For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
ASARRIGAPDAKNRIVLLDAAEALMIDEGYAAVTSRRVAERAGLKPQLVHYYFRTMDDLFLAVFRRRAEE GLAAQARALDSPQPLWALWRFGIDPSATRLTMEIMGVANHRKALRTEIGRYAERFRDEQTKAMTAALDRY GVNAADVPPIVWTFLATSVSRVMVMEQALGMSAGHAEVLEFCEGWLRRIEGEPLPIEAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4779 | - | - | 100% (201) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_6032 | - | 2e-34 | 38.83% (188) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_6628 | - | 5e-31 | 37.95% (195) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 2e-05 | 31.75% (63) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2518 | - | 1e-81 | 73.13% (201) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 2e-05 | 31.75% (63) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 8e-05 | 30.88% (68) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4089c | - | 4e-08 | 25.52% (192) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4693 | - | 7e-80 | 72.68% (194) | transcriptional regulator |
| M. avium 104 | MAV_0966 | - | 4e-80 | 70.35% (199) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_3070 | - | 1e-85 | 74.49% (196) | PUTATIVE probable regulatory protein |
| M. ulcerans Agy99 | MUL_0675 | - | 7e-10 | 30.97% (155) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4140 | - | 6e-83 | 74.49% (196) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0310|M.bovis_AF2122/97 ------------------------MGVP-----------AKKKQQQGERS
Rv0302|M.tuberculosis_H37Rv ------------------------MGVP-----------AKKKQQQGERS
MSMEG_4779|M.smegmatis_MC2_155 ------------------------MASA------------RRIGAPDAKN
TH_3070|M.thermoresistible__bu ------------------------MASG------------RRIGTPDAKN
MMAR_4693|M.marinum_M ------------------------MTSA------------RRIGAPDAKN
MAV_0966|M.avium_104 ------------------------MTSASSGASSGASSGARRIGAPDAKN
Mflv_2518|M.gilvum_PYR-GCK ------------------------MAAP------------RRIGAPDAKN
Mvan_4140|M.vanbaalenii_PYR-1 ------------------------MTSP------------RRIGAPDAKN
MUL_0675|M.ulcerans_Agy99 ------------------------MPTA---------------AERGAQT
MAB_4089c|M.abscessus_ATCC_199 ------------------------MSGRPR---------RISPIREGNST
MLBr_00815|M.leprae_Br4923 MNNLAKAAQRRTVRPIDRGRLSDDIATPNQ----------RSNRLSRDKR
:
Mb0310|M.bovis_AF2122/97 RESILDATERLMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAM
Rv0302|M.tuberculosis_H37Rv RESILDATERLMATKGYAATSISDIRDACGLAPSSIYWHFGSKEGVLAAM
MSMEG_4779|M.smegmatis_MC2_155 RIVLLDAAEALMIDEGYAAVTSRRVAERAGLKPQLVHYYFRTMDDLFLAV
TH_3070|M.thermoresistible__bu RGVLLDAAERLMLEEGYVAVTSRRVAEKAGLKPQLVHYYFRTMDDLFLEV
MMAR_4693|M.marinum_M RGVLLDTAEELMIEEGYAAVTSRRVASEAGLKPQLVHYYFRTMEELFLEL
MAV_0966|M.avium_104 RGLLLDAAERLMLEEGYAAVTSRRLASRAGLKPQLVHYYFRTMEELFLEV
Mflv_2518|M.gilvum_PYR-GCK RVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAV
Mvan_4140|M.vanbaalenii_PYR-1 RVVLLDAAEQLLIEEGYAAVTSRRVADRAGLKPQLVHYYFRTMEDLFLAV
MUL_0675|M.ulcerans_Agy99 RAALMAAAVAVIAERGWGAATTRMVAERAGLPPGLVHYHFASLNDLLIDA
MAB_4089c|M.abscessus_ATCC_199 RDEILDASAELFTTDGFAATTTRRIAESVGIQQASLYYHFKTKDDILDAL
MLBr_00815|M.leprae_Br4923 RGQLLIVASDVFVDHGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAV
* :: .: :: *: *. : . *: :: :* : :
Mb0310|M.bovis_AF2122/97 MERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLL
Rv0302|M.tuberculosis_H37Rv MERGAQRFFAAIPTWDEAHGPVEQRSERQLTELVSLQSQHPDFLRLFYLL
MSMEG_4779|M.smegmatis_MC2_155 FRRRAEEGLAAQARALDSPQPL--WALWRFGIDPSATRLTMEIMGVANHR
TH_3070|M.thermoresistible__bu FRRRAEEGLRAQEEAFASPQPL--WALWRFGTDPAGTRLTMELMGLANHR
MMAR_4693|M.marinum_M FRRRAEEGLRAQAQALQSPKPL--WALWRLGSDPAFARISMEFMALANHR
MAV_0966|M.avium_104 FRRRAEEGLAVQAQALQSDQPL--WAVWRFGTDPAFTQISMEFMALANHR
Mflv_2518|M.gilvum_PYR-GCK FHRRAEEGLAVLSTALRSAQPL--WALWRFSTAPEATRLTMEFMGLANHR
Mvan_4140|M.vanbaalenii_PYR-1 FHRRAEEGLAVLSTALASPQPL--WALWRFSTAPEATRLTMEFMGLANHR
MUL_0675|M.ulcerans_Agy99 ALQAAREEAAQVLDGLAGDSSS--QGIDRLIDAVSSYDVDDRNQNPAILV
MAB_4089c|M.abscessus_ATCC_199 LAMTIDQPLHYAALIADRPEAPVVRLYALALGDAAQLAASRWNLGALYLL
MLBr_00815|M.leprae_Br4923 LERHMNNLVSSVQQALRTTTNN--RQRLHAAVQAFFDFIEHDGQGYRLIF
.
Mb0310|M.bovis_AF2122/97 SMERSQDPVVAAVVRRVRN---TAIARFRDSITHLLPSDIPPGKADLVVA
Rv0302|M.tuberculosis_H37Rv SMERSQDPAVAAVVRRVRN---TAIARFRDSITHLLPSDIPPGKADLVVA
MSMEG_4779|M.smegmatis_MC2_155 KALRTEIGRYAERFRDEQT---KAMTAALDRYG-VNAADVPPIVWTFLAT
TH_3070|M.thermoresistible__bu PALRAEMARYAERFREKER---DAIAAILERYG-IDASDVPPVVWAVFAA
MMAR_4693|M.marinum_M KALRAEIAHYAERFRDEQR---RVITAALQRYG-VDSQDVPPVVWTVLMA
MAV_0966|M.avium_104 KDMRAEIAYYAERFRDEQQ---RAVAAALERYG-VQNKDVPPVVWTVLMT
Mflv_2518|M.gilvum_PYR-GCK KALRAEIVYYAERFRQEQN---RAISDALQRYG-MVSDDVPPVVWTVFAT
Mvan_4140|M.vanbaalenii_PYR-1 KALRAEIVYYAERFRQEQN---RAIADALQRYG-TDFTDVPPVVWTVFAT
MUL_0675|M.ulcerans_Agy99 FGEMLLAATRYERLRMGLA---EILGDYRSTLR-QWLADQGGAIDPEATA
MAB_4089c|M.abscessus_ATCC_199 PDLRAERFSAFRRKRDQLRTHYQELAAAACRASMLRAGVERLPFRLVESV
MLBr_00815|M.leprae_Br4923 ENDNITEPRVAAQVRVATESCIDAVFALISADSRLDPHRARMVAVGLVGI
* :
Mb0310|M.bovis_AF2122/97 ELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET--
Rv0302|M.tuberculosis_H37Rv ELTAFAVALSDGVYFAGHLEPDTTDVERMYRRLRQALEALIPVLLEET--
MSMEG_4779|M.smegmatis_MC2_155 SVSRVMVMEQALGMSAGHAEVLEFCEGWLRRIEGEPLPIEAAG-------
TH_3070|M.thermoresistible__bu AVSRMLVMEKAIGMSVGHKEILEFCEDWLRRLEGEPLPASDPDSVASA--
MMAR_4693|M.marinum_M SLSRFLVLEKALGMSGGHAETIELVESYLRRLEGEP--------------
MAV_0966|M.avium_104 SLSRFLVLEQAIGMSSGHAETVQLVESYLRRLEGEPKPIAGAPSSWTVHQ
Mflv_2518|M.gilvum_PYR-GCK SVSQALVMERALGMDTGHAETFAFCEQWIRRFEGEPSPELADGHEMAPAQ
Mvan_4140|M.vanbaalenii_PYR-1 SVSQALVMERALGMDTGHAETFAFCEEWIRRLEGDPLPPLDQRA------
MUL_0675|M.ulcerans_Agy99 ALMFAAIDGLVLHRVIDPRLRTLAIRPTLRRLAGLPTAQTDERTPS----
MAB_4089c|M.abscessus_ATCC_199 IMLRADGDSIAPEALADATLRVVGVTGDAGEIEGAARVLLGQLGWPVAIP
MLBr_00815|M.leprae_Br4923 SVDCARYWLDTNRPISKSDAVEGTVQFAWGGLSHVPLTRL----------
: .
Mb0310|M.bovis_AF2122/97 -------------------------
Rv0302|M.tuberculosis_H37Rv -------------------------
MSMEG_4779|M.smegmatis_MC2_155 -------------------------
TH_3070|M.thermoresistible__bu -------------------------
MMAR_4693|M.marinum_M -------------------------
MAV_0966|M.avium_104 GRIEQSTPLGPSLDTTTAPSTVRSQ
Mflv_2518|M.gilvum_PYR-GCK P------------------------
Mvan_4140|M.vanbaalenii_PYR-1 -------------------------
MUL_0675|M.ulcerans_Agy99 -------------------------
MAB_4089c|M.abscessus_ATCC_199 KR-----------------------
MLBr_00815|M.leprae_Br4923 -------------------------