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AVDRQPEGVRGHMAAPNVDIREFEIHETDAELNDLRMRLAAARLPETETVYRDRPDPRRWDQGVPLADLV EVAHYWRTRYDWRKFEARLNEIGQFRTTIDNLGIHFLHRRSTRTDATPLIMTHGWPGSVAEFVDVIDELA DPEDPAAPAFHVVAPSLPGFGYSDKPSTTGWGTEKIAAAWVQLMDRLGYDRFLAHGGDWGGNITTVLGGR FPDHVLGIHSTFAEAPPGLSTDGLTETQRRWTEETRDFWGRRAAYAKQQATRPQTIGYSLVDSPVGLLAW ILDKFADWSDTEDSPFEAISRDRILDDVTLYWLTRTGASAARIYYESHNSLDPELRVDVPSAITMYPRDI EKSPRPWAQERYRQMVRWNSPDRGGHFPSLEVPEFFVKDLQEGLSAVLSACAVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3407 | - | - | 100% (405) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_5658 | - | 4e-92 | 45.12% (379) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_6858 | - | 2e-89 | 46.11% (373) | epoxide hydrolase 1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 1e-10 | 34.65% (101) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_0644 | - | 3e-94 | 45.29% (382) | epocide hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1833c | - | 1e-10 | 34.65% (101) | haloalkane dehalogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3556 | - | 3e-08 | 29.79% (141) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3314 | - | 1e-89 | 43.49% (384) | hydrolase |
| M. avium 104 | MAV_2202 | - | 5e-96 | 47.33% (374) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_2132 | - | 1e-40 | 51.55% (161) | epoxide hydrolase 1 |
| M. ulcerans Agy99 | MUL_3052 | - | 2e-09 | 31.43% (105) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_4998 | - | 1e-94 | 48.79% (373) | epocide hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3314|M.marinum_M --------------------MRPFRIDVPDDVIDDLKARLTRTRWPEAEC
MAV_2202|M.avium_104 --------------------MKPFRIDVPDDVLDDLRARLARTRWPEAEC
Mflv_0644|M.gilvum_PYR-GCK -------------MRA----VRPFSIHVADDVLDDLRTRLSRTRWPEAEC
Mvan_4998|M.vanbaalenii_PYR-1 -------------MAH----IQPFRIAIPDADLADLTARLQRTRWPEAEC
TH_2132|M.thermoresistible__bu -------------MPS----VKPFRIAVPDDDLDDLRHRLARTRWPDREC
MSMEG_3407|M.smegmatis_MC2_155 MAVDRQPEGVRGHMAAPNVDIREFEIHETDAELNDLRMRLAAARLPETET
Mb1864c|M.bovis_AF2122/97 ----------------------MSIDFTPDPQLYPFESRWFDSSRGR---
Rv1833c|M.tuberculosis_H37Rv ----------------------MSIDFTPDPQLYPFESRWFDSSRGR---
MUL_3052|M.ulcerans_Agy99 ------------------MGRQFTPDFTPDPKLYPFASRWFDSSRGR---
MAB_3556|M.abscessus_ATCC_1997 ----------------------MGNTLTVQTALLDVEVRRHGNPE-----
: : . *
MMAR_3314|M.marinum_M VD-------DWSQGIPLSYTRDLAAYWANEYDWRAREAALNRFDQFITEI
MAV_2202|M.avium_104 VD-------DWSQGMPLAYTRELADYWANDYDWRAREAALNRFDQFVTEI
Mflv_0644|M.gilvum_PYR-GCK VP-------DWTQGIPLGYTRELAAYWADGYDWRSREAALNRFDQFVVEI
Mvan_4998|M.vanbaalenii_PYR-1 VD-------DWSQGIPLSYTRELAAYWADEYDWRAREASLNRFEQFTTEI
TH_2132|M.thermoresistible__bu VD-------DWGQGVPLDYVRDLAGYWADGYDWRAREAALNRFDQFITEL
MSMEG_3407|M.smegmatis_MC2_155 VYRDRPDPRRWDQGVPLADLVEVAHYWRTRYDWRKFEARLNEIGQFRTTI
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Rv1833c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3052|M.ulcerans_Agy99 --------------------------------------------------
MAB_3556|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3314|M.marinum_M DGLDLHFIHQRSPHQDAFPLLITHGWPGSVVEFHKVIEPLTNPTAHGGRA
MAV_2202|M.avium_104 DGLDIHFIHQRSPHADAFPLLITHGWPGSIVEFHKVIEPLTNPAS--GRG
Mflv_0644|M.gilvum_PYR-GCK HGVDIHFIHQRSPHQEAFPLVITHGWPGSIVEFHNVIEPLTNPTAHGGRA
Mvan_4998|M.vanbaalenii_PYR-1 DGLPIHFIHARSTRPDAFPLIITHGWPGSVVEFHKVIEPLT---------
TH_2132|M.thermoresistible__bu DGLDIHFIHQRSPHPDAFPLLITHGWPGSIVEFHKVIGPLTDPTAHGGTA
MSMEG_3407|M.smegmatis_MC2_155 DNLGIHFLHRRSTRTDATPLIMTHGWPGSVAEFVDVIDELADPED---PA
Mb1864c|M.bovis_AF2122/97 ----IHYVDE----GTGPPILLCHGNPTWSFLYRDIIVALR---------
Rv1833c|M.tuberculosis_H37Rv ----IHYVDE----GTGPPILLCHGNPTWSFLYRDIIVALR---------
MUL_3052|M.ulcerans_Agy99 ----LHYIDE----SDGPPILLCHGNPTWSFLYRHIIVALR---------
MAB_3556|M.abscessus_ATCC_1997 -------------NTDKLPVVLLHGWPDSVATWTHVIPALAS--------
*::: ** * : .:* *
MMAR_3314|M.marinum_M EDAFHVVCPSLPG-----YGFSGKPSSTGWGVDRIARAWETLMQNLGYQR
MAV_2202|M.avium_104 EDAFHVVCPSLPG-----YGFSGKPTRAGWGVERIARAWETLMLRLGYQR
Mflv_0644|M.gilvum_PYR-GCK EDAFHVVCPALPG-----YGFSGKPTNAGWGVGKIAQAWETLMLRLGYQR
Mvan_4998|M.vanbaalenii_PYR-1 DAGFHVVCPSLPG-----YGFSGKPRSTGWGVERIAAAWDELMVRLGYRR
TH_2132|M.thermoresistible__bu ADAFHVVCPSLPG-----YGFSGKPTTTGWGVGRIATXXX----------
MSMEG_3407|M.smegmatis_MC2_155 APAFHVVAPSLPG-----FGYSDKPSTTGWGTEKIAAAWVQLMDRLGYDR
Mb1864c|M.bovis_AF2122/97 -DRFRCVAPDYLG-----FGLSERPSGFGYQIDEHARVIGEFVDHLGLDR
Rv1833c|M.tuberculosis_H37Rv -DRFRCVAPDYLG-----FGLSERPSGFGYQIDEHARVIGEFVDHLGLDR
MUL_3052|M.ulcerans_Agy99 -DHFRCIAPDYLG-----FGLSEHPGTFGYKVDEHAQVVGEFVDHLGLDN
MAB_3556|M.abscessus_ATCC_1997 -AGHQVYAPSVRGTGQTKFRYADTPRTG--RLGDLLRDLFAVCDQLKLER
.: .* * : : *
MMAR_3314|M.marinum_M YGAQGGDWGAAVTTQIGRNGGRCVAIHLNMPIAMPTRTALTNPTAAEQEV
MAV_2202|M.avium_104 YGAQGGDWGAAVTTQIGRNRGHCVAIHLNMPIGRPGQEALTNPTEQERAA
Mflv_0644|M.gilvum_PYR-GCK YGAQGGDWGAAITTQMGRNRGHCAAIHLNMPIAYPPAGGITDPTEEEQLA
Mvan_4998|M.vanbaalenii_PYR-1 YGAQGGDWGGAVTTQIGRNIGHCVAIHTNMPIGRAP-KDLSDPTPDEQAA
TH_2132|M.thermoresistible__bu ------------AARAPR------------------------PTS-----
MSMEG_3407|M.smegmatis_MC2_155 FLAHGGDWGGNITTVLGGRFPDHVLGIHSTFAEAPPGLSTDGLTETQRRW
Mb1864c|M.bovis_AF2122/97 YLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMS
Rv1833c|M.tuberculosis_H37Rv YLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMS
MUL_3052|M.ulcerans_Agy99 YLTMGQDWGGPISMAVAVERAERVRGIVLGNTWFWPADTLTMKAFSTVMS
MAB_3556|M.abscessus_ATCC_1997 FHLVGHDWGARTAFACGIVAPHRIASLSAISAGWHP--------AGHGPA
:
MMAR_3314|M.marinum_M LAALAYHRKWGTGYFKQQSTRPQTVGYGLTDSPVGQLAWIVEKFWAWMDC
MAV_2202|M.avium_104 LAALANHRKRGTGYSKQQSTRPQTLGYGLADSPVGQLAWIVEKFWDWADC
Mflv_0644|M.gilvum_PYR-GCK LAALTTYQRWETGYSEQQSTRPQTVGYGLADSPVGQMAWIVEKFAAWMDC
Mvan_4998|M.vanbaalenii_PYR-1 LERLGYYQRWDSGYSKQQSTRPQTLGYGLVDSPVGQLAWIVEKFWSWTDC
TH_2132|M.thermoresistible__bu ---IRPWRRRCTG-----TTTP----------------------------
MSMEG_3407|M.smegmatis_MC2_155 TEETRDFWGRRAAYAKQQATRPQTIGYSLVDSPVGLLAWILDKFADWSDT
Mb1864c|M.bovis_AF2122/97 SPPVQYAILRRNFFVER--LIPAGTEHRPSSAVMAHYRAVQPNAAARRGV
Rv1833c|M.tuberculosis_H37Rv SPPVQYAILRRNFFVER--LIPAGTEHRPSSAVMAHYRAVQPNAAARRGV
MUL_3052|M.ulcerans_Agy99 SLPMQYAILHHNFFVER--LIPAGTTHRPSSAVMEHYRGVQPTASARVGV
MAB_3556|M.abscessus_ATCC_1997 LSSLQAQRFWYQWLLNTPAGADLLRRERRELVELIWRDWSPNWKFSDQEF
MMAR_3314|M.marinum_M AGNPENVLTRDELLDNVMMYWVNAAAASSARLYWESFKVWGQTERVELPT
MAV_2202|M.avium_104 DGHPENALSRDELLDNVMVYWVTNTAASSARLYWESFSAWGGGDRVELPT
Mflv_0644|M.gilvum_PYR-GCK DGHPENVLSRDELLDNVMMYWATNSGSSSARLYWESFKTLDATTRVELPT
Mvan_4998|M.vanbaalenii_PYR-1 DGHPENALTRDELLDNVMLYWATGTGASSARLYWESFGSFAGGGAVTLPT
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_3407|M.smegmatis_MC2_155 EDSPFEAISRDRILDDVTLYWLTRTGASAARIYYESHNSLDPELRVDVPS
Mb1864c|M.bovis_AF2122/97 AEMPKQILAARPLLARLAREVPATLGTKPTLLIWG-MKDVAFRPKTIIPR
Rv1833c|M.tuberculosis_H37Rv AEMPKQILAARPLLARLAREVPATLGTKPTLLIWG-MKDVAFRPKTIIPR
MUL_3052|M.ulcerans_Agy99 AEMPKQILAARPLLARLASEVPAQLGTKPALLVWG-MKDFAFRPEPMLAR
MAB_3556|M.abscessus_ATCC_1997 DDTFTSLQSSDWLEVTLSYYRARWGWGPVIDDPFEKQIAQATAISVPSLV
MMAR_3314|M.marinum_M GVASFPKEVLRAPRAWCEPNY-NITHWTTMPRGGHFAAFEQPELFVGDVR
MAV_2202|M.avium_104 GVAAFPGELLKAPRSWCEPAY-NITHWTDMPRGGHFAAFEQPELFVEDLR
Mflv_0644|M.gilvum_PYR-GCK GIAAFPKEVLRAPRSWCEPIY-NITHWTTMPRGGHFAALEQPRLFVDDIR
Mvan_4998|M.vanbaalenii_PYR-1 GVAAFPLEILRSPRHWCEPHY-NITRWTTMPRGGHFAAFEQPGPFVEEVG
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_3407|M.smegmatis_MC2_155 AITMYPRDIEKSPRPWAQERYRQMVRWNSPDRGGHFPSLEVPEFFVKDLQ
Mb1864c|M.bovis_AF2122/97 LSATFPDHVL-----------------VELPNAKHFIQEDAPDRIAAAII
Rv1833c|M.tuberculosis_H37Rv LSATFPDHVL-----------------VELPNAKHFIQEDAPDRIAAAII
MUL_3052|M.ulcerans_Agy99 MRAVFADHIL-----------------VELPEAKHLIQEDAPDEIAAAII
MAB_3556|M.abscessus_ATCC_1997 LHGDSDNCVLPIASEGMNQHFPHGFSRLTTPGVGHFPQREDPLWVSGALL
MMAR_3314|M.marinum_M AFFATVR------
MAV_2202|M.avium_104 VFFATVR------
Mflv_0644|M.gilvum_PYR-GCK AFFESVR------
Mvan_4998|M.vanbaalenii_PYR-1 SFFADFR------
TH_2132|M.thermoresistible__bu -------------
MSMEG_3407|M.smegmatis_MC2_155 EGLSAVLSACAVR
Mb1864c|M.bovis_AF2122/97 ERFG---------
Rv1833c|M.tuberculosis_H37Rv ERFG---------
MUL_3052|M.ulcerans_Agy99 ARFG---------
MAB_3556|M.abscessus_ATCC_1997 QWFKEWGNAR---