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AVCGAGIAGLALAERMSALGAEVVLVERSPGPPNQGAMIDLFGAGYEAADAIGILDAIRDVSYSIGDTGL VDELGRRRAGLPYGRIAKALEDRLCRITRTDLHKVLLDNLPTNVDLRFGTSVSEVTHGDDRAVVTLDDGA RLDVDLLVGADGMHSTVRALAFGAEAQYLRYLGFHFAAFVFDASDMDDTAGDHVVITDTVDRQLGLYALR NGQTAVFAAYRAADPEPPPDARAALRDRFAGMGWLVPEVLERCPPSADIYFGQVAQVEMPRWSTNRVVLV GDACSAVSPLTGPGASLALAGAYVLSEQLRRTSSVERALDFYERLWRPTVEEKQESARAVSGWMLSPSSS QLSIRRAGLRFTWRPLINRFVETTLAGEPTAVIAMLRQGMSDSDSPIASN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3108 | - | - | 100% (401) | FAD-dependent oxidoreductase |
| M. marinum M | MMAR_0939 | - | 8e-51 | 34.62% (364) | oxidoreductase |
| M. marinum M | MMAR_2185 | - | 2e-39 | 32.73% (385) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0590c | - | 1e-53 | 36.58% (339) | hypothetical protein Mb0590c |
| M. gilvum PYR-GCK | Mflv_2621 | - | 1e-21 | 28.06% (335) | monooxygenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0575c | - | 6e-54 | 34.85% (373) | hypothetical protein Rv0575c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1431 | - | 3e-42 | 31.37% (357) | hypothetical protein MAB_1431 |
| M. avium 104 | MAV_1408 | - | 8e-35 | 32.92% (322) | hypothetical protein MAV_1408 |
| M. smegmatis MC2 155 | MSMEG_1980 | - | 2e-48 | 36.73% (343) | hypothetical protein MSMEG_1980 |
| M. thermoresistible (build 8) | TH_0132 | - | 7e-05 | 24.11% (224) | POSSIBLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_2358 | - | 0.0 | 97.36% (341) | FAD-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3960 | - | 3e-21 | 30.00% (350) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2621|M.gilvum_PYR-GCK -------MSARISVIGAGISGLAAAVALERAGHHVSVIEQRTDTG-AGSG
Mvan_3960|M.vanbaalenii_PYR-1 -------MPAHTIVIGAGIAGLATAVALRRVGHDVTVIEQRTDLT-SGAG
MMAR_3108|M.marinum_M -----------MAVCGAGIAGLALAERMSALGAEVVLVERSPGPPNQGAM
MUL_2358|M.ulcerans_Agy99 ---------MRVAVCGAGIAGLALAERMSALGAEVVFVERSPGPPNQGAM
MAB_1431|M.abscessus_ATCC_1997 MQPARGNGAGTVLICGAGIAGTVVAYRLARAGLRPTVVERSADLRQAGNA
MAV_1408|M.avium_104 --------MSDVLVSGASVAGTAAAFWLGRHGHSVTVVERHRGPRPGGQA
Mb0590c|M.bovis_AF2122/97 ---------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYM
Rv0575c|M.tuberculosis_H37Rv ---------MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYM
MSMEG_1980|M.smegmatis_MC2_155 ---------MRIAISGAGIAGPTLAYWLMRAGHEPTLIEAAPRLRTGGYV
TH_0132|M.thermoresistible__bu -----------VPWPGPSFPSTGSAGPRTELDDRIRMVAVDDGAK---MM
*..... * . .:
Mflv_2621|M.gilvum_PYR-GCK ISLWPNALAALDQIGLGDSVRDAGGRVTAGAIRWRDGTWVRRPSVRRIVD
Mvan_3960|M.vanbaalenii_PYR-1 ISIWPNALAALDQIGLGDNVRQAGGRVTAGAIRWRDGTWLRRPSAQRIVH
MMAR_3108|M.marinum_M IDLFGAGYEAADAIGILDAIRDVSYSIGDTGLVDELGRRRAGLPYGRIAK
MUL_2358|M.ulcerans_Agy99 IDLFGAGYEAADAIGILDAIRDVSYPIGDTGLVDELGRRRAGLPYGRIAK
MAB_1431|M.abscessus_ATCC_1997 VDLRGPALQVMADMGVLAELETRATQLSEFFRIDSSGKRVFTMAPHVIGG
MAV_1408|M.avium_104 IDVRGPALGVLERMGLLAAAAKRRTQIRGSSVVDRDGNELSRDTEAAISG
Mb0590c|M.bovis_AF2122/97 IDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRR
Rv0575c|M.tuberculosis_H37Rv IDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRR
MSMEG_1980|M.smegmatis_MC2_155 VDFWGLGYEVACRMGIEPALREQGYDITAIRSVTPDGRIRANLDTAGIRR
TH_0132|M.thermoresistible__bu LGVKAAGVTHDSSGRVASVQLDNGTEIRCTELIVADG------ARSTLGR
:.. . : : * :
Mflv_2621|M.gilvum_PYR-GCK ALG----EPLVVVRRSRLTDILREALP-AGTVRTGLAATRVSVGASSVRI
Mvan_3960|M.vanbaalenii_PYR-1 ALG----EPLVVVRRSALTEILLDALP-PDTVQTGLSATALSIAAATARV
MMAR_3108|M.marinum_M ALEDR----LCRITRTDLHKVLLDNLPTNVDLRFGTSVSEVTHGDDRAVV
MUL_2358|M.ulcerans_Agy99 ALEDR----LCRITRTDLHKVLLDNLPTNVDLRFGTSVSEVTHGDDRAVV
MAB_1431|M.abscessus_ATCC_1997 ---------EIELLRTELNAVLFNAAQTGVEYRFGDSIRSLHERGDDVAV
MAV_1408|M.avium_104 PTGGPIEGPDIELLRDDLVELLYGASQWTAEYLFDDTITALDDRGAAVRV
Mb0590c|M.bovis_AF2122/97 MVG----DDFTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRL
Rv0575c|M.tuberculosis_H37Rv MVG----DDFTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRL
MSMEG_1980|M.smegmatis_MC2_155 VTH----DKFTSLPRGDLAATIYSTIDGKVETVFGDSIASITEHEDGVAV
TH_0132|M.thermoresistible__bu ALG----RQWHQQTVYGIAIRAYAESPRHDEPWITSHLELRSAEGELLPG
:
Mflv_2621|M.gilvum_PYR-GCK TLSDGEVRESDAVVGADGVNSVLARTLNGPLR--TRYVGYTAWRGIAAHP
Mvan_3960|M.vanbaalenii_PYR-1 TLSDGRTREADAVVGADGVNSMVARALNGPLP--SRYVGYTAWRGVAAYR
MMAR_3108|M.marinum_M TLDDGARLDVDLLVGADGMHSTVRALAFGAEAQYLRYLGFHFAAFVFDAS
MUL_2358|M.ulcerans_Agy99 TLDDGARLDVDLLVGADGIHSTVRALAFGAEVQYLRYLGFHFAAFVFDAS
MAB_1431|M.abscessus_ATCC_1997 TFDSGRHGHFDVVIGADGLHSRTRTLAFGPESDFVRHLGCYQAHFTTGNV
MAV_1408|M.avium_104 SFERAAPRDFDLVIGADGLHSNVRRLVFGPEDEFIERLGTHAAIFTVPNF
Mb0590c|M.bovis_AF2122/97 TFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGY
Rv0575c|M.tuberculosis_H37Rv TFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGY
MSMEG_1980|M.smegmatis_MC2_155 GLAGGTQREFDLVVGADGLHSHVRQLAFGRAPDPEHYLGCLVAAAVVDGY
TH_0132|M.thermoresistible__bu YGWIFPLGNGEVNIGVGALSTAKRPADAALRPLLSFYTGLRRDEWGFPGP
. : :*...: : . *
Mflv_2621|M.gilvum_PYR-GCK LDPELGG----ETLGPGTQVGHVPLGPDHTYWFATERTAEGGSAPGGEHA
Mvan_3960|M.vanbaalenii_PYR-1 LDPALAG----ETMSAGTEVGHVPLGPDHTYWFATERTREGSRSAGGEHA
MMAR_3108|M.marinum_M DMDDTAGDHVVITDTVDRQLGLYALRNGQTAVFAAYRAADPEPPPDARAA
MUL_2358|M.ulcerans_Agy99 DMDDTAGDHVVITDTVDRQLGLYALRNGQTAVFAAYRAADPEPPPDARAA
MAB_1431|M.abscessus_ATCC_1997 LGLRNA--GLLLNRPGRTLGCYTVHQSRELVIGLFFESAQRAYDRADPAA
MAV_1408|M.avium_104 LGLDYW--QMWHYGDSTMAGVYSARDNAEARAMLGFMDAELRLDYRDTEA
Mb0590c|M.bovis_AF2122/97 RPRDER--SYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVAPKDE
Rv0575c|M.tuberculosis_H37Rv RPRDER--SYVLYNTVDRQLARFALRGDRTMFLFVFRAEHDNPGVAPKDE
MSMEG_1980|M.smegmatis_MC2_155 RPRDDL--VYMTFSAPGHSVGRVALRGDRTLFLFILRSD-DATVPGSHDE
TH_0132|M.thermoresistible__bu PRAALS---------ALLPMGGAVSGVAGPNWMLIGDAAACVNPLNGEGI
Mflv_2621|M.gilvum_PYR-GCK Y---LTAKVADWADPIPRLVATTDPGDLLRNDLYDRARAARWSDGRAVLI
Mvan_3960|M.vanbaalenii_PYR-1 Y---LTAKLAGWADPIPALLASTDPADVLRNDLYDRAQPRDWSRGPAVIV
MMAR_3108|M.marinum_M ----LRDRFAGMGWLVPEVLERCPPSADIYFGQVAQVEMPRWSTNRVVLV
MUL_2358|M.ulcerans_Agy99 ----LRDRFAGMGWLVPEVLERCPPSGDIYFGQVAQVEMPRWSTNRVVLV
MAB_1431|M.abscessus_ATCC_1997 QRHWIHRVFEGMGWRTAELLEAMWTCDDFYFDSIAQVSLANPCRGRVALI
MAV_1408|M.avium_104 QFAELERRMAGEGWVRPQLLEYMRTAPDFYFDEMSQIKMDRWSRGRVALV
Mb0590c|M.bovis_AF2122/97 ----LRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLI
Rv0575c|M.tuberculosis_H37Rv ----LRDQFGDVGWESRDILAALDDVEDLYFDVVSQIRMDRWSRGRVLLI
MSMEG_1980|M.smegmatis_MC2_155 RIALLKREFSDLGWECERITDALDDVDDLYLDVVSQIRMDRWSRGRTVLV
TH_0132|M.thermoresistible__bu DYGLETGRFAAG-------LLGSGDLSQAWPALLQRHYGHGFSVARRLAS
. : .
Mflv_2621|M.gilvum_PYR-GCK GDAAHPMRPHLGQGGCQGIEDAAILA-RFLELADDVPTAFERFEAFRKPR
Mvan_3960|M.vanbaalenii_PYR-1 GDAAHPMRPHLGQGGCQGLEDAAILA-RFVGLSPDLPAAFDRFGAFRRRR
MMAR_3108|M.marinum_M GDACSAVSPLTGPGASLALAGAYVLSEQLRRTSSVER-ALDFYERLWRPT
MUL_2358|M.ulcerans_Agy99 GDACSAGSPLTGPGASLALAGAYVLSEQLRRTSSVER-ALDFYERLWSPT
MAB_1431|M.abscessus_ATCC_1997 GDAAYGPSLFSGMGATLAVVGAAILADEISCHPGDHRQAFTRYQRRIREM
MAV_1408|M.avium_104 GDAGYCCSPLSGQGTSVALLGAYILAGELKAAGEDHEAGFANYHREFADY
Mb0590c|M.bovis_AF2122/97 GDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRRAFDAYEKRLRPF
Rv0575c|M.tuberculosis_H37Rv GDAAGCISLLGGEGTGLAITEAYVLAGELARAGGDHRRAFDAYEKRLRPF
MSMEG_1980|M.smegmatis_MC2_155 GDAAACISLLGGEGTGLAMAEAYVLAGELA-AHRDHRDAFSAYETALRPL
TH_0132|M.thermoresistible__bu LLTRPRFLPLTGPVAMRSTKLMNIAVRVMGNLVTDEDSDWVARVWRTAGA
: * . : :
Mflv_2621|M.gilvum_PYR-GCK VGMLVREAQTLGRIVNVRPAVLSGLAGRATALIP----------ERMVTA
Mvan_3960|M.vanbaalenii_PYR-1 VRPLVRESAAIGRIVNLRPAFLSGVASRASALIP----------EWAVAS
MMAR_3108|M.marinum_M VEEKQESARAVSGWMLSPSSSQLSIRRAGLRFTWRPLINRFVETTLAGEP
MUL_2358|M.ulcerans_Agy99 VEEKQESAR-------------------GLRLDA-------VAVVLTALD
MAB_1431|M.abscessus_ATCC_1997 ARLSRELAQASRGWFMPPADAHDIPPESQLAADR----------ESDVLR
MAV_1408|M.avium_104 VQRNQWLVVDN------------IPGGAPIPQEV----------FERIVA
Mb0590c|M.bovis_AF2122/97 IEGKQASAAKFIWFFRHPN----PIRPVVSQRCD----------AHDELR
Rv0575c|M.tuberculosis_H37Rv IEGKQASAAKFIWFFATRTRFGLWFRNVAMRTMN----------FGPLAT
MSMEG_1980|M.smegmatis_MC2_155 IAAKQEAARRYLAVFIPKTNLGIAFRDLCMRVVN----------AVPWTD
TH_0132|M.thermoresistible__bu GSRRLDERPPFS--------------------------------------
Mflv_2621|M.gilvum_PYR-GCK HLAWIAAGSAFVLPTAADLAR
Mvan_3960|M.vanbaalenii_PYR-1 HLASIAAGSAFILPTAGDVGG
MMAR_3108|M.marinum_M TAVIAMLRQGMSDSDSPIASN
MUL_2358|M.ulcerans_Agy99 SPRRAALH--LAPADQPIR--
MAB_1431|M.abscessus_ATCC_1997 DRTLAAMQAAFGNPSSPARN-
MAV_1408|M.avium_104 SITLKDY--------------
Mb0590c|M.bovis_AF2122/97 -PAGDAVRRQRA---------
Rv0575c|M.tuberculosis_H37Rv -LFAGSVRDDFELPDYTW---
MSMEG_1980|M.smegmatis_MC2_155 RLLARTFSDDFALPEYRL---
TH_0132|M.thermoresistible__bu ---------------------