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LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAELRASALSYSSVLSTLTGEEWHGPASASMTAAAA PYVAWMSVTAVRAEQAGAQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATEAQY AEMWSQDAMAMYGYAGASAAATQLTPFTEPVQTTNASGLAAQSAAIAHATGASAGAQQTTLSQLIAAIPS VLQGLSSSTAATSASGPSGLLGILGSGSSWLDKLWALLDPNSNFWNTIASSGLFLPSNTIAPFLGLLGGV AAADAAGDVLGEATSGGLGGALVAPLGSAGGLGGTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALG GTPMVAPPPAVAAGMPGMPFGTMGGQGFGRAVPQYGFRPNFVARPPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | - | 100% (399) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1731c | PPE22 | 9e-98 | 51.10% (409) | PPE family protein |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 6e-95 | 50.12% (411) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0768 | - | 3e-32 | 27.54% (414) | PPE protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 0.0 | 99.50% (399) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-46 | 33.10% (429) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 3e-29 | 28.35% (388) | PPE family protein |
| M. marinum M | MMAR_2683 | - | 1e-156 | 71.32% (401) | PPE family protein, PPE31 |
| M. avium 104 | MAV_2914 | - | 1e-87 | 46.93% (407) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-36 | 30.27% (413) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-37 | 32.84% (402) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 1e-154 | 70.57% (401) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-35 | 30.05% (416) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1836|M.bovis_AF2122/97 ---------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAELRAS
Rv1807|M.tuberculosis_H37Rv ---------LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAELRAS
MMAR_2683|M.marinum_M -----MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAELRVT
MUL_3074|M.ulcerans_Agy99 -----MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAELRVT
MAV_2914|M.avium_104 --------MIDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAEMRSA
MLBr_01182|M.leprae_Br4923 --------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAA
MSMEG_0619|M.smegmatis_MC2_155 ------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAA
Mvan_0415|M.vanbaalenii_PYR-1 ------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAEYAAA
MAB_0809c|M.abscessus_ATCC_199 -----MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSAT
TH_3113|M.thermoresistible__bu ------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAA
Mflv_0768|M.gilvum_PYR-GCK MANIGIPVPPSWVAFPPEINTSRLQAGAGAVPMLQAAAGWEAFAISLETQ
: .** ::: : *.*. .: ** * :.
Mb1836|M.bovis_AF2122/97 ALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAGAQAE
Rv1807|M.tuberculosis_H37Rv ALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAGAQAE
MMAR_2683|M.marinum_M VLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESAVQAA
MUL_3074|M.ulcerans_Agy99 VLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESAVQAA
MAV_2914|M.avium_104 AASYGAVISELTSADWFGPSSMSMLAAVTPYLTWLTDTATRAEEAAAQAN
MLBr_01182|M.leprae_Br4923 AQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTATQLT
MSMEG_0619|M.smegmatis_MC2_155 AAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHE
Mvan_0415|M.vanbaalenii_PYR-1 AAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAAAQHE
MAB_0809c|M.abscessus_ATCC_199 AQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHG
TH_3113|M.thermoresistible__bu AVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLE
Mflv_0768|M.gilvum_PYR-GCK ADELASSLASLS-QNWQGMASERAVTAAMPMVLWLRMLSLQAHKRALQAS
. : : : * .: * *: : . . *
Mb1836|M.bovis_AF2122/97 AAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATEAQYA
Rv1807|M.tuberculosis_H37Rv AAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATEAQYA
MMAR_2683|M.marinum_M AAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPAIAAVEAQYC
MUL_3074|M.ulcerans_Agy99 AAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVEAQYC
MAV_2914|M.avium_104 SAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIAATEAEYG
MLBr_01182|M.leprae_Br4923 VAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYT
MSMEG_0619|M.smegmatis_MC2_155 TAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYV
Mvan_0415|M.vanbaalenii_PYR-1 AAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTEADYV
MAB_0809c|M.abscessus_ATCC_199 AAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADYV
TH_3113|M.thermoresistible__bu AAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYA
Mflv_0768|M.gilvum_PYR-GCK AQASSWTVAATGTPQLPEIELNHVTNATLHATNFLGVNGIPIALNEADYI
* : * : : *:. * :*.:* * .* **:*
Mb1836|M.bovis_AF2122/97 EMWSQDAMAMYGYAGASAAAT-QLTPFTEPV-------------------
Rv1807|M.tuberculosis_H37Rv EMWSQDAMAMYGYAGASAAAT-QLTPFTEPV-------------------
MMAR_2683|M.marinum_M EMWAQDAMAMYGYAGSSAAAT-RLSEFLEPQ-------------------
MUL_3074|M.ulcerans_Agy99 EMWAQDAMAMYGYAGSSAAAT-RLSEFLAPQ-------------------
MAV_2914|M.avium_104 QMWAQDAAAMNGYAVASTAAT-RLTPMTAPR-------------------
MLBr_01182|M.leprae_Br4923 EMWIQDAAAMTSYQASVLEAVGATKAFTAPP-------------------
MSMEG_0619|M.smegmatis_MC2_155 RMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASASVQQ
Mvan_0415|M.vanbaalenii_PYR-1 RMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAADVTA
MAB_0809c|M.abscessus_ATCC_199 RMWVQAATTMATYQTASEVALASAPPSTPPPSILHD------------HD
TH_3113|M.thermoresistible__bu RMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAITGAH
Mflv_0768|M.gilvum_PYR-GCK RMWNQAAAVMTAYETETVLNTTFEPVAPPKPIAVPPG-------------
.** * * .* *
Mb1836|M.bovis_AF2122/97 ----QTTNASGLAAQSAAIAHATGASAGAQQTTLSQLIAAIPS-------
Rv1807|M.tuberculosis_H37Rv ----QTTNASGLAAQSAAIAHATGASAGAQQTTLSQLIAAIPS-------
MMAR_2683|M.marinum_M ----HNTNPAGLLAQ---------------QSTLAQLMSAVPN-------
MUL_3074|M.ulcerans_Agy99 ----HNTNPAGLLAQ---------------QSTLAQLMSAVPN-------
MAV_2914|M.avium_104 ----SNTSPEGVAAQ---------------ATSVTNAAQAPAG-------
MLBr_01182|M.leprae_Br4923 ----LGVNEVGLAQEVVEEVVEEVVEEVVEAEQAISQAALDQA-------
MSMEG_0619|M.smegmatis_MC2_155 MSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK-------
Mvan_0415|M.vanbaalenii_PYR-1 FAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR-------
MAB_0809c|M.abscessus_ATCC_199 HGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG-------
TH_3113|M.thermoresistible__bu VTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLLAPLL
Mflv_0768|M.gilvum_PYR-GCK ----SEAAFAGAMSGAVPGAGEAVMRNAIISKVSSTAKLDTAN-------
Mb1836|M.bovis_AF2122/97 ------------------VLQGLSSSTAATSASGPSGLLG-----ILGSG
Rv1807|M.tuberculosis_H37Rv ------------------VLQGLSSSTAATFASGPSGLLG-----IVGSG
MMAR_2683|M.marinum_M ------------------VLQGLASSN--TSASAPSGLLST---LLSGNG
MUL_3074|M.ulcerans_Agy99 ------------------VLQGLASSN--TSASAPSGLLST---LLSGNG
MAV_2914|M.avium_104 ------------------TVQSTVSSS------GLAGLLS-------GSD
MLBr_01182|M.leprae_Br4923 ------------------VNEGMEATVVPQVDQQVNVDVATPQTAVPDSS
MSMEG_0619|M.smegmatis_MC2_155 -------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWP
Mvan_0415|M.vanbaalenii_PYR-1 -------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWV
MAB_0809c|M.abscessus_ATCC_199 -------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHAAQLASTIG
TH_3113|M.thermoresistible__bu PGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAVSGML
Mflv_0768|M.gilvum_PYR-GCK ------------------QIAGRAEGTLRGVVDRAGSHAEK-----SQGL
Mb1836|M.bovis_AF2122/97 SSWLDKLWALLDPNSNFWNTIASSG---LFLPSNTIAPFLGLLGGVAAAD
Rv1807|M.tuberculosis_H37Rv SSWLDKLWALLDPNSNFWNTIASSG---LFLPSNTIAPFLGLLGGVAAAD
MMAR_2683|M.marinum_M QSWLATLWSEFGPNANIWNTIASTG---FLLPSNMVTPFLGMLGTAAVAD
MUL_3074|M.ulcerans_Agy99 QSWLATLWSEFGPNANIWNTIASTG---FLLPSNMVTPFLGMLDTAAVAD
MAV_2914|M.avium_104 NSAFGTFTNGNFFSTAVVNGSLAGG---PFNPQFIISSVQGVLAAQHATT
MLBr_01182|M.leprae_Br4923 SAAAPQLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLA
MSMEG_0619|M.smegmatis_MC2_155 TWGMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAA
Mvan_0415|M.vanbaalenii_PYR-1 GASILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAAS
MAB_0809c|M.abscessus_ATCC_199 QFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPGSVEDAPMA
TH_3113|M.thermoresistible__bu AQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAA
Mflv_0768|M.gilvum_PYR-GCK EQAPQQGMQMGMQMASQLGSTLGQMPQQMMQGVTQPFQQLTQPLQQMSSL
Mb1836|M.bovis_AF2122/97 AAGDVLGEATSGGLGGALVAPLGSAGG--LGGTVAAGLGNAATVGTLSVP
Rv1807|M.tuberculosis_H37Rv AAGDVLGEATSGGLGGALVAPLGSAGG--LGGTVAAGLGNAATVGTLSVP
MMAR_2683|M.marinum_M AAEDALGTTGSGALGGALSAPLGSVGG--QAGLAAA--GNAAIVGKLSVP
MUL_3074|M.ulcerans_Agy99 AAEDALRTTGSGALGGALSAPLGSVGG--QAGLAAA--GNAAIVGKLSVP
MAV_2914|M.avium_104 LGG--LGDFAADAEG-AATADLAASTG--GSAPVAAGMGRAQLVGSLSVP
MLBr_01182|M.leprae_Br4923 PTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVP
MSMEG_0619|M.smegmatis_MC2_155 P----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATF
Mvan_0415|M.vanbaalenii_PYR-1 SPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASF
MAB_0809c|M.abscessus_ATCC_199 ASAG-TALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PPVGDPGFS
TH_3113|M.thermoresistible__bu P---VPAGGPSLPSGSSAPPAP-TGSAAPTTGTAPGGAGSPPPAGHSVPP
Mflv_0768|M.gilvum_PYR-GCK FGGMMNGDKGAQIGMVGATPFSNHPAIGGTGPATGSGLVRAASLPGAGGS
. .
Mb1836|M.bovis_AF2122/97 PSWTAAAPLASPLGSALGGTPMVAPP-----PAVAAGMPGMPFGTMGGQG
Rv1807|M.tuberculosis_H37Rv PSWTAAAPLASPLGSALGGTPMVAPP-----PAVAAGMPGMPFGTMGGQG
MMAR_2683|M.marinum_M PSWTGAAPLASPLGSALGGTPMVAPP-----PTAAAGMPGVPFGNMAGQP
MUL_3074|M.ulcerans_Agy99 PSWTGAAPLASPLGSALGGTPMVAPP-----PTAAAGMPGMPFGNMAGQP
MAV_2914|M.avium_104 QGWANAATINPGQAAVPATGVTGLTD-----AASAAGGPGGVAGPVGGTG
MLBr_01182|M.leprae_Br4923 QTWTTASQPVTAATRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSG
MSMEG_0619|M.smegmatis_MC2_155 VPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRR
Mvan_0415|M.vanbaalenii_PYR-1 VPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRR
MAB_0809c|M.abscessus_ATCC_199 FPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETAAARQARR
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
Mflv_0768|M.gilvum_PYR-GCK APQTPLMSNLVGSGLQPTSPVAVGAG-----AGPGAGVGLAPVGTGGGMG
: .
Mb1836|M.bovis_AF2122/97 -------------------------------------FGRAVPQYGFRPN
Rv1807|M.tuberculosis_H37Rv -------------------------------------FGRAVPQYGFRPN
MMAR_2683|M.marinum_M -------------------------------------FGRALPQYGFRPT
MUL_3074|M.ulcerans_Agy99 -------------------------------------FGRALPQYGFRPT
MAV_2914|M.avium_104 RR-----------------------------------LRRAIPKYGFRPV
MLBr_01182|M.leprae_Br4923 TG-----------------------------------GVNTALRLQPRAF
MSMEG_0619|M.smegmatis_MC2_155 RKKGAQIEERGYADAYMDYE-EPDEDPAPQPEPRVRASERGSDAMGFTGT
Mvan_0415|M.vanbaalenii_PYR-1 RRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGT
MAB_0809c|M.abscessus_ATCC_199 RRDKGKQQGRG--IEYMDMN---ATARCEEPAPDTTASHRGAGTMGFAGT
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHGH-RHEHQQPASMSAATAPSAAGIRVLGGAGR
Mflv_0768|M.gilvum_PYR-GCK -------------------------------------AGGPMGMFGQRGK
Mb1836|M.bovis_AF2122/97 FVARPPAAG-----------------------------------------
Rv1807|M.tuberculosis_H37Rv FVARPPAAG-----------------------------------------
MMAR_2683|M.marinum_M FVARPPAAG-----------------------------------------
MUL_3074|M.ulcerans_Agy99 FVARPPAAG-----------------------------------------
MAV_2914|M.avium_104 VMPRPPAAG-----------------------------------------
MLBr_01182|M.leprae_Br4923 VMPRNPAAG-----------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 VTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGP
Mvan_0415|M.vanbaalenii_PYR-1 VSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPDERHNHHDGKD
MAB_0809c|M.abscessus_ATCC_199 VIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDPEHGRQD---------
TH_3113|M.thermoresistible__bu ISRTRGSVPHAEITP------GDPTEPSSPTDRAHRPAEPN---------
Mflv_0768|M.gilvum_PYR-GCK SGGNKPGLN-------------------APAPLDHDLGEDEDEEW-----
Mb1836|M.bovis_AF2122/97 --
Rv1807|M.tuberculosis_H37Rv --
MMAR_2683|M.marinum_M --
MUL_3074|M.ulcerans_Agy99 --
MAV_2914|M.avium_104 --
MLBr_01182|M.leprae_Br4923 --
MSMEG_0619|M.smegmatis_MC2_155 RR
Mvan_0415|M.vanbaalenii_PYR-1 SQ
MAB_0809c|M.abscessus_ATCC_199 --
TH_3113|M.thermoresistible__bu --
Mflv_0768|M.gilvum_PYR-GCK --