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TTVPRRGFNDAVTGIWSLLAPAYDLAILQQWVYRPPHDEVLAQLRAHKSRRIADIACGTGILSARIEREL HPDEIYGVDMSHGMLDQARAKSDRVRWLRGPAEQLPFDDGALDAVVTITAFHFFDQPAALREFHRVLAPG GLVAVSSLSARQPLLQLPAASKWKPQHSPSPAEMRALFEGAGFTISDQHRVRRPVWTRLVPDLITVGTKS *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2765 | - | - | 100% (211) | methyltransferase (methylase) |
| M. ulcerans Agy99 | MUL_0820 | - | 9e-13 | 32.49% (197) | methyltransferase |
| M. ulcerans Agy99 | MUL_1436 | - | 2e-11 | 37.96% (108) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3374 | - | 1e-12 | 39.81% (108) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_4877 | - | 3e-11 | 40.62% (96) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv3342 | - | 1e-12 | 39.81% (108) | methyltransferase (methylase) |
| M. leprae Br4923 | MLBr_00130 | - | 3e-12 | 37.25% (102) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4613 | - | 6e-61 | 56.87% (211) | similarity with UbiE/COQ5 methyltransferase |
| M. marinum M | MMAR_3533 | - | 1e-119 | 98.10% (211) | methyltransferase (methylase) |
| M. avium 104 | MAV_2111 | - | 6e-95 | 79.05% (210) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 3e-11 | 37.93% (116) | methyltransferase |
| M. thermoresistible (build 8) | TH_1968 | - | 2e-10 | 37.04% (108) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. vanbaalenii PYR-1 | Mvan_4620 | - | 8e-13 | 36.84% (133) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2765|M.ulcerans_Agy99 -----------MTTVP-------------------RRGFNDAVTGIWS--
MMAR_3533|M.marinum_M -----------MTTVP-------------------RRGFNDAVTGIWS--
MAV_2111|M.avium_104 -----------MTAPQ-------------------RRGLNDVVTRMWS--
MAB_4613|M.abscessus_ATCC_1997 -----------MTTADGLHSGDP--------SPVHRRAFNDQVTRFWG--
Mb3374|M.bovis_AF2122/97 -----------MTCSR------------------------RDMSLSFG--
Rv3342|M.tuberculosis_H37Rv -----------MTCSR------------------------RDMSLSFG--
Mflv_4877|M.gilvum_PYR-GCK -----------MTAES------------------------DRRSLSFG--
TH_1968|M.thermoresistible__bu --------------------------------------------LSFG--
MSMEG_0098|M.smegmatis_MC2_155 MDTALRRAMDLLIDPPAEPDFSKGYLDLLGRGDSTAPKNTGLIQKAWAS-
Mvan_4620|M.vanbaalenii_PYR-1 ----------------------------------------------MS--
MLBr_00130|M.leprae_Br4923 ---MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDEIMFINWAYE
.
MUL_2765|M.ulcerans_Agy99 ---LLAPAYDLAILQQWVYRPPHDEVLAQLRAHKSRRIADIACGTGILSA
MMAR_3533|M.marinum_M ---LLAPAYDLAILQQWVYRPPHDEVLAQLRAHNSRRIADIACGTGILSD
MAV_2111|M.avium_104 ---FLAPAYDLPFLQQWVYRPPHNEVIAQLRNHGSRRIADIACGTGILSE
MAB_4613|M.abscessus_ATCC_1997 ---RAARAYDWAPLQQWVYRPAQDEMLAQLRQHKSQRIVDIACGTGILAT
Mb3374|M.bovis_AF2122/97 ---SAVGAYERGRPS---YPPEAIDWLLPAAARR---VLDLGAGTGKLTT
Rv3342|M.tuberculosis_H37Rv ---SAVGAYERGRPS---YPPEAIDWLLPAAARR---VLDLGAGTGKLTT
Mflv_4877|M.gilvum_PYR-GCK ---AEAAAYERGRPS---YPPEAIDWLLADSGSRRLEVLDLGAGTGKLTT
TH_1968|M.thermoresistible__bu ---AEAAAYERGRPS---YPPEAIDWLLP-SDAR--DVLDLGAGTGKLTT
MSMEG_0098|M.smegmatis_MC2_155 --PLGSKLYDRAQLLNRRLVASTRPPVEWLRIPPGGTVLDIGCGPGNITA
Mvan_4620|M.vanbaalenii_PYR-1 ---FVVASEAYGRFMGRYAEPLAEAFVAFAGVGVGDKVLDVGCGPGALTA
MLBr_00130|M.leprae_Br4923 EDPPMALPLEASDEPNRAHINLYHRTATQVNLSG-KRILEVSCGHGGGAS
: ::..* * :
MUL_2765|M.ulcerans_Agy99 RIERELHPDEIYG-VDMSHGMLDQARAKSD--RVRWLRGPAEQLPFDDGA
MMAR_3533|M.marinum_M RIERELHPDEIYG-VDMSHGMLDQARAKSD--RVRWLRGPAEQLPFDDGA
MAV_2111|M.avium_104 RIQRELNPDEIYG-VDMSDGMLNQARAKSD--RVQWLRAPAEQLPFDDGA
MAB_4613|M.abscessus_ATCC_1997 RIQDELEPEQVHG-VDMSEGMLAQAKARSS--LVNWQFAPAEKLPFDDGA
Mb3374|M.bovis_AF2122/97 RLVERG--LDVVA-VDPIPEMLDVLRAALP--QTVALLGTAEEIPLDDNS
Rv3342|M.tuberculosis_H37Rv RLVERG--LDVVA-VDPIPEMLDVLRAALP--QTVALLGTAEEIPLDDNS
Mflv_4877|M.gilvum_PYR-GCK RLVERG--LDVVA-VDPIPEMLDLLRTSLP--DTPALLGTAEEIPLPDDS
TH_1968|M.thermoresistible__bu RLVERG--LNVTA-VDPIPEMLELLSKSLP--DTPALLGTAEEIPLPDNS
MSMEG_0098|M.smegmatis_MC2_155 QLARAAGLDGLALGVDISEPMLARAVAAEAGRQVGFVRADAQQLPFRDEV
Mvan_4620|M.vanbaalenii_PYR-1 RLRSVG--ADIAA-IDPSPPFIDAIRRSFP--DVDVRQGPAEELPYDSAA
MLBr_00130|M.leprae_Br4923 YLTRALHPASYTG-LDLNPAGIKLCQKRHQLPGLEFVRGDAENLPFDNES
: :* : . *:::* .
MUL_2765|M.ulcerans_Agy99 LDAVVTITAFHFF-DQPAALREFHRVLAPGGLVAVSSLS-----------
MMAR_3533|M.marinum_M LDAVVTTTAFHFF-DQPAALREFHRVLAPGGLVAVSSLS-----------
MAV_2111|M.avium_104 LDAVVTTSAFHFF-DQPAALREFHRVLAPGGLVAVSALS-----------
MAB_4613|M.abscessus_ATCC_1997 LDAVVSTSAFHFF-DQPAALTEFHRVLTPGGFAAITTFTPDR--------
Mb3374|M.bovis_AF2122/97 VDAVLVAQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDERLGWVREL
Rv3342|M.tuberculosis_H37Rv VDAVLVAQAWHWV-DPARAIPEVARVLRPGGRLGLVWNTRDERLGWVREL
Mflv_4877|M.gilvum_PYR-GCK VDAVLVAQAWHWF-DETRAVKEIARVLRPGGSLGLVWNNRDERLGWVKDL
TH_1968|M.thermoresistible__bu VDAVLVAQAWHWF-DVDRAVREVARVLRPGGRLGLVWNTRDERMGWVKEL
MSMEG_0098|M.smegmatis_MC2_155 FDAATSLAVFQLIPDPVAAVSEIVRVLKPGGRVAIMVPT-----------
Mvan_4620|M.vanbaalenii_PYR-1 FDAALAQLVVHFMTDPVAGLRQMSRVTRPGGVVAACVWDGPTG-------
MLBr_00130|M.leprae_Br4923 FDVVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRP----------
.*.. . : . : :. ** *** .
MUL_2765|M.ulcerans_Agy99 ---------------ARQPLLQLPAASKWKPQHSPSPAEMRALFEGAGFT
MMAR_3533|M.marinum_M ---------------ARQPLLQLPAASKWKPQHSPSPAEMRALFEGAGFT
MAV_2111|M.avium_104 ---------------TRRPLLQASADSRWKPQHNASAPEMRKLFEDAGFV
MAB_4613|M.abscessus_ATCC_1997 ---------------TSAPILRRVFGDR-IPASVPSKAEMRLMFETAGFE
Mb3374|M.bovis_AF2122/97 GEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASRSYC
Rv3342|M.tuberculosis_H37Rv GEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASRSYC
Mflv_4877|M.gilvum_PYR-GCK GDIIGHEGDPWSQSVELPAPFTGVERHHVEWTSYLTPQALIDLVASRSYC
TH_1968|M.thermoresistible__bu GRIIGDEHDPLSKTVTLPEPFTDVQRHQVEWTNYLTPQALIDLVASRSYC
MSMEG_0098|M.smegmatis_MC2_155 -----------------AGAVKPVTFLARGGARIFGDDELGDIFENVGLV
Mvan_4620|M.vanbaalenii_PYR-1 ----------ALAPFWDAVHVVDPEAEDEALLSGARSGHLTELFEAAGLR
MLBr_00130|M.leprae_Br4923 ---------------SNKVGEWEVDFANSRLQQLSQREINAEVLRGIASN
:. .
MUL_2765|M.ulcerans_Agy99 ISDQHRVRRPVWTRLVP-------------------------DLITVGTK
MMAR_3533|M.marinum_M ISDQHRVRRPVWTRLVP-------------------------DLITVGAK
MAV_2111|M.avium_104 IGDQYRIPRPAWTRLVS-------------------------DLLTVGTK
MAB_4613|M.abscessus_ATCC_1997 VTVQRPVHHPFTLPFIEF------------------------DRLTVGIK
Mb3374|M.bovis_AF2122/97 ITSPAQVRTKTLDRVRQLLATHPAL---------ANSNGLALPYVTVCVR
Rv3342|M.tuberculosis_H37Rv ITSPAQVRTKTLDRVRQLLATHPAL---------ANSNGLALPYVTVCVR
Mflv_4877|M.gilvum_PYR-GCK ITSPERVRARTLDRVRELLTTHPAL---------ANSSGLALPYVTVCVR
TH_1968|M.thermoresistible__bu ITSPAKVRARTLERVRELLATHPAL---------ANNSGLALPYITVCIR
MSMEG_0098|M.smegmatis_MC2_155 G---VRVKTHGFIQWVR------------------------------GTK
Mvan_4620|M.vanbaalenii_PYR-1 DVVEDSIAVDVVHPTFEQWWEPYTYGVGPAGDYVQQLDDEGRARLESAAR
MLBr_00130|M.leprae_Br4923 SQKSRDLVDRHLPAFLRFAGREFIG-----------VQGTQLSRYLEGGE
: .
MUL_2765|M.ulcerans_Agy99 S--------------------
MMAR_3533|M.marinum_M S--------------------
MAV_2111|M.avium_104 RD-------------------
MAB_4613|M.abscessus_ATCC_1997 R--------------------
Mb3374|M.bovis_AF2122/97 ATLA-----------------
Rv3342|M.tuberculosis_H37Rv ATLA-----------------
Mflv_4877|M.gilvum_PYR-GCK ATLA-----------------
TH_1968|M.thermoresistible__bu ATLA-----------------
MSMEG_0098|M.smegmatis_MC2_155 L--------------------
Mvan_4620|M.vanbaalenii_PYR-1 ERLGKGPFTVTAVAWAARGTA
MLBr_00130|M.leprae_Br4923 LSYRMYSFAKD----------