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AHIQPFRIDVPDSVLTDLAERLQRTRWPEPECVDDWSQGIPLAYTRELADYWANEYDWRSRESMLNRFDQ FTTEIDGLDIHFVHQRSPRPDAFPLIITHGWPGSIVEFQKVIAPLTEAGFHVVCPSLPGYGFSGKPTATG WGVERIAAAWDELMVRLGYDRYGAQGGDWGAAVTTQIGRNVGHCVAIHTNMPFGRPPKSLSDPDADEVAA LERLGYYQKWDSGYSKQQATRPQTLGYGLVDSPVAQMAWIVEKFWSWMDCDGHPENVLTKDELLDNVMLY WATATGASSARLYWESFGAFGGGDPVTLPTGVASFPKEILRSPRHWCEGNYTITRWTTMPRGGHFAAFEQ PSSFVDDVAAFFDDFR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1749 | - | - | 100% (367) | epocide hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0644 | - | e-160 | 68.98% (374) | epocide hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_0561 | - | e-160 | 68.98% (374) | epocide hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 1e-07 | 29.76% (84) | haloalkane dehalogenase |
| M. tuberculosis H37Rv | Rv3617 | ephA | 3e-08 | 35.29% (85) | epoxide hydrolase EphA |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0679c | - | 9e-08 | 28.21% (117) | hydrolase |
| M. marinum M | MMAR_3314 | - | 1e-167 | 72.19% (374) | hydrolase |
| M. avium 104 | MAV_2202 | - | 1e-171 | 74.46% (372) | epoxide hydrolase |
| M. smegmatis MC2 155 | MSMEG_5658 | - | 1e-176 | 77.26% (365) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_4567 | - | 3e-68 | 74.00% (150) | PUTATIVE epoxide hydrolase |
| M. ulcerans Agy99 | MUL_4193 | ephA | 8e-08 | 35.00% (80) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_4998 | - | 0.0 | 84.20% (367) | epocide hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1749|M.gilvum_PYR-GCK --MAHIQPFRIDVPDSVLTDLAERLQRTRWPEPECVDDWSQGIPLAYTRE
Mvan_4998|M.vanbaalenii_PYR-1 --MAHIQPFRIAIPDADLADLTARLQRTRWPEAECVDDWSQGIPLSYTRE
MSMEG_5658|M.smegmatis_MC2_155 MTDSLIRPFRIAVPDADLDDLKSRLSRTRWPEPETVDDWGQGIPLDYTRE
MMAR_3314|M.marinum_M -----MRPFRIDVPDDVIDDLKARLTRTRWPEAECVDDWSQGIPLSYTRD
MAV_2202|M.avium_104 -----MKPFRIDVPDDVLDDLRARLARTRWPEAECVDDWSQGMPLAYTRE
TH_4567|M.thermoresistible__bu --------------------------------------------------
Rv3617|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4193|M.ulcerans_Agy99 --------------------------------------------------
MAB_0679c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
Mflv_1749|M.gilvum_PYR-GCK LADYWANEYDWRSRESMLNRFDQFTTEIDGLDIHFVHQRSPRPDAFPLII
Mvan_4998|M.vanbaalenii_PYR-1 LAAYWADEYDWRAREASLNRFEQFTTEIDGLPIHFIHARSTRPDAFPLII
MSMEG_5658|M.smegmatis_MC2_155 LAEYWANGYDWRAREQALNRFDHYVTELDGLDIHFIHQRCARPDAFPLLL
MMAR_3314|M.marinum_M LAAYWANEYDWRAREAALNRFDQFITEIDGLDLHFIHQRSPHQDAFPLLI
MAV_2202|M.avium_104 LADYWANDYDWRAREAALNRFDQFVTEIDGLDIHFIHQRSPHADAFPLLI
TH_4567|M.thermoresistible__bu --------------------------------VVIVSATAWRIVGYAGLI
Rv3617|M.tuberculosis_H37Rv -----------------MGAPTERLVDTNGVRLRVVEAG--EPGAPVVIL
MUL_4193|M.ulcerans_Agy99 ----------------MVATSTERLVDTNGVRLRVTEAG--ERGAPVVIL
MAB_0679c|M.abscessus_ATCC_199 -------------------MSRLSTFTNDGLTFDVIDEG--ALDGPVIVA
Mb1864c|M.bovis_AF2122/97 -------MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEG----TGPPILL
. . :
Mflv_1749|M.gilvum_PYR-GCK THGWPGSIVEFQKVIAPLT---------EAGFHVVCPSLPGYGFSGKP-T
Mvan_4998|M.vanbaalenii_PYR-1 THGWPGSVVEFHKVIEPLT---------DAGFHVVCPSLPGYGFSGKP-R
MSMEG_5658|M.smegmatis_MC2_155 THGWPGSIVEFHKVIEPLT---------EAGFDVVCPSLPGYGFSGKP-T
MMAR_3314|M.marinum_M THGWPGSVVEFHKVIEPLTNPTAHGGRAEDAFHVVCPSLPGYGFSGKP-S
MAV_2202|M.avium_104 THGWPGSIVEFHKVIEPLTNPAS--GRGEDAFHVVCPSLPGYGFSGKP-T
TH_4567|M.thermoresistible__bu AGG-----VWLAQATAPVAG-----------------AQPGDDDSGD--S
Rv3617|M.tuberculosis_H37Rv AHGFPELAYSWRHQIPALA---------DAGYHVLAPDQRGYGGSSRPEA
MUL_4193|M.ulcerans_Agy99 AHGFPELAYSWRHQIPVLA---------EAGYHVLAPDQRGYGGSSRPEA
MAB_0679c|M.abscessus_ATCC_199 LHGFPERATMWEEVIPQLTG---------AGFRVLAPNQRGYSPGARPVG
Mb1864c|M.bovis_AF2122/97 CHGNPTWSFLYRDIIVALR----------DRFRCVAPDYLGFGLSERP-S
* . : * . .
Mflv_1749|M.gilvum_PYR-GCK ATGWGVERIAAAWDELMVRLGYDRYGAQGGDWGAAVTTQIGRNVGHCVAI
Mvan_4998|M.vanbaalenii_PYR-1 STGWGVERIAAAWDELMVRLGYRRYGAQGGDWGGAVTTQIGRNIGHCVAI
MSMEG_5658|M.smegmatis_MC2_155 TTGWGIGRIAQAWDTLMTRLGYDRYGAQGGDWGAAVTTQIGRNVGNCVGI
MMAR_3314|M.marinum_M STGWGVDRIARAWETLMQNLGYQRYGAQGGDWGAAVTTQIGRNGGRCVAI
MAV_2202|M.avium_104 RAGWGVERIARAWETLMLRLGYQRYGAQGGDWGAAVTTQIGRNRGHCVAI
TH_4567|M.thermoresistible__bu GAGRSSQ---SATPAASAQAGSARAGSS--QAGSPRTADARRN-----GS
Rv3617|M.tuberculosis_H37Rv IEAYDIHRLTADLVGLLDDVGAERAVWVGHDWGAVVVWNAPLLHADRVAA
MUL_4193|M.ulcerans_Agy99 IEDYDIHQLTADLVGLLDDVGAERAAWVGHDWGAVVVWNAPLLHPDRVAA
MAB_0679c|M.abscessus_ATCC_199 VRNYAVDKLEGDIIALVDQAGVRKFHVLAHDWGAAVAWQLAGNHADRVQT
Mb1864c|M.bovis_AF2122/97 GFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRVRG
* : : *.
Mflv_1749|M.gilvum_PYR-GCK HTNMPFGRPPKS-LSDPDADEV---AALERLGYYQKWDSGYSKQQATRPQ
Mvan_4998|M.vanbaalenii_PYR-1 HTNMPIGRAPKD-LSDPTPDEQ---AALERLGYYQRWDSGYSKQQSTRPQ
MSMEG_5658|M.smegmatis_MC2_155 HVNMPIARPPAEGVGEMTEEVR---QALERMQYYRKWDSGYMKQQSTRPQ
MMAR_3314|M.marinum_M HLNMPIAMPTRTALTNPTAAEQ---EVLAALAYHRKWGTGYFKQQSTRPQ
MAV_2202|M.avium_104 HLNMPIGRPGQEALTNPTEQER---AALAALANHRKRGTGYSKQQSTRPQ
TH_4567|M.thermoresistible__bu PVRFGAGRGPIX-------------------XXYRRWDSGYAKQQSTRPQ
Rv3617|M.tuberculosis_H37Rv VAALSVPALPRAQVPPTQAFRSRFGENFFYILYFQEPGIADAELNGDPAR
MUL_4193|M.ulcerans_Agy99 VAGLSVPVLPRAQVPPIQAFRQRFGEHFFYILYFQQPGVADAELNGDPAR
MAB_0679c|M.abscessus_ATCC_199 LSILSVPHPRAFQDAMLRGQLL----HSWYMLLFQIPRLPEWLFGFNETE
Mb1864c|M.bovis_AF2122/97 VVLGNTWFWPADTLAMKAFSRVMSSPPVQYAILRRNFFVERLIPAGTEHR
: .
Mflv_1749|M.gilvum_PYR-GCK TLG--YGLVDSP------VAQMAWIVEKFWSWMDCDGHPENVLTKDELLD
Mvan_4998|M.vanbaalenii_PYR-1 TLG--YGLVDSP------VGQLAWIVEKFWSWTDCDGHPENALTRDELLD
MSMEG_5658|M.smegmatis_MC2_155 TVG--YGLVDSP------VGQLAWIVEKFWSWMDCDGHPENVLSRDELLD
MMAR_3314|M.marinum_M TVG--YGLTDSP------VGQLAWIVEKFWAWMDCAGNPENVLTRDELLD
MAV_2202|M.avium_104 TLG--YGLADSP------VGQLAWIVEKFWDWADCDGHPENALSRDELLD
TH_4567|M.thermoresistible__bu TLG--YGLVDSP------VGQLAWIVEKFWAWTDCDGHPENVLSRDELLD
Rv3617|M.tuberculosis_H37Rv TMRRMIGGLRPPGDQSAAMRMLAPGPDGFIDRLPEPAGLPAWISQEELDH
MUL_4193|M.ulcerans_Agy99 TMRRMIGGQRSPTDQGAALRMVAPGPEGFIDRLPEPDAPPSWISRDELDH
MAB_0679c|M.abscessus_ATCC_199 AFK----KFGKS-----WMKVSDRLAERIRELFSEPGATTATVN----WY
Mb1864c|M.bovis_AF2122/97 PSS-------------AVMAHYRAVQPNAAARRGVAEMPKQILAARPLLA
. : :
Mflv_1749|M.gilvum_PYR-GCK NVMLYWATATGASS-----ARLYWESFGAFGGGDPVTLPTGVASFPKEIL
Mvan_4998|M.vanbaalenii_PYR-1 NVMLYWATGTGASS-----ARLYWESFGSFAGGGAVTLPTGVAAFPLEIL
MSMEG_5658|M.smegmatis_MC2_155 NVMLYWVTASAASS-----ARLYWESYDTFAGGDFVTLPTGVASFPKEIL
MMAR_3314|M.marinum_M NVMMYWVNAAAASS-----ARLYWESFKVWGQTERVELPTGVASFPKEVL
MAV_2202|M.avium_104 NVMVYWVTNTAASS-----ARLYWESFSAWGGGDRVELPTGVAAFPGELL
TH_4567|M.thermoresistible__bu NVMLYWVTGSAASS-----ARLYWESFAVFGSTDRVRVPTGVARFPREIN
Rv3617|M.tuberculosis_H37Rv YIGEFTRTGFTGGLNWYRNFDRNWETTADLAGKTISVPSLFIAGTADPVL
MUL_4193|M.ulcerans_Agy99 YISEFTRTGFTGGLNWYRNFDRNWETTADLEGATITVPSLFMAGTKDPVL
MAB_0679c|M.abscessus_ATCC_199 RAMRYSLRSPARPS---------------------RVPTLFIWSDGDSAV
Mb1864c|M.bovis_AF2122/97 RLAREVPATLGTKP------------------------TLLIWGMKDVAF
. :
Mflv_1749|M.gilvum_PYR-GCK RSPR--HWCEGNYTITRWTTMPRGGHFAAFEQPSSFVDDVAAFFDDFR--
Mvan_4998|M.vanbaalenii_PYR-1 RSPR--HWCEPHYNITRWTTMPRGGHFAAFEQPGPFVEEVGSFFADFR--
MSMEG_5658|M.smegmatis_MC2_155 RAPR--AWCEKAYNVTHFTMMPRGGHFAAFEQPELFVEDVAKFFDSVR--
MMAR_3314|M.marinum_M RAPR--AWCEPNYNITHWTTMPRGGHFAAFEQPELFVGDVRAFFATVR--
MAV_2202|M.avium_104 KAPR--SWCEPAYNITHWTDMPRGGHFAAFEQPELFVEDLRVFFATVR--
TH_4567|M.thermoresistible__bu QAPR--HWCEAIYPITHWTDMPRGGHFAAFEQPELFVEDVRTFFRTIR--
Rv3617|M.tuberculosis_H37Rv TFTRTDRAAEVISGPYREVLIDGAGHWLQQERPGEVTAALLEFLTGLELR
MUL_4193|M.ulcerans_Agy99 SFARSDRASEVITGPYREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW-
MAB_0679c|M.abscessus_ATCC_199 TRAAADATPKYVEAPYRFEVFEGVSHWIAEERPLETAALVLEHIAEYSA-
Mb1864c|M.bovis_AF2122/97 RPKTIIPRLSATFPDHVLVELPNAKHFIQEDAPDRIAAAIIERFG-----
. . *: : * : :