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MTDSLIRPFRIAVPDADLDDLKSRLSRTRWPEPETVDDWGQGIPLDYTRELAEYWANGYDWRAREQALNR FDHYVTELDGLDIHFIHQRCARPDAFPLLLTHGWPGSIVEFHKVIEPLTEAGFDVVCPSLPGYGFSGKPT TTGWGIGRIAQAWDTLMTRLGYDRYGAQGGDWGAAVTTQIGRNVGNCVGIHVNMPIARPPAEGVGEMTEE VRQALERMQYYRKWDSGYMKQQSTRPQTVGYGLVDSPVGQLAWIVEKFWSWMDCDGHPENVLSRDELLDN VMLYWVTASAASSARLYWESYDTFAGGDFVTLPTGVASFPKEILRAPRAWCEKAYNVTHFTMMPRGGHFA AFEQPELFVEDVAKFFDSVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5658 | - | - | 100% (370) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_6858 | - | e-108 | 51.87% (374) | epoxide hydrolase 1 |
| M. smegmatis MC2 155 | MSMEG_3407 | - | 4e-92 | 45.12% (379) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 7e-07 | 32.14% (84) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_1749 | - | 1e-176 | 77.26% (365) | epocide hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1833c | - | 7e-07 | 32.14% (84) | haloalkane dehalogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3556 | - | 4e-07 | 30.61% (98) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3314 | - | 1e-168 | 72.46% (374) | hydrolase |
| M. avium 104 | MAV_2202 | - | 1e-170 | 74.19% (372) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_4567 | - | 1e-70 | 79.33% (150) | PUTATIVE epoxide hydrolase |
| M. ulcerans Agy99 | MUL_4778 | ephF | 5e-08 | 32.43% (111) | epoxide hydrolase EphF |
| M. vanbaalenii PYR-1 | Mvan_4998 | - | 1e-172 | 74.79% (365) | epocide hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1749|M.gilvum_PYR-GCK --MAHIQPFRIDVPDSVLTDLAERLQRTRWPEPECVDDWSQGIPLAYTRE
Mvan_4998|M.vanbaalenii_PYR-1 --MAHIQPFRIAIPDADLADLTARLQRTRWPEAECVDDWSQGIPLSYTRE
MSMEG_5658|M.smegmatis_MC2_155 MTDSLIRPFRIAVPDADLDDLKSRLSRTRWPEPETVDDWGQGIPLDYTRE
MMAR_3314|M.marinum_M -----MRPFRIDVPDDVIDDLKARLTRTRWPEAECVDDWSQGIPLSYTRD
MAV_2202|M.avium_104 -----MKPFRIDVPDDVLDDLRARLARTRWPEAECVDDWSQGMPLAYTRE
TH_4567|M.thermoresistible__bu --------------------------------------------------
Mb1864c|M.bovis_AF2122/97 ------------------------------------------MSIDFT--
Rv1833c|M.tuberculosis_H37Rv ------------------------------------------MSIDFT--
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
MAB_3556|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1749|M.gilvum_PYR-GCK LADYWANEYDWRSRESMLNRFDQFTTEIDGLDIHFVHQRSPRPDAFPLII
Mvan_4998|M.vanbaalenii_PYR-1 LAAYWADEYDWRAREASLNRFEQFTTEIDGLPIHFIHARSTRPDAFPLII
MSMEG_5658|M.smegmatis_MC2_155 LAEYWANGYDWRAREQALNRFDHYVTELDGLDIHFIHQRCARPDAFPLLL
MMAR_3314|M.marinum_M LAAYWANEYDWRAREAALNRFDQFITEIDGLDLHFIHQRSPHQDAFPLLI
MAV_2202|M.avium_104 LADYWANDYDWRAREAALNRFDQFVTEIDGLDIHFIHQRSPHADAFPLLI
TH_4567|M.thermoresistible__bu --------------------------------VVIVSATAWRIVGYAGLI
Mb1864c|M.bovis_AF2122/97 -------------PDPQLYPFESRWFDSSRGRIHYVDEG----TGPPILL
Rv1833c|M.tuberculosis_H37Rv -------------PDPQLYPFESRWFDSSRGRIHYVDEG----TGPPILL
MUL_4778|M.ulcerans_Agy99 -----------MSTLPALDGVEHRFVDLDG-GITIHVADAGPADGPAVML
MAB_3556|M.abscessus_ATCC_1997 --------------MGNTLTVQTALLDVEVRRHGNPENT----DKLPVVL
. ::
Mflv_1749|M.gilvum_PYR-GCK THGWPGSIVEFQKVIAPLT---------EAGFHVVCPSLPGYG---FSGK
Mvan_4998|M.vanbaalenii_PYR-1 THGWPGSVVEFHKVIEPLT---------DAGFHVVCPSLPGYG---FSGK
MSMEG_5658|M.smegmatis_MC2_155 THGWPGSIVEFHKVIEPLT---------EAGFDVVCPSLPGYG---FSGK
MMAR_3314|M.marinum_M THGWPGSVVEFHKVIEPLTNPTAHGGRAEDAFHVVCPSLPGYG---FSGK
MAV_2202|M.avium_104 THGWPGSIVEFHKVIEPLTNPAS--GRGEDAFHVVCPSLPGYG---FSGK
TH_4567|M.thermoresistible__bu AGG-----VWLAQATAPVAG-----------------AQPGDD---DSGD
Mb1864c|M.bovis_AF2122/97 CHGNPTWSFLYRDIIVALR----------DRFRCVAPDYLGFG---LSER
Rv1833c|M.tuberculosis_H37Rv CHGNPTWSFLYRDIIVALR----------DRFRCVAPDYLGFG---LSER
MUL_4778|M.ulcerans_Agy99 VHGFPENWWEWHELIGPLAA---------DGYRVLCPDLRGAG---WSSA
MAB_3556|M.abscessus_ATCC_1997 LHGWPDSVATWTHVIPALAS---------AGHQVYAPSVRGTGQTKFRYA
* . .: * .
Mflv_1749|M.gilvum_PYR-GCK PTATGWGVERIAAAWDELMVRLGYDRYGAQGGDWGAAVTTQIGRNVGHCV
Mvan_4998|M.vanbaalenii_PYR-1 PRSTGWGVERIAAAWDELMVRLGYRRYGAQGGDWGGAVTTQIGRNIGHCV
MSMEG_5658|M.smegmatis_MC2_155 PTTTGWGIGRIAQAWDTLMTRLGYDRYGAQGGDWGAAVTTQIGRNVGNCV
MMAR_3314|M.marinum_M PSSTGWGVDRIARAWETLMQNLGYQRYGAQGGDWGAAVTTQIGRNGGRCV
MAV_2202|M.avium_104 PTRAGWGVERIARAWETLMLRLGYQRYGAQGGDWGAAVTTQIGRNRGHCV
TH_4567|M.thermoresistible__bu -SGAGRSSQ---SATPAASAQAGSARAGSS--QAGSPRTADARRN-----
Mb1864c|M.bovis_AF2122/97 PSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRV
Rv1833c|M.tuberculosis_H37Rv PSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRV
MUL_4778|M.ulcerans_Agy99 PRSR-YTKKEMADDLAGVLDRLGIASVRLVAHDWGGPVAFIMMLRYPAKV
MAB_3556|M.abscessus_ATCC_1997 DTPRTGRLGDLLRDLFAVCDQLKLERFHLVGHDWGARTAFACGIVAPHRI
. : *. :
Mflv_1749|M.gilvum_PYR-GCK AIHTNMPFGRPPKS--LSDPDADEVAALERLGYYQKWDSGYSKQQATRPQ
Mvan_4998|M.vanbaalenii_PYR-1 AIHTNMPIGRAPKD--LSDPTPDEQAALERLGYYQRWDSGYSKQQSTRPQ
MSMEG_5658|M.smegmatis_MC2_155 GIHVNMPIARPPAEG-VGEMTEEVRQALERMQYYRKWDSGYMKQQSTRPQ
MMAR_3314|M.marinum_M AIHLNMPIAMPTRTA-LTNPTAAEQEVLAALAYHRKWGTGYFKQQSTRPQ
MAV_2202|M.avium_104 AIHLNMPIGRPGQEA-LTNPTEQERAALAALANHRKRGTGYSKQQSTRPQ
TH_4567|M.thermoresistible__bu GSPVRFGAGRGPIX-----------------XXYRRWDSGYAKQQSTRPQ
Mb1864c|M.bovis_AF2122/97 RGVVLGNTWFWPADT-LAMKAFSRVMSSPPVQYAILRRNFFVER--LIPA
Rv1833c|M.tuberculosis_H37Rv RGVVLGNTWFWPADT-LAMKAFSRVMSSPPVQYAILRRNFFVER--LIPA
MUL_4778|M.ulcerans_Agy99 TGFFGMNTAAPWFPR-DLGMVRDIWRFWYQIPILLP---VIGPRVIADPK
MAB_3556|M.abscessus_ATCC_1997 ASLSAISAGWHPAGHGPALSSLQAQRFWYQWLLNTPAGADLLRRERRELV
:
Mflv_1749|M.gilvum_PYR-GCK TLGYGLVDSPVA-QMAWIVEKFWSWMDCDGHPENVLT----KDELLDNVM
Mvan_4998|M.vanbaalenii_PYR-1 TLGYGLVDSPVG-QLAWIVEKFWSWTDCDGHPENALT----RDELLDNVM
MSMEG_5658|M.smegmatis_MC2_155 TVGYGLVDSPVG-QLAWIVEKFWSWMDCDGHPENVLS----RDELLDNVM
MMAR_3314|M.marinum_M TVGYGLTDSPVG-QLAWIVEKFWAWMDCAGNPENVLT----RDELLDNVM
MAV_2202|M.avium_104 TLGYGLADSPVG-QLAWIVEKFWDWADCDGHPENALS----RDELLDNVM
TH_4567|M.thermoresistible__bu TLGYGLVDSPVG-QLAWIVEKFWAWTDCDGHPENVLS----RDELLDNVM
Mb1864c|M.bovis_AF2122/97 GTEHRPSSAVMA-HYRAVQPNAAARRGVAEMPKQILA----ARPLLARLA
Rv1833c|M.tuberculosis_H37Rv GTEHRPSSAVMA-HYRAVQPNAAARRGVAEMPKQILA----ARPLLARLA
MUL_4778|M.ulcerans_Agy99 ARYFRVLTSWVGGGFTIADEDVRMYVERMRQPGHAVAGSRWYRTFQSSEA
MAB_3556|M.abscessus_ATCC_1997 ELIWRDWSPNWKFSDQEFDDTFTSLQSSDWLEVTLSYYR--ARWGWGPVI
.
Mflv_1749|M.gilvum_PYR-GCK LYWATATGASSARLYWESFGAFGGGDPVTLPTGVASFPKEILRSPRHWCE
Mvan_4998|M.vanbaalenii_PYR-1 LYWATGTGASSARLYWESFGSFAGGGAVTLPTGVAAFPLEILRSPRHWCE
MSMEG_5658|M.smegmatis_MC2_155 LYWVTASAASSARLYWESYDTFAGGDFVTLPTGVASFPKEILRAPRAWCE
MMAR_3314|M.marinum_M MYWVNAAAASSARLYWESFKVWGQTERVELPTGVASFPKEVLRAPRAWCE
MAV_2202|M.avium_104 VYWVTNTAASSARLYWESFSAWGGGDRVELPTGVAAFPGELLKAPRSWCE
TH_4567|M.thermoresistible__bu LYWVTGSAASSARLYWESFAVFGSTDRVRVPTGVARFPREINQAPRHWCE
Mb1864c|M.bovis_AF2122/97 REVPATLGTKPTLLIWG-MKDVAFRPKTIIPRLSATFPDHVL--------
Rv1833c|M.tuberculosis_H37Rv REVPATLGTKPTLLIWG-MKDVAFRPKTIIPRLSATFPDHVL--------
MUL_4778|M.ulcerans_Agy99 LPWMRG-EYADARVDVPVRWLHGTDDPVLTPQLLRGYEDHIS--------
MAB_3556|M.abscessus_ATCC_1997 DDPFEKQIAQATAISVPSLVLHGDSDNCVLPIASEGMNQHFPHG------
: : . * ..
Mflv_1749|M.gilvum_PYR-GCK GNYTITRWTTMPRGGHFAAFEQPSSFVDDVAAFFDDFR---
Mvan_4998|M.vanbaalenii_PYR-1 PHYNITRWTTMPRGGHFAAFEQPGPFVEEVGSFFADFR---
MSMEG_5658|M.smegmatis_MC2_155 KAYNVTHFTMMPRGGHFAAFEQPELFVEDVAKFFDSVR---
MMAR_3314|M.marinum_M PNYNITHWTTMPRGGHFAAFEQPELFVGDVRAFFATVR---
MAV_2202|M.avium_104 PAYNITHWTDMPRGGHFAAFEQPELFVEDLRVFFATVR---
TH_4567|M.thermoresistible__bu AIYPITHWTDMPRGGHFAAFEQPELFVEDVRTFFRTIR---
Mb1864c|M.bovis_AF2122/97 --------VELPNAKHFIQEDAPDRIAAAIIERFG------
Rv1833c|M.tuberculosis_H37Rv --------VELPNAKHFIQEDAPDRIAAAIIERFG------
MUL_4778|M.ulcerans_Agy99 ----DFEVEFVDGVGHWIVEQRPDLVLDRLRAFLRIET---
MAB_3556|M.abscessus_ATCC_1997 -----FSRLTTPGVGHFPQREDPLWVSGALLQWFKEWGNAR
*: : * . : :