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TKPRGRGGRERIVAAAAALFEAQGITATTMEQIAAKAPVSKRTLYAHFPTKDDLVVEFLQYVYRSGLTVE SALYDADVPARERILAMFTVPTRGDGPVRGCPFVAAATEFPDPDSPAHAYTRERKQAFTLRIAELLTELG ADDPHGLAEQLAILTDGVASRSMVFNDARRGDVGRAAAEALLTAAGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6503 | - | - | 100% (188) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2153 | - | 8e-27 | 38.80% (183) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6244 | - | 6e-17 | 33.89% (180) | TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3198c | - | 6e-33 | 43.78% (185) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_3506 | - | 1e-09 | 33.09% (136) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3173c | - | 7e-33 | 43.78% (185) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2458c | - | 6e-14 | 30.63% (160) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2062 | - | 7e-10 | 37.07% (116) | hypothetical protein MMAR_2062 |
| M. avium 104 | MAV_1243 | - | 6e-32 | 44.94% (178) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_3775 | - | 4e-13 | 31.35% (185) | PUTATIVE TetR-family protein transcriptional regulator |
| M. ulcerans Agy99 | MUL_5004 | - | 2e-07 | 34.13% (167) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4792 | - | 4e-20 | 35.91% (181) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3198c|M.bovis_AF2122/97 -MPPVTRTTEPPRRG--GRGARQRILKAAAELFYCEGINATGVELIANKA
Rv3173c|M.tuberculosis_H37Rv -MPPVTRTTEPPRRG--GRGARQRILKAAAELFYCEGINATGVELIANKA
MSMEG_6503|M.smegmatis_MC2_155 ----MTK----PR----GRGGRERIVAAAAALFEAQGITATTMEQIAAKA
MAV_1243|M.avium_104 -MDGVTELEKGPRGRRRGRGARERILGAAQQLFRERGINNTGMDLLCAAA
Mvan_4792|M.vanbaalenii_PYR-1 -MP--------------AEDPRQRAIDAAVELFHREGFGAVGIDRLTTSI
TH_3775|M.thermoresistible__bu ---------------MAETDDKNRVLATATTLFNERGVQAVGMDAIRDAA
MAB_2458c|M.abscessus_ATCC_199 MSSATVPTAADSARTARVLGPADRLLQTATDLFATQGIRSVGIDQILREA
MMAR_2062|M.marinum_M --------MAIPEATTAAVPARERILGAAYDLFSRRGIRAVGTDEVIERA
Mflv_3506|M.gilvum_PYR-GCK ---MSHNVTSSAREDPRIGHSRRVILRAALAEFAAHGYTGFRMESVAARA
MUL_5004|M.ulcerans_Agy99 --------MVRPAQTVRSERTREALRQAAVVRFLAQGVEETSAEQIAADA
:* * .* : :
Mb3198c|M.bovis_AF2122/97 SVSKRTLYQHFPSKSALVEEYLRGLRQAAGE-ADKMPKASNAT-PRERLL
Rv3173c|M.tuberculosis_H37Rv SVSKRTLYQHFPSKSALVEEYLRGLRQAAGE-ADKMPKASNAT-PRERLL
MSMEG_6503|M.smegmatis_MC2_155 PVSKRTLYAHFPTKDDLVVEFLQYVYRSGLT-VESALYDADVP-ARERIL
MAV_1243|M.avium_104 QVSKRTAYQHFGSKDELIAEYLR--RLDVDT-TSEVFERDDLT-PRERLL
Mvan_4792|M.vanbaalenii_PYR-1 GMSKRTLYKYFDSKDDLLLAVLDS-CEGMAL-RDLPDEDDDSS-PRDRIL
TH_3775|M.thermoresistible__bu GISLKRLYSCFRSKADLVAAVLEQRDADVRR-AMTEYVQSRAADPRDRIL
MAB_2458c|M.abscessus_ATCC_199 GVAKASLYSSFGSKDALVVAYLEELDQRDRN-RWNAAVAAQRD-PIAKVL
MMAR_2062|M.marinum_M GVARATLYRHFATKDDLVLAVLQRREELWTFGLIEQKSRARGNTPEEQLL
Mflv_3506|M.gilvum_PYR-GCK EVGRSTVYRHWPDKGALIADALAGLSRQPDP----AHEDSAATARRRAHI
MUL_5004|M.ulcerans_Agy99 GVSLRTFYRHFRSKHDLLFADYTGLHWFRAALDARPVDEAIIDSVQTAIF
:. * : * *: :
Mb3198c|M.bovis_AF2122/97 ALFDRP-NRGDGR------MRGCPFHNAAVEAAGEMPGVERIVHSHKRDY
Rv3173c|M.tuberculosis_H37Rv ALFDRP-NRGDGR------MRGCPFHNAAVEAAGEMPGVERIVHSHKRDY
MSMEG_6503|M.smegmatis_MC2_155 AMFTVP-TRGDGP------VRGCPFVAAATEFPDPDSPAHAYTRERKQAF
MAV_1243|M.avium_104 AVFATPPAFTDEP------MPLCPFIAAAVEISDPQHPARVRAREYKTSV
Mvan_4792|M.vanbaalenii_PYR-1 AVFDAQAKYCTDPD-----FAGCFFVNIATEFRDPDHRAVRIAADHKAKL
TH_3775|M.thermoresistible__bu AVFDFLAHWFAESD-----FRGCMFINTIGELGGTSTDVRRIARLHKTAV
MAB_2458c|M.abscessus_ATCC_199 TFFDLAATAAESRN-----FRGCLYANAATEFPG---LQLEPVRTHREWF
MMAR_2062|M.marinum_M AIFDVLHEWFQSRDG----YEGCSFINVLLELGADHPAGRACIG-HIDHV
Mflv_3506|M.gilvum_PYR-GCK LLNHLAQALTDSPVS----ACVPALIHAAANDDAFRDRLHRFSAQRRQRL
MUL_5004|M.ulcerans_Agy99 AFPYDVEAVAKIATLRGGELDPSRIVRHIQEVQADFAEVIAAQLLRRSCA
. :
Mb3198c|M.bovis_AF2122/97 IKGLARLAREAGAAHPRSLGNQLAVLFEGAAALSTSLD-DAGPWAHARAA
Rv3173c|M.tuberculosis_H37Rv IKGLARLAREAGAAHPRSLGNQLAVLFEGAAALSTSLD-DAGPWAHARAA
MSMEG_6503|M.smegmatis_MC2_155 TLRIAELLTELGADDPHGLAEQLAILTDGVASRSMVFN-DARRGDVGRAA
MAV_1243|M.avium_104 AARLSETAREAGAADPELLGEQLALLLDGASVRTRALGSDAFPTAAGIAA
Mvan_4792|M.vanbaalenii_PYR-1 TQFLVRQARLAGVAAPDDLAEQLTVLHTGAADYALLYG---HYPDSTRTA
TH_3775|M.thermoresistible__bu RDYLADLV--AAAELPSELAEQLAILADGAIVAATIWGDGTDAAAAARRA
MAB_2458c|M.abscessus_ATCC_199 RATVAALLREAGLARPDSIARQVQLLYDGALTGSKIDK-SVVPITLARRL
MMAR_2062|M.marinum_M RGIVRERAVAAGLHDVEDFAWSWHILMKGAIILAAVGDPDSARRAQRMAQ
Mflv_3506|M.gilvum_PYR-GCK TATIAEGVASGEFP-PTVDPEIASAALSGAVFYRALMTADAPDTDFVADL
MUL_5004|M.ulcerans_Agy99 AAGTSAQTPDARVRTAVTARCIAAAVFGAMEVWMLGEDRSLGELARVCQL
.
Mb3198c|M.bovis_AF2122/97 AEVLIDQATARPV----------
Rv3173c|M.tuberculosis_H37Rv AEVLIDQATARPV----------
MSMEG_6503|M.smegmatis_MC2_155 AEALLTAAGL-------------
MAV_1243|M.avium_104 ALVERAIPPTAR-----------
Mvan_4792|M.vanbaalenii_PYR-1 VAALLTAAGL-------------
TH_3775|M.thermoresistible__bu AATLISAS---------------
MAB_2458c|M.abscessus_ATCC_199 TRQLIG-----------------
MMAR_2062|M.marinum_M VLIEQHRAAGAAAC---------
Mflv_3506|M.gilvum_PYR-GCK LDEVLGR----------------
MUL_5004|M.ulcerans_Agy99 ALETSRAGLTNTWCPDRPRTVSS