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TESLDLQFATAYRGESAEFGAGIRPPWSLGEPQPELATLIEQGKVHGEVLDAGCGEAALAMALAGRGHPV VGLDISPTAVELAGREAARPGLTNASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVELREGCQRSI VRAAAPGASYFVLVFDKAALSGDGPINGVTEEELRDAVSKHWVIDEIRPARIHANLPPEVPGCPPSTLAT NPRAASPSVRGCSQPIWADGTPHAVYSPANEG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0662 | - | - | 100% (243) | methyltransferase |
| M. ulcerans Agy99 | MUL_3309 | - | 1e-20 | 29.83% (238) | methyltransferase |
| M. ulcerans Agy99 | MUL_0081 | - | 4e-11 | 43.90% (82) | hypothetical protein MUL_0081 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0575c | - | 1e-76 | 68.78% (205) | benzoquinone methyltransferase |
| M. gilvum PYR-GCK | Mflv_1324 | - | 7e-52 | 53.52% (213) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0560c | - | 1e-76 | 68.78% (205) | benzoquinone methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0393 | - | 5e-70 | 66.34% (202) | methyltransferase |
| M. marinum M | MMAR_0909 | - | 1e-110 | 96.10% (205) | methyltransferase |
| M. avium 104 | MAV_0119 | - | 7e-75 | 68.69% (198) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2539 | - | 3e-70 | 66.50% (200) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_1722 | - | 1e-57 | 57.00% (207) | CONSERVED HYPOTHETICAL PROTEIN |
| M. vanbaalenii PYR-1 | Mvan_5471 | - | 3e-52 | 53.30% (212) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0662|M.ulcerans_Agy99 ----------------MTESLDLQFATAYRGESAEFGAGIRPPWSLGEPQ
MMAR_0909|M.marinum_M ----------------MTESLDLQFETAYRGESAEFGAGIRPPWSLGEPQ
MAV_0119|M.avium_104 --------------MGMSQPTHEMFEAAYRGESPEMGEGARPPWSIGEPQ
MSMEG_2539|M.smegmatis_MC2_155 ----------------MTTP-EDLFESAYRGEAPNFG-GVRPPWSIGEPQ
Mb0575c|M.bovis_AF2122/97 MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQ
Rv0560c|M.tuberculosis_H37Rv MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQ
MAB_0393|M.abscessus_ATCC_1997 -----------MTDKTATEEFDLAFDAAYRGEAPDGR-GARPPWSIGEPQ
Mflv_1324|M.gilvum_PYR-GCK ------------------MAEVMDWDSAYRGEGE-FE--GEPPWNIGEPQ
Mvan_5471|M.vanbaalenii_PYR-1 ---------------MAHMTDVMDWDSAYRGEGD-FE--GEPPWNIGEPQ
TH_1722|M.thermoresistible__bu --------MATEDPGTGDPTDTIDWDSVYRQEAPGFD--GPPPWNIGEPQ
: :.** *. ***.:****
MUL_0662|M.ulcerans_Agy99 PELATLIEQGKVHGEVLDAGCGEAALAMALAGRGHPVVGLDISPTAVELA
MMAR_0909|M.marinum_M PELATLIEQGKVHGEVLDAGCGEAALALALAGRGHPVVGLDMSPTAVELA
MAV_0119|M.avium_104 PEIAALIEAGKFHGDVLDAGCGEAAVSLYLAERGFTTVGLDQSPTAIKLA
MSMEG_2539|M.smegmatis_MC2_155 PEIRKLIDAGKFHGEVLDAGCGEAATALYLAAQGFTTVGLDQSPTAIELA
Mb0575c|M.bovis_AF2122/97 PELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELA
Rv0560c|M.tuberculosis_H37Rv PELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELA
MAB_0393|M.abscessus_ATCC_1997 PEIAMLIAEGKVRGEVLDAGCGEAATSLYLAEVGHTTVGLDSAPKAIELA
Mflv_1324|M.gilvum_PYR-GCK PELAALWRDGRFRSEVLDAGCGHAELSLALAADGYTVTGVDISPTAMAAA
Mvan_5471|M.vanbaalenii_PYR-1 PELAALWRDGKFRSEVLDAGCGHAELSLALAADGYTVTGVDLSPTAVAAA
TH_1722|M.thermoresistible__bu PELAALHRAGAFRSDVLDAGCGHAEISMALAADGYTVVGIDLSPTAIAAA
**: * * .:.:***.***.* :: ** *....*:* :* *: *
MUL_0662|M.ulcerans_Agy99 GREAARPGLTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVEL
MMAR_0909|M.marinum_M GREAARRGLTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVEL
MAV_0119|M.avium_104 REKAARRGLTS-ASFEVADISDFTGY----DGRFGTIVDSTLFHSMPVEL
MSMEG_2539|M.smegmatis_MC2_155 RAEAARRGLTN-ATFEVADISSFTGY----DGRFGTIVDSTLFHSMPVEL
Mb0575c|M.bovis_AF2122/97 RHEAAKRGLAN-ASFEVADASSFTGY----DGRFDTIVDSTLFHSMPVES
Rv0560c|M.tuberculosis_H37Rv RHEAAKRGLAN-ASFEVADASSFTGY----DGRFDTIVDSTLFHSMPVES
MAB_0393|M.abscessus_ATCC_1997 KGYAAERGLTN-ASFAVADISSFTGY----DGRFDTIIDSTLFHSMPVGL
Mflv_1324|M.gilvum_PYR-GCK SAAAAERGLSEKASFVAADITALSGF----DGRFSTVVDSTLFHSLPVES
Mvan_5471|M.vanbaalenii_PYR-1 TAASAERGLSERTSFVAADITTLTGF----DGRFATVVDSTLFHSLPVES
TH_1722|M.thermoresistible__bu NRTAQERGLAT-ASFVQGDITDFGGY----DGRFNTIIDSTLFHSIPVQA
: . **: ::* .* : : .: *** *::*******:**
MUL_0662|M.ulcerans_Agy99 REGCQRSIVRAAAPGASYFVLVFDKAALSGDGPING----VTEEELRDAV
MMAR_0909|M.marinum_M REGYQRSIVRAAAPGASYFVLVFDKAALSGDGPING----VTEEELRDAV
MAV_0119|M.avium_104 REGYQRSIVQAAAPGASYFVLVFDRNAMPAEGPVNA----VTEDELREVV
MSMEG_2539|M.smegmatis_MC2_155 RDGYQQSIVRAAAPGATYVVLVFDKTTMGDTGPANP----VTDDELRDVV
Mb0575c|M.bovis_AF2122/97 REGYLQSIVRAAAPGASYFVLVFDRAAIP-EGPINA----VTEDELRAAV
Rv0560c|M.tuberculosis_H37Rv REGYLQSIVRAAAPGASYFVLVFDRAAIP-EGPINA----VTEDELRAAV
MAB_0393|M.abscessus_ATCC_1997 RAGYQRSIVRAAAPGARYYVLVFDRAAFPAESPVNA----VTENELRDAV
Mflv_1324|M.gilvum_PYR-GCK RAGYLESVHRAARPGAGFFVLVFAKGAFPADTEQGP--NEVSEIELREAV
Mvan_5471|M.vanbaalenii_PYR-1 RDGYLQSVHRAAAPGAGYFVLVFAKGAFPAEMEGGP--NEVTELELREAV
TH_1722|M.thermoresistible__bu RDGYLRSIHRAAAPGARYFALVFAKGAFPEEMEQGPGPNPVDEDELREAV
* * .*: :** *** : .*** : :: . * : *** .*
MUL_0662|M.ulcerans_Agy99 SKHWVIDEIRPARIHANLPPEVPGCPPSTLATNPRAASPSVRGCSQPIWA
MMAR_0909|M.marinum_M SKYWVIDEIRPARIHANLPPEVSGMPAFDARDEP-EGRKSVG--------
MAV_0119|M.avium_104 GKYWVIDEIRPARIHANVPENFLAAFEAFAGADIRDEDNGRKSVG-----
MSMEG_2539|M.smegmatis_MC2_155 GRYWVIDDISPARIHANVPAEFT-DFAAFAGSDIRDEGNGRKSVA-----
Mb0575c|M.bovis_AF2122/97 SKYWIIDEIKPARLYARFPAGFA-GMPALL--DIREEPNGLQSIG-----
Rv0560c|M.tuberculosis_H37Rv SKYWIIDEIKPARLYARFPAGFA-GMPALL--DIREEPNGLQSIG-----
MAB_0393|M.abscessus_ATCC_1997 SKYWAIDEIRPAKIYANFNGFEPGVARGFARHEIEPD--GRASVA-----
Mflv_1324|M.gilvum_PYR-GCK SPYWTIDDIRPALIHTNVPKLPGMPPPPLDMLDDRGHLRMQ---------
Mvan_5471|M.vanbaalenii_PYR-1 SRYWIIDDIRPALIDTNVPKLPGMPPPPLDMLDDRGRLRMQ---------
TH_1722|M.thermoresistible__bu SKYWEIDEIRPAFIHANMP--PDVPGVESFDTDEKGRTKLP---------
. :* **:* ** : :.. :
MUL_0662|M.ulcerans_Agy99 DGTPHAVYSPANEG-
MMAR_0909|M.marinum_M -----AWLLSAHLG-
MAV_0119|M.avium_104 -----AWLLSAHLG-
MSMEG_2539|M.smegmatis_MC2_155 -----GWLLQAHLG-
Mb0575c|M.bovis_AF2122/97 -----GWLLSAHLG-
Rv0560c|M.tuberculosis_H37Rv -----GWLLSAHLG-
MAB_0393|M.abscessus_ATCC_1997 -----AWLLSAHLAG
Mflv_1324|M.gilvum_PYR-GCK -----AFLLSAHKEP
Mvan_5471|M.vanbaalenii_PYR-1 -----AFLLQAHKES
TH_1722|M.thermoresistible__bu -----AFLLSAHKA-
. *: