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RVAVCGAGIAGLALAERMSALGAEVVFVERSPGPPNQGAMIDLFGAGYEAADAIGILDAIRDVSYPIGDT GLVDELGRRRAGLPYGRIAKALEDRLCRITRTDLHKVLLDNLPTNVDLRFGTSVSEVTHGDDRAVVTLDD GARLDVDLLVGADGIHSTVRALAFGAEVQYLRYLGFHFAAFVFDASDMDDTAGDHVVITDTVDRQLGLYA LRNGQTAVFAAYRAADPEPPPDARAALRDRFAGMGWLVPEVLERCPPSGDIYFGQVAQVEMPRWSTNRVV LVGDACSAGSPLTGPGASLALAGAYVLSEQLRRTSSVERALDFYERLWSPTVEEKQESARGLRLDAVAVV LTALDSPRRAALHLAPADQPIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2358 | - | - | 100% (373) | FAD-dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_1770 | - | 3e-36 | 33.62% (348) | oxidoreductase |
| M. ulcerans Agy99 | MUL_4482 | - | 2e-33 | 32.61% (322) | hypothetical protein MUL_4482 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 3e-52 | 36.36% (341) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 3e-22 | 28.31% (378) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 3e-52 | 36.36% (341) | hypothetical protein Rv0575c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1431 | - | 3e-38 | 32.38% (315) | hypothetical protein MAB_1431 |
| M. marinum M | MMAR_3108 | - | 0.0 | 97.36% (341) | FAD-dependent oxidoreductase |
| M. avium 104 | MAV_1408 | - | 3e-34 | 31.99% (347) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_1980 | - | 5e-47 | 36.23% (345) | hypothetical protein MSMEG_1980 |
| M. thermoresistible (build 8) | TH_1880 | - | 1e-07 | 26.20% (332) | flavin-type hydroxylase |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 1e-19 | 29.97% (377) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2621|M.gilvum_PYR-GCK -------MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG-AGSG
Mvan_3960|M.vanbaalenii_PYR-1 -------MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLT-SGAG
MUL_2358|M.ulcerans_Agy99 ---------MRVAVCGAGIAGLALAERMSALGAEVVFVERSPGPPNQGAM
MMAR_3108|M.marinum_M -----------MAVCGAGIAGLALAERMSALGAEVVLVERSPGPPNQGAM
MAB_1431|M.abscessus_ATCC_1997 MQPARGNGAGTVLICGAGIAGTVVAYRLARAGLRPTVVERSADLRQAGNA
MAV_1408|M.avium_104 --------MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPRPGGQA
Mb0590c|M.bovis_AF2122/97 ---------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYM
Rv0575c|M.tuberculosis_H37Rv ---------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYM
MSMEG_1980|M.smegmatis_MC2_155 ---------MRIAISGAGIAGPTLAYWLMRAGHEPTLIEAAPRLRTGGYV
TH_1880|M.thermoresistible__bu --------VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAHVRS
: *.. :* * : * .:*
Mflv_2621|M.gilvum_PYR-GCK ISLWPNALAALDQIGLGDSVRDAGGRVTAGAIRWRDGTWVRRPS--VRRI
Mvan_3960|M.vanbaalenii_PYR-1 ISIWPNALAALDQIGLGDNVRQAGGRVTAGAIRWRDGTWLRRPS--AQRI
MUL_2358|M.ulcerans_Agy99 IDLFGAGYEAADAIGILDAIRDVSYPIGDTGLVDELGRRRAGLP--YGRI
MMAR_3108|M.marinum_M IDLFGAGYEAADAIGILDAIRDVSYSIGDTGLVDELGRRRAGLP--YGRI
MAB_1431|M.abscessus_ATCC_1997 VDLRGPALQVMADMGVLAELETRATQLSEFFRIDSSGKRVFTMA--PHVI
MAV_1408|M.avium_104 IDVRGPALGVLERMGLLAAAAKRRTQIRGSSVVDRDGNELSRDT--EAAI
Mb0590c|M.bovis_AF2122/97 IDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLG--VDVF
Rv0575c|M.tuberculosis_H37Rv IDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLG--VDVF
MSMEG_1980|M.smegmatis_MC2_155 VDFWGLGYEVACRMGIEPALREQGYDITAIRSVTPDGRIRANLD--TAGI
TH_1880|M.thermoresistible__bu LGLHVRSIEMLDQRGLLDRFLAHGQRHPVGGFFAAIAKPPAELDTAHG--
:.. . *: .
Mflv_2621|M.gilvum_PYR-GCK VDALG----EPLVVVRRSRLTDILRE--ALP-AGTVRTGLAATRVSVGAS
Mvan_3960|M.vanbaalenii_PYR-1 VHALG----EPLVVVRRSALTEILLD--ALP-PDTVQTGLSATALSIAAA
MUL_2358|M.ulcerans_Agy99 AKALEDR----LCRITRTDLHKVLLD--NLPTNVDLRFGTSVSEVTHGDD
MMAR_3108|M.marinum_M AKALEDR----LCRITRTDLHKVLLD--NLPTNVDLRFGTSVSEVTHGDD
MAB_1431|M.abscessus_ATCC_1997 GG---------EIELLRTELNAVLFN--AAQTGVEYRFGDSIRSLHERGD
MAV_1408|M.avium_104 SGPTGGPIEGPDIELLRDDLVELLYG--ASQWTAEYLFDDTITALDDRGA
Mb0590c|M.bovis_AF2122/97 RRMVG----DDFTSLPRGDLAAAIYT--TIEDQVETIFDDSIATIDEHRD
Rv0575c|M.tuberculosis_H37Rv RRMVG----DDFTSLPRGDLAAAIYT--TIEDQVETIFDDSIATIDEHRD
MSMEG_1980|M.smegmatis_MC2_155 RRVTH----DKFTSLPRGDLAATIYS--TIDGKVETVFGDSIASITEHED
TH_1880|M.thermoresistible__bu -----------YVLGIRQPVTDRLLAEWAAERGAVIRRGCAVVGLDQDAA
* : : . : :
Mflv_2621|M.gilvum_PYR-GCK SVRITLSDGEVRESDAVVGADGVNSVLARTLNGPLR--TRYVGYTAWRGI
Mvan_3960|M.vanbaalenii_PYR-1 TARVTLSDGRTREADAVVGADGVNSMVARALNGPLP--SRYVGYTAWRGV
MUL_2358|M.ulcerans_Agy99 RAVVTLDDGARLDVDLLVGADGIHSTVRALAFGAEVQYLRYLGFHFAAFV
MMAR_3108|M.marinum_M RAVVTLDDGARLDVDLLVGADGMHSTVRALAFGAEAQYLRYLGFHFAAFV
MAB_1431|M.abscessus_ATCC_1997 DVAVTFDSGRHGHFDVVIGADGLHSRTRTLAFGPESDFVRHLGCYQAHFT
MAV_1408|M.avium_104 AVRVSFERAAPRDFDLVIGADGLHSNVRRLVFGPEDEFIERLGTHAAIFT
Mb0590c|M.bovis_AF2122/97 GVRLTFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACV
Rv0575c|M.tuberculosis_H37Rv GVRLTFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACV
MSMEG_1980|M.smegmatis_MC2_155 GVAVGLAGGTQREFDLVVGADGLHSHVRQLAFGRAPDPEHYLGCLVAAAV
TH_1880|M.thermoresistible__bu GITVELADGSVQRARYLVGCDGGRSTVRKLAG--IGFPGEPARSETLLGE
: : ::*.** .* .
Mflv_2621|M.gilvum_PYR-GCK AAHPLDPELGG----ETLGPGTQVGHVPLGPDHTYWFATERTAEGGSAPG
Mvan_3960|M.vanbaalenii_PYR-1 AAYRLDPALAG----ETMSAGTEVGHVPLGPDHTYWFATERTREGSRSAG
MUL_2358|M.ulcerans_Agy99 FDASDMDDTAGDHVVITDTVDRQLGLYALRNGQTAVFAAYRAADPEPPPD
MMAR_3108|M.marinum_M FDASDMDDTAGDHVVITDTVDRQLGLYALRNGQTAVFAAYRAADPEPPPD
MAB_1431|M.abscessus_ATCC_1997 TGNVLGLRNA--GLLLNRPGRTLGCYTVHQSRELVIGLFFESAQRAYDRA
MAV_1408|M.avium_104 VPNFLGLDYW--QMWHYGDSTMAGVYSARDNAEARAMLGFMDAELRLDYR
Mb0590c|M.bovis_AF2122/97 VDGYRPRDER--SYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVA
Rv0575c|M.tuberculosis_H37Rv VDGYRPRDER--SYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVA
MSMEG_1980|M.smegmatis_MC2_155 VDGYRPRDDL--VYMTFSAPGHSVGRVALRGDRTLFLFILRSD-DATVPG
TH_1880|M.thermoresistible__bu MSLSADPATVAAVVAEVRKTQLRFGAMPLGDGVYRVIVPAEGVAGDRAEP
Mflv_2621|M.gilvum_PYR-GCK GEHAY---LTAKVA-DWADPIPRLVATTDPGDLLRNDLYDRARAARWSDG
Mvan_3960|M.vanbaalenii_PYR-1 GEHAY---LTAKLA-GWADPIPALLASTDPADVLRNDLYDRAQPRDWSRG
MUL_2358|M.ulcerans_Agy99 ARAA----LRDRFA-GMGWLVPEVLERCPPSGDIYFGQVAQVEMPRWSTN
MMAR_3108|M.marinum_M ARAA----LRDRFA-GMGWLVPEVLERCPPSADIYFGQVAQVEMPRWSTN
MAB_1431|M.abscessus_ATCC_1997 DPAAQRHWIHRVFE-GMGWRTAELLEAMWTCDDFYFDSIAQVSLANPCRG
MAV_1408|M.avium_104 DTEAQFAELERRMA-GEGWVRPQLLEYMRTAPDFYFDEMSQIKMDRWSRG
Mb0590c|M.bovis_AF2122/97 PKDE----LRDQFG-DVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRG
Rv0575c|M.tuberculosis_H37Rv PKDE----LRDQFG-DVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRG
MSMEG_1980|M.smegmatis_MC2_155 SHDERIALLKREFS-DLGWECERITDALDDVDDLYLDVVSQIRMDRWSRG
TH_1880|M.thermoresistible__bu TLDEFRRRLKAFAGTDFGAHTPRWLSRFGDAT---------RLAERYRAG
: . . .
Mflv_2621|M.gilvum_PYR-GCK RAVLIGDAAHPMRPHLGQGGCQGIEDAAILA-RFLELADDVPT--AFERF
Mvan_3960|M.vanbaalenii_PYR-1 PAVIVGDAAHPMRPHLGQGGCQGLEDAAILA-RFVGLSPDLPA--AFDRF
MUL_2358|M.ulcerans_Agy99 RVVLVGDACSAGSPLTGPGASLALAGAYVLSEQLRRTSSVER---ALDFY
MMAR_3108|M.marinum_M RVVLVGDACSAVSPLTGPGASLALAGAYVLSEQLRRTSSVER---ALDFY
MAB_1431|M.abscessus_ATCC_1997 RVALIGDAAYGPSLFSGMGATLAVVGAAILADEISCHPGDHRQ--AFTRY
MAV_1408|M.avium_104 RVALVGDAGYCCSPLSGQGTSVALLGAYILAGELKAAGEDHEA--GFANY
Mb0590c|M.bovis_AF2122/97 RVLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRR--AFDAY
Rv0575c|M.tuberculosis_H37Rv RVLLIGDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRR--AFDAY
MSMEG_1980|M.smegmatis_MC2_155 RTVLVGDAAACISLLGGEGTGLAMAEAYVLAGELA-AHRDHRD--AFSAY
TH_1880|M.thermoresistible__bu RVFLAGDAAHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTY
. : *** * * .: * *. .: : :
Mflv_2621|M.gilvum_PYR-GCK EAFRKPRVGMLVREAQTLGRIVNVRPAVLSGLAGRATALIP---------
Mvan_3960|M.vanbaalenii_PYR-1 GAFRRRRVRPLVRESAAIGRIVNLRPAFLSGVASRASALIP---------
MUL_2358|M.ulcerans_Agy99 ERLWSPTVEEKQESAR-------------------GLRLDA-------VA
MMAR_3108|M.marinum_M ERLWRPTVEEKQESARAVSGWMLSPSSSQLSIRRAGLRFTWRPLINRFVE
MAB_1431|M.abscessus_ATCC_1997 QRRIREMARLSRELAQASRGWFMPPADAHDIPPESQLAADR---------
MAV_1408|M.avium_104 HREFADYVQRNQWLVVDN------------IPGGAPIPQEV---------
Mb0590c|M.bovis_AF2122/97 EKRLRPFIEGKQASAAKFIWFFRHPN----PIRPVVSQRCD---------
Rv0575c|M.tuberculosis_H37Rv EKRLRPFIEGKQASAAKFIWFFATRTRFGLWFRNVAMRTMN---------
MSMEG_1980|M.smegmatis_MC2_155 ETALRPLIAAKQEAARRYLAVFIPKTNLGIAFRDLCMRVVN---------
TH_1880|M.thermoresistible__bu HAERHPVAADVLNNTRAQMELMSPEPGPRAVRWLLAELMDFEEVN--RYL
Mflv_2621|M.gilvum_PYR-GCK -ERMVTAHLAWIAAGSAFVLPTAADLAR----------------------
Mvan_3960|M.vanbaalenii_PYR-1 -EWAVASHLASIAAGSAFILPTAGDVGG----------------------
MUL_2358|M.ulcerans_Agy99 VVLTALDSPRRAALH--LAPADQPIR------------------------
MMAR_3108|M.marinum_M TTLAGEPTAVIAMLRQGMSDSDSPIASN----------------------
MAB_1431|M.abscessus_ATCC_1997 -ESDVLRDRTLAAMQAAFGNPSSPARN-----------------------
MAV_1408|M.avium_104 -FERIVASITLKDY------------------------------------
Mb0590c|M.bovis_AF2122/97 -AHDELR-PAGDAVRRQRA-------------------------------
Rv0575c|M.tuberculosis_H37Rv -FGPLAT-LFAGSVRDDFELPDYTW-------------------------
MSMEG_1980|M.smegmatis_MC2_155 -AVPWTDRLLARTFSDDFALPEYRL-------------------------
TH_1880|M.thermoresistible__bu TEKITAIGVRYHTMGDGHGLLGRRMRDIPLTGGRLYARMHAGRGVLLDRT
Mflv_2621|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3960|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2358|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3108|M.marinum_M --------------------------------------------------
MAB_1431|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_1408|M.avium_104 --------------------------------------------------
Mb0590c|M.bovis_AF2122/97 --------------------------------------------------
Rv0575c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_1980|M.smegmatis_MC2_155 --------------------------------------------------
TH_1880|M.thermoresistible__bu GTLSVSGWADRVDHIVDPGAALDVPAVLLRPDGHVAWVGADHPGQQDLTA
Mflv_2621|M.gilvum_PYR-GCK ----------
Mvan_3960|M.vanbaalenii_PYR-1 ----------
MUL_2358|M.ulcerans_Agy99 ----------
MMAR_3108|M.marinum_M ----------
MAB_1431|M.abscessus_ATCC_1997 ----------
MAV_1408|M.avium_104 ----------
Mb0590c|M.bovis_AF2122/97 ----------
Rv0575c|M.tuberculosis_H37Rv ----------
MSMEG_1980|M.smegmatis_MC2_155 ----------
TH_1880|M.thermoresistible__bu RLSRWFGAPA