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TGPTGSEFDFDALYRGESPAEGVPPITSVPWDTKAPKENVVAWEQAGLVHGHVLDIGCGLGDNAIYLAQQ GYRVTALDISPTALITAERRAADAGVDVTFAVADATRLDGYDDVFDTVVDSGMFHCLSDDAKGSYAAAVH RATRAGATLLLGAFSDANLQHDNWQAAWVSEDTLRSSLDDGGWDITSLTTETIRVPGAALAGSGDEGGAD EFDAAFFLVQAQRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3041 | - | - | 100% (225) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2067 | - | 6e-28 | 39.88% (168) | methyltransferase type 12 |
| M. smegmatis MC2 155 | MSMEG_2539 | - | 9e-26 | 37.27% (220) | thiopurine S-methyltransferase (tpmt) superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1412c | - | 2e-74 | 63.89% (216) | putative transferase |
| M. gilvum PYR-GCK | Mflv_4471 | - | 2e-27 | 37.31% (201) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1377c | - | 2e-74 | 63.89% (216) | putative transferase |
| M. leprae Br4923 | MLBr_01723 | - | 1e-06 | 34.62% (78) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_0868c | - | 5e-40 | 41.75% (206) | hypothetical protein MAB_0868c |
| M. marinum M | MMAR_2193 | - | 3e-71 | 62.96% (216) | NodS-like (sam)-dependent methyltransferase |
| M. avium 104 | MAV_3570 | - | 1e-30 | 37.50% (208) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_1722 | - | 8e-26 | 32.19% (233) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3309 | - | 4e-30 | 40.91% (198) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | 5e-31 | 39.46% (185) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1412c|M.bovis_AF2122/97 ----------------MPG-----IDFDALYRGESPGEGLPPITTPPWDT
Rv1377c|M.tuberculosis_H37Rv ----------------MPG-----IDFDALYRGESPGEGLPPITTPPWDT
MMAR_2193|M.marinum_M ------------------------MDFDALYRGESPRPGVAPMTTPPWDT
MSMEG_3041|M.smegmatis_MC2_155 ----------------MTGPTGSEFDFDALYRGESPAEGVPPITSVPWDT
MAV_3570|M.avium_104 -----------MTASFDPADPAR---FEEMYRDQRTSHGLPAA--TPWDI
MUL_3309|M.ulcerans_Agy99 -----------MTAP-DPTDPTR---FEEMYRDQRVAHGLPAA--TPWDI
MAB_0868c|M.abscessus_ATCC_199 -----------MTASTQPPDVPSQETFEAVYNGKPMFEGAPAAG-VPWDI
Mflv_4471|M.gilvum_PYR-GCK ---------------MDMDQTPTLSRFDDFYKDED--------KTPPWVI
Mvan_1888|M.vanbaalenii_PYR-1 -----------------MDLTPRLSRFDEFYKN----------QTPPWVI
TH_1722|M.thermoresistible__bu ----------MATEDPGTGDPTDTIDWDSVYRQEAPGFDGP----PPWNI
MLBr_01723|M.leprae_Br4923 MTRSTEISANAVPNPHATAEQVAAARKDSKLAQVLYHDWEAENYDEKWSI
: *
Mb1412c|M.bovis_AF2122/97 KAPK-----------DNVIGWHTGGWVHGDVLDIGCGLGDNAIYLARNGY
Rv1377c|M.tuberculosis_H37Rv KAPK-----------DNVIGWHTGGWVHGDVLDIGCGLGDNAIYLARNGY
MMAR_2193|M.marinum_M KAPK-----------ENVIAWQAGGWVHGDVLDIGCGLGDNAIYLAAHGH
MSMEG_3041|M.smegmatis_MC2_155 KAPK-----------ENVVAWEQAGLVHGHVLDIGCGLGDNAIYLAQQGY
MAV_3570|M.avium_104 GGPQ-----------PVVRQLVALGAVKGEVLDPGTGPGHHAIYYASQGF
MUL_3309|M.ulcerans_Agy99 GGPQ-----------PVVEQLVALGAVKGEVLDPGTGPGHHAIYYASKGY
MAB_0868c|M.abscessus_ATCC_199 RDAQ-----------PRIKELAAYGALRGAILDIGCGLGENSIYLTQQGL
Mflv_4471|M.gilvum_PYR-GCK GEPQ-----------PAVVDIERAGLITGRVLDVGCGTGERTILLTAAGY
Mvan_1888|M.vanbaalenii_PYR-1 GEPQ-----------QAIVELEQAGLIGGRVLDVGCGTGEHTILLARAGY
TH_1722|M.thermoresistible__bu GEPQ-----------PELAALHRAGAFRSDVLDAGCGHAEISMALAADGY
MLBr_01723|M.leprae_Br4923 SYDQRCVDYVRHCFDAIVPDELFTELPYDCALELGCGTGFFLLNLIQSGV
: : . *: * * . : *
Mb1412c|M.bovis_AF2122/97 QVTG--LDISPTALTTAKRRASDAGVDVK-FAVGDATKLTGYTGAFDTVI
Rv1377c|M.tuberculosis_H37Rv QVTG--LDISPTALTTAKRRASDAGVDVK-FAVGDATKLTGYTGAFDTVI
MMAR_2193|M.marinum_M PVTG--LDISPTALITAARRADDAGVHVT-FAVADATKLDGYTDAFDTVI
MSMEG_3041|M.smegmatis_MC2_155 RVTA--LDISPTALITAERRAADAGVDVT-FAVADATRLDGYDDVFDTVV
MAV_3570|M.avium_104 SATG--IDGSAAAIERARANARTAGVSVN-FELADATKLDGFDGRFDTVV
MUL_3309|M.ulcerans_Agy99 SATG--IDGSATAIERARDNAAKAGVSVN-FQVADATRLEGLDNRFDTVV
MAB_0868c|M.abscessus_ATCC_199 SVTG--LDFSPSAIEQAKQRAAAAGVTVD-LHVADATKLDGWDAQFDTVI
Mflv_4471|M.gilvum_PYR-GCK DVLG--VDGAPSAVEQARHNAKTRVVDAR-FDVADALDLG-DEPAYDTII
Mvan_1888|M.vanbaalenii_PYR-1 DVLG--IDGAPTAVEQARRNAEAQGVDAR-FELADALHLG-PDPTYDTIV
TH_1722|M.thermoresistible__bu TVVG--IDLSPTAIAAANRTAQERGLATASFVQGDITDFGGYDGRFNTII
MLBr_01723|M.leprae_Br4923 ARRGSVTDLSPGMVKIATRNGQSLGLDIN-GRVADAEGIPYDDNTFDLVV
. * :. : * . : .* : :: ::
Mb1412c|M.bovis_AF2122/97 DCGMFHCLDDDG--KRSYAASVHR--------ATRPGATLLLSCFSNAMP
Rv1377c|M.tuberculosis_H37Rv DCGMFHCLDDDG--KRSYAASVHR--------ATRPGATLLLSCFSNAMP
MMAR_2193|M.marinum_M DSGMFHCLDDEG--KRSYAAAVHR--------ATRPGATLLMSCFCDANP
MSMEG_3041|M.smegmatis_MC2_155 DSGMFHCLSDDA--KGSYAAAVHR--------ATRAGATLLLGAFSDANL
MAV_3570|M.avium_104 DCAFYHVFATEPELRSSYARALHR--------ATKPGARLYMFEFGEHDV
MUL_3309|M.ulcerans_Agy99 DCAFYHTFGTAPELQRSYVQALWR--------ATKPGARLYMYEFGAHQV
MAB_0868c|M.abscessus_ATCC_199 DSAVYHCFDHEG--HRQYASALHR--------ATRPGARWFIACFGDGSV
Mflv_4471|M.gilvum_PYR-GCK DSALFHIFDDAD--REKYVRSLGR--------ATAPGSVVHLLALSDTG-
Mvan_1888|M.vanbaalenii_PYR-1 DSALFHIFDDAD--RATYVRSLHA--------ATRPGSVVHLLALSDSG-
TH_1722|M.thermoresistible__bu DSTLFHSIPVQA--RDGYLRSIHR--------AAAPGARYFALVFAKGAF
MLBr_01723|M.leprae_Br4923 GHAVLHHIPDVELSLREVLRVLKPGGRFVFAGEPTDVGNRYARVFADLTW
. . * : : . . :
Mb1412c|M.bovis_AF2122/97 PDEEWPRS-----------TVSEQTLRDVLGGAGWDIESLEPATVR---R
Rv1377c|M.tuberculosis_H37Rv PDEEWPRS-----------TVSEQTLRDVLGGAGWDIESLEPATVR---R
MMAR_2193|M.marinum_M PNEQQPRP-----------AVPEQTLRDVLGGAGWEIAALDPVTVN---R
MSMEG_3041|M.smegmatis_MC2_155 QHDNWQAA-----------WVSEDTLRSSLDDGGWDITSLTTETIRVPGA
MAV_3570|M.avium_104 NGFKMMRS-----------LSE-NDFRDVLPAAGWEISYLGPTTYQVNLS
MUL_3309|M.ulcerans_Agy99 NGLTAIRS-----------LPE-ENFREMLPLGGWEITYLGPTTYRTTVS
MAB_0868c|M.abscessus_ATCC_199 NGITMPFG-----------VQDPDEIKSVLSEARWNIQYFGRTTYLGSRA
Mflv_4471|M.gilvum_PYR-GCK ---RGFGP-----------EVSEETIRAAFADPGWDIEALTTTYYRGVIT
Mvan_1888|M.vanbaalenii_PYR-1 ---RGFGP-----------EVSEHTIRAAFG-AGWEVEALTETTYRGVVI
TH_1722|M.thermoresistible__bu PEEMEQGPGP--------NPVDEDELREAVS-KYWEIDEIRPAFIHANMP
MLBr_01723|M.leprae_Br4923 KVTIRVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMAT
. : :: :
Mb1412c|M.bovis_AF2122/97 EL-------DGTE-------------------------------------
Rv1377c|M.tuberculosis_H37Rv EL-------DGTE-------------------------------------
MMAR_2193|M.marinum_M QLGGS----DGQP-------------------------------------
MSMEG_3041|M.smegmatis_MC2_155 ALAGSGDEGGADE-------------------------------------
MAV_3570|M.avium_104 AETIQMMAARNPD----------------MADEAAKLLERFRAMEPWLQA
MUL_3309|M.ulcerans_Agy99 METLETMAARNPE----------------VADQVGPLVERFKTIQPWLTD
MAB_0868c|M.abscessus_ATCC_199 AFVGAALAGIDPEQMPADM--RERYQRPGVAEQAQQTFERLQQLD----D
Mflv_4471|M.gilvum_PYR-GCK APHADAMGLDVGT-------------------------------------
Mvan_1888|M.vanbaalenii_PYR-1 DAHTEALNLPAGT-------------------------------------
TH_1722|M.thermoresistible__bu PDVPGVESFDTDE------------------------------------K
MLBr_01723|M.leprae_Br4923 NAGAVQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKTL
Mb1412c|M.bovis_AF2122/97 --VEMAFWNVRAQRRGS-----------
Rv1377c|M.tuberculosis_H37Rv --VEMAFWNVRAQRRGS-----------
MMAR_2193|M.marinum_M --IKLAFWYVRARRQN------------
MSMEG_3041|M.smegmatis_MC2_155 --FDAAFFLVQAQRR-------------
MAV_3570|M.avium_104 GRVHAPFWEVHATRVD------------
MUL_3309|M.ulcerans_Agy99 GIAHVPFWEVHATRPD------------
MAB_0868c|M.abscessus_ATCC_199 DMIHMPFFNIVAERG-------------
Mflv_4471|M.gilvum_PYR-GCK -VVDEPAWLARIRRL-------------
Mvan_1888|M.vanbaalenii_PYR-1 -VVDEPAWSARIRRL-------------
TH_1722|M.thermoresistible__bu GRTKLPAFLLSAHKA-------------
MLBr_01723|M.leprae_Br4923 SWVDANVWRRVIPKSWFYNIIITGVKPS
. : :