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PPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATGVELIANKASVSKRTLYQHFPSKSALVEEYLRG LRQAAGEADKMPKASNATPRERLLALFDRPNRGDGRMRGCPFHNAAVEAAGEMPGVERIVHSHKRDYIKG LARLAREAGAAHPRSLGNQLAVLFEGAAALSTSLDDAGPWAHARAAAEVLIDQATARPV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3173c | - | - | 100% (200) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR/ACRR-FAMILY) |
| M. tuberculosis H37Rv | Rv3557c | - | 2e-07 | 38.75% (80) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 4e-07 | 31.25% (96) | transcriptional repressor (probably TETR-family) MCE3R |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3198c | - | 1e-112 | 100.00% (200) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_5272 | - | 1e-07 | 29.30% (157) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 2e-06 | 30.61% (98) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_2458c | - | 6e-18 | 34.08% (179) | TetR family transcriptional regulator |
| M. marinum M | MMAR_2062 | - | 8e-15 | 32.98% (188) | hypothetical protein MMAR_2062 |
| M. avium 104 | MAV_2097 | - | 3e-67 | 69.47% (190) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2153 | - | 6e-52 | 58.20% (189) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3775 | - | 8e-16 | 35.33% (184) | PUTATIVE TetR-family protein transcriptional regulator |
| M. ulcerans Agy99 | MUL_4837 | - | 8e-08 | 28.09% (178) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4792 | - | 8e-19 | 39.35% (155) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3173c|M.tuberculosis_H37Rv ----------------------MPPVTRTTEPPRRGGRGARQRILKAAAE
Mb3198c|M.bovis_AF2122/97 ----------------------MPPVTRTTEPPRRGGRGARQRILKAAAE
MAV_2097|M.avium_104 ----------------------MSKRRDVKHVTTGGGRGARRRILDTATE
MSMEG_2153|M.smegmatis_MC2_155 ----------------------MSDTT----AERRGGRGARERLLSSASR
TH_3775|M.thermoresistible__bu ----------------------------------MAETDDKNRVLATATT
Mvan_4792|M.vanbaalenii_PYR-1 ----------------------------------MPAEDPRQRAIDAAVE
Mflv_5272|M.gilvum_PYR-GCK ------------------------MRRARNTD---SPTEQESAILKAAAE
MUL_4837|M.ulcerans_Agy99 ------------------------MGTETSTDGVESITDLDRTILDTAHA
MAB_2458c|M.abscessus_ATCC_199 -------------------MSSATVPTAADSARTARVLGPADRLLQTATD
MMAR_2062|M.marinum_M ---------------------------MAIPEATTAAVPARERILGAAYD
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
: *
Rv3173c|M.tuberculosis_H37Rv LFYCEGINATGVELIANKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGE
Mb3198c|M.bovis_AF2122/97 LFYCEGINATGVELIANKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGE
MAV_2097|M.avium_104 LFYRDGINATGVERLAAEASVSKRTLYQHFPSKNAVVEEYLRGIQQAVGD
MSMEG_2153|M.smegmatis_MC2_155 LFYRNGIHATGVEALIQHANVSKRTLYQHFSSKNELVEHYLRRIDGAGGS
TH_3775|M.thermoresistible__bu LFNERGVQAVGMDAIRDAAGISLKRLYSCFRSKADLVAAVLEQRDADVRR
Mvan_4792|M.vanbaalenii_PYR-1 LFHREGFGAVGIDRLTTSIGMSKRTLYKYFDSKDDLLLAVLDSCEGMALR
Mflv_5272|M.gilvum_PYR-GCK EVALVGVGRLSMDVVARQAGVSRSTLYRRFPSRDALITELGRQTFEFAMA
MUL_4837|M.ulcerans_Agy99 VFETYGVRRANIEDVATRAGVSRSTIYRRFPTKDELFERVVRREAELFFA
MAB_2458c|M.abscessus_ATCC_199 LFATQGIRSVGIDQILREAGVAKASLYSSFGSKDALVVAYLEELDQRDRN
MMAR_2062|M.marinum_M LFSRRGIRAVGTDEVIERAGVARATLYRHFATKDDLVLAVLQRREELWTF
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
. * . : : .:: :* * :: :
Rv3173c|M.tuberculosis_H37Rv -ADK-MPKASNATPRERLLALFDRPNR---GDGRMRGCPFHNAAVEAAGE
Mb3198c|M.bovis_AF2122/97 -ADK-MPKASNATPRERLLALFDRPNR---GDGRMRGCPFHNAAVEAAGE
MAV_2097|M.avium_104 -PIHPEADATNRSPRARLLALFDTPAP---GDALMRGCPFHNAAVEAGQT
MSMEG_2153|M.smegmatis_MC2_155 -PMEKPLLNQELPPRDRLLAIFDAVP-----VARFRGCPFHNAAVESAGE
TH_3775|M.thermoresistible__bu -AMTEYVQSRAADPRDRILAVFDFLAHWF-AESDFRGCMFINTIGELGGT
Mvan_4792|M.vanbaalenii_PYR-1 -DLPD--EDDDSSPRDRILAVFDAQAKYC-TDPDFAGCFFVNIATEFRDP
Mflv_5272|M.gilvum_PYR-GCK -RLQTVAIDDG--PQQAAVAAFREGVRLL-TGEPVMRR-FLQLDGEFTAT
MUL_4837|M.ulcerans_Agy99 -ALNQATNGHN--PREAVIEAFTLGVRLI-RDSPLYSR-IAESEPELFG-
MAB_2458c|M.abscessus_ATCC_199 -RWNAAVAAQR-DPIAKVLTFFDLAATAA-ESRNFRGCLYANAATEFPG-
MMAR_2062|M.marinum_M GLIEQKSRARGNTPEEQLLAIFDVLHEWFQSRDGYEGCSFINVLLELGAD
MLBr_00815|M.leprae_Br4923 --SVQQALRTTTNNRQRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPR-
. :
Rv3173c|M.tuberculosis_H37Rv MPGVERIVHSHKRDYIKGLARLAREAGAAHPR----SLGNQLAVLFEGAA
Mb3198c|M.bovis_AF2122/97 MPGVERIVHSHKRDYIKGLARLAREAGAAHPR----SLGNQLAVLFEGAA
MAV_2097|M.avium_104 MPEVRSIVREHKRTYIDGLAELARRAGASDPQ----LLGNQLAVLYEGAA
MSMEG_2153|M.smegmatis_MC2_155 LSAVEDIVRDHKRRFAELLVQVATEAGAADPY----ALGPQLLVLFEGAA
TH_3775|M.thermoresistible__bu STDVRRIARLHKTAVRDYLA--DLVAAAELPS----ELAEQLAILADGAI
Mvan_4792|M.vanbaalenii_PYR-1 DHRAVRIAADHKAKLTQFLVRQARLAGVAAPD----DLAEQLTVLHTGAA
Mflv_5272|M.gilvum_PYR-GCK TEMVAEARLFLVS-AATAMAKALRAAGATMPDSELLAVAEVHIRLAASLV
MUL_4837|M.ulcerans_Agy99 --MFSRSHVFPIGQFADGIAHTLRRCGADAPDADLANIADILLRVAVGII
MAB_2458c|M.abscessus_ATCC_199 --LQLEPVRTHREWFRATVAALLREAGLARPD----SIARQVQLLYDGAL
MMAR_2062|M.marinum_M HPAGRACIG-HIDHVRGIVRERAVAAGLHDVE----DFAWSWHILMKGAI
MLBr_00815|M.leprae_Br4923 ---VAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGISVDCAR
: .
Rv3173c|M.tuberculosis_H37Rv ALSTSLDDAGPWAHARAAAEVLIDQATARPV---
Mb3198c|M.bovis_AF2122/97 ALSTSLDDAGPWAHARAAAEVLIDQATARPV---
MAV_2097|M.avium_104 ALSTSLNDPSPWAHARAAAHTLIDRAVSRDDGD-
MSMEG_2153|M.smegmatis_MC2_155 ALATSLNDTGAFVHARAAAAQLIDCAVRGQIGR-
TH_3775|M.thermoresistible__bu VAATIWGDGTDAAAAARRAAATLISAS-------
Mvan_4792|M.vanbaalenii_PYR-1 DYALLYGHYPDSTRTAVAALLTAAGL--------
Mflv_5272|M.gilvum_PYR-GCK QVNTDVLDVTDDEAVARYARTYLAPLVR------
MUL_4837|M.ulcerans_Agy99 MFPTERLDTSDDAAVREYAARYLIPIITL-----
MAB_2458c|M.abscessus_ATCC_199 TGSKIDKSVVPITLARRLTRQLIG----------
MMAR_2062|M.marinum_M ILAAVG-DPDSARRAQRMAQVLIEQHRAAGAAAC
MLBr_00815|M.leprae_Br4923 YWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL
. .