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MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDEIVFINWAYEEDPPMDLPLEASDEPNRAHINLY HRTATQVDLGGKQVLEVSCGHGGGASYLTRTLHPASYTGLDLNQAGIKLCKKRHRLPGLDFVRGDAENLP FDDESFDVVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPNNEIAAWEADLAATPLRQLSQRQIN AEVLRGIGNNSQKSRDLVDRHLPAFLRFAGREFIGVQGTQLSRYLEGGELSYRMYCFTKD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2952 | - | - | 100% (270) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. tuberculosis H37Rv | Rv1523 | - | 2e-79 | 59.76% (251) | methyltransferase |
| M. tuberculosis H37Rv | Rv3038c | - | 2e-09 | 34.65% (101) | hypothetical protein Rv3038c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2976 | - | 1e-161 | 100.00% (270) | methyltransferase (methylase) |
| M. gilvum PYR-GCK | Mflv_2768 | - | 3e-09 | 28.83% (111) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_00130 | - | 1e-136 | 83.70% (270) | hypothetical protein MLBr_00130 |
| M. abscessus ATCC 19977 | MAB_4103c | - | 2e-77 | 57.20% (250) | methyltransferase |
| M. marinum M | MMAR_3170 | - | 1e-130 | 82.59% (270) | methyltransferase |
| M. avium 104 | MAV_3903 | - | 3e-09 | 31.43% (140) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0393 | - | 1e-74 | 55.95% (252) | Fmt protein |
| M. thermoresistible (build 8) | TH_1636 | - | 7e-80 | 59.35% (246) | POSSIBLE METHYLTRANSFERASE (METHYLASE) |
| M. ulcerans Agy99 | MUL_2377 | - | 1e-130 | 82.22% (270) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_0109 | - | 8e-11 | 36.46% (96) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2952|M.tuberculosis_H37Rv --------------------------------------------------
Mb2976|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00130|M.leprae_Br4923 --------------------------------------------------
MMAR_3170|M.marinum_M --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_0393|M.smegmatis_MC2_155 --------------------------------------------------
TH_1636|M.thermoresistible__bu --------------------------------------------------
MAB_4103c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3903|M.avium_104 --------------------------------------------------
Mflv_2768|M.gilvum_PYR-GCK MTTLAENSAPSSETTEEFAQRIVGALDAASLALLVSIGHQTHLFDTMANL
Rv2952|M.tuberculosis_H37Rv ---------MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDE-IV
Mb2976|M.bovis_AF2122/97 ---------MAFSRTHSLLARAGSTSTYKRVWRYWYPLMTRGLGNDE-IV
MLBr_00130|M.leprae_Br4923 ---------MAFTRIHSFLASAGNTSMYKRVWRFWYPLMTHKLGTDE-IM
MMAR_3170|M.marinum_M ---------MAFSPAHRLLARMGSTSIYKRVWRYWYPLMTRGLGADK-IA
MUL_2377|M.ulcerans_Agy99 ---------MAFSPAHRLLARLGSTSIYKRVWRYWYPLMTRGLGADK-IA
MSMEG_0393|M.smegmatis_MC2_155 ------------MEARDRVAWRLNIKVAQQAQKLVYRYATRRLKDDD-VV
TH_1636|M.thermoresistible__bu -----------VRESRDQVFRKLNEKLTQHGQKFIYSYASRRLDDDD-VV
MAB_4103c|M.abscessus_ATCC_199 -----------MQRSRDWVMFKLNAVFTQRVQKFIYRHATRKLETED-VV
Mvan_0109|M.vanbaalenii_PYR-1 ---------MTHTVLRMTERLLIDPPEHPDTSKGYLDLLGDEPDSNRGAI
MAV_3903|M.avium_104 ------------------MTRSTDAVPTPHATAEQVEAARHDSKLAQVLY
Mflv_2768|M.gilvum_PYR-GCK PPSTSTQIADAAGLNERYVREWLGGVAAGRIVDYDPAAQTFSLPAHRAAV
.
Rv2952|M.tuberculosis_H37Rv FINWAYEEDPPMDLPLEA-SDEPNRAHINLYHRTATQVDLG---------
Mb2976|M.bovis_AF2122/97 FINWAYEEDPPMDLPLEA-SDEPNRAHINLYHRTATQVDLG---------
MLBr_00130|M.leprae_Br4923 FINWAYEEDPPMALPLEA-SDEPNRAHINLYHRTATQVNLS---------
MMAR_3170|M.marinum_M FLNWAYEEDPPIDLTLEV-SDEPNRDHINMYHRTATHVELS---------
MUL_2377|M.ulcerans_Agy99 FLNWAYEEDPPIDLTLEV-SDEPNRDHINMYHRTATHVELS---------
MSMEG_0393|M.smegmatis_MC2_155 FLNYGYEEDPPMGIPLSE-SDELNRYSIQLYHSTAAQADVE---------
TH_1636|M.thermoresistible__bu FLNYGYEEDPPMGLPLSE-TDEPNRYSIQLYHRTAGQADLT---------
MAB_4103c|M.abscessus_ATCC_199 FLNYGYEEEPAMGVPLSA-SDEPDRYSIQLYHSTATQADLG---------
Mvan_0109|M.vanbaalenii_PYR-1 QALWASRLG---SMFYDN-AQTLARRLMTAWQQPTEWLNVPV--------
MAV_3903|M.avium_104 HDWEAETYDEKWSISYDQRCIDYARGRFDAIVPEHVLRELP---------
Mflv_2768|M.gilvum_PYR-GCK LTRTAGPDNLARVTQFIPLLSEVEQKVIACFRDGGGLSYAEYPRFHTLMA
. : :
Rv2952|M.tuberculosis_H37Rv ----------------------------GKQVLEVSCGHGGGASYLTRTL
Mb2976|M.bovis_AF2122/97 ----------------------------GKQVLEVSCGHGGGASYLTRTL
MLBr_00130|M.leprae_Br4923 ----------------------------GKRILEVSCGHGGGASYLTRAL
MMAR_3170|M.marinum_M ----------------------------GKRVLEVSCGHGGGASYLTRTL
MUL_2377|M.ulcerans_Agy99 ----------------------------GKRVLEVSCGHGGGASYLTRTL
MSMEG_0393|M.smegmatis_MC2_155 ----------------------------GKRVLEVGCGHGGGASYLARTF
TH_1636|M.thermoresistible__bu ----------------------------GKRVLEVGCGHGGGASYLMRTL
MAB_4103c|M.abscessus_ATCC_199 ----------------------------GQRVLEVGCGHGGGASYLVRAL
Mvan_0109|M.vanbaalenii_PYR-1 ----------------------------GGTALDVGSGPGNVTGALGRAV
MAV_3903|M.avium_104 ----------------------------YDRALELGCGTG---FFLLNLI
Mflv_2768|M.gilvum_PYR-GCK EQSGEVFDAALVDGILPMAEGLTDRLRQGVDVADFGCGSGHAVNVMAKAF
:...* * : . .
Rv2952|M.tuberculosis_H37Rv HP-ASYTG--LDLNQAGIKLCKKRHRLPGLDFVR--GDAENLPFDDESFD
Mb2976|M.bovis_AF2122/97 HP-ASYTG--LDLNQAGIKLCKKRHRLPGLDFVR--GDAENLPFDDESFD
MLBr_00130|M.leprae_Br4923 HP-ASYTG--LDLNPAGIKLCQKRHQLPGLEFVR--GDAENLPFDNESFD
MMAR_3170|M.marinum_M HP-ASYTG--LDLNRAGIKLCQRRHNLPGLDFVR--GDAENLPFEDESFD
MUL_2377|M.ulcerans_Agy99 HP-ASYTG--LDLNRAGIKLCQRRHNLPGLDFVR--GDAENLPFEDESFD
MSMEG_0393|M.smegmatis_MC2_155 RP-ATYTG--LDLNSDGINFCRRRHNIAGLEFVQ--GDAQDLPFPDKNFD
TH_1636|M.thermoresistible__bu GP-MSYVG--LDLNPAGIEFCRKKHRLPGLEFVV--GDAQDLPFGAESFD
MAB_4103c|M.abscessus_ATCC_199 QP-ASYTG--LDLNPDGISFCRRRHDLPGLEFVQ--GDAEDLPFPDESFD
Mvan_0109|M.vanbaalenii_PYR-1 GPGGLALG--VDISEPMLARAVRAEAGPNVGFIR--ADAQHLPFRDESFD
MAV_3903|M.avium_104 QSGVARRGSVTDLSPGMVKVATRNGQSLGLDIDGRVADAEGIPYEDDTFD
Mflv_2768|M.gilvum_PYR-GCK PA-SRFTG--IDFSEEGLAAGRDEARRLGLTNASFNATDVATYDAAESFD
. * *:. : .: . ..**
Rv2952|M.tuberculosis_H37Rv VVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPNN--------EI
Mb2976|M.bovis_AF2122/97 VVLNVEASHCYPHFRRFLAEVVRVLRPGGYFPYADLRPNN--------EI
MLBr_00130|M.leprae_Br4923 VVINIEASHCYPHFPRFLAEVVRVLRPGGHLAYADLRPSN--------KV
MMAR_3170|M.marinum_M VVLNVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPSN--------EI
MUL_2377|M.ulcerans_Agy99 VVLKVEASHCYPHFSRFLAEVVRVLRPGGYLLYTDLRPSN--------EI
MSMEG_0393|M.smegmatis_MC2_155 AVLNVESSHLYPRFDVFLTEVARVLRPGGYFLYTDARPRY--------DI
TH_1636|M.thermoresistible__bu AVINIESSHLYPRFSRFLSEVARVLRPGGHFLYADARQPH--------EF
MAB_4103c|M.abscessus_ATCC_199 AVINVESSHLYPHFPVFLTEVARVLRPGGNFLYTDARSVQ--------DV
Mvan_0109|M.vanbaalenii_PYR-1 AVVSIAMLQLIPDPAVALAEMVRVLRPGRRMAVMVP--------------
MAV_3903|M.avium_104 LVVGHAVLHHIPDVELSLREVIRVLRPGGRFVFAGEPTSAGDVYARELST
Mflv_2768|M.gilvum_PYR-GCK VITAFDAIHDQAHPARVLANIHAALRPGGTFLMVDIKSSS----------
: : . * :: .**** :
Rv2952|M.tuberculosis_H37Rv AAWEADLAATPLRQLS-QRQINAEVLRGIGNNSQKSRDLVDRHLPAFLRF
Mb2976|M.bovis_AF2122/97 AAWEADLAATPLRQLS-QRQINAEVLRGIGNNSQKSRDLVDRHLPAFLRF
MLBr_00130|M.leprae_Br4923 GEWEVDFANSRLQQLS-QREINAEVLRGIASNSQKSRDLVDRHLPAFLRF
MMAR_3170|M.marinum_M AEWEADLAGSPLRQLS-QREINAEVVRGIEKNSHTSRVLVDRNLPAFLRF
MUL_2377|M.ulcerans_Agy99 AEWEADLAGSPLRQLS-QREINAEVVRGIEKNSHTSRVLVDRNLPAFLRF
MSMEG_0393|M.smegmatis_MC2_155 PEWERALADAPLQMLS-QRAINFEVVRGMEKNLDALESVVDRVAPALLRD
TH_1636|M.thermoresistible__bu AEWEAALAAAPLDMVS-ARVINAEVVRGMEQILPVWEDVIERVAPAFLRR
MAB_4103c|M.abscessus_ATCC_199 AGWKVALANAPLRMVS-ERGINAEVRRGMEKNLARWRYVIDRATPAPLRG
Mvan_0109|M.vanbaalenii_PYR-1 ---TAGPAAGLLRYLP-NAGAHAFGDDELGDTFES---------------
MAV_3903|M.avium_104 LTWRIATNVTKLPGLGSWRRPQAELDESSRAAALEAIVDLHTFTPGDLER
Mflv_2768|M.gilvum_PYR-GCK -RLENNIGVPFAPYLYTVSAMHCMSVS-LGLDGDGLGTCWGREVATTMLA
: :
Rv2952|M.tuberculosis_H37Rv AGREFIGVQGTQLSRYLEGGELSYRMYCFTKD------------------
Mb2976|M.bovis_AF2122/97 AGREFIGVQGTQLSRYLEGGELSYRMYCFTKD------------------
MLBr_00130|M.leprae_Br4923 AGREFIGVQGTQLSRYLEGGELSYRMYSFAKD------------------
MMAR_3170|M.marinum_M ADR----AVGRQLSRYLEGGELSYRMYCFTKDFAASR-------------
MUL_2377|M.ulcerans_Agy99 ADR----AVGRQLSRYLEGGELSYRMYCFTKDFAASR-------------
MSMEG_0393|M.smegmatis_MC2_155 WIQKY-GPARRAYEELR-ENTTEYRMYCFVKPAE----------------
TH_1636|M.thermoresistible__bu RVREF-APARRAWEELRTEGSTEYRMYCFTKPPEHADIP-----------
MAB_4103c|M.abscessus_ATCC_199 IVRRF-APAQRAYDDLRAGGSVEYRMYRFVKA------------------
Mvan_0109|M.vanbaalenii_PYR-1 --------LGLAGVRINTVGTIQWVRGRKS--------------------
MAV_3903|M.avium_104 MAANAGATEVRTVSEEFTAAMFGWPVRTFEASVPPGRLGWGWAKFAFNGW
Mflv_2768|M.gilvum_PYR-GCK DAG-----FGDVQVREIESDPINYYYIARK--------------------
:
Rv2952|M.tuberculosis_H37Rv -------------------------------
Mb2976|M.bovis_AF2122/97 -------------------------------
MLBr_00130|M.leprae_Br4923 -------------------------------
MMAR_3170|M.marinum_M -------------------------------
MUL_2377|M.ulcerans_Agy99 -------------------------------
MSMEG_0393|M.smegmatis_MC2_155 -------------------------------
TH_1636|M.thermoresistible__bu -------------------------------
MAB_4103c|M.abscessus_ATCC_199 -------------------------------
Mvan_0109|M.vanbaalenii_PYR-1 -------------------------------
MAV_3903|M.avium_104 KTLSWVDANIWRRVVPKGWFYNVMVTGVKPT
Mflv_2768|M.gilvum_PYR-GCK -------------------------------