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VARVVKAGPRTAKDKDAGTRQRLIEATAQVIRDEGYAAATTRRIAAQAGVRSALVYYYFDTLDDLYIAVL RNGADVALERMREAVAADDPLRALWLLNSDARLSVLNTEFMALANHRKTIGAELKAYSERVRDIETTAVA MVMRTHGIDTEQYPPVVMSMLLTQSARSLSNEEAVGVTQGHAEFRAFVDQILQRFTPTEPAT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6032 | - | - | 100% (202) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4779 | - | 2e-34 | 38.83% (188) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_6628 | - | 1e-28 | 36.08% (194) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1561 | - | 1e-09 | 27.69% (195) | transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1588 | - | 2e-64 | 64.67% (184) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1534 | - | 1e-09 | 27.69% (195) | transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 4e-05 | 31.58% (76) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4089c | - | 3e-09 | 40.28% (72) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4693 | - | 2e-36 | 39.11% (179) | transcriptional regulator |
| M. avium 104 | MAV_0847 | - | 5e-66 | 68.97% (174) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2984 | - | 2e-66 | 67.23% (177) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0675 | - | 2e-09 | 42.11% (76) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_5169 | - | 4e-64 | 62.30% (191) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0847|M.avium_104 -------------------------------------------MIEATAR
TH_2984|M.thermoresistible__bu --------------------MPTTRQNRRSSDSGSVDTGARSRLIEATAQ
Mflv_1588|M.gilvum_PYR-GCK --------------------MPAAAKSR------PAD--ARGRLIEATAK
Mvan_5169|M.vanbaalenii_PYR-1 --------------------MAASPKGR------GSDPNARQRLIEATAR
MSMEG_6032|M.smegmatis_MC2_155 --------------------MARVVKAG-PRTAKDKDAGTRQRLIEATAQ
MMAR_4693|M.marinum_M --------------------MTSARRIG------APDAKNRGVLLDTAEE
Mb1561|M.bovis_AF2122/97 --------------------MSRASARRRRAVSDEDKSQRRDEILAAAKI
Rv1534|M.tuberculosis_H37Rv --------------------MSRASARRRRAVSDEDKSQRRDEILAAAKI
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASD
MAB_4089c|M.abscessus_ATCC_199 -----------------------MSGRPRRISPIREGNSTRDEILDASAE
MUL_0675|M.ulcerans_Agy99 --------------------MPTAAERG---------AQTRAALMAAAVA
:: .:
MAV_0847|M.avium_104 LMREEGYAAATSRRVAAEAGVKQALVYYYFPTMDDLFVEVLRAGAESALT
TH_2984|M.thermoresistible__bu IMREEGYAAATSRRVAARAGVKQALVYYYFPTMDDLFVEVLRTGAEAALE
Mflv_1588|M.gilvum_PYR-GCK VMRDEGYAAATSRRVAAEAGVKQALVYYYFPTMDDLFVEVLRVGGESSLE
Mvan_5169|M.vanbaalenii_PYR-1 VMRDEGYAAATSRRVAAEAGVKQALVYYYFPTMDDLFVEVLRAGGESALE
MSMEG_6032|M.smegmatis_MC2_155 VIRDEGYAAATTRRIAAQAGVRSALVYYYFDTLDDLYIAVLRNGADVALE
MMAR_4693|M.marinum_M LMIEEGYAAVTSRRVASEAGLKPQLVHYYFRTMEELFLELFRRRAEEGLR
Mb1561|M.bovis_AF2122/97 VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
Rv1534|M.tuberculosis_H37Rv VFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRA
MLBr_00815|M.leprae_Br4923 VFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVS
MAB_4089c|M.abscessus_ATCC_199 LFTTDGFAATTTRRIAESVGIQQASLYYHFKTKDDILDALLAMTIDQPLH
MUL_0675|M.ulcerans_Agy99 VIAERGWGAATTRMVAERAGLPPGLVHYHFASLNDLLIDAALQAAREEAA
:: *: *. :* .*: :: :* : ::
MAV_0847|M.avium_104 RMRALLT-----EDDPLQALWLMNSDTALTALNAEF-MALANHRKAIGAE
TH_2984|M.thermoresistible__bu RMRTALT-----DDDPLRALWELNSDTRLTSLNSEF-IALANHRKAIRAE
Mflv_1588|M.gilvum_PYR-GCK HMRAALT-----NDDPLRALWLINSEAGRTGLNAEF-MALANHRKAIRVE
Mvan_5169|M.vanbaalenii_PYR-1 HMRAALT-----NDDPLHALWLINNDASRTGLNTEF-MALANHRKAIRVE
MSMEG_6032|M.smegmatis_MC2_155 RMREAVA-----ADDPLRALWLLNSDARLSVLNTEF-MALANHRKTIGAE
MMAR_4693|M.marinum_M AQAQALQ-----SPKPLWALWRLGSDPAFARISMEF-MALANHRKALRAE
Mb1561|M.bovis_AF2122/97 HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDK-ATVKLLFRDAYAL
Rv1534|M.tuberculosis_H37Rv HVAAELARVGGSTEAPLRALLQAAVQATFEFFETDK-ATVKLLFRDAYAL
MLBr_00815|M.leprae_Br4923 SVQQALR-----TTTNNRQRLHAAVQAFFDFIEHDG-QGYRLIFENDNIT
MAB_4089c|M.abscessus_ATCC_199 YAALIADR----PEAPVVRLYALALGDAAQLAASRWNLGALYLLPDLRAE
MUL_0675|M.ulcerans_Agy99 QVLDGLAG----DSSSQGIDRLIDAVSSYDVDDRNQNPAILVFGEMLLAA
MAV_0847|M.avium_104 LKAYAERVR--------DIETAAATMVLRANGIDL-EEYPPVAISMLIAQ
TH_2984|M.thermoresistible__bu LKAYAERVR--------DIETAAVTVALRARGVDL-DDHPPVAVSMLIAQ
Mflv_1588|M.gilvum_PYR-GCK LKAYAERVR--------DIETAAVTVALRANGVDL-QEHPPVVVSMLIAQ
Mvan_5169|M.vanbaalenii_PYR-1 LRAYAERVR--------DIETAAVTVALRANGVDL-DEHPPVVISMLIAQ
MSMEG_6032|M.smegmatis_MC2_155 LKAYSERVR--------DIETTAVAMVMRTHGIDT-EQYPPVVMSMLLTQ
MMAR_4693|M.marinum_M IAHYAERFR--------DEQRRVITAALQRYGVDS-QDVPPVVWTVLMAS
Mb1561|M.bovis_AF2122/97 GGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQ
Rv1534|M.tuberculosis_H37Rv GGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQ
MLBr_00815|M.leprae_Br4923 EPRVAAQVRVATES---CIDAVFALISADSRLDPHRARMVAVGLVGISVD
MAB_4089c|M.abscessus_ATCC_199 RFSAFRRKRDQLRTHYQELAAAACRASMLRAGVERLPFRLVESVIMLRAD
MUL_0675|M.ulcerans_Agy99 TRYERLRMG------LAEILGDYRSTLRQWLADQGGAIDPEATAALMFAA
: :
MAV_0847|M.avium_104 ---AAR-SLCNE--KAVGVTQGHDELRAFVQRQLSRLTAPAVASTTSA--
TH_2984|M.thermoresistible__bu ---IAR-SLCNE--RAVGVTLGHDELRAFMDRLMTQLGAPARASAPPPAQ
Mflv_1588|M.gilvum_PYR-GCK ---IAR-SLCNE--DAVGVTLGHEEMRAWVDRQLALLAAEPGG-------
Mvan_5169|M.vanbaalenii_PYR-1 ---VAR-SLCNE--VAVGVTLGHDEMRAYVERQLKLLAPVTGG-------
MSMEG_6032|M.smegmatis_MC2_155 ---SAR-SLSNE--EAVGVTQGHAEFRAFVDQILQRFTPTEPAT------
MMAR_4693|M.marinum_M ---LSR-FLVLE--KALGMSGGHAETIELVESYLRRLEGEP---------
Mb1561|M.bovis_AF2122/97 ---LAHRRLNTD--DNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAAR
Rv1534|M.tuberculosis_H37Rv ---LAHRRLNTD--DNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAAR
MLBr_00815|M.leprae_Br4923 ---CARYWLDTN--RPISKSDAVEGTVQFAWGGLSHVPLTRL--------
MAB_4089c|M.abscessus_ATCC_199 GDSIAPEALADATLRVVGVTGDAGEIEGAARVLLGQLGWPVAIPKR----
MUL_0675|M.ulcerans_Agy99 IDGLVLHRVIDPRLRTLAIRPTLRRLAGLPTAQTDERTPS----------
: :
MAV_0847|M.avium_104 -
TH_2984|M.thermoresistible__bu R
Mflv_1588|M.gilvum_PYR-GCK -
Mvan_5169|M.vanbaalenii_PYR-1 -
MSMEG_6032|M.smegmatis_MC2_155 -
MMAR_4693|M.marinum_M -
Mb1561|M.bovis_AF2122/97 T
Rv1534|M.tuberculosis_H37Rv T
MLBr_00815|M.leprae_Br4923 -
MAB_4089c|M.abscessus_ATCC_199 -
MUL_0675|M.ulcerans_Agy99 -