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MRAIIAKDRTAGIDGLALAEVPYPHAAENDVIVAVHAAAFTPGELDWPGTWTDRAGRDRTPSVPGHEVSG VVAELGFGTTGLAVGQRVFGLTDWCRNGTLAEYVAVEARNLAPLSATIDHTTAAALPISGLTAWQGLFTH GHLTPGETVLIHGAAGGVGSIAVQLAREAGAHVIGSGRTADREYVLEVGAEAFVDLEHDRLEDVGEVDLV LDVIGGQILYRSAALVRPTGSVVSIVEPPRIPADNGRAVFFVVEPDRAGLVELEQRLRDGRLRPRVGTVY PLADAKEAFAPAQRPRGKSVIRVIEES
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5762 | - | - | 100% (307) | zinc-binding oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_4442 | - | e-115 | 64.38% (306) | zinc-binding oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3409 | - | 5e-26 | 31.86% (317) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1947c | fadB5 | 3e-25 | 31.82% (264) | oxidoreductase FADB5 |
| M. gilvum PYR-GCK | Mflv_2124 | - | 4e-36 | 33.74% (326) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv1912c | fadB5 | 3e-25 | 31.82% (264) | oxidoreductase FADB5 |
| M. leprae Br4923 | MLBr_00118 | - | 2e-21 | 29.75% (242) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_3307c | - | 1e-116 | 66.34% (303) | putative zinc-binding oxidoreductase |
| M. marinum M | MMAR_1738 | - | 5e-60 | 43.55% (310) | oxidoreductase |
| M. avium 104 | MAV_0242 | - | 1e-27 | 32.13% (333) | quinone oxidoreductase |
| M. thermoresistible (build 8) | TH_1665 | - | 4e-26 | 33.64% (321) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_2935 | fadB5 | 6e-25 | 38.07% (176) | oxidoreductase FadB5 |
| M. vanbaalenii PYR-1 | Mvan_5758 | - | 8e-25 | 36.32% (234) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5762|M.smegmatis_MC2_155 ----MRAIIAKDRTAGIDGLALAEVPYPHAAENDVIVAVHAAAFTPGELD
MAB_3307c|M.abscessus_ATCC_199 ----MKAIVAEQGAKG-AGLSLTAVPYPHAAENDVIVQVHAAGFTPGELD
MMAR_1738|M.marinum_M ----MRALRAHR-RGGPETLAVERAPVPVPAAGEVVVAVRAAGITFDELT
Mflv_2124|M.gilvum_PYR-GCK MSDRMKAVVLARFGGA-DAFELRDVAVPHVGPRQVRVRVHATAVNPLDYQ
Mvan_5758|M.vanbaalenii_PYR-1 ----MRAAVLTAYN---SPLLVDELPDPEPGPGEVLVRVMASGVNPLDIK
Mb1947c|M.bovis_AF2122/97 ----MRAVVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADHL
Rv1912c|M.tuberculosis_H37Rv ----MRAVVITKHGDPSVLQVRQRPDPPPPGPGQLRVAVRAAGVNFADHL
MUL_2935|M.ulcerans_Agy99 ----MRAVVITKHGDPSVLQVQQRPDPPPPGPGQLRIAVRAAGVNFADHL
MLBr_00118|M.leprae_Br4923 ----MHAIVAESANQMVWREVPDVT----AGPGEVLIEVAASGVNRADVL
MAV_0242|M.avium_104 -MATMRAIVAESADQLSWQEVADVS----AGPGEVVVKVAAAGVNRADVL
TH_1665|M.thermoresistible__bu ----MRAISVQTSGQLSWVEVPDIE----PGESEVLIAVHTAGINRADLL
*:* . :: : * ::... :
MSMEG_5762|M.smegmatis_MC2_155 WPGTWTDRAGRDRTPSVPGHEVSGVVAELGFGTTGLAVGQRVFGLTDWCR
MAB_3307c|M.abscessus_ATCC_199 WPGTWADRSGRSRGPSIPGHEVSGIVVELGYGTTGLTVGQRVFGITDWTR
MMAR_1738|M.marinum_M WDQTWT-RDGVSRTPVIPSHEVSGVIHEIGSGTEDFHCGDEVYGLIGFDR
Mflv_2124|M.gilvum_PYR-GCK IRRG-DYTDLVP-LPAIIGHDISGVIEEVGSHVTEFRAGDAVY-YTPKIF
Mvan_5758|M.vanbaalenii_PYR-1 IRRGEAPHAQLP-PPAVLGIDMAGVVEAVGPRVDRFTVGDEVFGMTGGVG
Mb1947c|M.bovis_AF2122/97 ARVG--LYPDAPKLPAVVGYEVAGTVEAVGDGVDPNRVGERVLAGTRFGG
Rv1912c|M.tuberculosis_H37Rv ARVG--LYPDAPKLPAVVGYEVAGTVEAVGDGVDPNRVGERVLAGTRFGG
MUL_2935|M.ulcerans_Agy99 ARVG--LYPDAPKLPAVVGYEVAGTVEAAGAGVDESRIGERVLAGTRFGG
MLBr_00118|M.leprae_Br4923 QVAG--KYPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQEVCALLAGGG
MAV_0242|M.avium_104 QAAG--KYPPPPGASETIGMEVSGVIAEVGDGVTEWSVGQEVCALLAGGG
TH_1665|M.thermoresistible__bu QAAG--KYPPPPGASEILGLEVSGTVAAVGAGVSGWTVGQPVCALLAGGG
. . :::* : . . *: *
MSMEG_5762|M.smegmatis_MC2_155 N--GTLAEYVAVEARNLAPLSATIDHTTAAALPISGLTAWQGLFTHGHLT
MAB_3307c|M.abscessus_ATCC_199 N--GALAQYVAVEARNLAPLSADVDHTVAAALPVSGLTAWQGLFLHGHIV
MMAR_1738|M.marinum_M D--GAAADFVAVPAAHLAAKPATISHTVAAALPLAGLTALQALVDHAAVR
Mflv_2124|M.gilvum_PYR-GCK GGPGSYAEQHVADVDLVGRKPDNLDHLEAASLTLVGGTVWESLVTRAQLT
Mvan_5758|M.vanbaalenii_PYR-1 GLQGSLAELAAVDARLIAHKPRTLSMAQAAALPLGFITSWEGLVDRAGVG
Mb1947c|M.bovis_AF2122/97 Y-----CEIVNVAATDSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLR
Rv1912c|M.tuberculosis_H37Rv Y-----CEIVNVAATDSVVLPDALSFEQGAAVPVNYATAWAALHGYGSLR
MUL_2935|M.ulcerans_Agy99 Y-----SEIVNVTATDSVVLPEGLSFEQGAAVPVNYATAWAALHGYGSLR
MLBr_00118|M.leprae_Br4923 Y-----AEYVAVPASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLS
MAV_0242|M.avium_104 Y-----AEYVAVPAGQLLPIPAGVDLVDAAGLPEVACTVWSNLVLIAGLR
TH_1665|M.thermoresistible__bu Y-----AEYVAVPAEQVMPIPESVEIRYAAALPEVACTVWSNLVMTAGLS
.: . . . :. .*.:. * * . :
MSMEG_5762|M.smegmatis_MC2_155 PGETVLIHGAAGGVGSIAVQLAREAGAHVIGSGRT-ADREYVLEVGAEAF
MAB_3307c|M.abscessus_ATCC_199 AGQSVLIHGAAGAVGSVAVQLAHEAGAHVIGTGRG-GQRDQVLGLKADDF
MMAR_1738|M.marinum_M PGEAVLVHGGAGGVGALVVQLAAILGANVTATVRS-DAGELVSRLGAQRV
Mflv_2124|M.gilvum_PYR-GCK VGETILIHGGAGGVGTIAIQVAKAMGARVITTAKA-GDHAFVNSLGADVA
Mvan_5758|M.vanbaalenii_PYR-1 TGQQVLIHGGAGGVGFLAVQLALARGAQVYATGST-SSQAVIRAAGA-VP
Mb1947c|M.bovis_AF2122/97 AGERVLIHAAAGGVGIAAVQFAKAAKAEVHGTASP-QKHQKLAEFGVDRA
Rv1912c|M.tuberculosis_H37Rv AGERVLIHAAAGGVGIAAVQFAKAAKAEVHGTASP-QKHQKLAEFGVDRA
MUL_2935|M.ulcerans_Agy99 AGERVLVHAAAGGVGIAAVQFAKAAGAQVHGTASP-GKHQRLAELGVDRA
MLBr_00118|M.leprae_Br4923 AGQLLLLHGGTSGIGSHGIQVARALGAKVAVTAGSEEKLEFCRALGAQIT
MAV_0242|M.avium_104 NGQLLLVHGGASGIGSHAIQVARALGARVAVTAGSAEKLGFCRELGADIT
TH_1665|M.thermoresistible__bu AGEWVLIHGGASGVGSHAVQVARALDARVAVTAGTRHKLELCRELGAEVT
*: :*:*..:..:* :*.* *.* : .
MSMEG_5762|M.smegmatis_MC2_155 VDLEHDRLEDVG-------EVDLVLDVIGGQILYRSAALVRP-TGSVVSI
MAB_3307c|M.abscessus_ATCC_199 VDLTTDTLEDIG-------QVDVVFDVIGGEILDRSAQLVRA-GGALITI
MMAR_1738|M.marinum_M IDTRTEAFERTAT------DFDVVIDTVGGDTLDRSFAVLRP-GGRLVTL
Mflv_2124|M.gilvum_PYR-GCK IDHTSTDYVDAVAEATRGRGVDVVFDTIGGDTLTRSPLSLAD-SGRVVSI
Mvan_5758|M.vanbaalenii_PYR-1 IDYTATTVDEYVAAHTGGEGFDVVADNVGGATLDASFTAVKRYTGHVVSA
Mb1947c|M.bovis_AF2122/97 IDYRRDGWWQGLG------PYDVVLDALGGTSLRRSYTLLRP-GGRLVGY
Rv1912c|M.tuberculosis_H37Rv IDYRRDGWWQGLG------PYDVVLDALGGTSLRRSYTLLRP-GGRLVGY
MUL_2935|M.ulcerans_Agy99 IDYRRDGWWKGLD------SYDLVLDALGDTYLRRSYELLRP-GGRLVGY
MLBr_00118|M.leprae_Br4923 INYRDEDFVARLQQQNG--GADVILDIMGAAYLDRNIDALAI-DGQLIVI
MAV_0242|M.avium_104 INYRDEDFVARLADETG--GADVILDIMGAAYLDRNIDALAT-DGQLVII
TH_1665|M.thermoresistible__bu ICYREEDFVERVRAETDGAGADVVLDIMGAAYLGRNVDALAT-DGRLVVI
: *:: * :* * . : * ::
MSMEG_5762|M.smegmatis_MC2_155 VEPP---RIPADNGRAVFFVVEPDR-------------------------
MAB_3307c|M.abscessus_ATCC_199 AEPP---RVIPEGARAVFFVVEADR-------------------------
MMAR_1738|M.marinum_M SAPPPAGKADEHGVTAMFFIVTPNR-------------------------
Mflv_2124|M.gilvum_PYR-GCK VDIARPQNLIEAWGRNAAYHFVFTRQ-----------------NRGKLDA
Mvan_5758|M.vanbaalenii_PYR-1 LGWG-THSLAPLSFRGAAYSGVFTLM-----------------PLLTGRG
Mb1947c|M.bovis_AF2122/97 GISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRLWDD
Rv1912c|M.tuberculosis_H37Rv GISNMQHGEKRSMRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRLWDD
MUL_2935|M.ulcerans_Agy99 GVSNMQEGEKRSLRRVAPHALSMLRGFNLMKQLEESKTVIGLNMLRLWDD
MLBr_00118|M.leprae_Br4923 GLQGGVKGELNLGKVLSKRARIIG------------STLRARPVNGPNSK
MAV_0242|M.avium_104 GMQGGVKAELNIGKLLAKRARVIG------------TTLRGRPVSGPNSK
TH_1665|M.thermoresistible__bu GMQGGRRAELDLGKLVAKRAAVFG------------TALRGRPVTGPHGK
MSMEG_5762|M.smegmatis_MC2_155 -----AGLVELEQRLRDGRLRPRVGTVYPLADAKEAFAPAQ---RPRGKS
MAB_3307c|M.abscessus_ATCC_199 -----RQLTILENKLRDGRIRQNIGSVIPLEDALSAFDIDR---KTPGKT
MMAR_1738|M.marinum_M -----DQLNRLGELVGSGRLHVEIAQSFPLANGREAFESGRGAARRAGKT
Mflv_2124|M.gilvum_PYR-GCK LTMLVERGLVKPVLGATLPLARMGEAHELLENRRSYALRGKVAIDVAGET
Mvan_5758|M.vanbaalenii_PYR-1 RDHHGEIVAEAAALADSGRLAPRLHPTTFPLDAVNDAHTAVESGSATGKV
Mb1947c|M.bovis_AF2122/97 RRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAP-EAHRILAARENVGKV
Rv1912c|M.tuberculosis_H37Rv RRTLEPWIAPLTKALNDGTILPIVHAIVPFAEAP-EAHRILAARENVDKV
MUL_2935|M.ulcerans_Agy99 RGTLEPWIAPLSEALGQGTAAPIVHAAIPFAEAP-EAHRILAARENIGKV
MLBr_00118|M.leprae_Br4923 SEIVAAVTASIWPMIADGSVRPIIGARMAVQQAA-DAHQLLLSGKVSGKI
MAV_0242|M.avium_104 TEIVQAVTASVWPMIADGRVRPIIGARLPIQQAG-DAHRRLVASEVTGKI
TH_1665|M.thermoresistible__bu ADIVRAVVENVWPMVASDQVRPVVGAEFPIQEAQ-AAHELLASGDVYGKV
: .:
MSMEG_5762|M.smegmatis_MC2_155 VIRVIEES---------
MAB_3307c|M.abscessus_ATCC_199 IVQIAAV----------
MMAR_1738|M.marinum_M VITVGQ-----------
Mflv_2124|M.gilvum_PYR-GCK VALPPRIS---------
Mvan_5758|M.vanbaalenii_PYR-1 VVEPNV-----------
Mb1947c|M.bovis_AF2122/97 VLVP-------------
Rv1912c|M.tuberculosis_H37Rv VLVP-------------
MUL_2935|M.ulcerans_Agy99 VLVP-------------
MLBr_00118|M.leprae_Br4923 VLTVAGSGTETLLSRHH
MAV_0242|M.avium_104 VLTV-------------
TH_1665|M.thermoresistible__bu LLCVED-----------
: