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VARVAESDRRRWDRRYASLGPAAVSAVRPPALLQAHLKLVPAAGRALDLGCGQGLGAVWLARRGLDVLGL DISPVAIAQARDLAERSGVSARCRFDVVDLDDGLPDGPPVDLIVCHNFRDRRLDAAIIERLAPGGLVALV ALSEVGAAAGTYRAAPGELSTAFAELDPIAAGEGDGRAWLLARA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3115 | - | - | 100% (184) | methyltransferase |
| M. ulcerans Agy99 | MUL_4684 | - | 1e-07 | 38.46% (104) | hypothetical protein MUL_4684 |
| M. ulcerans Agy99 | MUL_0662 | - | 1e-06 | 45.76% (59) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3351c | - | 1e-10 | 30.64% (173) | methyltransferase |
| M. gilvum PYR-GCK | Mflv_3243 | - | 1e-52 | 55.56% (180) | methyltransferase type 12 |
| M. tuberculosis H37Rv | Rv3322c | - | 2e-10 | 30.64% (173) | methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1977 | - | 3e-11 | 42.45% (106) | putative methyltransferase |
| M. marinum M | MMAR_2640 | - | 1e-98 | 96.74% (184) | methyltransferase |
| M. avium 104 | MAV_2957 | - | 1e-70 | 69.61% (181) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4544 | - | 3e-54 | 56.91% (188) | methyltransferase small subunit |
| M. thermoresistible (build 8) | TH_2727 | - | 5e-30 | 59.43% (106) | PUTATIVE thiopurine S-methyltransferase (tpmt) superfamily |
| M. vanbaalenii PYR-1 | Mvan_2956 | - | 9e-52 | 56.50% (177) | methyltransferase type 12 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3351c|M.bovis_AF2122/97 ----------------------------------MSVQTDPALREHPNRV
Rv3322c|M.tuberculosis_H37Rv ----------------------------------MSVQTDPALREHPNRV
MUL_3115|M.ulcerans_Agy99 ---------------------------------MARVAE-------SDRR
MMAR_2640|M.marinum_M MSRTAERADRLSIRYPVCSPTAQVRRSCRGRRMVARVAE-------SDRR
MAV_2957|M.avium_104 ------------------------------------MGE-------ADRH
TH_2727|M.thermoresistible__bu --------------------------------------------------
Mflv_3243|M.gilvum_PYR-GCK ------------------------------------MAD-------ADRE
Mvan_2956|M.vanbaalenii_PYR-1 ------------------------------------MPATSYSRLMTDRG
MSMEG_4544|M.smegmatis_MC2_155 ------------------------------------MSE-------HDRA
MAB_1977|M.abscessus_ATCC_1997 -----------------------------------MDPAEHARHTRDVYD
Mb3351c|M.bovis_AF2122/97 DWNARYERAG----SAHAPFAPVPWLADVLRAGVPDGPVLELASGRSGTA
Rv3322c|M.tuberculosis_H37Rv DWNARYERAG----SAHAPFAPVPWLADVLRAGVPDGPVLELASGRSGTA
MUL_3115|M.ulcerans_Agy99 RWDRRYASL---GPAAVSAVRPPALLQAHLKLVPAAGRALDLGCGQGLGA
MMAR_2640|M.marinum_M RWDRRYASL---GPAAVSAARPPALLQAHLKLVPTAGRALDLGCGQGLGA
MAV_2957|M.avium_104 RWDERYAAN---GPPPLSSVAPPGVFARHADVFPAAGRALDLACGQGTAA
TH_2727|M.thermoresistible__bu --------------------------------------------------
Mflv_3243|M.gilvum_PYR-GCK HWDRRYTAR---DRTLAGHAALPAVFASHSDLFPTAGYAIELACGTGAAA
Mvan_2956|M.vanbaalenii_PYR-1 HWDRRYTAR---GSLSVDDVALPARFTPFADVFPTGGRAVELACGAGAAS
MSMEG_4544|M.smegmatis_MC2_155 RWDAAYTDRPLGAGLPDGPAGPPRAFAGHVDEFPTAGSALDVACGSGENS
MAB_1977|M.abscessus_ATCC_1997 RLAPVWSATT--DDGPFNGLLERPALRSLIPRPLAGRSVLDAGCGSGAQC
Mb3351c|M.bovis_AF2122/97 LALAAHGRQVTAIDVSDVALLQLDSEAVRRGVADRLNLVQADLGCWEPGE
Rv3322c|M.tuberculosis_H37Rv LALAAHGRQVTAIDVSDVALLQLDSEAVRRGVADRLNLVQADLGCWEPGE
MUL_3115|M.ulcerans_Agy99 VWLARRGLDVLGLDISPVAIAQARDLAERSGVSARCRFDVVDLDDGLPDG
MMAR_2640|M.marinum_M VWLARRGLDVLGLDISPVAIAQARDLAERSGVSARCCFDVVDLDDGLPDG
MAV_2957|M.avium_104 VWLALRGLRVLGLDVSPVAIGQARDLARRAGVGERCRFDVADLDRGLPVG
TH_2727|M.thermoresistible__bu -------MDVLGVDVSPIAIAQARALAAANGVSNRCRFEVFDLDDGLPAG
Mflv_3243|M.gilvum_PYR-GCK VWLARRGLRVWACDISPVAVAAATERARLDGQSERCTFEVVDLDHGIPGV
Mvan_2956|M.vanbaalenii_PYR-1 VWLAKRGLSVWACDASSVAIAQAEDLAERCGQAHRCRFEVVDLDAGLPAG
MSMEG_4544|M.smegmatis_MC2_155 VWLARRGLHVWGIDVSPVAITQATQFAARNGVAQRCRFDVVDLDDGLPDG
MAB_1977|M.abscessus_ATCC_1997 AWLLGEGADVTGLDLSPAMVDQARQRCG-----SAAKLMVADLADDLPLE
* . * * : . : ** *
Mb3351c|M.bovis_AF2122/97 T-RFALVLS----RLFWDAAIFHRACEAVMPGGVLAWESLALSG------
Rv3322c|M.tuberculosis_H37Rv T-RFALVLS----RLFWDAAIFHRACEAVMPGGVLAWESLALSG------
MUL_3115|M.ulcerans_Agy99 P-PVDLIVC----HNFRDRRLDAAIIERLAPGGLVALVALS---------
MMAR_2640|M.marinum_M P-PVDVIVC----HNFRDRRLDAAIIDRLAPGGLVALVALS---------
MAV_2957|M.avium_104 P-PADVIVC----CKFRDRRLDRAIVERLAPGGLLAIAVLS---------
TH_2727|M.thermoresistible__bu P-PADVILC----HLYRDPRLDRPIIERLAPGGLLAITVLS---------
Mflv_3243|M.gilvum_PYR-GCK G-PADVVLC----SMFRDPRLDAALVERLAPGGLLAVSALS---------
Mvan_2956|M.vanbaalenii_PYR-1 D-PVDVLLC----NMFRDPRLDGPIVDRLAVGGVLAISALS---------
MSMEG_4544|M.smegmatis_MC2_155 P-PVDVVLC----HRFRDPRLYEALRARLAPGGLLAICVLS---------
MAB_1977|M.abscessus_ATCC_1997 PRSFDGVTCSLALHYLRDWQVPLASFARILRPGGWVVISLDHPFGAPLPD
: . * : : * . *
Mb3351c|M.bovis_AF2122/97 -----------------AEAGTASAKRRVKPGEPACLLPADFTVVHEGQG
Rv3322c|M.tuberculosis_H37Rv -----------------AEAGTASAKRRVKPGEPACLLPADFTVVHEGQG
MUL_3115|M.ulcerans_Agy99 ------------------EVGAAAGTYRAAPGE----LSTAFAELDPIAA
MMAR_2640|M.marinum_M ------------------EVGAAAGTYRAAPGE----LSAAFAELDPIAA
MAV_2957|M.avium_104 ------------------EVGAGPGPFRAAPGE----LTAAFADLQPIAA
TH_2727|M.thermoresistible__bu ------------------EVGVGPX-------------SHTLAGPAPQAR
Mflv_3243|M.gilvum_PYR-GCK ------------------EVGAAPGRFRAGPGE----LLRAFGAVDVIEH
Mvan_2956|M.vanbaalenii_PYR-1 ------------------EVGAAPGRFRARPGE----LVAAFGSLELITH
MSMEG_4544|M.smegmatis_MC2_155 ------------------EVGAEAGRFRAPAGE----LRAHFGALQVIAE
MAB_1977|M.abscessus_ATCC_1997 QRGGYFQHQLVSDTWNKADVEVTQHFWRRPLGQ----VADAFADAGLLIE
:. . :
Mb3351c|M.bovis_AF2122/97 NCDSAPSRIMIARRSPLPGA--------------------
Rv3322c|M.tuberculosis_H37Rv NCDSAPSRIMIARRSPLPGA--------------------
MUL_3115|M.ulcerans_Agy99 GEGDGRAWLLARA---------------------------
MMAR_2640|M.marinum_M GEGDGRAWLLARA---------------------------
MAV_2957|M.avium_104 GEADGQAWLLARASQSEPMVERR-----------------
TH_2727|M.thermoresistible__bu ----SRAWPVAGNRSS------------------------
Mflv_3243|M.gilvum_PYR-GCK GEADGQAWLLGRRRGLPQRAPQAHRDPDDRPAHPDELL--
Mvan_2956|M.vanbaalenii_PYR-1 GEEAGQAWLLARRR--------------------------
MSMEG_4544|M.smegmatis_MC2_155 NERDGEAWLLAR----------------------------
MAB_1977|M.abscessus_ATCC_1997 RISEPRPSAEAIRRFPAELRNVVDSPSFIVYRLRYWGAPA
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