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VALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAADPALATVVKRSNRAHLIHFAAANLR NPGAPVPANLGPEPLRMARDLVRVGLDALALDIYRIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTA NEFVDTTLAGITTEMQLERDKLTRDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQA QGDHSHLDRVADAFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIE GFRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASPALKTTLLTFI NQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQQWREKQTSDPPAKKESNGTKM R
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1488 | - | - | 100% (421) | transcriptional activator protein |
| M. bovis AF2122 / 97 | Mb2391c | - | e-167 | 69.93% (409) | hypothetical protein Mb2391c |
| M. bovis AF2122 / 97 | Mb1226c | - | e-149 | 64.18% (402) | hypothetical protein Mb1226c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4621 | - | 3e-14 | 23.38% (325) | hypothetical protein Mflv_4621 |
| M. tuberculosis H37Rv | Rv1453 | - | 0.0 | 99.76% (421) | transcriptional activator protein |
| M. leprae Br4923 | MLBr_01052 | - | 1e-147 | 61.67% (407) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 8e-59 | 34.43% (395) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_2258 | - | 1e-169 | 69.34% (411) | transcriptional activator protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_2971 | - | 4e-08 | 25.61% (246) | regulatory protein |
| M. thermoresistible (build 8) | TH_3143 | - | 7e-22 | 26.52% (396) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0944 | - | 1e-147 | 64.68% (402) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4621|M.gilvum_PYR-GCK --------------------------------------------------
TH_3143|M.thermoresistible__bu --------------------------------------------------
Mb1488|M.bovis_AF2122/97 --------------------------------------------------
Rv1453|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2258|M.marinum_M --------------------------------------------------
MLBr_01052|M.leprae_Br4923 --------------------------------------------------
MUL_0944|M.ulcerans_Agy99 --------------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 -------------------------------------------------M
MSMEG_2971|M.smegmatis_MC2_155 MLSLSALLADPTLELTLLVPGSPGAVDREVLWLHNTELPDPSPYIRATEL
Mflv_4621|M.gilvum_PYR-GCK --------------MLDSSEVQDTPGHAVHHLFRDLGDLVRELPESIHGL
TH_3143|M.thermoresistible__bu --------------VVVSGYNADDISSTVALIVDRLLENSGEDVERIQRR
Mb1488|M.bovis_AF2122/97 ---------------MALRETSPRIHELIREAARIALNPTQEWLDEFDRA
Rv1453|M.tuberculosis_H37Rv ---------------MALRETSPRIHELIREAARIALNPTQEWLDEFDRA
MMAR_2258|M.marinum_M ---------------MKSRELSPRVRDLIREAARVALNPSQQWLEEFDRA
MLBr_01052|M.leprae_Br4923 ---------------MARQHPSPRVRELIREGARIALNPTQEWIDQLDRA
MUL_0944|M.ulcerans_Agy99 ---------------MPWQRPSSRIRELIREGARRALNAGPEWIEELDRE
MAB_2657c|M.abscessus_ATCC_199 NEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGEVAGDLTAA
MSMEG_2971|M.smegmatis_MC2_155 VLTNGLWRGTVDSTMFVDALLRARAAGVVFGLTEQTPAAPADLVEACSSA
: :
Mflv_4621|M.gilvum_PYR-GCK LIEQV--AELAADQQLKELLSDTVAANVDTWFSV-VRHSIPFDRMESPTA
TH_3143|M.thermoresistible__bu ILADI--DELRSDPRLVELLRSSVAGNVETVLTV-IRYGIDLDRVEPPTA
Mb1488|M.bovis_AF2122/97 ILAAN--PSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPE
Rv1453|M.tuberculosis_H37Rv ILAAN--PSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPE
MMAR_2258|M.marinum_M TLAAA--PPIAENPDLATVISRANRANLRHFAASNLRNPGDPVPANLGAE
MLBr_01052|M.leprae_Br4923 TFAAN--PAIANDPVLAKVVRRASRAHLVHWATANLRDPGAPVPAHLGPE
MUL_0944|M.ulcerans_Agy99 TVSAN--PTIANDPVLAKVVKRVNRANLVHWAAANVRHPGAPVPANLGGE
MAB_2657c|M.abscessus_ATCC_199 SLEDPRYRTIADDPVIAEVDARLTVSNLKHWLTSNISEPGHRVRPATGSA
MSMEG_2971|M.smegmatis_MC2_155 ELPLATVSIAVPFTAITQAAARIQSDARQAALSKLVRRGNALASSIARGG
. : : :
Mflv_4621|M.gilvum_PYR-GCK ALEHARRMAQREVPVNALLR---AYRLGHQYGLNLIIAGLRSADLPPEEK
TH_3143|M.thermoresistible__bu ALEYARRAAQHGIALSALIR---AYRLGQQEMLERILREVRETELDPDLR
Mb1488|M.bovis_AF2122/97 PLRMARDLVRVGLDALALD----IYRIGQNVAWRRWTDIAFGLTSDPDEL
Rv1453|M.tuberculosis_H37Rv PLRMARDLVRVGLDALALD----IYRIGQNVAWRRWTDIAFGLTSDPDEL
MMAR_2258|M.marinum_M PLRMARDLVRLGLDTLALD----VYRVGQNVAWQRWTDIVFGLTTDPQEL
MLBr_01052|M.leprae_Br4923 PLTMARDLVRRGRDVLALD----IYRVGQYTAWRRWMEIAFTLTSDPQEL
MUL_0944|M.ulcerans_Agy99 PLRMARDLVRRGLEALTLD----IYRIGQYIAWRLWINIAFDLTSDPQEL
MAB_2657c|M.abscessus_ATCC_199 MRTYARDVVLRGLTTDDIQ----SWRAVQRVGWKWWLAACFQVTDDKEQL
MSMEG_2971|M.smegmatis_MC2_155 GAEGILDVLRRDHDLPLLVVDRLGRRLAGDIGDDEDVQVAADALNRHPPP
: *
Mflv_4621|M.gilvum_PYR-GCK LALIEHITRVSFRYIDW-----------MSEQVLETYQTERAEWDERRRS
TH_3143|M.thermoresistible__bu LSVYERISSTSFAYIDW-----------ISQQVSDTYDTERERWLEHRNN
Mb1488|M.bovis_AF2122/97 HELLDVPFRTANEFVDT-----------TLAGITTEMQLERDKLTRDVPA
Rv1453|M.tuberculosis_H37Rv HELLDVPFRTANEFVDT-----------TLAGITTEMQLERDKLTRDVPA
MMAR_2258|M.marinum_M RELLDVPFRSAAAFIDT-----------TLAGIAAQMELEHHELSRNICA
MLBr_01052|M.leprae_Br4923 REILNVSAQSINEYVAA-----------TLEAIATHMQLERDELTRSTHA
MUL_0944|M.ulcerans_Agy99 HELLDVSAKSVNEFIEA-----------TLAGIAAQVQLEHDELTRGNHA
MAB_2657c|M.abscessus_ATCC_199 CELIEVTSNSLTTFVDD-----------SIAELAEHVRRVREELAGGSQL
MSMEG_2971|M.smegmatis_MC2_155 LEVALPSGDTASVYLVEGAMGDVDAGLFCLRPLPSLKPLERDALDQAARY
: :: : :
Mflv_4621|M.gilvum_PYR-GCK LRAQAIRDILNGRD---VDLTEASSAMRYFLGATHVALMVWLDRD-----
TH_3143|M.thermoresistible__bu IRAVRVREILDSDEP--IDIDTASAALGYPLRGRHLALVLWMTR------
Mb1488|M.bovis_AF2122/97 ERRKIVQLLIDGAP---ISREHAEARLGYPLDRSHTAAVIWGDQ------
Rv1453|M.tuberculosis_H37Rv ERRKIVQLLIDGAP---ISREHAEARLGYPLDRSHTAAVIWGDQ------
MMAR_2258|M.marinum_M ERRRIVELLLNGAP---ISRDSAESRLGYPLDRSHTAAIIWSDR------
MLBr_01052|M.leprae_Br4923 ERLEVVDLILEGAP---VTQERAEARLGYRLGLTHTAAVIWSDD------
MUL_0944|M.ulcerans_Agy99 DRLEVVGHLLEGAP---ISRERAETRLGYSLIRAHTAAIIWSDD------
MAB_2657c|M.abscessus_ATCC_199 QRYATVELLLQGAD---IAPARAEAQLGYALTGSHIGAVVWVD-------
MSMEG_2971|M.smegmatis_MC2_155 LSLEVTRQQALQAIESRFSSELLEMVLSGAARARDVAERLRAFGIDPSSA
. . : . . :
Mflv_4621|M.gilvum_PYR-GCK ----AGADTDEFIAMERFMQHAVSATGAKQS-VYFSIDRLVGCAWMTV-H
TH_3143|M.thermoresistible__bu ----SDLPGGELLRLERFARAVAEAFQLRNTPLFVAEDTVSGWAWLAINH
Mb1488|M.bovis_AF2122/97 -------AQGDHSHLDRVADAFGHAGGCPHPLVVVAGAATR---WVWVKD
Rv1453|M.tuberculosis_H37Rv -------AQGDHSHLDRVADAFGHAGGCPHPLVVVAGAATR---WVWVKD
MMAR_2258|M.marinum_M -------SDGDHRDLDRAVDAFCNAVGCASSLAIMSAATTR---WVWVRD
MLBr_01052|M.leprae_Br4923 -------LDGDHGYLDQAAEAFSHVVESTQQLIVVASAATR---WVWLAD
MUL_0944|M.ulcerans_Agy99 -------FDGDHSNLDRAADAFCHAVGSSQDLTVVANAATR---WVWLAE
MAB_2657c|M.abscessus_ATCC_199 -------SEKEIAALERASEQVMRACGADRRLTVVAGTVAL---WLWIPA
MSMEG_2971|M.smegmatis_MC2_155 LAVYTVVVGDGAVRPPGSTDEIEDFFNRHSIPAVVIPGSQDTVVVFGWHR
. .
Mflv_4621|M.gilvum_PYR-GCK RPSDYLSQLRDFVRAQPD-----GPRLSVGEPLPGIEGFRRTYRQAEQAR
TH_3143|M.thermoresistible__bu VVTEPVRTIRELAETADN-----GVHVALGTVDDGLEGFRRSHRRARDAR
Mb1488|M.bovis_AF2122/97 APGFDIDLIHEVLHDIP------DARIAIGATAPGIEGFRRSHRDALTTA
Rv1453|M.tuberculosis_H37Rv APGFDIDLIHEVLHDIP------DARIAIGATAPGIEGFRRSHRDALTTA
MMAR_2258|M.marinum_M VDVFDCSRIRQVMRELP------HVRIAIGTTEPGVDGFRRSHRDALTAA
MLBr_01052|M.leprae_Br4923 ALALDVPEVQKALLNLS------KARVAIGTSSAGIEGFRRSHLEALTAQ
MUL_0944|M.ulcerans_Agy99 ATNLDIDTIEQAVDNAS------DARIAIGTKASGIEGFRRSHLEALTTQ
MAB_2657c|M.abscessus_ATCC_199 KTTPTVAVLMDSLGRRS------GVRVALGRAATGMAGFRRTHMDAAAAQ
MSMEG_2971|M.smegmatis_MC2_155 DMTALVGLAEDLVQTLTARFPADRAVIGVGDLAADASALREPLIRARETC
. :.:* . .:*.. * :
Mflv_4621|M.gilvum_PYR-GCK VVAVAADGSSRHRIVAARDPGVALASMLMTDDATLKEWIHDVLGPLAQNT
TH_3143|M.thermoresistible__bu KVAAAS--AIPPRITAADDYGISVSALLTENLADTRRWVLDTLGPLASDT
Mb1488|M.bovis_AF2122/97 RMIIRLE--SPHRVAFFTD--VEMVALLTENAEGADDFIQRTLGNLESAS
Rv1453|M.tuberculosis_H37Rv RMIIRLE--SPHRVAFFTD--VEMVALLTENAEGADDFIQRTLGNLESAS
MMAR_2258|M.marinum_M RMLIRLR--SPQQVAFFGD--VEMIALLTENPDGADEFIKNTLGDFEEAS
MLBr_01052|M.leprae_Br4923 RTLARLK--SHQQVAFFAD--VQLVSLITQNPEDAKEFITSTLGDFESAS
MUL_0944|M.ulcerans_Agy99 RTLARLK--SDQRVAFFSD--VQIVALITQNTQAANEFITSTLGELESAA
MAB_2657c|M.abscessus_ATCC_199 RLLARLG--SPLSVVRYED--VHLMDLLSADPASADQFVTDVLGEFQSAS
MSMEG_2971|M.smegmatis_MC2_155 HVLRRRT--TEPKVGTYADIGTHRMLLGLHDRSVLRRFADDILGPLDQHD
: * : : : ** : .
Mflv_4621|M.gilvum_PYR-GCK ASD-QRLRDTLRVFLRAGSSFKAAANELQIHANTVKYRVNRALERRGRPI
TH_3143|M.thermoresistible__bu AND-ARLRETLLVFLHVGSSYTAAAERLLLHPNSVRYRVNRAVERRARPI
Mb1488|M.bovis_AF2122/97 P----ALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPL
Rv1453|M.tuberculosis_H37Rv P----ALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPL
MMAR_2258|M.marinum_M P----ALQHTLLTFISQQCNASRAARLLYTHRNTLMHRLETAQRLLPKPL
MLBr_01052|M.leprae_Br4923 P----ALQQTLLTFINEQCNASRAAKRLFTHRNTLLRRIESAEKLLPRPL
MUL_0944|M.ulcerans_Agy99 P----ELQATLLMFINEQCNASRAAKRLYTHRNTLLRRIEAAQRLLPRPL
MAB_2657c|M.abscessus_ATCC_199 P----VLHQTVLTYVEEALNRTSTAERLYTHRNTIDRRLARVDELLPKPF
MSMEG_2971|M.smegmatis_MC2_155 EQYGTALVRTLRTFLANDGHWAKTATELYVHVNTLRNRIARISELTGRDV
* *: :: :* * * *:: *: . : .
Mflv_4621|M.gilvum_PYR-GCK AAERLDVEVALLMCYWLGEVALNPTQALGRS-----------
TH_3143|M.thermoresistible__bu GEDRLEVELALLACRHFQQAVLQPAD----------------
Mb1488|M.bovis_AF2122/97 ADTTIHVAVALEAQQWREKQTSDPPAK-----KESNGTKMR-
Rv1453|M.tuberculosis_H37Rv ADTTIHVAVALEAQQWREKPTSDPPAK-----KESNGTKMR-
MMAR_2258|M.marinum_M EDTTVRVAVALEVLQWRSKQPGNPAASGAGKPDDRTPPEQRP
MLBr_01052|M.leprae_Br4923 DHTSVHIAVALEALQWRGDQTNTSGPR-----AGRNDGVPA-
MUL_0944|M.ulcerans_Agy99 AHTSVHVAVALEALQWRGDNIAKLPTP-----TSQDDEVPA-
MAB_2657c|M.abscessus_ATCC_199 ARNPIEVAAALTLLRVRAGR----------------------
MSMEG_2971|M.smegmatis_MC2_155 ARLEDRVDLFLALEADALG-----------------------
: *