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TEPFEVRITEAEIADLRDRLRRTRWPEPEPVDDWSQGIPLAYVQELCHSWAHDYDFGFAERLNAFPQFRD TIDGLGIHFLHVRSPEPTAFPLVLTHGWPGSVLEFLEVLGPLTDPRAHGGDPADAFHVVAPSLPGYGWSD KPSTTGWGITRIARAWDTLMVSLGYQRYGAQGGDWGSAVSGALGEVAPERVAGVHLNMGSVAAGTFDDPT PAELANLAAANEFQRTGRGYSAQQATRPQTLGYGLTDSPAGQAAWIAEKFWAWTDNNGHPEDAVSRQQIL DEISVYWFTASATSSARLYWESFANFRDKVTAPSGLSIYPRDISRPSRREAELRFTDLRWFEELPRGGHF AAMEQPESLVEQVRGFFRLIR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6858 | - | - | 100% (372) | epoxide hydrolase 1 |
| M. smegmatis MC2 155 | MSMEG_5658 | - | e-108 | 51.87% (374) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_3407 | - | 2e-89 | 46.11% (373) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 3e-09 | 33.33% (111) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_1749 | - | 1e-115 | 54.05% (370) | epocide hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1833c | - | 3e-09 | 33.33% (111) | haloalkane dehalogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3556 | - | 2e-07 | 33.59% (128) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3314 | - | 1e-117 | 55.20% (375) | hydrolase |
| M. avium 104 | MAV_2202 | - | 1e-117 | 55.20% (375) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_2132 | - | 9e-55 | 61.44% (153) | epoxide hydrolase 1 |
| M. ulcerans Agy99 | MUL_3052 | - | 3e-07 | 29.25% (106) | haloalkane dehalogenase |
| M. vanbaalenii PYR-1 | Mvan_4998 | - | 1e-115 | 55.68% (370) | epocide hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3314|M.marinum_M ---MRPFRIDVPDDVIDDLKARLTRTRWPEAECVDDWSQGIPLSYTRDLA
MAV_2202|M.avium_104 ---MKPFRIDVPDDVLDDLRARLARTRWPEAECVDDWSQGMPLAYTRELA
Mflv_1749|M.gilvum_PYR-GCK MAHIQPFRIDVPDSVLTDLAERLQRTRWPEPECVDDWSQGIPLAYTRELA
Mvan_4998|M.vanbaalenii_PYR-1 MAHIQPFRIAIPDADLADLTARLQRTRWPEAECVDDWSQGIPLSYTRELA
TH_2132|M.thermoresistible__bu MPSVKPFRIAVPDDDLDDLRHRLARTRWPDRECVDDWGQGVPLDYVRDLA
MSMEG_6858|M.smegmatis_MC2_155 --MTEPFEVRITEAEIADLRDRLRRTRWPEPEPVDDWSQGIPLAYVQELC
Mb1864c|M.bovis_AF2122/97 ----------------------MSIDFTPDPQ-------------LYPFE
Rv1833c|M.tuberculosis_H37Rv ----------------------MSIDFTPDPQ-------------LYPFE
MUL_3052|M.ulcerans_Agy99 ------------------MGRQFTPDFTPDPK-------------LYPFA
MAB_3556|M.abscessus_ATCC_1997 ------------------------------------------MGNTLTVQ
.
MMAR_3314|M.marinum_M AYWANEYDWRAREAALNRFDQFITEIDGLDLHFIHQRSPHQDAFPLLITH
MAV_2202|M.avium_104 DYWANDYDWRAREAALNRFDQFVTEIDGLDIHFIHQRSPHADAFPLLITH
Mflv_1749|M.gilvum_PYR-GCK DYWANEYDWRSRESMLNRFDQFTTEIDGLDIHFVHQRSPRPDAFPLIITH
Mvan_4998|M.vanbaalenii_PYR-1 AYWADEYDWRAREASLNRFEQFTTEIDGLPIHFIHARSTRPDAFPLIITH
TH_2132|M.thermoresistible__bu GYWADGYDWRAREAALNRFDQFITELDGLDIHFIHQRSPHPDAFPLLITH
MSMEG_6858|M.smegmatis_MC2_155 HSWAHDYDFGFAER-LNAFPQFRDTIDGLGIHFLHVRSPEPTAFPLVLTH
Mb1864c|M.bovis_AF2122/97 SRWFDSSRGR--------------------IHYVD----EGTGPPILLCH
Rv1833c|M.tuberculosis_H37Rv SRWFDSSRGR--------------------IHYVD----EGTGPPILLCH
MUL_3052|M.ulcerans_Agy99 SRWFDSSRGR--------------------LHYID----ESDGPPILLCH
MAB_3556|M.abscessus_ATCC_1997 TALLDVEVRR------------------------HGNPENTDKLPVVLLH
. . . *::: *
MMAR_3314|M.marinum_M GWPGSVVEFHKVIEPLTNPTAHGGRAEDAFHVVCPSLPG-----YGFSGK
MAV_2202|M.avium_104 GWPGSIVEFHKVIEPLTNPAS--GRGEDAFHVVCPSLPG-----YGFSGK
Mflv_1749|M.gilvum_PYR-GCK GWPGSIVEFQKVIAPLT---------EAGFHVVCPSLPG-----YGFSGK
Mvan_4998|M.vanbaalenii_PYR-1 GWPGSVVEFHKVIEPLT---------DAGFHVVCPSLPG-----YGFSGK
TH_2132|M.thermoresistible__bu GWPGSIVEFHKVIGPLTDPTAHGGTAADAFHVVCPSLPG-----YGFSGK
MSMEG_6858|M.smegmatis_MC2_155 GWPGSVLEFLEVLGPLTDPRAHGGDPADAFHVVAPSLPG-----YGWSDK
Mb1864c|M.bovis_AF2122/97 GNPTWSFLYRDIIVALR----------DRFRCVAPDYLG-----FGLSER
Rv1833c|M.tuberculosis_H37Rv GNPTWSFLYRDIIVALR----------DRFRCVAPDYLG-----FGLSER
MUL_3052|M.ulcerans_Agy99 GNPTWSFLYRHIIVALR----------DHFRCIAPDYLG-----FGLSEH
MAB_3556|M.abscessus_ATCC_1997 GWPDSVATWTHVIPALAS---------AGHQVYAPSVRGTGQTKFRYADT
* * : .:: .* .: .*. * : :
MMAR_3314|M.marinum_M PSSTGWGVDRIARAWETLMQNLGYQRYGAQGGDWGAAVTTQIGRNGGRCV
MAV_2202|M.avium_104 PTRAGWGVERIARAWETLMLRLGYQRYGAQGGDWGAAVTTQIGRNRGHCV
Mflv_1749|M.gilvum_PYR-GCK PTATGWGVERIAAAWDELMVRLGYDRYGAQGGDWGAAVTTQIGRNVGHCV
Mvan_4998|M.vanbaalenii_PYR-1 PRSTGWGVERIAAAWDELMVRLGYRRYGAQGGDWGGAVTTQIGRNIGHCV
TH_2132|M.thermoresistible__bu PTTTGWGVGRIATXXX----------------------------------
MSMEG_6858|M.smegmatis_MC2_155 PSTTGWGITRIARAWDTLMVSLGYQRYGAQGGDWGSAVSGALGEVAPERV
Mb1864c|M.bovis_AF2122/97 PSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRV
Rv1833c|M.tuberculosis_H37Rv PSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRV
MUL_3052|M.ulcerans_Agy99 PGTFGYKVDEHAQVVGEFVDHLGLDNYLTMGQDWGGPISMAVAVERAERV
MAB_3556|M.abscessus_ATCC_1997 PRTG--RLGDLLRDLFAVCDQLKLERFHLVGHDWGARTAFACGIVAPHRI
* :
MMAR_3314|M.marinum_M AIHLNMPIAMPTRTA-LTNPTAAEQEVLAALAYHRKWGTGYFKQQSTRPQ
MAV_2202|M.avium_104 AIHLNMPIGRPGQEA-LTNPTEQERAALAALANHRKRGTGYSKQQSTRPQ
Mflv_1749|M.gilvum_PYR-GCK AIHTNMPFGRPPK-S-LSDPDADEVAALERLGYYQKWDSGYSKQQATRPQ
Mvan_4998|M.vanbaalenii_PYR-1 AIHTNMPIGRAPK-D-LSDPTPDEQAALERLGYYQRWDSGYSKQQSTRPQ
TH_2132|M.thermoresistible__bu -------AARAPR------PTS--------IRPWRRRCTG-----TTTP-
MSMEG_6858|M.smegmatis_MC2_155 AG-VHLNMGSVAAGT-FDDPTPAELANLAAANEFQRTGRGYSAQQATRPQ
Mb1864c|M.bovis_AF2122/97 RGVVLGNTWFWPADT-LAMKAFSRVMSSPPVQYAILRRNFFVER--LIPA
Rv1833c|M.tuberculosis_H37Rv RGVVLGNTWFWPADT-LAMKAFSRVMSSPPVQYAILRRNFFVER--LIPA
MUL_3052|M.ulcerans_Agy99 RGIVLGNTWFWPADT-LTMKAFSTVMSSLPMQYAILHHNFFVER--LIPA
MAB_3556|M.abscessus_ATCC_1997 ASLSAISAGWHPAGHGPALSSLQAQRFWYQWLLNTPAGADLLRRERRELV
MMAR_3314|M.marinum_M TVGYGLTDSPVGQLAWIVEKFWAWMDCAGNPENVLT---RDELLDNVMMY
MAV_2202|M.avium_104 TLGYGLADSPVGQLAWIVEKFWDWADCDGHPENALS---RDELLDNVMVY
Mflv_1749|M.gilvum_PYR-GCK TLGYGLVDSPVAQMAWIVEKFWSWMDCDGHPENVLT---KDELLDNVMLY
Mvan_4998|M.vanbaalenii_PYR-1 TLGYGLVDSPVGQLAWIVEKFWSWTDCDGHPENALT---RDELLDNVMLY
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_6858|M.smegmatis_MC2_155 TLGYGLTDSPAGQAAWIAEKFWAWTDNNGHPEDAVS---RQQILDEISVY
Mb1864c|M.bovis_AF2122/97 GTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILA---ARPLLARLARE
Rv1833c|M.tuberculosis_H37Rv GTEHRPSSAVMAHYRAVQPNAAARRGVAEMPKQILA---ARPLLARLARE
MUL_3052|M.ulcerans_Agy99 GTTHRPSSAVMEHYRGVQPTASARVGVAEMPKQILA---ARPLLARLASE
MAB_3556|M.abscessus_ATCC_1997 ELIWRDWSPNWKFSDQEFDDTFTSLQSSDWLEVTLSYYRARWGWGPVIDD
MMAR_3314|M.marinum_M WVNAAAASSARLYWESFKVWGQTERVELPTGVASFPKEVLRAPRAWCEPN
MAV_2202|M.avium_104 WVTNTAASSARLYWESFSAWGGGDRVELPTGVAAFPGELLKAPRSWCEPA
Mflv_1749|M.gilvum_PYR-GCK WATATGASSARLYWESFGAFGGGDPVTLPTGVASFPKEILRSPRHWCEGN
Mvan_4998|M.vanbaalenii_PYR-1 WATGTGASSARLYWESFGSFAGGGAVTLPTGVAAFPLEILRSPRHWCEPH
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_6858|M.smegmatis_MC2_155 WFTASATSSARLYWESFANFR--DKVTAPSGLSIYPRDISRPSRREAELR
Mb1864c|M.bovis_AF2122/97 VPATLGTKPTLLIWG-MKDVAFRPKTIIPRLSATFPDHVL----------
Rv1833c|M.tuberculosis_H37Rv VPATLGTKPTLLIWG-MKDVAFRPKTIIPRLSATFPDHVL----------
MUL_3052|M.ulcerans_Agy99 VPAQLGTKPALLVWG-MKDFAFRPEPMLARMRAVFADHIL----------
MAB_3556|M.abscessus_ATCC_1997 PFEKQIAQATAISVPSLVLHGDSDNCVLPIASEGMNQHFPHGFSR-----
MMAR_3314|M.marinum_M YN-ITHWTTMPRGGHFAAFEQPELFVGDVRAFFATVR---
MAV_2202|M.avium_104 YN-ITHWTDMPRGGHFAAFEQPELFVEDLRVFFATVR---
Mflv_1749|M.gilvum_PYR-GCK YT-ITRWTTMPRGGHFAAFEQPSSFVDDVAAFFDDFR---
Mvan_4998|M.vanbaalenii_PYR-1 YN-ITRWTTMPRGGHFAAFEQPGPFVEEVGSFFADFR---
TH_2132|M.thermoresistible__bu ----------------------------------------
MSMEG_6858|M.smegmatis_MC2_155 FTDLRWFEELPRGGHFAAMEQPESLVEQVRGFFRLIR---
Mb1864c|M.bovis_AF2122/97 -------VELPNAKHFIQEDAPDRIAAAIIERFG------
Rv1833c|M.tuberculosis_H37Rv -------VELPNAKHFIQEDAPDRIAAAIIERFG------
MUL_3052|M.ulcerans_Agy99 -------VELPEAKHLIQEDAPDEIAAAIIARFG------
MAB_3556|M.abscessus_ATCC_1997 -------LTTPGVGHFPQREDPLWVSGALLQWFKEWGNAR