0064|M.smegmatis_MC2_155 AAELAAALTNLTSV-WTGAASERAVAATMPMITWLQTTAAQAQKRALQAS
Mb1815|M.bovis_AF2122/97 ATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAA
Rv1787|M.tuberculosis_H37Rv ATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAA
MAV_2928|M.avium_104 ASGYHSVIAELTSGPWVGPASLSMVSAITPYVGWLSAVAAQAEETASQGR
MMAR_2669|M.marinum_M ASGYSSVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAASQAR
MUL_3089|M.ulcerans_Agy99 ASGYSLVIAELTSSPWLGPASRSMMSAVAPYVTWLSAAAAQTETAASQAR
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MAB_2254c|M.abscessus_ATCC_199 ATELTQLLGVTAAGVWQGSSATQYVASHTPYLAWLTQQSATSAANAALHE
TH_3569|M.thermoresistible__bu AAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATAGRHE
* : : * :: * ** : : .
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADY-
Mvan_0077|M.vanbaalenii_PYR-1 AQATAWASAATSTPQLPEIETNHITNAVLNATNFLGVNTVPIAVNEADY-
MSMEG_0064|M.smegmatis_MC2_155 AQASSYSLALATTPPLPEIEQNHITHGVLEATNFLGINTVPIALNEMDYF
Mb1815|M.bovis_AF2122/97 AAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQY-
Rv1787|M.tuberculosis_H37Rv AAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQY-
MAV_2928|M.avium_104 AAAAAFEAAFAMTVPPPVIAANRVLLATLVATNFFGQNTPAIAATEAQY-
MMAR_2669|M.marinum_M AAAAAYETAFVMTVPPPVIAANRVLLMTLVATNFFGQNTPAIAATEAQY-
MUL_3089|M.ulcerans_Agy99 AAAAAYETAFVMTVPPPVIAANRVLLMALVATNFFGQNTPAIAATEAQY-
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEY-
MAB_2254c|M.abscessus_ATCC_199 TSAAAYTTALAAMPTLPELATNHTVHGILVGTNFFGINTIPIALNEADY-
TH_3569|M.thermoresistible__bu TAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNEADY-
. * :: * . : *: * :*::* * .** * :*
Mflv_0768|M.gilvum_PYR-GCK IRMWNQAAAVMTAYETETVLNT--TFEPVAPPKPIAVPPGSEAAFAGAMS
Mvan_0077|M.vanbaalenii_PYR-1 IRMWNQAAAVMTGYETETILNS--TFEPVAPPKPITVFGSTQAAMATAIG
MSMEG_0064|M.smegmatis_MC2_155 VRMWNQAAGAMDVYHAETTVNL--LFEPIMPMKPIVLPGVGETTAAAALA
Mb1815|M.bovis_AF2122/97 AEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTNSAGVVAQVAAVA--
Rv1787|M.tuberculosis_H37Rv AEMWAQDAVAMYGYAAASASAS-RLIPFAAPPKTTNSAGVVAQVAAVA--
MAV_2928|M.avium_104 MEMWAQDAAAMYGYAAASQTAS-TLSPFAAPPNTTAPEGESDQAAAVSQA
MMAR_2669|M.marinum_M MEMWAQDAAAMYSYAGSSALAT-ELPRFAPPPDTTSVNAAGGQSAVVAQA
MUL_3089|M.ulcerans_Agy99 MEMWAQDAAAMYSYAGSSAPAT-ELPRFAPPPDTTSVNAAGGQSAVVAQA
MLBr_01182|M.leprae_Br4923 TEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEEVVE
MAB_2254c|M.abscessus_ATCC_199 VRMWVQAATTMGVYQGVSSTAVAAAAPTTTSPLIMPPG-SELSRMAADMS
TH_3569|M.thermoresistible__bu VRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMATTQ
.** * * * * .
Mflv_0768|M.gilvum_PYR-GCK GAVPGAGEAVMRNAIISKVSSTAKLDTANQIAGRAEGTLRGVVDRAGSHA
Mvan_0077|M.vanbaalenii_PYR-1 SAAPGIASAAARNATFTKVSVVGKLDEVNQKAGHAEGLLQQAADSGRSQA
MSMEG_0064|M.smegmatis_MC2_155 QTAPRVAEGVMRNAVIEGVSAIATIESVGLAAGHAAAQANFAEQRGQGAA
Mb1815|M.bovis_AF2122/97 -------------------AMPGLLQR-------LSSAASVS------WS
Rv1787|M.tuberculosis_H37Rv -------------------AMPGLLQR-------LSSAASVS------WS
MAV_2928|M.avium_104 MAQPAGSTAQTAANTSSQLATPQALSAGTSQAATQASSSSAS------QT
MMAR_2669|M.marinum_M AATPAGDSAQTIT-----ATIPQLLSSAGVPGLQQLSLSSVSSMSPSAAS
MUL_3089|M.ulcerans_Agy99 AATPAGDSAQTIT-----ATIPQLLSSAGVPGLQQRSLSSVSSMSPSAAS
MLBr_01182|M.leprae_Br4923 EVVEEVVEAEQAIS-------QAALDQAVNEGMEATVVPQVDQQVNVDVA
MAB_2254c|M.abscessus_ATCC_199 GFAAQAQATESGS------ALDSS----------NSVIDQLLN----FFR
TH_3569|M.thermoresistible__bu QIGSQATAADSGT------ALNLSDLIANLLQYYQDYLDQLFGPIVDFLR
Mflv_0768|M.gilvum_PYR-GCK EKSQGLEQAPQ----QGMQMGMQMASQLGSTLGQMPQQMMQGVTQPFQQL
Mvan_0077|M.vanbaalenii_PYR-1 EQGQLLQQAPQ----QGMQMGMQMASQLGSTLGQLPQQMMQGVTQPFQQL
MSMEG_0064|M.smegmatis_MC2_155 QKGENAGQEAGRESGKNMQQGMQMVMQMGSQAAQAPAQLASMFQSGVQTM
Mb1815|M.bovis_AF2122/97 NPNDWWLVR-------LLGS--------------ITPTERTTIVRLLG-Q
Rv1787|M.tuberculosis_H37Rv NPNDWWLVR-------LLGS--------------ITPTERTTIVRLLG-Q
MAV_2928|M.avium_104 GPFTWLTSA-------LQNLQQSGLPTPTNNYLGLSPTFYTVMLKQTSGL
MMAR_2669|M.marinum_M SPTVWQIIQTQ-----VQNFLTYGLPTPDNNYAGLYPGMYNALRQTLQ--
MUL_3089|M.ulcerans_Agy99 SPTVWQIIQTQ-----VQNFLTYGLPTPDNNYAGLYPGMYNALRQTLQ--
MLBr_01182|M.leprae_Br4923 TPQTAVPDSSS-----AAAPQLWGGFAQHLSPINDTLSMINNHAGMANAG
MAB_2254c|M.abscessus_ATCC_199 DPLGTLRQIIE-----DFIRNPGAALATWLPFLLVLASMTYVLFAQVFWL
TH_3569|M.thermoresistible__bu DPIGNLFQLID-----DFLTNPAGALVTWWPLLFAVAYQVFTNLVG--WP
Mflv_0768|M.gilvum_PYR-GCK TQPLQQMSSLFGGM--MNGDK-GAQIGMVGATPFSNHPAIGGTGPATG--
Mvan_0077|M.vanbaalenii_PYR-1 TQPLQQMSSLFGQMGGLGGDR-GAQIGMLGATPFSNHPAIGGSGAATG--
MSMEG_0064|M.smegmatis_MC2_155 TQPLQQATQMVSQFASMGGSERAMQVGLMGASPFSNHPMLGGSGPSTG--
Mb1815|M.bovis_AF2122/97 SYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAS-----
Rv1787|M.tuberculosis_H37Rv SYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGAS-----
MAV_2928|M.avium_104 GYFSNGITAFWSQLAQQLVSGPGGSTAGAGGAWYPTPQFASLGLGNLGSV
MMAR_2669|M.marinum_M AYFGVGIGNSGWSIAQQLTFGPGGTTAGAGGAWYPTPEFAALGADT----
MUL_3089|M.ulcerans_Agy99 AYFGVGIGNFGWSIAQQLTLGPGGTTAGAGGAWYPTPEFAALGADT----
MLBr_01182|M.leprae_Br4923 LSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSG----
MAB_2254c|M.abscessus_ATCC_199 FWAALLSAPLWLPLLILAAWQYLQPPAVDAAPADEIRPELGSTVNGQREH
TH_3569|M.thermoresistible__bu TWAMILASPVLIPLAITLG-------------------------------
:
Mflv_0768|M.gilvum_PYR-GCK SGLVRAASLPGAGGSAPQTPLMSNLVGSGLQPT-SPVAVGAGAGPGAGVG
Mvan_0077|M.vanbaalenii_PYR-1 AGLVRAASLPGAGGTAARTPLMSNLVGSGLQPTVSAVAVGAGAGAGAGAG
MSMEG_0064|M.smegmatis_MC2_155 AGLVRAMSLPGAGGTAPRTPLLSNLLG----ISGEMKAAPAGAGSAAAGG
Mb1815|M.bovis_AF2122/97 ---RAVSASLARANKIGALSVPPSWVKTT-ALTE-PGAHAVSANPTVGS-
Rv1787|M.tuberculosis_H37Rv ---RAVSASLARANKIGALSVPPSWVKTT-ALTESPVAHAVSANPTVGS-
MAV_2928|M.avium_104 GGASHVSAISAGAGRAGALSVPQQWATLTSAVSPAVSEEGSAVQAAAGG-
MMAR_2669|M.marinum_M -WHWHPMASFASSSKVGGLSVPASWGTAPGAVEQASTKLVSTNFTTSPGE
MUL_3089|M.ulcerans_Agy99 -WHWHPMASFASSSKVGGLSVPASWGTTPGAVEQASTKLVSTNFTTSPGE
MLBr_01182|M.leprae_Br4923 ---GHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATES
MAB_2254c|M.abscessus_ATCC_199 IEPLPAIALAPTATPVPTASASAPSAPAPAPAPTAAGAGFAPYLVGAIPD
TH_3569|M.thermoresistible__bu -----------VAGLVMIADQAQPPAEEAAPEEDVAAP------VRAEPQ
.
Mflv_0768|M.gilvum_PYR-GCK LAPVGTGGGMGAGGPMGMFGQRGKSGGNKPGLNAPAPLDHDLGEDEDEEW
Mvan_0077|M.vanbaalenii_PYR-1 LAPVGAGSGMGGGGPMGMLGQRGKSGGNKPGLNAPAPLEHDLSEDDDDDW
MSMEG_0064|M.smegmatis_MC2_155 LAPVGAGAGGGAGAPVAHAGQNSKSGGKKDGLVAPTPLTYDLSEDEDDEW
Mb1815|M.bovis_AF2122/97 -SHG--PHGLLRGLPLGSRITRRSGA-FAHRYGFRHSVVARPPSAG----
Rv1787|M.tuberculosis_H37Rv -SHG--PHGLLRGLPLGSRITRRSGA-FAHRYGFRHSVVARPPSAG----
MAV_2928|M.avium_104 -APGGAANGLLRGMPVGALGRRGAAAGYVNKYGFRYSVLTRPPSAG----
MMAR_2669|M.marinum_M ANPANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG----
MUL_3089|M.ulcerans_Agy99 ANPANGLNAALRGFPVGSRGAQRTGN-LGVRYGFRYPVLTRPPSAG----
MLBr_01182|M.leprae_Br4923 ESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG----
MAB_2254c|M.abscessus_ATCC_199 EPPAIQFGPTLNEGNKAQAPASGISAAAAAAASARSRARRKRGARVKDPA
TH_3569|M.thermoresistible__bu NPLPLTXXX-----------------------------------------
Mflv_0768|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 --------------------------------------------------
Mb1815|M.bovis_AF2122/97 --------------------------------------------------
Rv1787|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2928|M.avium_104 --------------------------------------------------
MMAR_2669|M.marinum_M --------------------------------------------------
MUL_3089|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MAB_2254c|M.abscessus_ATCC_199 PQYMDMNVTVDADYGEPPGSAQRQSTASARGAGHLGLAGTSPKTTATAAG
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0768|M.gilvum_PYR-GCK ------------------------------------
Mvan_0077|M.vanbaalenii_PYR-1 ------------------------------------
MSMEG_0064|M.smegmatis_MC2_155 ------------------------------------
Mb1815|M.bovis_AF2122/97 ------------------------------------
Rv1787|M.tuberculosis_H37Rv ------------------------------------
MAV_2928|M.avium_104 ------------------------------------
MMAR_2669|M.marinum_M ------------------------------------
MUL_3089|M.ulcerans_Agy99 ------------------------------------
MLBr_01182|M.leprae_Br4923 ------------------------------------
MAB_2254c|M.abscessus_ATCC_199 LVARGSAGSDTDVPETARIVPMIPTTWSTDSDEAID
TH_3569|M.thermoresistible__bu ------------------------------------